Cell death and deubiquitinases: Perspectives in cancer

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Bhattacharya, Seemana ^a   Ghosh, Mrinal Kanti ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

A20 PROTEIN; BETA CATENIN; CASPASE; CYLINDROMATOSIS PROTEIN; DEUBIQUITINASE; DNA; GRANZYME A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL 2; PROTEIN P53; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR FOXO; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN SPECIFIC PROTEASE 7; UNCLASSIFIED DRUG; WNT PROTEIN; ENZYME INHIBITOR;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL DIVISION; CELL SURVIVAL; CYTOSOL; DNA DAMAGE; DNA REPAIR; DOUBLE STRAND BREAK REPAIR; DOUBLE STRANDED DNA BREAK; ENDOPLASMIC RETICULUM STRESS; ENZYME SPECIFICITY; EXCISION REPAIR; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; LYSOSOME; M PHASE CELL CYCLE CHECKPOINT; MALIGNANT NEOPLASTIC DISEASE; MITOCHONDRIAL PERMEABILITY; MITOSIS; NECROPTOSIS; ONCOGENE; PROTEIN TARGETING; PYROPTOSIS; REGULATORY MECHANISM; SENESCENCE; SIGNAL TRANSDUCTION; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; NEOPLASM; PATHOLOGY;

CELL DEATH; ENZYME INHIBITORS; HUMANS; NEOPLASMS; SIGNAL TRANSDUCTION; UBIQUITIN-SPECIFIC PROTEASES;

EID: 84904808417     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/435197     Document Type: Article

References (179)

1. Bröker L. E., Kruyt F. A. E., Giaccone G., Cell death independent of caspases: a review. Clinical Cancer Research 2005 11 9 3155 3162 10.1158/1078-0432.CCR-04-2223 2-s2.0-18244392443 (Pubitemid 40627860)
2. Vaux D. L., Haecker G., Strasser A., An evolutionary perspective on apoptosis. Cell 1994 76 5 777 779 10.1016/0092-8674(94)90350-6 2-s2.0-0028326952 (Pubitemid 24085313)
3. Wu Y., Tan H., Huang Q., Kim Y., Pan N., Ong W., Liu Z., Ong C., Shen H., Autophagy plays a protective role during zVAD-induced necrotic cell death. Autophagy 2008 4 4 457 466 2-s2.0-43949085388 (Pubitemid 351705142)
4. Green D. R., Victor B., The pantheon of the fallen: why are there so many forms of cell death? Trends in Cell Biology 2012 22 11 555 556 10.1016/j.tcb.2012.08.008 2-s2.0-84867866959
5. Reiner T., Parrondo R., de las Pozas A., Palenzuela D., Perez-Stable C., Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity. PLoS ONE 2013 8 2 e56234
6. Cao M. N., Zhou Y. B., Gao A. H., Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth. Biochimica et Biophysica Acta 2014 1840 6 2004 2013 10.1016/j.bbagen.2014.02.006
7. Altun M., Kramer H. B., Willems L. I., McDermott J. L., Leach C. A., Goldenberg S. J., Kumar K. G. S., Konietzny R., Fischer R., Kogan E., MacKeen M. M., McGouran J., Khoronenkova S. V., Parsons J. L., Dianov G. L., Nicholson B., Kessler B. M., Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chemistry and Biology 2011 18 11 1401 1412 10.1016/j.chembiol.2011.08.018 2-s2.0-82255181181
8. Guédat P., Colland F., Patented small molecule inhibitors in the ubiquitin proteasome system. BMC Biochemistry 2007 8 supplement 1, article S14 10.1186/1471-2091-8-S1-S14 2-s2.0-38449114884 (Pubitemid 351813994)
9. D'Arcy P., Brnjic S., Olofsson M. H., Fryknäs M., Lindsten K., De Cesare M., Perego P., Sadeghi B., Hassan M., Larsson R., Linder S., Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nature Medicine 2011 17 12 1636 1640 10.1038/nm.2536 2-s2.0-84856085129
10. Kapuria V., Peterson L. F., Fang D., Bornmann W. G., Talpaz M., Donato N. J., Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis. Cancer Research 2010 70 22 9265 9276 10.1158/0008-5472.CAN-10-1530 2-s2.0-78549247880
11. Mermerian A. H., Case A., Stein R. L., Cuny G. D., Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorganic & Medicinal Chemistry Letters 2007 17 13 3729 3732 10.1016/j.bmcl.2007.04.027 2-s2.0-34250160956 (Pubitemid 46898801)
12. Chen J., Dexheimer T. S., Ai Y., Liang Q., Villamil M. A., Inglese J., Maloney D. J., Jadhav A., Simeonov A., Zhuang Z., Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chemistry & Biology 2011 18 11 1390 1400 10.1016/j.chembiol.2011.08.014 2-s2.0-82255194029
13. Colland F., Formstecher E., Jacq X., Reverdy C., Planquette C., Conrath S., Trouplin V., Bianchi J., Aushev V. N., Camonis J., Calabrese A., Borg-Capra C., Sippl W., Collura V., Boissy G., Rain J., Guedat P., Delansorne R., Daviet L., Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Molecular Cancer Therapeutics 2009 8 8 2286 2295 10.1158/1535-7163.MCT-09-0097 2-s2.0-68849126660
14. Reverdy C., Conrath S., Lopez R., Planquette C., Atmanene C., Collura V., Harpon J., Battaglia V., Vivat V., Sippl W., Colland F., Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme. Chemistry and Biology 2012 19 4 467 477 10.1016/j.chembiol.2012.02.007 2-s2.0-84860112066
15. Yamaguchi M., Miyazaki M., Kodrasov M. P., Rotinsulu H., Losung F., Mangindaan R. E. P., De Voogd N. J., Yokosawa H., Nicholson B., Tsukamoto S., Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor. Bioorganic and Medicinal Chemistry Letters 2013 23 13 3884 3886 10.1016/j.bmcl.2013.04.066 2-s2.0-84878839876
16. Daviet L., Colland F., Targeting ubiquitin specific proteases for drug discovery. Biochimie 2008 90 2 270 283 10.1016/j.biochi.2007.09.013 2-s2.0-38849110179 (Pubitemid 351187762)
