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Volumn 4 MAY, Issue , 2014, Pages

Depolarization controls TRAIL-sensitization and tumor-selective killing of cancer cells: Crosstalk with ROS

Author keywords

Aapoptosis; Depolarization; Endoplasmic reticulum stress; Oxidative stress; ROS; Sensitization; TRAIL; Tumor selective killing

Indexed keywords

ALLYL SULFIDE; BEVACIZUMAB; CAPSAICIN; CARBOPLATIN; CASPASE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; CONATUMUMAB; CYTOCHROME C; DEATH RECEPTOR 4; DEATH RECEPTOR 5; DULANERMIN; EPIGALLOCATECHIN GALLATE; HERBACEOUS AGENT; MAPATUMUMAB; PACLITAXEL; PANCRATISTATIN; PIPERLONGUMINE; PROTEIN BCL 2; PROTEIN MCL 1; REACTIVE OXYGEN METABOLITE; TIGATUZUMAB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND RECEPTOR 3; UNCLASSIFIED DRUG; UNINDEXED DRUG; WOGONIN;

EID: 84904618232     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00128     Document Type: Review
Times cited : (53)

References (123)
  • 1
    • 0037273848 scopus 로고    scopus 로고
    • Apo2L/TRAIL and its death and decoy
    • doi: 10.1038/sj.cdd.4401187
    • LeBlanc HN, Ashkenazi A. Apo2L/TRAIL and its death and decoy. Cell Death Differ (2003) 10:66-75. doi: 10.1038/sj.cdd.4401187
    • (2003) Cell Death Differ , vol.10 , pp. 66-75
    • LeBlanc, H.N.1    Ashkenazi, A.2
  • 2
    • 52649109068 scopus 로고    scopus 로고
    • The TRAIL apoptotic pathway in cancer onset, progression and therapy
    • doi:10.1038/nrc2465
    • Johnstone RW, Frew AJ, Smyth MJ. The TRAIL apoptotic pathway in cancer onset, progression and therapy. Nat Rev Cancer (2008) 8:782-98. doi:10.1038/nrc2465
    • (2008) Nat Rev Cancer , vol.8 , pp. 782-798
    • Johnstone, R.W.1    Frew, A.J.2    Smyth, M.J.3
  • 3
    • 54249107246 scopus 로고    scopus 로고
    • The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway
    • doi:10.1038/onc.2008.298
    • Wang S. The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway. Oncogene (2008) 27:6207-15. doi:10.1038/onc.2008.298
    • (2008) Oncogene , vol.27 , pp. 6207-6215
    • Wang, S.1
  • 4
    • 79960913158 scopus 로고    scopus 로고
    • Targeting the extrinsic apoptosis signaling pathway for cancer therapy
    • doi:10.1007/s00262-011-1008-4
    • Sayers TJ. Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother (2011) 60:1173-80. doi:10.1007/s00262-011-1008-4
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1173-1180
    • Sayers, T.J.1
  • 5
    • 84892844933 scopus 로고    scopus 로고
    • Hepatocyte expression of TRAIL pathway regulators correlates with histopathological and clinical parameters in chronic HCV infection
    • doi:10.1016/j.prp.2013.10.005
    • Brost S, Zimmermann A, Koschny R, Sykora J, Stremmel W, Schirmacher P, et al. Hepatocyte expression of TRAIL pathway regulators correlates with histopathological and clinical parameters in chronic HCV infection. Pathol Res Pract (2014) 210:83-91. doi:10.1016/j.prp.2013.10.005
    • (2014) Pathol Res Pract , vol.210 , pp. 83-91
    • Brost, S.1    Zimmermann, A.2    Koschny, R.3    Sykora, J.4    Stremmel, W.5    Schirmacher, P.6
  • 6
    • 84878377581 scopus 로고    scopus 로고
    • TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner
    • e447
    • Badmann A, Langsch S, Keogh A, Brunner T, Kaufmann T, Corazza N. TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner. Cell Death Dis (2012) 20(3):e447. doi:10.1038/cddis.2012.185
    • (2012) Cell Death Dis , vol.20 , pp. 3
    • Badmann, A.1    Langsch, S.2    Keogh, A.3    Brunner, T.4    Kaufmann, T.5    Corazza, N.6
  • 7
    • 80655149472 scopus 로고    scopus 로고
    • Death receptor 5 signaling promotes hepatocyte lipoapoptosis
    • doi:10.1074/jbc.M111.280420
    • Cazanave SC, Mott JL, Bronk SF, Werneburg NW, Fingas CD, Meng XW, et al. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. J Biol Chem (2011) 286:39336-48. doi:10.1074/jbc.M111.280420
    • (2011) J Biol Chem , vol.286 , pp. 39336-39348
    • Cazanave, S.C.1    Mott, J.L.2    Bronk, S.F.3    Werneburg, N.W.4    Fingas, C.D.5    Meng, X.W.6
  • 8
    • 33748316625 scopus 로고    scopus 로고
    • TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality
    • doi:10.1172/JCI27726
    • Corazza N, Jakob S, Schaer C, Frese S, Keogh A, Stroka D, et al. TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest (2006) 116:2493-9. doi:10.1172/JCI27726
    • (2006) J Clin Invest , vol.116 , pp. 2493-2499
    • Corazza, N.1    Jakob, S.2    Schaer, C.3    Frese, S.4    Keogh, A.5    Stroka, D.6
  • 10
    • 35348877298 scopus 로고    scopus 로고
    • Barriers to effective TRAIL-targeted therapy of malignancy
    • Dyer MJ, MacFarlane M, Cohen GM. Barriers to effective TRAIL-targeted therapy of malignancy. J Clin Oncol (2007) 25(28):4505-6.
