The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

Oncogene

Volumn 32, Issue 4, 2013, Pages 471-478

  Li, X ^a   Stevens, P D ^a   Yang, H ^b   Gulhati, P ^a,c,d   Wang, W ^a   Evers, B M ^a,c   Gao, T ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b TAIZHOU HOSPITAL OF ZHEJIANG PROVINCE   (China)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

Akt; deubiquitination; PHLPP; tumor suppressor; USP46

Indexed keywords

PH DOMAIN LEUCINE RICH REPEATS PROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; POLYUBIQUITIN; PROTEIN KINASE B; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; USP46 ENZYME;

ARTICLE; CANCER CELL; CARCINOGENESIS; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; DEUBIQUITINATION; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; SIGNAL TRANSDUCTION; UBIQUITINATION; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; ENDOPEPTIDASES; GENES, TUMOR SUPPRESSOR; HCT116 CELLS; HEK293 CELLS; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UBIQUITINATION; UP-REGULATION;

EID: 84873055250     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.66     Document Type: Article

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