17. Colombo M., Vallese S., Peretto I., Jacq X., Rain J., Colland F., Guedat P., Synthesis and biological evaluation of 9-oxo-9 H -indeno[1,2-b]pyrazine-2,3- dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 2010 5 4 552 558 10.1002/cmdc.200900409 2-s2.0-77950678464
18. Lee B., Lee M. J., Park S., Oh D., Elsasser S., Chen P., Gartner C., Dimova N., Hanna J., Gygi S. P., Wilson S. M., King R. W., Finley D., Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 2010 467 7312 179 184 10.1038/nature09299 2-s2.0-77956527159
19. Kulathu Y., Komander D., Atypical ubiquitylation-the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages. Nature Reviews Molecular Cell Biology 2012 13 8 508 523 10.1038/nrm3394 2-s2.0-84864222562
20. Fraile J. M., Quesada V., Rodríguez D., Freije J. M. P., López-Otín C., Deubiquitinases in cancer: new functions and therapeutic options. Oncogene 2012 31 19 2373 2388 10.1038/onc.2011.443 2-s2.0-84861380457
21. Reyes-Turcu F. E., Ventii K. H., Wilkinson K. D., Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annual Review of Biochemistry 2009 78 363 397 10.1146/annurev.biochem.78.082307.091526 2-s2.0-67650620318
22. Kim J. H., Park K. C., Chung S. S., Bang O., Chung C. H., Deubiquitinating enzymes as cellular regulators. Journal of Biochemistry 2003 134 1 9 18 10.1093/jb/mvg107 2-s2.0-0042320492 (Pubitemid 37071174)
23. Ventii K. H., Wilkinson K. D., Protein partners of deubiquitinating enzymes. Biochemical Journal 2008 414 2 161 175 10.1042/BJ20080798 2-s2.0-50949126350
24. Hussain S., Zhang Y., Galardy P. J., DUBs and cancer: The role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors. Cell Cycle 2009 8 11 1688 1697 10.4161/cc.8.11.8739 2-s2.0-66749083491
25. Clague M. J., Coulson J. M., Urbé S., Cellular functions of the DUBs. Journal of Cell Science 2012 125 2 277 286 10.1242/jcs.090985 2-s2.0-84858119736
26. Duprez L., Wirawan E., Berghe T. V., Vandenabeele P., Major cell death pathways at a glance. Microbes and Infection 2009 11 13 1050 1062 10.1016/j.micinf.2009.08.013 2-s2.0-70349782208
27. Murphy J. M., Silke J., Ars Moriendi; the art of dying well-new insights into the molecular pathways of necroptotic cell death. EMBO Reports 2014 15 2 155 164
28. Kroemer G., Galluzzi L., Vandenabeele P., Abrams J., Alnemri E. S., Baehrecke E. H., Blagosklonny M. V., El-Deiry W. S., Golstein P., Green D. R., Hengartner M., Knight R. A., Kumar S., Lipton S. A., Malorni W., Nuñez G., Peter M. E., Tschopp J., Yuan J., Piacentini M., Zhivotovsky B., Melino G., Classification of cell death: recommendations of the nomenclature committee on cell death 2009. Cell Death and Differentiation 2009 16 1 3 11 10.1038/cdd.2008.150 2-s2.0-57649149333
29. Galluzzi L., Vitale I., Abrams J. M., Alnemri E. S., Baehrecke E. H., Blagosklonny M. V., Dawson T. M., Dawson V. L., El-Deiry W. S., Fulda S., Gottlieb E., Green D. R., Hengartner M. O., Kepp O., Knight R. A., Kumar S., Lipton S. A., Lu X., Madeo F., Malorni W., Mehlen P., Nũez G., Peter M. E., Piacentini M., Rubinsztein D. C., Shi Y., Simon H.-., Vandenabeele P., White E., Yuan J., Zhivotovsky B., Melino G., Kroemer G., Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death and Differentiation 2012 19 1 107 120 10.1038/cdd.2011.96 2-s2.0-84255210700
30. Bergsbaken T., Fink S. L., Cookson B. T., Pyroptosis: host cell death and inflammation. Nature Reviews Microbiology 2009 7 2 99 109 10.1038/nrmicro2070 2-s2.0-58449083290
31. Sperandio S., Poksay K., de Belle I., Lafuente M. J., Liu B., Nasir J., Bredesen D. E., Paraptosis: mediation by MAP kinases and inhibition by AIP-1/Alix. Cell Death and Differentiation 2004 11 10 1066 1075 10.1038/sj.cdd.4401465 2-s2.0-5044249067 (Pubitemid 39341632)
32. Castedo M., Perfettini J. L., Roumier T., Andreau K., Medema R., Kroemer G., Cell death by mitotic catastrophe: a molecular definition. Oncogene 2004 23 16 2825 2837 10.1038/sj.onc.1207528 2-s2.0-2342635919 (Pubitemid 38638845)
33. Rodier F., Campisi J., Four faces of cellular senescence. The Journal of Cell Biology 2011 192 4 547 556 10.1083/jcb.201009094 2-s2.0-79951912532
34. Shay J. W., Bacchetti S., A survey of telomerase activity in human cancer. European Journal of Cancer A 1997 33 5 787 791 10.1016/S0959-8049(97) 00062-2 2-s2.0-0031010342 (Pubitemid 27239490)
35. Kuilman T., Michaloglou C., Mooi W. J., Peeper D. S., The essence of senescence. Genes and Development 2010 24 22 2463 2479 10.1101/gad.1971610 2-s2.0-78349257844
36. Youle R. J., Strasser A., The BCL-2 protein family: opposing activities that mediate cell death. Nature Reviews Molecular Cell Biology 2008 9 1 47 59 10.1038/nrm2308 2-s2.0-37549048249
37. Engel T., Henshall D. C., Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? International Journal of Physiology, Pathophysiology and Pharmacology 2009 1 2 97 115 2-s2.0-76749107731
38. Salvesen G. S., Riedl S. J., Caspase mechanisms. Advances in Experimental Medicine and Biology 2008 615 13 23 10.1007/978-1-4020-6554-5-2 2-s2.0-43249114217
39. Oliver O. J., Menissier-de Murcia J., De Murcia G., Poly(ADP-Ribose) polymerase in the cellular response to DNA damage, apoptosis, and disease. The American Journal of Human Genetics 1999 64 5 1282 1288 10.1086/302389 2-s2.0-0033362084 (Pubitemid 30468745)