    • (2007) J Clin Oncol , vol.25 , Issue.28 , pp. 4505-4506
    • Dyer, M.J.1    MacFarlane, M.2    Cohen, G.M.3
  • 11
    • 84875230886 scopus 로고    scopus 로고
    • On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics
    • doi:10.1038/onc.2012.164
    • Dimberg LY, Anderson CK, Camidge R, Behbakht K, Thorburn A, Ford HL. On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics. Oncogene (2013) 32:1341-50. doi:10.1038/onc.2012.164
    • (2013) Oncogene , vol.32 , pp. 1341-1350
    • Dimberg, L.Y.1    Anderson, C.K.2    Camidge, R.3    Behbakht, K.4    Thorburn, A.5    Ford, H.L.6
  • 12
    • 0000707605 scopus 로고    scopus 로고
    • Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux
    • doi:10.1038/sj.cdd.4400296
    • McCarthy JV, Cotter TG. Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux. Cell Death Differ (1997) 4:756-70. doi:10.1038/sj.cdd.4400296
    • (1997) Cell Death Differ , vol.4 , pp. 756-770
    • McCarthy, J.V.1    Cotter, T.G.2
  • 13
    • 35748976248 scopus 로고    scopus 로고
    • Cell volume regulatory ion channels in cell proliferation and cell death
    • doi:10.1016/S0076-6879(07)28011-5
    • Lang F, Föller M, Lang K, Lang P, Ritter M, Vereninov A, et al. Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol (2007) 428:209-25. doi:10.1016/S0076-6879(07)28011-5
    • (2007) Methods Enzymol , vol.428 , pp. 209-225
    • Lang, F.1    Föller, M.2    Lang, K.3    Lang, P.4    Ritter, M.5    Vereninov, A.6
  • 14
    • 0035830843 scopus 로고    scopus 로고
    • Plasma membrane depolarization without repolarization is an early molecular event in anti-Fas-induced apoptosis
    • doi:10.1074/jbc.M005171200
    • Bortner CD, Gomez-Angelats M, Cidlowski JA. Plasma membrane depolarization without repolarization is an early molecular event in anti-Fas-induced apoptosis. J Biol Chem (2001) 276:4304-14. doi:10.1074/jbc.M005171200
    • (2001) J Biol Chem , vol.276 , pp. 4304-4314
    • Bortner, C.D.1    Gomez-Angelats, M.2    Cidlowski, J.A.3
  • 15
    • 65649143561 scopus 로고    scopus 로고
    • Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism
    • doi:10.1016/j.bcp.2009.03.025
    • Yin W, Li X, Feng S, Cheng W, Tang B, Shi YL, et al. Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism. Biochem Pharmacol (2009) 78:191-202. doi:10.1016/j.bcp.2009.03.025
    • (2009) Biochem Pharmacol , vol.78 , pp. 191-202
    • Yin, W.1    Li, X.2    Feng, S.3    Cheng, W.4    Tang, B.5    Shi, Y.L.6
  • 16
    • 9644262891 scopus 로고    scopus 로고
    • Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells
    • doi:10.1016/j.febslet.2004.10.075
    • Nolte F, Friedrich O, Rojewski M, Fink RH, Schrezenmeier H, Körper S. Depolarisation of the plasma membrane in the arsenic trioxide (As2O3)-and anti-CD95-induced apoptosis in myeloid cells. FEBS Lett (2004) 578:85-9. doi:10.1016/j.febslet.2004.10.075
    • (2004) FEBS Lett , vol.578 , pp. 85-89
    • Nolte, F.1    Friedrich, O.2    Rojewski, M.3    Fink, R.H.4    Schrezenmeier, H.5    Körper, S.6
  • 17
    • 33746491304 scopus 로고    scopus 로고
    • Neuroprotective effect of mifepristone involves neuron depolarization
    • doi:10.1096/fj.05-5832com
    • Ghoumari AM, Piochon C, Tomkiewicz C, Eychenne B, Levenes C, Dusart I, et al. Neuroprotective effect of mifepristone involves neuron depolarization. FASEB J (2006) 20:1377-86. doi:10.1096/fj.05-5832com
    • (2006) FASEB J , vol.20 , pp. 1377-1386
    • Ghoumari, A.M.1    Piochon, C.2    Tomkiewicz, C.3    Eychenne, B.4    Levenes, C.5    Dusart, I.6
  • 18
    • 33745228422 scopus 로고    scopus 로고
    • Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5
    • doi:10.1158/0008-5472.CAN-05-3544
    • Frese S, Frese-Schaper M, Andres AC, Miescher D, Zumkehr B, Schmid RA. Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5. Cancer Res (2006) 66:5867-74. doi:10.1158/0008-5472.CAN-05-3544
    • (2006) Cancer Res , vol.66 , pp. 5867-5874
    • Frese, S.1    Frese-Schaper, M.2    Andres, A.C.3    Miescher, D.4    Zumkehr, B.5    Schmid, R.A.6
  • 19
    • 84863569591 scopus 로고    scopus 로고
    • Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP-sensitive K+ channels and endoplasmic reticulum stress
    • doi:10.3892/ijo.2012.1483
    • Suzuki Y, Inoue T, Murai M, Suzuki-Karasaki M, Ochiai T, Ra C. Depolarization potentiates TRAIL-induced apoptosis in human melanoma cells: role for ATP-sensitive K+ channels and endoplasmic reticulum stress. Int J Oncol (2012) 41:465-75. doi:10.3892/ijo.2012.1483
    • (2012) Int J Oncol , vol.41 , pp. 465-475
    • Suzuki, Y.1    Inoue, T.2    Murai, M.3    Suzuki-Karasaki, M.4    Ochiai, T.5    Ra, C.6
  • 20
    • 84878006508 scopus 로고    scopus 로고
    • Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells
    • doi:10.1016/j.freeradbiomed.2013.04.020
    • Inoue T, Suzuki-Karasaki Y. Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells. Free Radic Biol Med (2013) 61:273-84. doi:10.1016/j.freeradbiomed.2013.04.020
    • (2013) Free Radic Biol Med , vol.61 , pp. 273-284
    • Inoue, T.1    Suzuki-Karasaki, Y.2
  • 21
    • 84894428398 scopus 로고    scopus 로고
    • Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells
    • doi:10.3892/ijo.2013.2215
    • Suzuki-Karasaki M, Ochiai T, Suzuki-Karasaki Y. Crosstalk between mitochondrial ROS and depolarization in the potentiation of TRAIL-induced apoptosis in human tumor cells. Int J Oncol (2014) 44:616-28. doi:10.3892/ijo.2013.2215
    • (2014) Int J Oncol , vol.44 , pp. 616-628
    • Suzuki-Karasaki, M.1    Ochiai, T.2    Suzuki-Karasaki, Y.3
  • 22
    • 84869799967 scopus 로고    scopus 로고
    • Diallyl trisulfide sensitizes human melanoma cells to TRAIL-induced cell death by promoting endoplasmic reticulum-mediated apoptosis
    • doi:10.3892/ijo.2012.1656
    • Murai M, Inoue T, Suzuki-Karasaki M, Ochiai T, Ra C, Nishida S, et al. Diallyl trisulfide sensitizes human melanoma cells to TRAIL-induced cell death by promoting endoplasmic reticulum-mediated apoptosis. Int J Oncol (2012) 41:2029-37. doi:10.3892/ijo.2012.1656
    • (2012) Int J Oncol , vol.41 , pp. 2029-2037
    • Murai, M.1    Inoue, T.2    Suzuki-Karasaki, M.3    Ochiai, T.4    Ra, C.5    Nishida, S.6
  • 23
    • 84873679865 scopus 로고    scopus 로고
    • Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation
    • doi:10.3892/ijo.2013.1769
    • Tochigi M, Inoue T, Suzuki-Karasaki M, Ochiai T, Ra C, Suzuki-Karasaki Y. Hydrogen peroxide induces cell death in human TRAIL-resistant melanoma through intracellular superoxide generation. Int J Oncol (2013) 42:863-72. doi:10.3892/ijo.2013.1769
    • (2013) Int J Oncol , vol.42 , pp. 863-872
    • Tochigi, M.1    Inoue, T.2    Suzuki-Karasaki, M.3    Ochiai, T.4    Ra, C.5    Suzuki-Karasaki, Y.6
  • 24
    • 36148994350 scopus 로고    scopus 로고
    • Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response
    • doi:10.1093/carcin/bgm173
    • Chen LH, Jiang CC, Kiejda KA, Wang YF, Thorne RF, Zhang XD, et al. Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response. Carcinogenesis (2007) 28:2328-36. doi:10.1093/carcin/bgm173
    • (2007) Carcinogenesis , vol.28 , pp. 2328-2336
    • Chen, L.H.1    Jiang, C.C.2    Kiejda, K.A.3    Wang, Y.F.4    Thorne, R.F.5    Zhang, X.D.6
  • 25
    • 34250888209 scopus 로고    scopus 로고
    • Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response
    • doi:10.1158/0008-5472.CAN-07-0213
