메뉴 건너뛰기




Volumn 45, Issue 6, 2012, Pages 487-498

Programmed cell death pathways in cancer: A review of apoptosis, autophagy and programmed necrosis

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; B RAF KINASE; BECLIN 1; CYTOCHROME C; CYTOKINE; DEATH RECEPTOR 4; FAS ANTIGEN; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MITOCHONDRIAL ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; NECROSTATIN 1; OSTEOCLAST DIFFERENTIATION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLASMA MEMBRANE DEATH RECEPTOR; PROCASPASE 3; PROCASPASE 8; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; PROTEIN P62; RAF PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84868197448     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2012.00845.x     Document Type: Article
Times cited : (1195)

References (116)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 0015383455 scopus 로고
    • Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 6
    • 50949097371 scopus 로고    scopus 로고
    • Crosstalk between autophagy and apoptosis in heart disease
    • Nishida K, Yamaguchi O, Otsu K (2008) Crosstalk between autophagy and apoptosis in heart disease. Circ. Res. 103, 343-351.
    • (2008) Circ. Res. , vol.103 , pp. 343-351
    • Nishida, K.1    Yamaguchi, O.2    Otsu, K.3
  • 7
    • 0029125701 scopus 로고
    • Protease activation during apoptosis: death by a thousand cuts?
    • Martin SJ, Green DR (1995) Protease activation during apoptosis: death by a thousand cuts? Cell 82, 349-352.
    • (1995) Cell , vol.82 , pp. 349-352
    • Martin, S.J.1    Green, D.R.2
  • 8
    • 0028290311 scopus 로고
    • Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes
    • Cohen GM, Sun XM, Fearnhead H, MacFarlane M, Brown DG, Snowden RT et al. (1994) Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol. 153, 507-516.
    • (1994) J. Immunol. , vol.153 , pp. 507-516
    • Cohen, G.M.1    Sun, X.M.2    Fearnhead, H.3    MacFarlane, M.4    Brown, D.G.5    Snowden, R.T.6
  • 9
    • 78649634631 scopus 로고    scopus 로고
    • Targeting apoptotic and autophagic pathways for cancer therapeutics
    • Liu JJ, Lin M, Yu JY, Liu B, Bao JK (2011) Targeting apoptotic and autophagic pathways for cancer therapeutics. Cancer Lett. 300, 105-114.
    • (2011) Cancer Lett. , vol.300 , pp. 105-114
    • Liu, J.J.1    Lin, M.2    Yu, J.Y.3    Liu, B.4    Bao, J.K.5
  • 10
    • 77954096426 scopus 로고    scopus 로고
    • A systems biology viewpoint on autophagy in health and disease
    • Huett A, Goel G, Xavier RJ (2010) A systems biology viewpoint on autophagy in health and disease. Curr. Opin. Gastroenterol. 26, 302-309.
    • (2010) Curr. Opin. Gastroenterol. , vol.26 , pp. 302-309
    • Huett, A.1    Goel, G.2    Xavier, R.J.3
  • 12
    • 80054087824 scopus 로고    scopus 로고
    • Mitochondrial ROS generation for regulation of autophagic pathways in cancer
    • Li ZY, Yang Y, Ming M, Liu B (2011) Mitochondrial ROS generation for regulation of autophagic pathways in cancer. Biochem. Biophys. Res. Commun. 414, 5-8.
    • (2011) Biochem. Biophys. Res. Commun. , vol.414 , pp. 5-8
    • Li, Z.Y.1    Yang, Y.2    Ming, M.3    Liu, B.4
  • 13
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ (2009) Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67-93.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 14
    • 67549142261 scopus 로고    scopus 로고
    • Life and death partners: apoptosis, autophagy and the cross-talk between them
    • Eisenberg-Lerner A, Bialik S, Simon HU, Kimchi A (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 16, 966-975.