40. 2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death and Differentiation 2008 15 12 1857 1864 10.1038/cdd.2008.123 2-s2.0-56349169766
41. Yu S. W., Wang H., Poitras M. F., Coombs C., Bowers W. J., Federoff H. J., Poirier G. G., Dawson T. M., Dawson V. L., Mediation of poly (ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science 2002 297 5579 259 263 10.1126/science.1072221 2-s2.0-0037067317 (Pubitemid 34761289)
42. Martinvalet D., Zhu P., Lieberman J., Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity 2005 22 3 355 370 10.1016/j.immuni.2005.02.004 2-s2.0-15244351845 (Pubitemid 40387477)
43. Bots M., Medema J. P., Granzymes at a glance. Journal of Cell Science 2006 119 24 5011 5014 10.1242/jcs.03239 2-s2.0-33846147328 (Pubitemid 46085180)
44. Riedl S. J., Salvesen G. S., The apoptosome: Signalling platform of cell death. Nature Reviews Molecular Cell Biology 2007 8 5 405 413 10.1038/nrm2153 2-s2.0-34247345833 (Pubitemid 46643237)
45. Green D. R., Kroemer G., The pathophysiology of mitochondrial cell death. Science 2004 305 5684 626 629 10.1126/science.1099320 2-s2.0-3442886811 (Pubitemid 39006738)
46. Spierings D., McStay G., Saleh M., Bender C., Chipuk J., Maurer U., Green D. R., Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis. Science 2005 310 5745 66 67 10.1126/science.1117105 2-s2.0-26444489119 (Pubitemid 41434533)
47. LaCasse E. C., Mahoney D. J., Cheung H. H., Plenchette S., Baird S., Korneluk R. G., IAP-targeted therapies for cancer. Oncogene 2008 27 48 6252 6275 10.1038/onc.2008.302 2-s2.0-54249123632
48. Kim I., Xu W., Reed J. C., Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities. Nature Reviews Drug Discovery 2008 7 12 1013 1030 10.1038/nrd2755 2-s2.0-57049117856
49. Høyer-Hansen M., Jäättelä M., Connecting endoplasmic reticulum stress to autophagy by unfolded protein response and calcium. Cell Death & Differentiation 2007 14 9 1576 1582 10.1038/sj.cdd.4402200 2-s2.0-34548037901 (Pubitemid 47278843)
50. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X., Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998 94 4 481 490 10.1016/S0092-8674(00)81589-5 2-s2.0-0032555716 (Pubitemid 28391864)
51. Nakagawa T., Yuan J., Cross-talk between two cysteine protease families: activation of caspase-12 by calpain in apoptosis. Journal of Cell Biology 2000 150 4 887 894 10.1083/jcb.150.4.887 2-s2.0-0034698878 (Pubitemid 30663424)
52. Wertz I. E., Dixit V. M., Regulation of death receptor signaling by the ubiquitin system. Cell Death and Differentiation 2010 17 1 14 24 10.1038/cdd.2009.168 2-s2.0-77449153351
53. Kischkel F. C., Lawrence D. A., Chuntharapai A., Schow P., Kim K. J., Ashkenazi A., Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5. Immunity 2000 12 6 611 620 10.1016/S1074-7613(00) 80212-5 2-s2.0-0033662433
54. Yang X., Khosravi-Far R., Chang H. Y., Baltimore D., Daxx, a novel fas-binding protein that activates JNK and apoptosis. Cell 1997 89 7 1067 1076 10.1016/S0092-8674(00)80294-9 2-s2.0-0031587883 (Pubitemid 127678740)
55. Micheau O., Tschopp J., Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003 114 2 181 190 10.1016/S0092-8674(03)00521-X 2-s2.0-0041853690 (Pubitemid 36936912)
56. Pobezinskaya Y. L., Liu Z., The role of TRADD in death receptor signaling. Cell Cycle 2012 11 5 871 876 10.4161/cc.11.5.19300 2-s2.0-84863272549
57. Ea C. K., Deng L., Xia Z. P., Pineda G., Chen Z. J., Activation of IKK by TNF α requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Molecular Cell 2006 22 2 245 257 10.1016/j.molcel.2006.03.026 2-s2.0-33646034316
58. Zaman M. M. U., Nomura T., Takagi T., Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis. Molecular and Cellular Biology 2013 33 24 4971 4984
59. Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., Zachariou A., Lopez J., MacFarlane M., Cain K., Meier P., The ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Molecular Cell 2011 43 3 432 448 10.1016/j.molcel.2011.06.006 2-s2.0-79960921946
60. Ouyang L., Shi Z., Zhao S., Wang F.-., Zhou T.-., Liu B., Bao J.-., Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Proliferation 2012 45 6 487 498 10.1111/j.1365-2184. 2012.00845.x 2-s2.0-84868197448
61. Xu Y., Huang S., Liu Z. G., Han J., Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. The Journal of Biological Chemistry 2006 281 13 8788 8795 10.1074/jbc.M508135200 2-s2.0-33646827842 (Pubitemid 43847985)
62. Shimizu S., Kanaseki T., Mizushima N., Mizuta T., Arakawa-Kobayashi S., Thompson C. B., Tsujimoto Y., Role of Bcl-2 family proteins in a non-apoptopic programmed cell death dependent on autophagy genes. Nature Cell Biology 2004 6 12 1221 1228 10.1038/ncb1192 2-s2.0-10344262564 (Pubitemid 39625121)
63. Takahashi Y., Coppola D., Matsushita N., Cualing H. D., Sun M., Sato Y., Liang C., Jung J. U., Cheng J. Q., Mulé J. J., Pledger W. J., Wang H., Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nature Cell Biology 2007 9 10 1142 1151 10.1038/ncb1634 2-s2.0-34848899280 (Pubitemid 47500490)