    • Jiang CC, Chen LH, Gillespie S, Kiejda KA, Mhaidat N, Wang YF, et al. Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response. Cancer Res (2007) 67:5880-8. doi:10.1158/0008-5472.CAN-07-0213
    • (2007) Cancer Res , vol.67 , pp. 5880-5888
    • Jiang, C.C.1    Chen, L.H.2    Gillespie, S.3    Kiejda, K.A.4    Mhaidat, N.5    Wang, Y.F.6
  • 26
    • 74049087498 scopus 로고    scopus 로고
    • 2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2
    • doi:10.1186/1476-4598-8-122
    • Liu H, Jiang CC, Lavis CJ, Croft A, Dong L, Tseng HY, et al. 2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2. Mol Cancer (2009) 8:122. doi:10.1186/1476-4598-8-122
    • (2009) Mol Cancer , vol.8 , pp. 122
    • Liu, H.1    Jiang, C.C.2    Lavis, C.J.3    Croft, A.4    Dong, L.5    Tseng, H.Y.6
  • 27
    • 23944478449 scopus 로고    scopus 로고
    • Mitochondria: a novel target for the chemoprevention of cancer
    • doi:10.1007/s10495-005-0792-8
    • Hail N Jr. Mitochondria: a novel target for the chemoprevention of cancer. Apoptosis (2005) 10:687-705. doi:10.1007/s10495-005-0792-8
    • (2005) Apoptosis , vol.10 , pp. 687-705
    • Hail, N.1
  • 28
    • 33746912767 scopus 로고    scopus 로고
    • The permeability transition pore complex in cancer cell death
    • doi:10.1038/sj.onc.1209609
    • Brenner C, Grimm S. The permeability transition pore complex in cancer cell death. Oncogene (2006) 25:4744-56. doi:10.1038/sj.onc.1209609
    • (2006) Oncogene , vol.25 , pp. 4744-4756
    • Brenner, C.1    Grimm, S.2
  • 29
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: critical control points
    • doi:10.1016/S0092-8674(04)00046-7
    • Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell (2004) 116:205-19. doi:10.1016/S0092-8674(04)00046-7
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 30
    • 0041810128 scopus 로고    scopus 로고
    • The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death
    • doi:10.2174/0929867033457278
    • Halestrap AP, Brennerb C. The adenine nucleotide translocase: a central component of the mitochondrial permeability transition pore and key player in cell death. Curr Med Chem (2003) 10:1507-25. doi:10.2174/0929867033457278
    • (2003) Curr Med Chem , vol.10 , pp. 1507-1525
    • Halestrap, A.P.1    Brennerb, C.2
  • 31
    • 68649095201 scopus 로고    scopus 로고
    • Mitochondrial calcium and the permeability transition in cell death
    • doi:10.1016/j.bbabio.2009.06.009
    • Lemasters JJ, Theruvath TP, Zhong Z, Nieminen AL. Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta (2009) 1787:1395-401. doi:10.1016/j.bbabio.2009.06.009
    • (2009) Biochim Biophys Acta , vol.1787 , pp. 1395-1401
    • Lemasters, J.J.1    Theruvath, T.P.2    Zhong, Z.3    Nieminen, A.L.4
  • 32
    • 70350023058 scopus 로고    scopus 로고
    • Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery
    • doi:10.1038/cdd.2009.118
    • Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G. Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery. Cell Death Differ (2009) 16:1419-25. doi:10.1038/cdd.2009.118
    • (2009) Cell Death Differ , vol.16 , pp. 1419-1425
    • Zhivotovsky, B.1    Galluzzi, L.2    Kepp, O.3    Kroemer, G.4
  • 34
    • 84855231244 scopus 로고    scopus 로고
    • Targeting mitochondria in fighting cancer
    • Gogvadze V. Targeting mitochondria in fighting cancer. Curr Pharm Des (2011) 17:4034-46.
    • (2011) Curr Pharm Des , vol.17 , pp. 4034-4046
    • Gogvadze, V.1
  • 35
    • 33645154135 scopus 로고    scopus 로고
    • Cellular response to endoplasmic reticulum stress: a matter of life or death
    • doi:10.1038/sj.cdd.4401817
    • Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ (2006) 13:363-73. doi:10.1038/sj.cdd.4401817
    • (2006) Cell Death Differ , vol.13 , pp. 363-373
    • Boyce, M.1    Yuan, J.2
  • 36
    • 1342305497 scopus 로고    scopus 로고
    • Caspase-12 and ER-stress-mediated apoptosis: the story so far
    • doi:10.1196/annals.1299.032
    • Szegezdi E, Fitzgerald U, Samali A. Caspase-12 and ER-stress-mediated apoptosis: the story so far. Ann N Y Acad Sci (2003) 1010:186-94. doi:10.1196/annals.1299.032
    • (2003) Ann N Y Acad Sci , vol.1010 , pp. 186-194
    • Szegezdi, E.1    Fitzgerald, U.2    Samali, A.3
  • 37
    • 0347285295 scopus 로고    scopus 로고
    • A trip to the ER: coping with stress
    • doi:10.1016/j.tcb.2003.11.001
    • Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends Cell Biol (2004) 14:20-8. doi:10.1016/j.tcb.2003.11.001
    • (2004) Trends Cell Biol , vol.14 , pp. 20-28
    • Rutkowski, D.T.1    Kaufman, R.J.2
  • 38
    • 23644436847 scopus 로고    scopus 로고
    • Endoplasmic reticulum quality control and apoptosis
    • Groenendyk J, Michalak M. Endoplasmic reticulum quality control and apoptosis. Acta Biochim Pol (2005) 52:381-95.
    • (2005) Acta Biochim Pol , vol.52 , pp. 381-395
    • Groenendyk, J.1    Michalak, M.2
  • 40
    • 33749341552 scopus 로고    scopus 로고
    • TNF receptor superfamily-induced cell death: redox-dependent execution
    • doi:10.1096/fj.05-5603rev
    • Shen HM, Pervaiz S. TNF receptor superfamily-induced cell death: redox-dependent execution. FASEB J (2006) 20:1589-98. doi:10.1096/fj.05-5603rev
    • (2006) FASEB J , vol.20 , pp. 1589-1598
    • Shen, H.M.1    Pervaiz, S.2
  • 41
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems, and apoptosis
    • doi:10.1016/j.freeradbiomed.2009.12.022
    • Circu ML, Aw TY. Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med (2010) 48:749-62. doi:10.1016/j.freeradbiomed.2009.12.022
    • (2010) Free Radic Biol Med , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 42
    • 0032571565 scopus 로고    scopus 로고
    • Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis
    • doi:10.1016/S0014-5793(98)00228-2
    • Suzuki Y, Ono Y, Hirabayashi Y. Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis. FEBS Lett (1998) 425:209-12. doi:10.1016/S0014-5793(98)00228-2
    • (1998) FEBS Lett , vol.425 , pp. 209-212
    • Suzuki, Y.1    Ono, Y.2    Hirabayashi, Y.3
  • 43
    • 18344389339 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism
    • doi:10.1053/jhep.2002.32969
    • Miñana JB, Gómez-Cambronero L, Lloret A, Pallardó FV, Del Olmo J, Escudero A, et al. Mitochondrial oxidative stress and CD95 ligand: a dual mechanism for hepatocyte apoptosis in chronic alcoholism. Hepatology (2002) 35:1205-14. doi:10.1053/jhep.2002.32969
    • (2002) Hepatology , vol.35 , pp. 1205-1214
    • Miñana, J.B.1    Gómez-Cambronero, L.2    Lloret, A.3    Pallardó, F.V.4    Del Olmo, J.5    Escudero, A.6
  • 44
    • 2942744672 scopus 로고    scopus 로고
    • Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells
    • doi:10.4049/jimmunol.173.1.285
    • Sato T, Machida T, Takahashi S, Iyama S, Sato Y, Kuribayashi K, et al. Fas-mediated apoptosome formation is dependent on reactive oxygen species derived from mitochondrial permeability transition in Jurkat cells. J Immunol (2004) 173:285-96. doi:10.4049/jimmunol.173.1.285
    • (2004) J Immunol , vol.173 , pp. 285-296
    • Sato, T.1    Machida, T.2    Takahashi, S.3    Iyama, S.4    Sato, Y.5    Kuribayashi, K.6
  • 45
    • 22844440003 scopus 로고    scopus 로고
    • Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
    • doi:10.1074/jbc.M414361200
    • Reinehr R, Becker S, Eberle A, Grether-Beck S, Häussinger D. Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. J Biol Chem (2005) 280:27179-94. doi:10.1074/jbc.M414361200
    • (2005) J Biol Chem , vol.280 , pp. 27179-27194
    • Reinehr, R.1    Becker, S.2    Eberle, A.3    Grether-Beck, S.4    Häussinger, D.5