    • (2009) Cell Death Differ. , vol.16 , pp. 966-975
    • Eisenberg-Lerner, A.1    Bialik, S.2    Simon, H.U.3    Kimchi, A.4
  • 15
    • 77956363593 scopus 로고    scopus 로고
    • Autophagic pathways as new targets for cancer drug development
    • Liu B, Cheng Y, Liu Q, Bao JK, Yang JM (2010) Autophagic pathways as new targets for cancer drug development. Acta Pharmacol. Sin. 31, 1154-1164.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 1154-1164
    • Liu, B.1    Cheng, Y.2    Liu, Q.3    Bao, J.K.4    Yang, J.M.5
  • 16
    • 84861195802 scopus 로고    scopus 로고
    • Necroptosis: an emerging form of programmed cell death
    • Wu W, Liu P, Li J (2012) Necroptosis: an emerging form of programmed cell death. Crit. Rev. Oncol. Hematol. 82, 249-258.
    • (2012) Crit. Rev. Oncol. Hematol. , vol.82 , pp. 249-258
    • Wu, W.1    Liu, P.2    Li, J.3
  • 17
    • 78649634982 scopus 로고    scopus 로고
    • Genetic control of necrosis - another type of programmed cell death
    • McCall K (2010) Genetic control of necrosis - another type of programmed cell death. Curr. Opin. Cell Biol. 22, 882-888.
    • (2010) Curr. Opin. Cell Biol. , vol.22 , pp. 882-888
    • McCall, K.1
  • 18
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: from caspases to alternative mechanisms
    • Leist M, Jaattela M (2001) Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2, 589-598.
    • (2001) Nat. Rev. Mol. Cell Biol. , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 19
    • 80054839348 scopus 로고    scopus 로고
    • Cell death pathology: cross-talk with autophagy and its clinical implications
    • Amelio I, Melino G, Knight RA (2011) Cell death pathology: cross-talk with autophagy and its clinical implications. Biochem. Biophys. Res. Commun. 414, 277-281.
    • (2011) Biochem. Biophys. Res. Commun. , vol.414 , pp. 277-281
    • Amelio, I.1    Melino, G.2    Knight, R.A.3
  • 20
    • 78651335479 scopus 로고    scopus 로고
    • Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts
    • Eum KH, Lee M (2011) Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts. Mol. Cell. Biochem. 348, 61-68.
    • (2011) Mol. Cell. Biochem. , vol.348 , pp. 61-68
    • Eum, K.H.1    Lee, M.2
  • 21
  • 22
    • 79960925702 scopus 로고    scopus 로고
    • Core signaling pathways of survival/death in autophagy-related cancer networks
    • Wang SY, Yu QJ, Zhang RD, Liu B (2011) Core signaling pathways of survival/death in autophagy-related cancer networks. Int. J. Biochem. Cell Biol. 43, 1263-1266.
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 1263-1266
    • Wang, S.Y.1    Yu, Q.J.2    Zhang, R.D.3    Liu, B.4
  • 23
    • 84861526009 scopus 로고    scopus 로고
    • Deconvoluting the context-dependent role for autophagy in cancer
    • White E (2012) Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer. 12, 401-410.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 401-410
    • White, E.1
  • 24
    • 41749114288 scopus 로고    scopus 로고
    • Autophagy: basic principles and relevance to disease
    • Kundu M, Thompson CB (2008) Autophagy: basic principles and relevance to disease. Annu. Rev. Pathol. 3, 427-455.
    • (2008) Annu. Rev. Pathol. , vol.3 , pp. 427-455
    • Kundu, M.1    Thompson, C.B.2
  • 25
    • 57649167477 scopus 로고    scopus 로고
    • Necroptosis: a specialized pathway of programmed necrosis
    • Galluzzi L, Kroemer G (2008) Necroptosis: a specialized pathway of programmed necrosis. Cell 135, 1161-1163.
    • (2008) Cell , vol.135 , pp. 1161-1163
    • Galluzzi, L.1    Kroemer, G.2
  • 26
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: towards a molecular definition
    • Golstein P, Kroemer G (2007) Cell death by necrosis: towards a molecular definition. Trends Biochem. Sci. 32, 37-43.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 27
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong WX, Ditsworth D, Bauer DE, Wang ZQ, Thompson CB (2004) Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev. 18, 1272-1282.