64. Cuddeback S. M., Yamaguchi H., Komatsu K., Miyashita T., Yamada M., Wu C., Singh S., Wang H., Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax. The Journal of Biological Chemistry 2001 276 23 20559 20565 10.1074/jbc.M101527200 2-s2.0-0035827622
65. Muñoz-Gámez J. A., Rodríguez-Vargas J. M., Quiles-Pérez R., PARP-1 is involved in autophagy induced by DNA damage. Autophagy 2009 5 1 61 74
66. Bidère N., Lorenzo H. K., Carmona S., Laforge M., Harper F., Dumont C., Senik A., Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. The Journal of Biological Chemistry 2003 278 33 31401 31411 10.1074/jbc.M301911200 2-s2.0-0043234207 (Pubitemid 36994661)
67. Cirman T., Orešić K., Mazovec G. D., Turk V., Reed J. C., Myers R. M., Salvesen G. S., Turk B., Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. The Journal of Biological Chemistry 2004 279 5 3578 3587 10.1074/jbc.M308347200 2-s2.0-0942265544 (Pubitemid 38140598)
68. Rodriguez-Rocha H., Garcia-Garcia A., Panayiotidis M. I., Franco R., DNA damage and autophagy. Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 2011 711 1-2 158 166 10.1016/j.mrfmmm.2011.03.007 2-s2.0-79956220703
69. Abraham R. T., Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes & Development 2001 15 17 2177 2196 10.1101/gad.914401 2-s2.0-0035449355 (Pubitemid 32843830)
70. Roos W. P., Kaina B., DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis. Cancer Letters 2013 332 2 237 248 10.1016/j.canlet.2012.01.007 2-s2.0-84876093576
71. Ozaki T., Nakagawara A., Role of p53 in cell death and human cancers. Cancers 2011 3 1 994 1013 10.3390/cancers3010994 2-s2.0-79953693902
72. Leontieva O. V., Gudkov A. V., Blagosklonny M. V., Weak p53 permits senescence during cell cycle arrest. Cell Cycle 2010 9 21 4323 4327 10.4161/cc.9.21.13584 2-s2.0-78349286289
73. Hanahan D., Weinberg R. A., Hallmarks of cancer: the next generation. Cell 2011 144 5 646 674 10.1016/j.cell.2011.02.013 2-s2.0-79952284127
74. Liu P., Cheng H., Roberts T. M., Zhao J. J., Targeting the phosphoinositide 3-kinase pathway in cancer. Nature Reviews Drug Discovery 2009 8 8 627 644 10.1038/nrd2926 2-s2.0-68249093818
75. Kroemer G., Galluzzi L., Brenner C., Mitochondrial membrane permeabilization in cell death. Physiological Reviews 2007 87 1 99 163 10.1152/physrev.00013.2006 2-s2.0-33845977959 (Pubitemid 46209992)
76. Ozes O. N., Mayo L. D., Gustin J. A., Pfeffer S. R., Pfeffer L. M., Donner D. B., NF- B activation by tumour necrosis factor requires tie Akt serine-threonine kinase. Nature 1999 401 6748 82 85 10.1038/43466 2-s2.0-0033517189 (Pubitemid 29418447)
77. Hanahan D., Weinberg R. A., The hallmarks of cancer. Cell 2000 100 1 57 70 10.1016/S0092-8674(00)81683-9 2-s2.0-0034614637 (Pubitemid 30046295)
78. Kasibhatla S., Tseng B., Why target apoptosis in cancer treatment? Molecular Cancer Therapeutics 2003 2 6 573 580 2-s2.0-1542322900
79. Reed J. C., Drug insight: cancer therapy strategies based on restoration of endogenous cell death mechanisms. Nature Clinical Practice Oncology 2006 3 7 388 398 10.1038/ncponc0538 2-s2.0-33745863017 (Pubitemid 44027293)
80. Reed J. C., Apoptosis-targeted therapies for cancer. Cancer Cell 2003 3 1 17 22 10.1016/S1535-6108(02)00241-6 2-s2.0-0038786580 (Pubitemid 37443888)
81. Reed J. C., Pellecchia M., Apoptosis-based therapies for hematologic malignancies. Blood 2005 106 2 408 418 10.1182/blood-2004-07-2761 2-s2.0-22144460556 (Pubitemid 40981231)
82. Fisher D. E., Apoptosis in cancer therapy: crossing the threshold. Cell 1994 78 4 539 542 10.1016/0092-8674(94)90518-5 2-s2.0-0028025563 (Pubitemid 24268576)
83. Friesen C., Fulda S., Debatin K.-M., Cytotoxic drugs and the CD95 pathway. Leukemia 1999 13 11 1854 1858 10.1038/sj.leu.2401333 2-s2.0-0032742205 (Pubitemid 29535271)
84. Green D. R., Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000 102 1 1 4 2-s2.0-0034616946
85. Brown J. M., Wouters B. G., Apoptosis: mediator or mode of cell killing by anticancer agents? Drug Resistance Updates 2001 4 2 135 136 10.1054/drup.2001.0193 2-s2.0-0034931001 (Pubitemid 32619572)
86. Schmitt C. A., Lowe S. W., Apoptosis is critical for drug response in vivo. Drug Resistance Updates 2001 4 2 132 134 10.1054/drup.2001.0188 2-s2.0-0034930374 (Pubitemid 32619571)
87. Grasso S., Piedad M., Carrasco-Garca E., Chapter 4. Cell death and cancer, novel therapeutic strategies. Apoptosis and Medicine 2012 InTech 10.5772/51285
88. Breitschopf K., Zeiher A. M., Dimmeler S., Ubiquitin-mediated degradation of the proapoptotic active form of bid. A functional consequence on apoptosis induction. The Journal of Biological Chemistry 2000 275 28 21648 21652 10.1074/jbc.M001083200 2-s2.0-0034647563 (Pubitemid 30481872)
89. Deveraux Q. L., Reed J. C., IAP family proteins-suppressors of apoptosis. Genes & Development 1999 13 3 239 252 10.1101/gad.13.3.239 2-s2.0-0033082995 (Pubitemid 29095796)
90. Fesik S. W., Shi Y., Controlling the caspases. Science 2001 294 5546 1477 1478 10.1126/science.1062236 2-s2.0-0035900312 (Pubitemid 33063910)
91. Gabrielli B., Brooks K., Pavey S., Defective cell cycle checkpoints as targets for anti-cancer therapies. Frontiers in Pharmacology 2012 3, article 9 10.3389/fphar.2012.00009 2-s2.0-84865971493