  • 46
    • 0033188158 scopus 로고    scopus 로고
    • Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I
    • doi:10.1089/ars.1999.1.3-285
    • Goossens V, Stangé G, Moens K, Pipeleers D, Grooten J. Regulation of tumor necrosis factor-induced, mitochondria- and reactive oxygen species-dependent cell death by the electron flux through the electron transport chain complex I. Antioxid Redox Signal (1999) 1:285-95. doi:10.1089/ars.1999.1.3-285
    • (1999) Antioxid Redox Signal , vol.1 , pp. 285-295
    • Goossens, V.1    Stangé, G.2    Moens, K.3    Pipeleers, D.4    Grooten, J.5
  • 47
    • 34249820757 scopus 로고    scopus 로고
    • TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death
    • doi:10.1016/j.molcel.2007.04.021
    • Kim YS, Morgan MJ, Choksi S, Liu ZG. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell (2007) 26:675-87. doi:10.1016/j.molcel.2007.04.021
    • (2007) Mol Cell , vol.26 , pp. 675-687
    • Kim, Y.S.1    Morgan, M.J.2    Choksi, S.3    Liu, Z.G.4
  • 48
    • 84863895451 scopus 로고    scopus 로고
    • The three Rs along the TRAIL: resistance, re-sensitization and reactive oxygen species (ROS)
    • doi:10.3109/10715762.2012.690514
    • Mellier G, Pervaiz S. The three Rs along the TRAIL: resistance, re-sensitization and reactive oxygen species (ROS). Free Radic Res (2012) 46:996-1003. doi:10.3109/10715762.2012.690514
    • (2012) Free Radic Res , vol.46 , pp. 996-1003
    • Mellier, G.1    Pervaiz, S.2
  • 49
    • 62449196599 scopus 로고    scopus 로고
    • LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors
    • doi:10.1158/0008-5472.CAN-08-1996
    • Shenoy K, Wu Y, Pervaiz S. LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. Cancer Res (2009) 69:1941-50. doi:10.1158/0008-5472.CAN-08-1996
    • (2009) Cancer Res , vol.69 , pp. 1941-1950
    • Shenoy, K.1    Wu, Y.2    Pervaiz, S.3
  • 50
    • 70350346849 scopus 로고    scopus 로고
    • Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin
    • doi:10.1111/j.1476-5381.2009.00245.x
    • Lee DH, Rhee JG, Lee YJ. Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. Br J Pharmacol (2009) 157:1189-202. doi:10.1111/j.1476-5381.2009.00245.x
    • (2009) Br J Pharmacol , vol.157 , pp. 1189-1202
    • Lee, D.H.1    Rhee, J.G.2    Lee, Y.J.3
  • 51
    • 34548152518 scopus 로고    scopus 로고
    • Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells
    • doi:10.1002/cncr.22888
    • Das A, Banik NL, Ray SK. Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells. Cancer (2007) 110:1083-95. doi:10.1002/cncr.22888
    • (2007) Cancer , vol.110 , pp. 1083-1095
    • Das, A.1    Banik, N.L.2    Ray, S.K.3
  • 52
    • 51349109112 scopus 로고    scopus 로고
    • Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds
    • doi:10.1016/j.canlet.2008.05.027
    • Powolny AA, Singh SV. Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds. Cancer Lett (2008) 269:305-14. doi:10.1016/j.canlet.2008.05.027
    • (2008) Cancer Lett , vol.269 , pp. 305-314
    • Powolny, A.A.1    Singh, S.V.2
  • 53
    • 80053371703 scopus 로고    scopus 로고
    • Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: protective role of mild heat preconditioning at 40°C
    • doi:10.1016/j.bbamcr.2011.07.021
    • Pallepati P, Averill-Bates DA. Activation of ER stress and apoptosis by hydrogen peroxide in HeLa cells: protective role of mild heat preconditioning at 40°C. Biochim Biophys Acta (2011) 1813:1987-99. doi:10.1016/j.bbamcr.2011.07.021
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 1987-1999
    • Pallepati, P.1    Averill-Bates, D.A.2
  • 54
    • 85047685805 scopus 로고    scopus 로고
    • NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis
    • doi:10.1038/sj.onc.1205489
    • Delhalle S, Deregowski V, Benoit V, Merville MP, Bours V. NF-kappaB-dependent MnSOD expression protects adenocarcinoma cells from TNF-alpha-induced apoptosis. Oncogene (2002) 21:3917-24. doi:10.1038/sj.onc.1205489
    • (2002) Oncogene , vol.21 , pp. 3917-3924
    • Delhalle, S.1    Deregowski, V.2    Benoit, V.3    Merville, M.P.4    Bours, V.5
  • 55
    • 0037564046 scopus 로고    scopus 로고
    • Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells
    • doi:10.1182/blood-2002-11-3559
    • Perez-Cruz I, Carcamo JM, Golde DW. Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells. Blood (2003) 102:336-43. doi:10.1182/blood-2002-11-3559
    • (2003) Blood , vol.102 , pp. 336-343
    • Perez-Cruz, I.1    Carcamo, J.M.2    Golde, D.W.3
  • 56
    • 67549084381 scopus 로고    scopus 로고
    • Superoxide is the major reactive oxygen species regulating autophagy
    • doi:10.1038/cdd.2009.49
    • Chen Y, Azad MB, Gibson SB. Superoxide is the major reactive oxygen species regulating autophagy. Cell Death Differ (2009) 16:1040-52. doi:10.1038/cdd.2009.49
    • (2009) Cell Death Differ , vol.16 , pp. 1040-1052
    • Chen, Y.1    Azad, M.B.2    Gibson, S.B.3
  • 57
    • 84867273800 scopus 로고    scopus 로고
    • ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy
    • doi:10.4161/auto.21211
    • Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK. ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy (2012) 8:1462-76. doi:10.4161/auto.21211
    • (2012) Autophagy , vol.8 , pp. 1462-1476
    • Wang, Y.1    Nartiss, Y.2    Steipe, B.3    McQuibban, G.A.4    Kim, P.K.5
  • 58
    • 84893825919 scopus 로고    scopus 로고
    • The four faces of autophagy: implications for cancer therapy
    • doi:10.1158/0008-5472.CAN-13-2966
    • Gewirtz DA. The four faces of autophagy: implications for cancer therapy. Cancer Res (2014) 74:647-51. doi:10.1158/0008-5472.CAN-13-2966
    • (2014) Cancer Res , vol.74 , pp. 647-651
    • Gewirtz, D.A.1
  • 59
    • 84884340172 scopus 로고    scopus 로고
    • Cytoprotective and nonprotective autophagy in cancer therapy
    • doi:10.4161/auto.25233
    • Gewirtz DA. Cytoprotective and nonprotective autophagy in cancer therapy. Autophagy (2013) 9:1263-5. doi:10.4161/auto.25233
    • (2013) Autophagy , vol.9 , pp. 1263-1265
    • Gewirtz, D.A.1
  • 60
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling
    • doi:10.1042/BJ20111451
    • Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J (2012) 441:523-40. doi:10.1042/BJ20111451
    • (2012) Biochem J , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 61
    • 84872606148 scopus 로고    scopus 로고
    • Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer
    • doi:10.1007/s00005-012-0205-y
    • Chaabane W, User SD, El-Gazzah M, Jaksik R, Sajjadi E, Rzeszowska-Wolny J, et al. Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer. Arch Immunol Ther Exp (2013) 61:43-58. doi:10.1007/s00005-012-0205-y
    • (2013) Arch Immunol Ther Exp , vol.61 , pp. 43-58
    • Chaabane, W.1    User, S.D.2    El-Gazzah, M.3    Jaksik, R.4    Sajjadi, E.5    Rzeszowska-Wolny, J.6
  • 62
    • 0037033433 scopus 로고    scopus 로고
    • Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
    • doi:10.1084/jem.20010659
    • Devadas S, Zaritskaya L, Rhee SG, Oberley L, Williams MS. Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med (2002) 195:59-70. doi:10.1084/jem.20010659
    • (2002) J Exp Med , vol.195 , pp. 59-70
    • Devadas, S.1    Zaritskaya, L.2    Rhee, S.G.3    Oberley, L.4    Williams, M.S.5
  • 63
    • 0028369668 scopus 로고
    • Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
    • Carter WO, Narayanan PK, Robinson JP. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J Leukoc Biol (1994) 55:253-8.