    • (2004) Genes Dev. , vol.18 , pp. 1272-1282
    • Zong, W.X.1    Ditsworth, D.2    Bauer, D.E.3    Wang, Z.Q.4    Thompson, C.B.5
  • 30
    • 33644840693 scopus 로고    scopus 로고
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N et al. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 1, 112-119.
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 112-119
    • Degterev, A.1    Huang, Z.2    Boyce, M.3    Li, Y.4    Jagtap, P.5    Mizushima, N.6
  • 31
    • 67349269527 scopus 로고    scopus 로고
    • Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis
    • Han W, Xie J, Li L, Liu Z, Hu X (2009) Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis. Apoptosis 14, 674-686.
    • (2009) Apoptosis , vol.14 , pp. 674-686
    • Han, W.1    Xie, J.2    Li, L.3    Liu, Z.4    Hu, X.5
  • 32
    • 84862006553 scopus 로고    scopus 로고
    • Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic: suppression of CYLD gene by LEF1
    • Liu P, Xu B, Shen W, Zhu H, Wu W, Fu Y et al. (2012) Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic: suppression of CYLD gene by LEF1. Leukemia. 26, 1293-1300.
    • (2012) Leukemia , vol.26 , pp. 1293-1300
    • Liu, P.1    Xu, B.2    Shen, W.3    Zhu, H.4    Wu, W.5    Fu, Y.6
  • 33
    • 79960913158 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis signaling pathway for cancer therapy
    • Sayers TJ (2011) Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol. Immunother. 60, 1173-1180.
    • (2011) Cancer Immunol. Immunother. , vol.60 , pp. 1173-1180
    • Sayers, T.J.1
  • 35
    • 79952240840 scopus 로고    scopus 로고
    • Understanding the role of the death receptor 5/FADD/caspase-8 death signaling in cancer metastasis
    • Sun SY (2011) Understanding the role of the death receptor 5/FADD/caspase-8 death signaling in cancer metastasis. Mol. Cell. Pharmacol. 3, 31-34.
    • (2011) Mol. Cell. Pharmacol. , vol.3 , pp. 31-34
    • Sun, S.Y.1
  • 37
    • 79551620159 scopus 로고    scopus 로고
    • Apoptosis and oncogenesis: give and take in the BCL-2 family
    • Llambi F, Green DR (2011) Apoptosis and oncogenesis: give and take in the BCL-2 family. Curr. Opin. Genet. Dev. 21, 12-20.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 12-20
    • Llambi, F.1    Green, D.R.2
  • 38
    • 76749107731 scopus 로고    scopus 로고
    • Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis?
    • Engel T, Henshall DC (2009) Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? IJPPP 1, 97-115.
    • (2009) IJPPP , vol.1 , pp. 97-115
    • Engel, T.1    Henshall, D.C.2
  • 40
    • 84862815471 scopus 로고    scopus 로고
    • Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer
    • Wen X, Lin ZQ, Liu B, Wei YQ (2012) Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer. Cell Prolif. 45, 217-224.
    • (2012) Cell Prolif. , vol.45 , pp. 217-224
    • Wen, X.1    Lin, Z.Q.2    Liu, B.3    Wei, Y.Q.4
  • 41
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 42
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6
  • 43
    • 80051761743 scopus 로고    scopus 로고
    • The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy
    • Kelly PN, Strasser A (2011) The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ. 18, 1414-1424.
    • (2011) Cell Death Differ. , vol.18 , pp. 1414-1424
    • Kelly, P.N.1    Strasser, A.2
  • 46
    • 0036022407 scopus 로고    scopus 로고
    • Initiator caspases in apoptosis signaling pathways
    • Chen M, Wang J (2002) Initiator caspases in apoptosis signaling pathways. Apoptosis 7, 313-319.