92. Schmitt C. A., Cellular senescence and cancer treatment. Biochimica et Biophysica Acta 2007 1775 1 5 20 10.1016/j.bbcan.2006.08.005 2-s2.0-33845338765 (Pubitemid 44881196)
93. Amerik A. Y., Hochstrasser M., Mechanism and function of deubiquitinating enzymes. Biochimica et Biophysica Acta: Molecular Cell Research 2004 1695 1-3 189 207 10.1016/j.bbamcr.2004.10.003 2-s2.0-9644268864 (Pubitemid 39574973)
94. Nicholson B., Marblestone J. G., Butt T. R., Mattern M. R., Deubiquitinating enzymes as novel anticancer targets. Future Oncology 2007 3 2 191 199 10.2217/14796694.3.2.191 2-s2.0-34247130844 (Pubitemid 46592727)
95. Sacco J. J., Coulson J. M., Clague M. J., Urbé S., Emerging roles of deubiquitinases in cancer-associated pathways. IUBMB Life 2010 62 2 140 157 10.1002/iub.300 2-s2.0-77949733627
96. Shan J., Zhao W., Gu W., Suppression of cancer cell growth by promoting cyclin D1 degradation. Molecular Cell 2009 36 3 469 476 10.1016/j.molcel.2009. 10.018 2-s2.0-70449105984
97. Faustrup H., Bekker-Jensen S., Bartek J., Lukas J., Mailand N., USP7 counteracts SCF β TrCP- but not APCCdh1 -mediated proteolysis of Claspin. The Journal of Cell Biology 2009 184 1 13 19 10.1083/jcb.200807137 2-s2.0-59849116083
98. Chen M., Gutierrez G. J., Ronai Z. A., Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proceedings of the National Academy of Sciences of the United States of America 2011 108 22 9119 9124 10.1073/pnas.1100028108 2-s2.0-79959335295
99. Kip1 Molecular & Cellular Biology 2009 29 11 547 558 10.1128/MCB.00437-09 2-s2.0-66849115410
100. Lu Y., Bedard N., Chevalier S., Wing S. S., Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells. PloS ONE 2011 6 1 e15936
101. Caballero O. L., Resto V., Patturajan M., Meerzaman D., Ming Z. G., Engles J., Yochem R., Ratovitski E., Sidransky D., Jen J., Interaction and colocalization of PGP9.5 with JAB1 and p27Kip1. Oncogene 2002 21 19 3003 3010 10.1038/sj/onc/1205390 2-s2.0-18344366884 (Pubitemid 34522899)
102. Pereg Y., Liu B. Y., O'Rourke K. M., Sagolla M., Dey A., Komuves L., French D. M., Dixit V. M., Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A. Nature Cell Biology 2010 12 4 400 406 10.1038/ncb2041 2-s2.0-77950517895
103. van Leuken R. J., Luna-Vargas M. P., Sixma T. K., Wolthuis R. M. F., Medema R. H., Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. Cell Cycle 2008 7 17 2710 2719 10.4161/cc.7.17.6553 2-s2.0-50849116784
104. Stegmeier F., Rape M., Draviam V. M., Nalepa G., Sowa M. E., Ang X. L., McDonald E. R. III, Li M. Z., Hannon G. J., Sorger P. K., Kirschner M. W., Harper J. W., Elledge S. J., Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature 2007 446 7138 876 881 10.1038/nature05694 2-s2.0-34247376926 (Pubitemid 46633164)
105. Li M., Chen D., Shiloh A., Luo J., Nikolaev A. Y., Qin J., Gu W., Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002 416 6886 648 653 10.1038/nature737 2-s2.0-0037061508 (Pubitemid 34406767)
106. Bhattacharya S., Ghosh MK., HAUSP, a novel deubiquitinase for Rb-MDM2 the critical regulator. FEBS Journal 2014 10.1111/febs.12843
107. Li M., Brooks C. L., Kon N., Gu W., A dynamic role of HAUSP in the p53-Mdm2 pathway. Molecular Cell 2004 13 6 879 886 10.1016/S1097-2765(04)00157-1 2-s2.0-1842421376 (Pubitemid 38438482)
108. Blanchette P., Gilchrist C. A., Baker R. T., Gray D. A., Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. Oncogene 2001 20 39 5533 5537 10.1038/sj.onc.1204823 2-s2.0-0035817743 (Pubitemid 32889490)
109. Oh Y. M., Kwon Y. E., Kim J. M., Bae S. J. S. J., Lee B. K., Yoo S. J., Chung C. H., Deshaies R. J., Seol J. H., Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nature Cell Biology 2009 11 3 295 302 10.1038/ncb1837 2-s2.0-61849153478
110. Huang X., Summers M. K., Pham V., Lill J. R., Liu J., Lee G., Kirkpatrick D. S., Jackson P. K., Fang G., Dixit V. M., Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Molecular Cell 2011 42 4 511 523 10.1016/j.molcel.2011.03.027 2-s2.0-79955977893
111. Jensen D. E., Proctor M., Marquis S. T., Gardner H. P., Ha S. I., Chodosh L. A., Ishov A. M., Tommerup N., Vissing H., Sekido Y., Minna J., Borodovsky A., Schultz D. C., Wilkinson K. D., Maul G. G., Barlev N., Berger S. L., Prendergast G. C., Rauscher F. J. III, BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 1998 16 9 1097 1112 10.1038/sj.onc.1201861 2-s2.0-15144342687 (Pubitemid 28127509)
112. Eletr Z. M., Wilkinson K. D., An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochemistry and Biophysics 2011 60 1-2 3 11 10.1007/s12013-011-9184-6 2-s2.0-79955934205
113. Stegmeier F., Sowa M. E., Nalepa G., Gygi S. P., Harper J. W., Elledge S. J., The tumor suppressor CYLD regulates entry into mitosis. Proceedings of the National Academy of Sciences of the United States of America 2007 104 21 8869 8874 10.1073/pnas.0703268104 2-s2.0-34547421345 (Pubitemid 47175403)
114. 2/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability. Cell Cycle 2010 9 18 3815 3822 10.4161/cc.9.18.13133 2-s2.0-77957002197
115. Murai J., Yang K., Dejsuphong D., Hirota K., Takeda S., D'Andrea A. D., The USP1/UAF1 complex promotes double-strand break repair through homologous recombination. Molecular and Cellular Biology 2011 31 12 2462 2469 10.1128/MCB.05058-11 2-s2.0-79958030960