    • (1994) J Leukoc Biol , vol.55 , pp. 253-258
    • Carter, W.O.1    Narayanan, P.K.2    Robinson, J.P.3
  • 64
    • 67349138865 scopus 로고    scopus 로고
    • Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity
    • doi:10.1016/j.molimm.2009.04.013
    • Suzuki Y, Yoshimaru T, Inoue T, Ra C. Discrete generations of intracellular hydrogen peroxide and superoxide in antigen-stimulated mast cells: reciprocal regulation of store-operated Ca2+ channel activity. Mol Immunol (2009) 46:2200-9. doi:10.1016/j.molimm.2009.04.013
    • (2009) Mol Immunol , vol.46 , pp. 2200-2209
    • Suzuki, Y.1    Yoshimaru, T.2    Inoue, T.3    Ra, C.4
  • 65
    • 34248166140 scopus 로고    scopus 로고
    • Simple quantitative detection of mitochondrial superoxide production in live cells
    • doi:10.1016/j.bbrc.2007.04.106
    • Mukhopadhyay P, Rajesh M, Yoshihiro K, Haskó G, Pacher P. Simple quantitative detection of mitochondrial superoxide production in live cells. Biochem Biophys Res Commun (2007) 358:203-8. doi:10.1016/j.bbrc.2007.04.106
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 203-208
    • Mukhopadhyay, P.1    Rajesh, M.2    Yoshihiro, K.3    Haskó, G.4    Pacher, P.5
  • 66
    • 58049131646 scopus 로고    scopus 로고
    • Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy
    • doi:10.1016/j.freeradbiomed.2008.09.042
    • Batinic-Haberle I, Cuzzocrea S, Rebouças JS, Ferrer-Sueta G, Mazzon E, Di Paola R, et al. Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med (2009) 46:192-201. doi:10.1016/j.freeradbiomed.2008.09.042
    • (2009) Free Radic Biol Med , vol.46 , pp. 192-201
    • Batinic-Haberle, I.1    Cuzzocrea, S.2    Rebouças, J.S.3    Ferrer-Sueta, G.4    Mazzon, E.5    Di Paola, R.6
  • 67
    • 23844496672 scopus 로고    scopus 로고
    • Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines
    • doi:10.1158/0008-5472.CAN-04-2628
    • Izeradjene K, Douglas L, Tillman DM, Delaney AB, Houghton JA. Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines. Cancer Res (2005) 65:7436-45. doi:10.1158/0008-5472.CAN-04-2628
    • (2005) Cancer Res , vol.65 , pp. 7436-7445
    • Izeradjene, K.1    Douglas, L.2    Tillman, D.M.3    Delaney, A.B.4    Houghton, J.A.5
  • 68
    • 0029979377 scopus 로고    scopus 로고
    • Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines
    • Jia L, Kelsey SM, Grahn MF, Jiang XR, Newland AC. Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor alpha-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines. Blood (1996) 87:2401-10.
    • (1996) Blood , vol.87 , pp. 2401-2410
    • Jia, L.1    Kelsey, S.M.2    Grahn, M.F.3    Jiang, X.R.4    Newland, A.C.5
  • 69
    • 34250885132 scopus 로고    scopus 로고
    • Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite
    • doi:10.1242/jcs.003228
    • Guidarelli A, Cerioni L, Cantoni O. Inhibition of complex III promotes loss of Ca2+ dependence for mitochondrial superoxide formation and permeability transition evoked by peroxynitrite. J Cell Sci (2007) 120:1908-14. doi:10.1242/jcs.003228
    • (2007) J Cell Sci , vol.120 , pp. 1908-1914
    • Guidarelli, A.1    Cerioni, L.2    Cantoni, O.3
  • 70
    • 0030580287 scopus 로고    scopus 로고
    • Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell
    • doi:10.1016/0014-5793(96)00989-1
    • Skulachev VP. Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell. FEBS Lett (1996) 397:7-10. doi:10.1016/0014-5793(96)00989-1
    • (1996) FEBS Lett , vol.397 , pp. 7-10
    • Skulachev, V.P.1
  • 71
    • 34548451974 scopus 로고    scopus 로고
    • Reactive oxygen species in mitochondria-mediated cell death
    • doi:10.1080/03602530701468516
    • Orrenius S. Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev (2007) 39:443-55. doi:10.1080/03602530701468516
    • (2007) Drug Metab Rev , vol.39 , pp. 443-455
    • Orrenius, S.1
  • 72
    • 34247490186 scopus 로고    scopus 로고
    • Mitochondria, oxidative stress and cell death
    • doi:10.1007/s10495-007-0756-2
    • Ott M, Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis (2007) 12:913-22. doi:10.1007/s10495-007-0756-2
    • (2007) Apoptosis , vol.12 , pp. 913-922
    • Ott, M.1    Gogvadze, V.2    Orrenius, S.3    Zhivotovsky, B.4
  • 73
    • 77649183649 scopus 로고    scopus 로고
    • Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
    • doi:10.1016/j.mam.2009.12.006
    • Ralph SJ, Rodríguez-Enríquez S, Neuzil J, Moreno-Sánchez R. Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. Mol Aspects Med (2010) 31:29-59. doi:10.1016/j.mam.2009.12.006
    • (2010) Mol Aspects Med , vol.31 , pp. 29-59
    • Ralph, S.J.1    Rodríguez-Enríquez, S.2    Neuzil, J.3    Moreno-Sánchez, R.4
  • 74
    • 34250789163 scopus 로고    scopus 로고
    • Role of cardiolipin in cytochrome c release from mitochondria
    • doi:10.1038/sj.cdd.4402135
    • Ott M, Zhivotovsky B, Orrenius S. Role of cardiolipin in cytochrome c release from mitochondria. Cell Death Differ (2007) 14:1243-7. doi:10.1038/sj.cdd.4402135
    • (2007) Cell Death Differ , vol.14 , pp. 1243-1247
    • Ott, M.1    Zhivotovsky, B.2    Orrenius, S.3
  • 75
    • 0026742850 scopus 로고
    • 10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria
    • doi:10.1111/j.1432-1033.1992.tb17285.x
    • Petit JM, Maftah A, Ratinaud MH, Julien R. 10N-nonyl acridine orange interacts with cardiolipin and allows the quantification of this phospholipid in isolated mitochondria. Eur J Biochem (1992) 209:267-73. doi:10.1111/j.1432-1033.1992.tb17285.x
    • (1992) Eur J Biochem , vol.209 , pp. 267-273
    • Petit, J.M.1    Maftah, A.2    Ratinaud, M.H.3    Julien, R.4
  • 77
    • 24944458177 scopus 로고    scopus 로고
    • Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death
    • doi:10.1111/j.1365-2141.2005.05656.x
    • Georgakis GV, Li Y, Humphreys R, Andreeff M, O'Brien S, Younes M, et al. Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death. Br J Haematol (2005) 130:501-10. doi:10.1111/j.1365-2141.2005.05656.x
    • (2005) Br J Haematol , vol.130 , pp. 501-510
    • Georgakis, G.V.1    Li, Y.2    Humphreys, R.3    Andreeff, M.4    O'Brien, S.5    Younes, M.6
  • 79
    • 0032487361 scopus 로고    scopus 로고
    • Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+
    • doi:10.1161/01.RES.83.7.730
    • Al-Mehdi AB, Zhao G, Dodia C, Tozawa K, Costa K, Muzykantov V, et al. Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circ Res (1998) 83:730-7. doi:10.1161/01.RES.83.7.730
    • (1998) Circ Res , vol.83 , pp. 730-737
    • Al-Mehdi, A.B.1    Zhao, G.2    Dodia, C.3    Tozawa, K.4    Costa, K.5    Muzykantov, V.6
  • 80
    • 27944467222 scopus 로고    scopus 로고
    • Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent
    • doi:10.1152/ajplung.00210.2005
    • Zhang Q, Matsuzaki I, Chatterjee S, Fisher AB. Activation of endothelial NADPH oxidase during normoxic lung ischemia is KATP channel dependent. Am J Physiol Lung Cell Mol Physiol (2005) 289:L954-61. doi:10.1152/ajplung.00210.2005
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289
    • Zhang, Q.1    Matsuzaki, I.2    Chatterjee, S.3    Fisher, A.B.4
  • 81
    • 84255167151 scopus 로고    scopus 로고
    • Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS
    • doi:10.1152/ajpheart.00298.2011