    • (2002) Apoptosis , vol.7 , pp. 313-319
    • Chen, M.1    Wang, J.2
  • 47
    • 69449095860 scopus 로고    scopus 로고
    • Caspases and kinases in a death grip
    • Kurokawa M, Kornbluth S (2009) Caspases and kinases in a death grip. Cell 138, 838-854.
    • (2009) Cell , vol.138 , pp. 838-854
    • Kurokawa, M.1    Kornbluth, S.2
  • 48
    • 79955755460 scopus 로고    scopus 로고
    • Conversation between apoptosis and autophagy: "Is it your turn or mine?"
    • Giansanti V, Torriglia A, Scovassi AI (2011) Conversation between apoptosis and autophagy: "Is it your turn or mine?". Apoptosis 16, 321-333.
    • (2011) Apoptosis , vol.16 , pp. 321-333
    • Giansanti, V.1    Torriglia, A.2    Scovassi, A.I.3
  • 49
    • 70349956567 scopus 로고    scopus 로고
    • Apoptosis and autophagy: regulation of caspase-9 by Phosphorylation
    • Allan LA, Clarke PR (2009) Apoptosis and autophagy: regulation of caspase-9 by Phosphorylation. FEBS J. 276, 6063-6073.
    • (2009) FEBS J. , vol.276 , pp. 6063-6073
    • Allan, L.A.1    Clarke, P.R.2
  • 50
    • 0035283038 scopus 로고    scopus 로고
    • Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes
    • Bratton SB, Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES et al. (2001) Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J. 20, 998-1009.
    • (2001) EMBO J. , vol.20 , pp. 998-1009
    • Bratton, S.B.1    Walker, G.2    Srinivasula, S.M.3    Sun, X.M.4    Butterworth, M.5    Alnemri, E.S.6
  • 51
    • 0032493910 scopus 로고    scopus 로고
    • Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9
    • Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H et al. (1998) Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase-9. Cell 94, 325-337.
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1    Haydar, T.F.2    Kuan, C.Y.3    Gu, Y.4    Taya, C.5    Karasuyama, H.6
  • 53
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: linking inflammation and immunity to cancer development and progression
    • Karin M, Greten FR (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5, 749-759.
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 55
    • 0033621839 scopus 로고    scopus 로고
    • NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis
    • Kühnel F, Zender L, Paul Y, Tietze MK, Trautwein C, Manns M et al. (2000) NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J. Biol. Chem. 275, 6421-6427.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6421-6427
    • Kühnel, F.1    Zender, L.2    Paul, Y.3    Tietze, M.K.4    Trautwein, C.5    Manns, M.6
  • 56
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: a treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM (2004) The IKK NF-κB system: a treasure trove for drug development. Nat. Rev. Drug Discov. 3, 17-26.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 57
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa) Bkinase-beta
    • Yin MJ, Yamamoto Y, Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I (kappa) Bkinase-beta. Nature 396, 77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 58
    • 84862893811 scopus 로고    scopus 로고
    • Cell growth inhibition and induction of apoptosis by snake venom toxin in ovarian cancer cell via inactivation of nuclear factor kappaB and signal transducer and activator of transcription 3
    • Song JK, Jo MR, Park MH, Song HS, An BJ, Song MJ et al. (2012) Cell growth inhibition and induction of apoptosis by snake venom toxin in ovarian cancer cell via inactivation of nuclear factor kappaB and signal transducer and activator of transcription 3. Arch. Pharm. Res. 35, 867-876.
    • (2012) Arch. Pharm. Res. , vol.35 , pp. 867-876
    • Song, J.K.1    Jo, M.R.2    Park, M.H.3    Song, H.S.4    An, B.J.5    Song, M.J.6
  • 59
    • 79958723466 scopus 로고    scopus 로고
    • Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression
    • Ling H, Zhang Y, Ng KY, Chew EH (2011) Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression. Breast Cancer Res. Treat. 126, 609-620.