116. Nicassio F., Corrado N., Vissers J. H. A., Areces L. B., Bergink S., Marteijn J. A., Geverts B., Houtsmuller A. B., Vermeulen W., Di Fiore P. P., Citterio E., Human USP3 is a chromatin modifier required for S phase progression and genome stability. Current Biology 2007 17 22 1972 1977 10.1016/j.cub.2007. 10.034 2-s2.0-36049036216 (Pubitemid 350088491)
117. Shao G., Lilli D. R., Patterson-Fortin J., Coleman K. A., Morrissey D. E., Greenberg R. A., The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks. Proceedings of the National Academy of Sciences of the United States of America 2009 106 9 3166 3171 10.1073/pnas.0807485106 2-s2.0-62549140202
118. Nakada S., Tai I., Panier S., Al-Hakim A., Iemura S., Juang Y., O'Donnell L., Kumakubo A., Munro M., Sicheri F., Gingras A., Natsume T., Suda T., Durocher D., Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature 2010 466 7309 941 946 10.1038/nature09297 2-s2.0-77955867565
119. Wiltshire T. D., Lovejoy C. A., Wang T., Xia F., O'Connor M. J., Cortez D., Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair. The Journal of Biological Chemistry 2010 285 19 14565 14571 10.1074/jbc.M110.104745 2-s2.0-77951985779
120. Schoenfeld A. R., Apgar S., Dolios G., Wang R., Aaronson S. A., BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage. Molecular and Cellular Biology 2004 24 17 7444 7455 10.1128/MCB.24.17.7444-7455.2004 2-s2.0-4344717012 (Pubitemid 39121473)
121. Zhang D., Zaugg K., Mak T. W., Elledge S. J., A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 2006 126 3 529 542 10.1016/j.cell.2006.06.039 2-s2.0-33746766974 (Pubitemid 44163600)
122. Luo J., Lu Z., Lu X., OTUD5 regulates p53 stability by deubiquitinating p53. PLoS ONE 2013 8 10 e77682
123. Parsons J. L., Dianova I. I., Khoronenkova S. V., Edelmann M. J., Kessler B. M., Dianov G. L., USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β Molecular Cell 2011 41 5 609 615 10.1016/j.molcel.2011.02.016 2-s2.0-79951997444
124. Khoronenkova S. V., Dianova I. I., Parsons J. L., Dianov G. L., USP7/HAUSP stimulates repair of oxidative DNA lesions. Nucleic Acids Research 2011 39 7 2604 2609 10.1093/nar/gkq1210 2-s2.0-79954575695
125. Khoronenkova S. V., Dianov G. L., USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair. Nucleic Acids Research 2013 41 3 1750 1756 10.1093/nar/gks1359 2-s2.0-84873696103
126. Busso C. S., Iwakuma T., Izumi T., Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway. Oncogene 2009 28 13 1616 1625 10.1038/onc.2009.5 2-s2.0-64049110265
127. Zhang X., Horibata K., Saijo M., Ishigami C., Ukai A., Kanno S., Tahara H., Neilan E. G., Honma M., Nohmi T., Yasui A., Tanaka K., Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. Nature Genetics 2012 44 5 593 597 10.1038/ng.2228 2-s2.0-84860336243
128. Oestergaard V. H., Langevin F., Kuiken H. J., Pace P., Niedzwiedz W., Simpson L. J., Ohzeki M., Takata M., Sale J. E., Patel K. J., Deubiquitination of FANCD2 is required for DNA crosslink repair. Molecular Cell 2007 28 5 798 809 10.1016/j.molcel.2007.09.020 2-s2.0-36749100034 (Pubitemid 350217050)
129. Huang T. T., Nijman S. M. B., Mirchandani K. D., Galardy P. J., Cohn M. A., Haas W., Gygi S. P., Ploegh H. L., Bernards R., D'Andrea A. D., Regulation of monoubiquitinated PCNA by DUB autocleavage. Nature Cell Biology 2006 8 4 339 347 10.1038/ncb1378 2-s2.0-33645708319
130. Nijman S. M. B., Huang T. T., Dirac A. M. G., Brummelkamp T. R., Kerkhoven R. M., D'Andrea A. D., Bernards R., The deubiquitinating enzyme USP1 regulates the fanconi anemia pathway. Molecular Cell 2005 17 3 331 339 10.1016/j.molcel.2005.01.008 2-s2.0-13244291457 (Pubitemid 40193305)
131. Guervilly J., Renaud E., Takata M., Rosselli F., USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. Human Molecular Genetics 2011 20 11 2171 2181 10.1093/hmg/ddr103 2-s2.0-79956027089
132. Matsuoka S., Ballif B. A., Smogorzewska A., McDonald E. R. III, Hurov K. E., Luo J., Bakalarski C. E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S. P., Elledge S. J., ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007 316 5828 1160 1166 10.1126/science.1140321 2-s2.0-34249947699 (Pubitemid 46877472)
133. Mu J., Wang Y., Luo H., Leng M., Zhang J., Yang T., Besusso D., Sung Y. J., Qin J., A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3- related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. The Journal of Biological Chemistry 2007 282 24 17330 17334 10.1074/jbc.C700079200 2-s2.0-34547107878 (Pubitemid 47100266)
134. Dar A., Shibata E., Dutta A., Deubiquitination of tip60 by USP7 determines the activity of the p53-dependent apoptotic pathway. Molecular and Cellular Biology 2013 33 16 3309 3320 10.1128/MCB.00358-13 2-s2.0-84881290170
135. Tang J., Qu L., Pang M., Yang X., Daxx is reciprocally regulated by Mdm2 and Hausp. Biochemical and Biophysical Research Communications 2010 393 3 542 545 10.1016/j.bbrc.2010.02.051 2-s2.0-77949261518
136. Gangula N. R., Maddika S., WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). The Journal of Biological Chemistry 2013 288 48 34545 34554 10.1074/jbc.M113.503383