    • Chatterjee S, Browning EA, Hong N, DeBolt K, Sorokina EM, Liu W, et al. Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. Am J Physiol Heart Circ Physiol (2012) 302:H105-14. doi:10.1152/ajpheart.00298.2011
    • (2012) Am J Physiol Heart Circ Physiol , vol.302
    • Chatterjee, S.1    Browning, E.A.2    Hong, N.3    DeBolt, K.4    Sorokina, E.M.5    Liu, W.6
  • 82
    • 84864344675 scopus 로고    scopus 로고
    • Targeting NADPH oxidases for the treatment of cancer and inflammation
    • doi:10.1007/s00018-012-1017-2
    • Bonner MY, Arbiser JL. Targeting NADPH oxidases for the treatment of cancer and inflammation. Cell Mol Life Sci (2012) 69:2435-42. doi:10.1007/s00018-012-1017-2
    • (2012) Cell Mol Life Sci , vol.69 , pp. 2435-2442
    • Bonner, M.Y.1    Arbiser, J.L.2
  • 83
    • 84890902048 scopus 로고    scopus 로고
    • Cysteine (C)-X-C receptor 4 regulates NADPH oxidase-2 during oxidative stress in prostate cancer cells
    • doi:10.1007/s12307-013-0136-0
    • Jones KJ, Chetram MA, Bethea DA, Bryant LK, Odero-Marah V, Hinton CV. Cysteine (C)-X-C receptor 4 regulates NADPH oxidase-2 during oxidative stress in prostate cancer cells. Cancer Microenviron (2013) 6:277-88. doi:10.1007/s12307-013-0136-0
    • (2013) Cancer Microenviron , vol.6 , pp. 277-288
    • Jones, K.J.1    Chetram, M.A.2    Bethea, D.A.3    Bryant, L.K.4    Odero-Marah, V.5    Hinton, C.V.6
  • 85
    • 34447647663 scopus 로고    scopus 로고
    • Impairment of Na(+),K(+)-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide
    • doi:10.1038/sj.leu.2404791
    • Yin W, Cheng W, Shen W, Shu L, Zhao J, Zhang J, et al. Impairment of Na(+),K(+)-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide. Leukemia (2007) 21:1669-78. doi:10.1038/sj.leu.2404791
    • (2007) Leukemia , vol.21 , pp. 1669-1678
    • Yin, W.1    Cheng, W.2    Shen, W.3    Shu, L.4    Zhao, J.5    Zhang, J.6
  • 86
    • 0026021362 scopus 로고
    • Production of large amounts of hydrogen peroxide by human tumor cells
    • Szatrowski TP, Nathan CF. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 51:794-8.
    • (1991) Cancer Res , vol.51 , pp. 794-798
    • Szatrowski, T.P.1    Nathan, C.F.2
  • 87
    • 59849084800 scopus 로고    scopus 로고
    • Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation
    • doi:10.1042/BJ20081258
    • Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. Biochem J (2009) 418:29-37. doi:10.1042/BJ20081258
    • (2009) Biochem J , vol.418 , pp. 29-37
    • Aykin-Burns, N.1    Ahmad, I.M.2    Zhu, Y.3    Oberley, L.W.4    Spitz, D.R.5
  • 88
    • 28244447656 scopus 로고    scopus 로고
    • Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress
    • doi:10.1074/jbc.M503296200
    • Hu Y, Rosen DG, Zhou Y, Feng L, Yang G, Liu J, et al. Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem (2005) 280:39485-92. doi:10.1074/jbc.M503296200
    • (2005) J Biol Chem , vol.280
    • Hu, Y.1    Rosen, D.G.2    Zhou, Y.3    Feng, L.4    Yang, G.5    Liu, J.6
  • 89
    • 21844432918 scopus 로고    scopus 로고
    • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    • doi:10.1038/nature03688
    • Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 436:123-7. doi:10.1038/nature03688
    • (2005) Nature , vol.436 , pp. 123-127
    • Radisky, D.C.1    Levy, D.D.2    Littlepage, L.E.3    Liu, H.4    Nelson, C.M.5    Fata, J.E.6
  • 90
    • 0030980641 scopus 로고    scopus 로고
    • Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts
    • doi:10.1126/science.275.5306.1649
    • Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER, et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 275:1649-52. doi:10.1126/science.275.5306.1649
    • (1997) Science , vol.275 , pp. 1649-1652
    • Irani, K.1    Xia, Y.2    Zweier, J.L.3    Sollott, S.J.4    Der, C.J.5    Fearon, E.R.6
  • 91
    • 0034637599 scopus 로고    scopus 로고
    • The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells
    • doi:10.1074/jbc.M002094200
    • Sattler M, Verma S, Shrikhande G, Byrne CH, Pride YB, Winkler T, et al. The BCR/ABL tyrosine kinase induces production of reactive oxygen species in hematopoietic cells. J Biol Chem (2000) 275:24273-8. doi:10.1074/jbc.M002094200
    • (2000) J Biol Chem , vol.275 , pp. 24273-24278
    • Sattler, M.1    Verma, S.2    Shrikhande, G.3    Byrne, C.H.4    Pride, Y.B.5    Winkler, T.6
  • 92
    • 0036285034 scopus 로고    scopus 로고
    • c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
    • doi:10.1016/S1097-2765(02)00520-8
    • Vafa O, Wade M, Kern S, Beeche M, Pandita TK, Hampton GM, et al. c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell (2002) 9:1031-44. doi:10.1016/S1097-2765(02)00520-8
    • (2002) Mol Cell , vol.9 , pp. 1031-1044
    • Vafa, O.1    Wade, M.2    Kern, S.3    Beeche, M.4    Pandita, T.K.5    Hampton, G.M.6
  • 93
    • 0348049803 scopus 로고    scopus 로고
    • Reactive oxygen species in oncogenic transformation
    • doi:10.1042/BST0311441
    • Behrend L, Henderson G, Zwacka RM. Reactive oxygen species in oncogenic transformation. Biochem Soc Trans (2003) 31:1441-4. doi:10.1042/BST0311441
    • (2003) Biochem Soc Trans , vol.31 , pp. 1441-1444
    • Behrend, L.1    Henderson, G.2    Zwacka, R.M.3
  • 94
    • 20844448882 scopus 로고    scopus 로고
    • Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species
    • doi:10.1182/blood-2004-03-0849
    • Kim JH, Chu SC, Gramlich JL, Pride YB, Babendreier E, Chauhan D, et al. Activation of the PI3K/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species. Blood (2005) 105:1717-23. doi:10.1182/blood-2004-03-0849
    • (2005) Blood , vol.105 , pp. 1717-1723
    • Kim, J.H.1    Chu, S.C.2    Gramlich, J.L.3    Pride, Y.B.4    Babendreier, E.5    Chauhan, D.6
  • 95
    • 68749117502 scopus 로고    scopus 로고
    • Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway
    • doi:10.1038/leu.2009.49
    • Naughton R, Quiney C, Turner SD, Cotter TG. Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway. Leukemia (2009) 23:1432-40. doi:10.1038/leu.2009.49
    • (2009) Leukemia , vol.23 , pp. 1432-1440
    • Naughton, R.1    Quiney, C.2    Turner, S.D.3    Cotter, T.G.4
  • 96
    • 0034699513 scopus 로고    scopus 로고
    • Superoxide dismutase as a target for the selective killing of cancer cells
    • doi:10.1038/35030140
    • Huang P, Feng L, Oldham EA, Keating MJ, Plunkett W. Superoxide dismutase as a target for the selective killing of cancer cells. Nature (2000) 407:390-5. doi:10.1038/35030140
    • (2000) Nature , vol.407 , pp. 390-395
    • Huang, P.1    Feng, L.2    Oldham, E.A.3    Keating, M.J.4    Plunkett, W.5
  • 97
    • 0037926836 scopus 로고    scopus 로고
    • Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents
    • doi:10.1182/blood-2002-08-2512
    • Zhou Y, Hileman EO, Plunkett W, Keating MJ, Huang P. Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood (2003) 101:4098-104. doi:10.1182/blood-2002-08-2512
    • (2003) Blood , vol.101 , pp. 4098-4104
    • Zhou, Y.1    Hileman, E.O.2    Plunkett, W.3    Keating, M.J.4    Huang, P.5
  • 98
    • 0032007312 scopus 로고    scopus 로고
    • Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity
    • Yu R, Mandlekar S, Harvey KJ, Ucker DS, Kong AN. Chemopreventive isothiocyanates induce apoptosis and caspase-3-like protease activity. Cancer Res (1998) 58:402-8.