    • (2011) Breast Cancer Res. Treat. , vol.126 , pp. 609-620
    • Ling, H.1    Zhang, Y.2    Ng, K.Y.3    Chew, E.H.4
  • 61
    • 0035156707 scopus 로고    scopus 로고
    • P53-dependent pathways of apoptosis
    • Benchimol S (2001) P53-dependent pathways of apoptosis. Cell Death Differ. 8, 1049-1051.
    • (2001) Cell Death Differ. , vol.8 , pp. 1049-1051
    • Benchimol, S.1
  • 65
    • 56449092072 scopus 로고    scopus 로고
    • MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1
    • Miller TE, Ghoshal K, Ramaswamy B, Roy S, Datta J, Shapiro CL et al. (2008) MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1. J. Biol. Chem. 283, 29897-29903.
    • (2008) J. Biol. Chem. , vol.283 , pp. 29897-29903
    • Miller, T.E.1    Ghoshal, K.2    Ramaswamy, B.3    Roy, S.4    Datta, J.5    Shapiro, C.L.6
  • 66
    • 78049489278 scopus 로고    scopus 로고
    • Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus
    • Linnstaedt SD, Gottwein E, Skalsky RL, Luftig MA, Cullen BR (2010) Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus. J. Virol. 84, 11670-11678.
    • (2010) J. Virol. , vol.84 , pp. 11670-11678
    • Linnstaedt, S.D.1    Gottwein, E.2    Skalsky, R.L.3    Luftig, M.A.4    Cullen, B.R.5
  • 67
    • 58649107855 scopus 로고    scopus 로고
    • MicroRNA and cancer - focus on apoptosis
    • Wang Y, Lee CG (2009) MicroRNA and cancer - focus on apoptosis. J. Cell Mol. Med. 13, 12-23.
    • (2009) J. Cell Mol. Med. , vol.13 , pp. 12-23
    • Wang, Y.1    Lee, C.G.2
  • 68
    • 70349320158 scopus 로고    scopus 로고
    • Causes and consequences of microRNA dysregulation in cancer
    • Croce CM (2009) Causes and consequences of microRNA dysregulation in cancer. Nat. Rev. Genet. 10, 704-714.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 704-714
    • Croce, C.M.1
  • 69
    • 51749088101 scopus 로고    scopus 로고
    • Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3
    • Tsang WP, Kwok TT (2008) Let-7a microRNA suppresses therapeutics-induced cancer cell death by targeting caspase-3. Apoptosis 13, 1215-1222.
    • (2008) Apoptosis , vol.13 , pp. 1215-1222
    • Tsang, W.P.1    Kwok, T.T.2
  • 70
  • 72
    • 43149090064 scopus 로고    scopus 로고
    • FIP200, a uLK-interacting protein, is required for autophagosome formation in mammalian cells
    • Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL et al. (2008) FIP200, a uLK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 181, 497-510.
    • (2008) J. Cell Biol. , vol.181 , pp. 497-510
    • Hara, T.1    Takamura, A.2    Kishi, C.3    Iemura, S.4    Natsume, T.5    Guan, J.L.6
  • 73
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the uLK1-Atg13-FIP200 complex required for autophagy
    • Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y et al. (2009) Nutrient-dependent mTORC1 association with the uLK1-Atg13-FIP200 complex required for autophagy. Mol. Biol. Cell 7, 1981-1991.
    • (2009) Mol. Biol. Cell , vol.7 , pp. 1981-1991
    • Hosokawa, N.1    Hara, T.2    Kaizuka, T.3    Kishi, C.4    Takamura, A.5    Miura, Y.6
  • 74
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS (2009) The double-edged sword of autophagy modulation in cancer. Clin. Cancer Res. 15, 5308-5316.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 75
    • 0037025173 scopus 로고    scopus 로고
    • Addiction to oncogenes - the Achilles heal of cancer
    • Weinstein IB (2002) Addiction to oncogenes - the Achilles heal of cancer. Science 297, 63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 76
    • 33746961739 scopus 로고    scopus 로고
    • Mechanisms of disease: oncogene addiction - a rationale for molecular targeting in cancer therapy
    • Weinstein IB, Joe AK (2006) Mechanisms of disease: oncogene addiction - a rationale for molecular targeting in cancer therapy. Nat. Clin. Pract. Oncol. 3, 448-457.