137. Zhang Z., Qinghui Y., Zhang Y., Zhang J., Xin Z., Haiying M., Yuepeng G., USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. Journal of Cancer Research and Clinical Oncology 2012 138 7 1231 1238 10.1007/s00432-012-1193-3 2-s2.0-84864355390
138. Li X., Stevens P. D., Yang H., Gulhati P., Wang W., Evers B. M., Gao T., The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene 2013 32 4 471 478 10.1038/onc.2012.66 2-s2.0-84873055250
139. Schwickart M., Huang X., Lill J. R., Liu J., Ferrando R., French D. M., Maecker H., O'Rourke K., Bazan F., Eastham-Anderson J., Yue P., Dornan D., Huang D. C. S., Dixit V. M., Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival. Nature 2010 463 7277 103 107 10.1038/nature08646 2-s2.0-73849083434
140. Pareja F., Ferraro D. A., Rubin C., Cohen-Dvashi H., Zhang F., Aulmann S., Ben-Chetrit N., Pines G., Navon R., Crosetto N., Köstler W., Carvalho S., Lavi S., Schmitt F., Dikic I., Yakhini Z., Sinn P., Mills G. B., Yarden Y., Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. Oncogene 2012 31 43 4599 4608 10.1038/onc.2011.587 2-s2.0-84867900349
141. Duex J. E., Sorkin A., RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis. Molecular Biology of the Cell 2009 20 6 1833 1844 10.1091/mbc.E08-08-0880 2-s2.0-65649090171
142. Qiu X., Goldberg A. L., Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proceedings of the National Academy of Sciences of the United States of America 2002 99 23 14843 14848 10.1073/pnas.232580999 2-s2.0-0037069388 (Pubitemid 35334571)
143. Zhao B., Schlesiger C., Masucci M. G., Lindsten K., The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway. Journal of Cellular and Molecular Medicine 2009 13 8 1886 1895 10.1111/j.1582-4934.2009.00682.x 2-s2.0-72949089936
144. Huang P. H., Xu A. M., White F. M., Oncogenic EGFR signaling networks in glioma. Science Signaling 2009 2 87 re6 10.1126/scisignal.287re6 2-s2.0-73949083511
145. Tran H., Hamada F., Schwarz-Romond T., Bienz M., Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains. Genes & Development 2008 22 4 528 542 10.1101/gad.463208 2-s2.0-39449084931 (Pubitemid 351272759)
146. Hayden M. S., Ghosh S., Shared principles in NF- B signaling. Cell 2008 132 3 344 362 10.1016/j.cell.2008.01.020 2-s2.0-38849199203 (Pubitemid 351192002)
147. Brummelkamp T. R., Nijman S. M. B., Dirac A. M. G., Bernards R., Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF- B. Nature 2003 424 6950 797 801 10.1038/nature01811 2-s2.0-0042467554 (Pubitemid 37021711)
148. Kovalenko A., Chable-Bessia C., Cantarella G., Israël A., Wallach D., Courtois G., The tumour suppressor CYLD negatively regulates NF- B signalling by deubiquitination. Nature 2003 424 6950 801 805 10.1038/nature01802 2-s2.0-0041967054 (Pubitemid 37021712)
149. Trompouki E., Hatzivassillou E., Tsichritzis T., Farmer H., Ashworth A., Mosialos G., CYLD is a deubiquitinating enzyme that negatively regulates NF- B activation by TNFR family members. Nature 2003 424 6950 793 796 10.1038/nature01803 2-s2.0-0042467558 (Pubitemid 37021710)
150. Yoshida H., Jono H., Kai H., Li J., The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 and TRAF7. The Journal of Biological Chemistry 2005 280 49 41111 41121 10.1074/jbc.M509526200 2-s2.0-28844460239 (Pubitemid 41780606)
151. Jono H., Lim J. H., Chen L., Xu H., Trompouki E., Pan Z. K., Mosialos G., Li J., NF- B is essential for induction of CYLD, the negative regulator of NF- B: evidence for a novel inducible autoregulatory feedback pathway. The Journal of Biological Chemistry 2004 279 35 36171 36174 10.1074/jbc.M406638200 2-s2.0-4344561190 (Pubitemid 39128950)
152. Massoumi R., Chmielarska K., Hennecke K., Pfeifer A., Fässler R., Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF- kappaB signaling. Cell 2006 125 4 665 677 10.1016/j.cell.2006.03.041 2-s2.0-33646531810
153. 1 transition. Molecular and Cellular Biology 2001 21 24 8428 8436 10.1128/MCB.21.24.8428-8436.2001 2-s2.0-0035196739 (Pubitemid 33108602)
154. Rocha S., Martin A. M., Meek D. W., Perkins N. D., p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF- B subunit with histone deacetylase 1. Molecular and Cellular Biology 2003 23 13 4713 4727 10.1128/MCB.23.13.4713-4727.2003 2-s2.0-0038409927 (Pubitemid 36740458)
155. Boone D. L., Turer E. E., Lee E. G., Ahmad R., Wheeler M. T., Tsui C., Hurley P., Chien M., Chai S., Hitotsumatsu O., McNally E., Pickart C., Ma A., The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nature Immunology 2004 5 10 1052 1060 2-s2.0-19944434223 (Pubitemid 41057725)
156. Wartz I. E., O'Rourke K. M., Zhou H., Eby M., Aravind L., Seshagiri S., Wu P., Wiesmann C., Baker R., Boone D. L., Ma A., Koonin E. V., Dixit V. M., De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF- B signalling. Nature 2004 430 7000 694 699 10.1038/nature02794 2-s2.0-3943054838 (Pubitemid 39061687)
157. Jin Z., Li Y., Pitti R., Lawrence D., Pham V. C., Lill J. R., Ashkenazi A., Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009 137 4 721 735 10.1016/j.cell.2009.03.015 2-s2.0-65549085701