    • (1998) Cancer Res , vol.58 , pp. 402-408
    • Yu, R.1    Mandlekar, S.2    Harvey, K.J.3    Ucker, D.S.4    Kong, A.N.5
  • 99
    • 1942451371 scopus 로고    scopus 로고
    • Selected isothiocyanates rapidly induce growth inhibition of cancer cells
    • Zhang Y, Tang L, Gonzalez V. Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Mol Cancer Ther (2003) 2:1045-52.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1045-1052
    • Zhang, Y.1    Tang, L.2    Gonzalez, V.3
  • 100
    • 23644454249 scopus 로고    scopus 로고
    • Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells
    • doi:10.1016/j.ejphar.2005.06.021
    • Wu SJ, Ng LT, Lin CC. Effects of antioxidants and caspase-3 inhibitor on the phenylethyl isothiocyanate-induced apoptotic signaling pathways in human PLC/PRF/5 cells. Eur J Pharmacol (2005) 518:96-106. doi:10.1016/j.ejphar.2005.06.021
    • (2005) Eur J Pharmacol , vol.518 , pp. 96-106
    • Wu, S.J.1    Ng, L.T.2    Lin, C.C.3
  • 101
    • 33748146888 scopus 로고    scopus 로고
    • Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
    • doi:10.1016/j.ccr.2006.08.009
    • Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell (2006) 10:241-52. doi:10.1016/j.ccr.2006.08.009
    • (2006) Cancer Cell , vol.10 , pp. 241-252
    • Trachootham, D.1    Zhou, Y.2    Zhang, H.3    Demizu, Y.4    Chen, Z.5    Pelicano, H.6
  • 102
    • 34548290810 scopus 로고    scopus 로고
    • Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound
    • doi:10.4161/cbt.6.5.4092
    • Wu XJ, Hua X. Targeting ROS: selective killing of cancer cells by a cruciferous vegetable derived pro-oxidant compound. Cancer Biol Ther (2007) 6:646-7. doi:10.4161/cbt.6.5.4092
    • (2007) Cancer Biol Ther , vol.6 , pp. 646-647
    • Wu, X.J.1    Hua, X.2
  • 103
    • 41349116311 scopus 로고    scopus 로고
    • Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis
    • doi:10.1182/blood-2007-06-096198
    • Baumann S, Fas SC, Giaisi M, Müller WW, Merling A, Gülow K, et al. Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis. Blood (2008) 111:2354-63. doi:10.1182/blood-2007-06-096198
    • (2008) Blood , vol.111 , pp. 2354-2363
    • Baumann, S.1    Fas, S.C.2    Giaisi, M.3    Müller, W.W.4    Merling, A.5    Gülow, K.6
  • 104
    • 78649794617 scopus 로고    scopus 로고
    • Different apoptotic effects of wogonin via induction of H2O2 generation and Ca2+ overload in malignant hepatoma and normal hepatic cells
    • doi:10.1002/jcb.22898
    • Wei L, Lu N, Dai Q, Rong J, Chen Y, Li Z, et al. Different apoptotic effects of wogonin via induction of H2O2 generation and Ca2+ overload in malignant hepatoma and normal hepatic cells. J Cell Biochem (2010) 111:1629-41. doi:10.1002/jcb.22898
    • (2010) J Cell Biochem , vol.111 , pp. 1629-1641
    • Wei, L.1    Lu, N.2    Dai, Q.3    Rong, J.4    Chen, Y.5    Li, Z.6
  • 105
    • 84864989279 scopus 로고    scopus 로고
    • Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells
    • doi:10.3390/ijms13089877
    • Tsai CF, Yeh WL, Huang SM, Tan TW, Lu DY. Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells. Int J Mol Sci (2012) 13:9877-92. doi:10.3390/ijms13089877
    • (2012) Int J Mol Sci , vol.13 , pp. 9877-9892
    • Tsai, C.F.1    Yeh, W.L.2    Huang, S.M.3    Tan, T.W.4    Lu, D.Y.5
  • 106
    • 79954486798 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway
    • doi:10.1002/jcb.23072
    • Yang WH, Fong YC, Lee CY, Jin TR, Tzen JT, Li TM, et al. Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway. J Cell Biochem (2011) 112:1601-11. doi:10.1002/jcb.23072
    • (2011) J Cell Biochem , vol.112 , pp. 1601-1611
    • Yang, W.H.1    Fong, Y.C.2    Lee, C.Y.3    Jin, T.R.4    Tzen, J.T.5    Li, T.M.6
  • 107
    • 0032997385 scopus 로고    scopus 로고
    • Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium
    • doi:10.1038/sj.cdd.4400465
    • Macho A, Calzado MA, Muñoz-Blanco J, Gómez-Díaz C, Gajate C, Mollinedo F, et al. Selective induction of apoptosis by capsaicin in transformed cells: the role of reactive oxygen species and calcium. Cell Death Differ (1999) 6:155-65. doi:10.1038/sj.cdd.4400465
    • (1999) Cell Death Differ , vol.6 , pp. 155-165
    • Macho, A.1    Calzado, M.A.2    Muñoz-Blanco, J.3    Gómez-Díaz, C.4    Gajate, C.5    Mollinedo, F.6
  • 108
    • 79957465966 scopus 로고    scopus 로고
    • Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells
    • doi:10.1371/journal.pone.0020151
    • Pramanik KC, Boreddy SR, Srivastava SK. Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One (2011) 6:e20151. doi:10.1371/journal.pone.0020151
    • (2011) PLoS One , vol.6
    • Pramanik, K.C.1    Boreddy, S.R.2    Srivastava, S.K.3
  • 109
    • 21244484687 scopus 로고    scopus 로고
    • Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis
    • doi:10.1007/s10495-005-1896-x
    • McLachlan A, Kekre N, McNulty J, Pandey S. Pancratistatin: a natural anti-cancer compound that targets mitochondria specifically in cancer cells to induce apoptosis. Apoptosis (2005) 10:619-30. doi:10.1007/s10495-005-1896-x
    • (2005) Apoptosis , vol.10 , pp. 619-630
    • McLachlan, A.1    Kekre, N.2    McNulty, J.3    Pandey, S.4
  • 110
    • 79955787711 scopus 로고    scopus 로고
    • Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells
    • doi:10.3892/ijo.2011.977
    • Griffin C, McNulty J, Pandey S. Pancratistatin induces apoptosis and autophagy in metastatic prostate cancer cells. Int J Oncol (2011) 38:1549-56. doi:10.3892/ijo.2011.977
    • (2011) Int J Oncol , vol.38 , pp. 1549-1556
    • Griffin, C.1    McNulty, J.2    Pandey, S.3
  • 111
    • 78751518833 scopus 로고    scopus 로고
    • Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts
    • doi:10.1158/1535-7163.MCT-10-0735