    • (2006) Nat. Clin. Pract. Oncol. , vol.3 , pp. 448-457
    • Weinstein, I.B.1    Joe, A.K.2
  • 78
    • 35348926002 scopus 로고    scopus 로고
    • The PI3K inhibitor arsenal: choose your weapon!
    • Crabbe T, Welham MJ, Ward SG (2007) The PI3K inhibitor arsenal: choose your weapon!. Trends Biochem. Sci. 32, 450-456.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 450-456
    • Crabbe, T.1    Welham, M.J.2    Ward, S.G.3
  • 79
    • 0001582482 scopus 로고
    • Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma
    • Staal SP (1987) Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc. Natl. Acad. Sci. USA 84, 5034-5037.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 5034-5037
    • Staal, S.P.1
  • 80
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith R, Jacinto E, Wullschleger S, Lorberg A, Crespo JL, Bonenfant D et al. (2002) Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468.
    • (2002) Mol. Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3    Lorberg, A.4    Crespo, J.L.5    Bonenfant, D.6
  • 81
    • 0034675919 scopus 로고    scopus 로고
    • Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
    • Zhang BH, Guan KL (2000) Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J. 19, 5429-5439.
    • (2000) EMBO J. , vol.19 , pp. 5429-5439
    • Zhang, B.H.1    Guan, K.L.2
  • 82
    • 84875398704 scopus 로고    scopus 로고
    • Tokgun O (2012) tumour suppressor PTEN enhanced enzyme activity of GPx, SOD and catalase by suppression of PI3K/AKT pathway in non-small cell lung cancer cell lines
    • doi: 10.3109/14756366.2011.654114.
    • Akca H, Demiray A, Aslan M, Acikbas I, Tokgun O (2012) tumour suppressor PTEN enhanced enzyme activity of GPx, SOD and catalase by suppression of PI3K/AKT pathway in non-small cell lung cancer cell lines. J. Enzyme Inhib. Med. Chem., doi: 10.3109/14756366.2011.654114.
    • J. Enzyme Inhib. Med. Chem.
    • Akca, H.1    Demiray, A.2    Aslan, M.3    Acikbas, I.4
  • 83
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E et al. (2004) Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904.
    • (2004) Genes Dev. , vol.18 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3    Manning, B.D.4    Reiling, J.H.5    Hafen, E.6
  • 84
    • 0036931949 scopus 로고    scopus 로고
    • Targeting the Raf kinase cascade in cancer therapy-novel molecular targets and therapeutic strategies
    • Lee JTJ, McCubrey JA (2002) Targeting the Raf kinase cascade in cancer therapy-novel molecular targets and therapeutic strategies. Expert Opin. Ther. Tar. 6, 659-678.
    • (2002) Expert Opin. Ther. Tar. , vol.6 , pp. 659-678
    • Lee, J.T.J.1    McCubrey, J.A.2
  • 85
    • 84859967413 scopus 로고    scopus 로고
    • The Ras protein superfamily: evolutionary tree and role of conserved amino acids
    • Rojas AM, Fuentes G, Rausell A, Valencia A (2012) The Ras protein superfamily: evolutionary tree and role of conserved amino acids. J. Cell Biol. 196, 189-201.
    • (2012) J. Cell Biol. , vol.196 , pp. 189-201
    • Rojas, A.M.1    Fuentes, G.2    Rausell, A.3    Valencia, A.4
  • 86
    • 77649254901 scopus 로고    scopus 로고
    • Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients
    • Jin Y, Shima Y, Furu M, Aoyama T, Nakamata T, Nakayama T et al. (2010) Absence of oncogenic mutations of RAS family genes in soft tissue sarcomas of 100 Japanese patients. Anticancer Res. 30, 245-251.
