The slow-releasing Hydrogen Sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Lee, Zheng Wei ^a   Zhou, Jianbiao ^b   Chen, Chien Shing ^a,c   Zhao, Yujun ^a   Tan, Choon Hong ^a   Li, Ling ^a   Moore, Philip Keith ^a   Deng, Lih Wen ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 9; GYY 4137; HYDROGEN SULFIDE; MORPHOLIN 4 IUM DIPHENYLPHOSPHINATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG; ZYJ 1122; MORPHOLINE DERIVATIVE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROBLAST; MOUSE; NEOPLASM; NONHUMAN; PROTEIN CLEAVAGE; TUMOR GROWTH; TUMOR XENOGRAFT; ANIMAL; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN HEPG2; CELL STRAIN HL 60; CHEMISTRY; DRUG SCREENING; MOUSE MUTANT; TUMOR CELL LINE; WESTERN BLOTTING;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HCT116 CELLS; HEP G2 CELLS; HL-60 CELLS; HUMANS; HYDROGEN SULFIDE; MICE; MICE, SCID; MORPHOLINES; ORGANOTHIOPHOSPHORUS COMPOUNDS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79959312178     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021077     Document Type: Article

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