Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 24, 2005, Pages 8567-8572

  Hideshima, Teru ^a   Bradner, James E ^a,b   Wong, Jason ^b   Chauhan, Dharminder ^a   Richardson, Paul ^a   Schreiber, Stuart L ^b,c   Anderson, Kenneth C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Histone deacetylase

Indexed keywords

ALPHA TUBULIN; BORTEZOMIB; CASPASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; NITUBACIN; PROTEASOME; PROTEASOME INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TUBACIN; UBIQUITIN; UNCLASSIFIED DRUG;

ACETYLATION; AGGRESOME; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOTOXICITY; DOSE TIME EFFECT RELATION; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; MULTIPLE MYELOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; STRESS; TUMOR CELL LINE; UBIQUITINATION;

ANILIDES; BORONIC ACIDS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HISTONE DEACETYLASES; HUMANS; HYDROXAMIC ACIDS; IMMUNOBLOTTING; INHIBITORY CONCENTRATION 50; MULTIPLE MYELOMA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEINS; PYRAZINES; RNA, SMALL INTERFERING; TUBULIN;

EID: 20844435806     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0503221102     Document Type: Article

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