    • (2010) Anticancer Res. , vol.30 , pp. 245-251
    • Jin, Y.1    Shima, Y.2    Furu, M.3    Aoyama, T.4    Nakamata, T.5    Nakayama, T.6
  • 87
    • 0038578688 scopus 로고    scopus 로고
    • GTPases and T cell activation
    • Cantrell DA (2003) GTPases and T cell activation. Immunol. Rev. 192, 122-130.
    • (2003) Immunol. Rev. , vol.192 , pp. 122-130
    • Cantrell, D.A.1
  • 88
    • 0029006126 scopus 로고
    • Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation
    • Marais R, Light Y, Paterson HF, Marshall CJ (1995) Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J. 14, 3136-3145.
    • (1995) EMBO J. , vol.14 , pp. 3136-3145
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Marshall, C.J.4
  • 90
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR et al. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126, 121-134.
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3    Syed, N.4    Smith, P.5    Harrison, P.R.6
  • 92
    • 0442325388 scopus 로고    scopus 로고
    • The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
    • Duran A, Serrano M, Leitges M, Flores JM, Picard S, Brown JP et al. (2004) The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis. Dev. Cell 6, 303-309.
    • (2004) Dev. Cell , vol.6 , pp. 303-309
    • Duran, A.1    Serrano, M.2    Leitges, M.3    Flores, J.M.4    Picard, S.5    Brown, J.P.6
  • 93
    • 48449101433 scopus 로고    scopus 로고
    • p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov AV, Karin M (2008) p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 134, 451-460.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 96
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7, 683-694.
    • (2001) Mol. Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 97
    • 79959918521 scopus 로고    scopus 로고
    • Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned?
    • Zhang X, Rielland M, Yalcin S, Ghaffari S (2011) Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned? Curr. Drug Targets 12, 1267-1283.
    • (2011) Curr. Drug Targets , vol.12 , pp. 1267-1283
    • Zhang, X.1    Rielland, M.2    Yalcin, S.3    Ghaffari, S.4
  • 98
    • 79954606824 scopus 로고    scopus 로고
    • Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells
    • Jiang Q, Wang Y, Li T, Shi K, Li Z, Ma Y et al. (2011) Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells. Mol. Biol. Cell 22, 1167-1180.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1167-1180
    • Jiang, Q.1    Wang, Y.2    Li, T.3    Shi, K.4    Li, Z.5    Ma, Y.6
  • 99
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, Bray K, Anderson D, Chen G et al. (2006) Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10, 51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3    Bray, K.4    Anderson, D.5    Chen, G.6
  • 100
    • 34250886966 scopus 로고    scopus 로고
    • Hsp90 regulates processing of NF-kB2 p100 involving protection of NF-kB-inducing kinase (NIK) from autophagy-mediated degradation
    • Qing G, Yan P, Qu Z, Liu H, Li H, Xiao G (2007) Hsp90 regulates processing of NF-kB2 p100 involving protection of NF-kB-inducing kinase (NIK) from autophagy-mediated degradation. Cell Res. 17, 520-530.
    • (2007) Cell Res. , vol.17 , pp. 520-530
    • Qing, G.1    Yan, P.2    Qu, Z.3    Liu, H.4    Li, H.5    Xiao, G.6
  • 102
    • 84862790135 scopus 로고    scopus 로고
    • MicroRNA-modulated autophagic signaling networks in cancer
    • Fu LL, Wen X, Bao JK, Liu B (2012) MicroRNA-modulated autophagic signaling networks in cancer. Int. J. Biochem. Cell Biol. 44, 733-736.
    • (2012) Int. J. Biochem. Cell Biol. , vol.44 , pp. 733-736
    • Fu, L.L.1    Wen, X.2    Bao, J.K.3    Liu, B.4
  • 103
    • 0028964232 scopus 로고
    • Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast
    • Stack JH, DeWald DB, Takegawa K, Emr SD (1995) Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 129, 321-334.
    • (1995) J. Cell Biol. , vol.129 , pp. 321-334
    • Stack, J.H.1    DeWald, D.B.2    Takegawa, K.3    Emr, S.D.4
  • 104
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
    • Kihara A, Noda T, Ishihara N, Ohsumi Y (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530.