    • Griffin C, Karnik A, McNulty J, Pandey S. Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts. Mol Cancer Ther (2011) 10:57-68. doi:10.1158/1535-7163.MCT-10-0735
    • (2011) Mol Cancer Ther , vol.10 , pp. 57-68
    • Griffin, C.1    Karnik, A.2    McNulty, J.3    Pandey, S.4
  • 112
    • 79960427057 scopus 로고    scopus 로고
    • Selective killing of cancer cells by a small molecule targeting the stress response to ROS
    • doi:10.1038/nature10167
    • Raj L, Ide T, Gurkar AU, Foley M, Schenone M, Li X, et al. Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature (2011) 475:231-4. doi:10.1038/nature10167
    • (2011) Nature , vol.475 , pp. 231-234
    • Raj, L.1    Ide, T.2    Gurkar, A.U.3    Foley, M.4    Schenone, M.5    Li, X.6
  • 113
    • 33947174588 scopus 로고    scopus 로고
    • Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells
    • doi:10.1007/s10495-006-0024-x
    • Karmakar S, Banik NL, Patel SJ, Ray SK. Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis (2007) 12:671-84. doi:10.1007/s10495-006-0024-x
    • (2007) Apoptosis , vol.12 , pp. 671-684
    • Karmakar, S.1    Banik, N.L.2    Patel, S.J.3    Ray, S.K.4
  • 114
    • 15244340234 scopus 로고    scopus 로고
    • A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts
    • Gosslau A, Chen M, Ho CT, Chen KY. A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts. Br J Cancer (2005) 92:513-21.
    • (2005) Br J Cancer , vol.92 , pp. 513-521
    • Gosslau, A.1    Chen, M.2    Ho, C.T.3    Chen, K.Y.4
  • 115
    • 84856521923 scopus 로고    scopus 로고
    • Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS
    • doi:10.1371/journal.pone.0030300
    • Chen V, Staub RE, Fong S, Tagliaferri M, Cohen I, Shtivelman E. Bezielle selectively targets mitochondria of cancer cells to inhibit glycolysis and OXPHOS. PLoS One (2012) 7:e30300. doi:10.1371/journal.pone.0030300
    • (2012) PLoS One , vol.7
    • Chen, V.1    Staub, R.E.2    Fong, S.3    Tagliaferri, M.4    Cohen, I.5    Shtivelman, E.6
  • 116
    • 84872249483 scopus 로고    scopus 로고
    • bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy
    • doi:10.1371/journal.pone.0053664
    • Basile V, Belluti S, Ferrari E, Gozzoli C, Ganassi S, Quaglino D, et al. bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS One (2013) 8:e53664. doi:10.1371/journal.pone.0053664
    • (2013) PLoS One , vol.8
    • Basile, V.1    Belluti, S.2    Ferrari, E.3    Gozzoli, C.4    Ganassi, S.5    Quaglino, D.6
  • 117
    • 34547163500 scopus 로고    scopus 로고
    • Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide
    • doi:10.1124/mol.106.032458
    • Pérez-Ortiz JM, Tranque P, Burgos M, Vaquero CF, Llopis J. Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide. Mol Pharmacol (2007) 72:407-17. doi:10.1124/mol.106.032458
    • (2007) Mol Pharmacol , vol.72 , pp. 407-417
    • Pérez-Ortiz, J.M.1    Tranque, P.2    Burgos, M.3    Vaquero, C.F.4    Llopis, J.5
  • 118
    • 84882686716 scopus 로고    scopus 로고
    • Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells
    • doi:10.1016/j.bbamcr.2013.04.011
    • Jangamreddy JR, Ghavami S, Grabarek J, Kratz G, Wiechec E, Fredriksson BA, et al. Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells. Biochim Biophys Acta (2013) 1833:2057-69. doi:10.1016/j.bbamcr.2013.04.011
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 2057-2069
    • Jangamreddy, J.R.1    Ghavami, S.2    Grabarek, J.3    Kratz, G.4    Wiechec, E.5    Fredriksson, B.A.6
  • 119
    • 1542305504 scopus 로고    scopus 로고
    • Glitazones differentially regulate primary astrocyte and glioma cell survival Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma.
    • doi:10.1074/jbc.M308518200
    • Pérez-Ortiz JM, Tranque P, Vaquero CF, Domingo B, Molina F, Calvo S, et al. Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. J Biol Chem (2004) 279:8976-85. doi:10.1074/jbc.M308518200
    • (2004) J Biol Chem , vol.279 , pp. 8976-8985
    • Pérez-Ortiz, J.M.1    Tranque, P.2    Vaquero, C.F.3    Domingo, B.4    Molina, F.5    Calvo, S.6
  • 120
    • 38349043984 scopus 로고    scopus 로고
    • Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species
    • doi:10.1242/jcs.011163
    • Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species. J Cell Sci (2007) 120:4155-66. doi:10.1242/jcs.011163
    • (2007) J Cell Sci , vol.120 , pp. 4155-4166
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 121
    • 37349067228 scopus 로고    scopus 로고
    • Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells
    • doi:10.1038/sj.cdd.4402233
    • Chen Y, McMillan-Ward E, Kong J, Israels SJ, Gibson SB. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ (2008) 15:171-82. doi:10.1038/sj.cdd.4402233
    • (2008) Cell Death Differ , vol.15 , pp. 171-182
    • Chen, Y.1    McMillan-Ward, E.2    Kong, J.3    Israels, S.J.4    Gibson, S.B.5
  • 122
    • 79959312178 scopus 로고    scopus 로고
    • The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo
    • doi:10.1371/journal.pone.0021077
    • Lee ZW, Zhou J, Chen CS, Zhao Y, Tan CH, Li L, et al. The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One (2011) 6:e21077. doi:10.1371/journal.pone.0021077
    • (2011) PLoS One , vol.6
    • Lee, Z.W.1    Zhou, J.2    Chen, C.S.3    Zhao, Y.4    Tan, C.H.5    Li, L.6
  • 123
    • 33748291763 scopus 로고    scopus 로고
    • Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway
    • doi:10.1158/1535-7163.MCT-06-0063
    • Hu H, Jiang C, Schuster T, Li GX, Daniel PT, Lü J. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther (2006) 5:1873-82. doi:10.1158/1535-7163.MCT-06-0063
    • (2006) Mol Cancer Ther , vol.5 , pp. 1873-1882
    • Hu, H.1    Jiang, C.2    Schuster, T.3    Li, G.X.4    Daniel, P.T.5    Lü, J.6


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