USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair

Nucleic Acids Research

Volumn 41, Issue 3, 2013, Pages 1750-1756

  Khoronenkova, Svetlana V ^a   Dianov, Grigory L ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MESSENGER RNA; MULE PROTEIN; PROTEIN P53; PROTEIN USP7S; REGULATOR PROTEIN; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; EXCISION REPAIR; GENE EXPRESSION REGULATION; MULE GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION; UPREGULATION;

CELL LINE, TUMOR; DNA DAMAGE; DNA REPAIR; DOWN-REGULATION; HUMANS; ISOENZYMES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN THIOLESTERASE; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84873696103     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks1359     Document Type: Article

References (19)

1. Vogelstein B., Lane D. and Levine A.J. (2000) Surfing the p53 network. Nature, 408, 307-310
2. Levine A.J. and Oren M. (2009) The first 30 years of p53: growing ever more complex. Nat. Rev. Cancer., 9, 749-758
3. de Rozieres S., Maya R., Oren M. and Lozano G. (2000) The loss of mdm2 induces p53-mediated apoptosis. Oncogene, 19, 1691-1697
4. Vousden K.H. and Prives C. (2009) Blinded by the light: the growing complexity of p53. Cell, 137, 413-431
5. Chen D., Kon N., Li,M., Zhang W., Qin J. and Gu,W. (2005 ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell, 121, 1071-1083
6. Leng R.P., Lin Y., Ma,W., Wu,H., Lemmers B., Chung S., Parant J.M., Lozano G., Hakem R. and Benchimol S. (2003 Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell, 112, 779-791
7. Dornan D., Wertz I., Shimizu H., Arnott D., Frantz G.D., Dowd P., O'Rourke K., Koeppen Hand Dixit V.M. (2004) The ubiquitin ligase COP1 is a critical negative regulator of p53 Nature, 429, 86-92
8. Parsons J.L., Tait P.S., Finch D., Dianova I.I., Edelmann M.J., Khoronenkova S.V., Kessler B.M., Sharma R.A., McKenna W.G. and Dianov G.L. (2009) Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO J., 28, 3207-3215
9. Markkanen E., van Loon B., Ferrari E., Parsons J.L., Dianov G.L. and Hubscher U. (2012) Regulation of oxidative DNA damage repair by DNA polymerase lambda and MutYH by cross-talk of phosphorylation and ubiquitination. Proc. Natl. Acad. Sci. USA, 109, 437-442
10. Khoronenkova S.V. and Dianov G.L. (2011) The emerging role of Mule and ARF in the regulation of base excision repair. FEBS Lett., 585, 2831-2835
11. Kon N., Zhong J., Qiang L., Accili D. and Gu,W. (2012 Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J. Biol. Chem., 287, 5102-5111
12. Kamijo T., van de Kamp E., Chong M.J., Zindy F., Diehl J.A., Sherr C.J. and McKinnon P.J. (1999) Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer Res., 59, 2464-2469
13. Khoronenkova S.V., Dianova I.I., Ternette N., Kessler B.M., Parsons J.L. and Dianov G.L. (2012) ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. Mol. Cell., 45, 801-813
14. Sowa M.E., Bennett E.J., Gygi S.P. and Harper J.W. (2009 Defining the human deubiquitinating enzyme interaction landscape. Cell, 138, 389-403
15. Dianova I.I., Bohr V.A. and Dianov G.L. (2001) Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair. Biochemistry, 40, 12639-12644
16. Petri S., Grimmler M., Over S., Fischer U. and Gruss O.J. (2007 Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex. J. Cell. Biol., 179, 451-465
17. Jin Y., Lee H., Zeng S.X., Dai M.S. and Lu,H. (2003) MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J., 22, 6365-6377
18. Adhikary S., Marinoni F., Hock A., Hulleman E., Popov N., Beier R., Bernard S., Quarto M., Capra M., Goettig S. et al. (2005) The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell, 123, 409-421
19. Yoon S.Y., Lee Y., Kim J.H., Chung A.S., Joo J.H., Kim C.N., Kim N.S., Choe I.S. and Kim J.W. (2005) Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein. Biochem. Biophys. Res. Commun., 326, 7-17