    • (2001) J. Cell Biol. , vol.152 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 105
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of Beclin-1 is required for Vps34 binding, autophagy and tumor-suppressor function
    • Furuya N, Yu J, Byfield M, Pattingre S, Levine B (2005) The evolutionarily conserved domain of Beclin-1 is required for Vps34 binding, autophagy and tumor-suppressor function. Autophagy 1, 46-52.
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.4    Levine, B.5
  • 106
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin-1-binding protein UVRAG
    • Liang C, Feng P, Ku B, Dotan I, Canaani D, Oh BH et al. (2006) Autophagic and tumour suppressor activity of a novel Beclin-1-binding protein UVRAG. Nat. Cell Biol. 8, 688-699.
    • (2006) Nat. Cell Biol. , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3    Dotan, I.4    Canaani, D.5    Oh, B.H.6
  • 107
    • 34848899280 scopus 로고    scopus 로고
    • Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    • Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y et al. (2007) Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 9, 1142-1151.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1142-1151
    • Takahashi, Y.1    Coppola, D.2    Matsushita, N.3    Cualing, H.D.4    Sun, M.5    Sato, Y.6
  • 108
  • 110
    • 67650812332 scopus 로고    scopus 로고
    • RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    • Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC et al. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332-336.
    • (2009) Science , vol.325 , pp. 332-336
    • Zhang, D.W.1    Shao, J.2    Lin, J.3    Zhang, N.4    Lu, B.J.5    Lin, S.C.6
  • 111
    • 34347344991 scopus 로고    scopus 로고
    • Sequential activation of poly (ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis
    • Moubarak RS, Yuste VJ, Artus C, Bouharrour A, Greer PA, Menissier-de Murcia J et al. (2007) Sequential activation of poly (ADP-ribose) polymerase 1, calpains, and Bax is essential in apoptosis-inducing factor-mediated programmed necrosis. Mol. Cell. Biol. 27, 4844-4862.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4844-4862
    • Moubarak, R.S.1    Yuste, V.J.2    Artus, C.3    Bouharrour, A.4    Greer, P.A.5    Menissier-de Murcia, J.6
  • 112
    • 33646827842 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymer-ase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation
    • Xu Y, Huang S, Liu ZG, Han J (2006) Poly (ADP-ribose) polymer-ase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. J. Biol. Chem. 281, 8788-8795.
    • (2006) J. Biol. Chem. , vol.281 , pp. 8788-8795
    • Xu, Y.1    Huang, S.2    Liu, Z.G.3    Han, J.4
  • 113
    • 63849124057 scopus 로고    scopus 로고
    • The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival
    • Hassa PO (2009) The molecular "Jekyll and Hyde" duality of PARP1 in cell death and cell survival. Front. Biosci. 14, 72-111.
    • (2009) Front. Biosci. , vol.14 , pp. 72-111
    • Hassa, P.O.1
  • 114
    • 34249820757 scopus 로고    scopus 로고
    • TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death
    • Kim YS, Morgan MJ, Choksi S, Liu ZG (2007) TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol. Cell 26, 675-687.
    • (2007) Mol. Cell , vol.26 , pp. 675-687
    • Kim, Y.S.1    Morgan, M.J.2    Choksi, S.3    Liu, Z.G.4
  • 115
    • 66449133280 scopus 로고    scopus 로고
    • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    • Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M et al. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112-1123.
    • (2009) Cell , vol.137 , pp. 1112-1123
    • Cho, Y.S.1    Challa, S.2    Moquin, D.3    Genga, R.4    Ray, T.D.5    Guildford, M.6
  • 116
    • 66749183275 scopus 로고    scopus 로고
    • Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
    • He S, Wang L, Miao L, Wang T, Du F, Zhao L et al. (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137, 1100-1111.
    • (2009) Cell , vol.137 , pp. 1100-1111
    • He, S.1    Wang, L.2    Miao, L.3    Wang, T.4    Du, F.5    Zhao, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.