158. Kato M., Sanada M., Kato I., Sato Y., Takita J., Takeuchi K., Niwa A., Chen Y., Nakazaki K., Nomoto J., Asakura Y., Muto S., Tamura A., Iio M., Akatsuka Y., Hayashi Y., Mori H., Igarashi T., Kurokawa M., Chiba S., Mori S., Ishikawa Y., Okamoto K., Tobinai K., Nakagama H., Nakahata T., Yoshino T., Kobayashi Y., Ogawa S., Frequent inactivation of A20 in B-cell lymphomas. Nature 2009 459 7247 712 716 10.1038/nature07969 2-s2.0-66649112854
159. Colleran A., Collins P. E., O'Carroll C., Ahmed A., Mao X., McManus B., Kiely P. A., Burstein E., Carmody R. J., Deubiquitination of NF- B by ubiquitin-specific protease-7 promotes transcription. Proceedings of the National Academy of Sciences of the United States of America 2013 110 2 618 623 10.1073/pnas.1208446110 2-s2.0-84872202679
160. Mahul-Mellier A.-L., Pazarentzos E., Datler C., Iwasawa R., Abuali G., Lin B., Grimm S., De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF. Cell Death and Differentiation 2012 19 5 891 899 10.1038/cdd.2011.185 2-s2.0-84859602197
161. Yamaguchi T., Kimura J., Miki Y., Yoshida K., The deubiquitinating enzyme USP11 controls an I B kinase α (IKK α)-p53 signaling pathway in response to Tumor Necrosis Factor α (TNF α). The Journal of Biological Chemistry 2007 282 47 33943 33948 10.1074/jbc.M706282200 2-s2.0-36348975260 (Pubitemid 350159476)
162. Enesa K., Zakkar M., Chaudhury H., Luong L. A., Rawlinson L., Mason J. C., Haskard D. O., Dean J. L. E., Evans P. C., NF- B suppression by the deubiquitinating enzyme cezanne: a novel negative feedback loop in pro-inflammatory signaling. The Journal of Biological Chemistry 2008 283 11 7036 7045 10.1074/jbc.M708690200 2-s2.0-43749122598
163. Harhaj E. W., Dixit V. M., Regulation of NF- B by deubiquitinases. Immunological Reviews 2012 246 1 107 124 10.1111/j.1600-065X.2012.01100.x 2-s2.0-84858725584
164. Stevenson L. F., Sparks A., Allende-Vega N., Xirodimas D. P., Lane D. P., Saville M. K., The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. The EMBO Journal 2007 26 4 976 986 10.1038/sj.emboj.7601567 2-s2.0-33847212425
165. Allende-Vega N., Sparks A., Lane D. P., Saville M. K., MdmX is a substrate for the deubiquitinating enzyme USP2a. Oncogene 2010 29 3 432 441 10.1038/onc.2009.330 2-s2.0-75149174149
166. Priolo C., Tang D., Brahamandan M., Benassi B., Sicinska E., Ogino S., Farsetti A., Porrello A., Finn S., Zimmermann J., Febbo P., Loda M., The isopeptidase USP2a protects human prostate cancer from apoptosis. Cancer Research 2006 66 17 8625 8632 10.1158/0008-5472.CAN-06-1374 2-s2.0-33746820622 (Pubitemid 44449177)
167. Hoffman B., Liebermann D. A., Apoptotic signaling by c-MYC. Oncogene 2008 27 50 6462 6472 10.1038/onc.2008.312 2-s2.0-54949149565
168. Popov N., Wanzel M., Madiredjo M., Zhang D., Beijersbergen R., Bernards R., Moll R., Elledge S. J., Eilers M., The ubiquitin-specific protease USP28 is required for MYC stability. Nature Cell Biology 2007 9 7 765 774 10.1038/ncb1601 2-s2.0-34347401998 (Pubitemid 47019463)
169. Ronai Z., Balancing Mdm2-a Daxx-HAUSP matter. Nature Cell Biology 2006 8 8 790 791 10.1038/ncb0806-790 2-s2.0-33746640122 (Pubitemid 44151581)
170. Van Der Horst A., de Vries-Smits A. M. M., Brenkman A. B., van Triest M. H., van den Broek N., Colland F., Maurice M. M., Burgering B. M. T., FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nature Cell Biology 2006 8 10 1064 1073 10.1038/ncb1469 2-s2.0-33749188883 (Pubitemid 44473601)
171. García-Santisteban I., Peters G. J., Giovannetti E., Rodríguez J. A., USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy. Molecular Cancer 2013 12 1, article e91 10.1186/1476-4598-12-91 2-s2.0-84881140678
172. Apraiz A., Boyano M. D., Asumendi A., Cell-centric view of apoptosis and apoptotic cell death-inducing antitumoral strategies. Cancers 2011 3 1 1042 1080 10.3390/cancers3011042 2-s2.0-79953701064
173. Jin W., Chang M., Paul E. M., Babu G., Lee A. J., Reiley W., Wright A., Zhang M., You J., Sun S., Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. Journal of Clinical Investigation 2008 118 5 1858 1866 10.1172/JCI34257 2-s2.0-43049124129 (Pubitemid 351632388)
174. Kisselev A. F., Goldberg A. L., Proteasome inhibitors: from research tools to drug candidates. Chemistry & Biology 2001 8 8 739 758 10.1016/S1074-5521(01)00056-4 2-s2.0-0034864799 (Pubitemid 32752454)
175. Mao X., Cao B., The ubiquitin-proteasomal system and blood cancer therapy. Hematology-Science and Practice 2012 InTech
176. Yao T., The role of ubiquitin in autophagy-dependent protein aggregate processing. Genes & Cancer 2010 1 7 779 786 10.1177/1947601910383277 2-s2.0-79952843826
177. Hideshima T., Bradner J. E., Wong J., Chauhan D., Richardson P., Schreiber S. L., Anderson K. C., Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proceedings of the National Academy of Sciences of the United States of America 2005 102 24 8567 8572 10.1073/pnas.0503221102 2-s2.0-20844435806 (Pubitemid 40862776)
178. Vugmeyster Y., Borodovsky A., Maurice M. M., Maehr R., Furman M. H., Ploegh H. L., The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Molecular Immunology 2002 39 7-8 431 441 10.1016/S0161-5890(02)00123-2 2-s2.0-0036842071 (Pubitemid 35284411)
179. Hersey P., Zhang X. D., Overcoming resistance of cancer cells to apoptosis. Journal of Cellular Physiology 2003 196 1 9 18 10.1002/jcp.10256 2-s2.0-0038284110 (Pubitemid 36676439)