-
1
-
-
47249124531
-
Chemistry, biology, and medicinal potential of narciclasine and its congeners
-
Kornienko A and Evidente A: Chemistry, biology, and medicinal potential of narciclasine and its congeners. Chem Rev 108: 1982-2014, 2008.
-
(2008)
Chem Rev
, vol.108
, pp. 1982-2014
-
-
Kornienko, A.1
Evidente, A.2
-
2
-
-
78751518833
-
Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts
-
Griffin C, Karnik A, McNulty J and Pandey S: Pancratistatin selectively targets cancer cell mitochondria and reduces growth of human colon tumor xenografts. Mol Cancer Ther 10: 57-68, 2011.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 57-68
-
-
Griffin, C.1
Karnik, A.2
McNulty, J.3
Pandey, S.4
-
3
-
-
21244439798
-
Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells
-
DOI 10.1007/s00280-004-0941-8
-
Kekre N, Griffin C, McNulty J and Pandey S: Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells. Cancer Chemother Pharmacol 56: 29-38, 2005. (Pubitemid 41201753)
-
(2005)
Cancer Chemotherapy and Pharmacology
, vol.56
, Issue.1
, pp. 29-38
-
-
Kekre, N.1
Griffin, C.2
McNulty, J.3
Pandey, S.4
-
4
-
-
79952743923
-
Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound
-
In press
-
Chatterjee SJ, McNulty J and Pandey S: Sensitization of human melanoma cells by tamoxifen to apoptosis induction by pancratistatin, a nongenotoxic natural compound. Melanoma Res (In press).
-
Melanoma Res
-
-
Chatterjee, S.J.1
McNulty, J.2
Pandey, S.3
-
5
-
-
45349084679
-
Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria
-
Siedlakowski P, McLachlan-Burgess A, Griffin C, Tirumalai SS, McNulty J and Pandey S: Synergy of pancratistatin and tamoxifen on breast cancer cells in inducing apoptosis by targeting mitochondria. Cancer Biol Ther 7: 376-384, 2007.
-
(2007)
Cancer Biol Ther
, vol.7
, pp. 376-384
-
-
Siedlakowski, P.1
McLachlan-Burgess, A.2
Griffin, C.3
Tirumalai, S.S.4
McNulty, J.5
Pandey, S.6
-
6
-
-
77649183649
-
Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger
-
Ralph SJ, Rodríguez-Enríquez S, Neuzil J and Moreno-Sánchez R: Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. Mol Aspects Med 31: 29-59, 2010.
-
(2010)
Mol Aspects Med
, vol.31
, pp. 29-59
-
-
Ralph, S.J.1
Rodríguez-Enríquez, S.2
Neuzil, J.3
Moreno-Sánchez, R.4
-
7
-
-
33749986298
-
Free radicals and antioxidants in normal physiological functions and human disease
-
DOI 10.1016/j.biocel.2006.07.001, PII S1357272506002196
-
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39: 44-84, 2007. (Pubitemid 44566469)
-
(2007)
International Journal of Biochemistry and Cell Biology
, vol.39
, Issue.1
, pp. 44-84
-
-
Valko, M.1
Leibfritz, D.2
Moncol, J.3
Cronin, M.T.D.4
Mazur, M.5
Telser, J.6
-
9
-
-
75449090789
-
Anticancer agents derived from natural products
-
Liu EH, Qi LW, Wu Q, Peng YB and Li P: Anticancer agents derived from natural products. Mini Rev Med Chem 9: 1547-1555, 2009.
-
(2009)
Mini Rev Med Chem
, vol.9
, pp. 1547-1555
-
-
Liu, E.H.1
Qi, L.W.2
Wu, Q.3
Peng, Y.B.4
Li, P.5
-
10
-
-
33748788835
-
Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins
-
DOI 10.1016/j.febslet.2006.05.072, PII S0014579306006892
-
Neuzil J, Wang XF, Dong LF, Low P and Ralph SJ: Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. FEBS Lett 580: 5125-5129, 2006. (Pubitemid 44415781)
-
(2006)
FEBS Letters
, vol.580
, Issue.22
, pp. 5125-5129
-
-
Neuzil, J.1
Wang, X.-F.2
Dong, L.-F.3
Low, P.4
Ralph, S.J.5
-
11
-
-
63549096948
-
Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II
-
Dong LF, Freeman R, Liu J, Zobalova R, Marin-Hernandez A, Stantic M, Rohlena J, Valis K, Rodriguez-Enriquez S, Butcher B, Goodwin J, Brunk UT, Witting PK, Moreno-Sanchez R, Scheffler IE, Ralph SJ and Neuzil J: Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res 15: 1593-1600, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 1593-1600
-
-
Dong, L.F.1
Freeman, R.2
Liu, J.3
Zobalova, R.4
Marin-Hernandez, A.5
Stantic, M.6
Rohlena, J.7
Valis, K.8
Rodriguez-Enriquez, S.9
Butcher, B.10
Goodwin, J.11
Brunk, U.T.12
Witting, P.K.13
Moreno-Sanchez, R.14
Scheffler, I.E.15
Ralph, S.J.16
Neuzil, J.17
-
12
-
-
77956218104
-
Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells
-
Xiao D, Powolny AA, Moura MB, Kelley EE, Bommareddy A, Kim SH, Hahm ER, Normolle D, van Houten B and Singh SV: Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. J Biol Chem 285: 26558-26569, 2010.
-
(2010)
J Biol Chem
, vol.285
, pp. 26558-26569
-
-
Xiao, D.1
Powolny, A.A.2
Moura, M.B.3
Kelley, E.E.4
Bommareddy, A.5
Kim, S.H.6
Hahm, E.R.7
Normolle, D.8
Van Houten, B.9
Singh, S.V.10
-
13
-
-
56049108345
-
Therapeutic starvation and autophagy in prostate cancer: A new paradigm for targeting metabolism in cancer therapy
-
DiPaola RS, Dvorzhinski D, Thalasila A, Garikapaty V, Doram D, May M, Bray K, Mathew R, Beaudoin B, Karp C, Stein M, Foran DJ and White E: Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy. Prostate 68: 1743-1752, 2008.
-
(2008)
Prostate
, vol.68
, pp. 1743-1752
-
-
DiPaola, R.S.1
Dvorzhinski, D.2
Thalasila, A.3
Garikapaty, V.4
Doram, D.5
May, M.6
Bray, K.7
Mathew, R.8
Beaudoin, B.9
Karp, C.10
Stein, M.11
Foran, D.J.12
White, E.13
-
14
-
-
77951911179
-
Regulation of autophagy in mammals and its interplay with apoptosis
-
Fimia GM and Piacentini M: Regulation of autophagy in mammals and its interplay with apoptosis. Cell Mol Life Sci 67: 1581-1588, 2010.
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 1581-1588
-
-
Fimia, G.M.1
Piacentini, M.2
-
15
-
-
77953699668
-
Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer
-
Dalby KN, Tekedereli I, Lopez-Berestein G and Ozpolat B: Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 6: 322-329, 2010.
-
(2010)
Autophagy
, vol.6
, pp. 322-329
-
-
Dalby, K.N.1
Tekedereli, I.2
Lopez-Berestein, G.3
Ozpolat, B.4
-
16
-
-
56549116658
-
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
-
Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB and Gorski SM: Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res Treat 112: 389-403, 2008.
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 389-403
-
-
Qadir, M.A.1
Kwok, B.2
Dragowska, W.H.3
To, K.H.4
Le, D.5
Bally, M.B.6
Gorski, S.M.7
-
17
-
-
69349087479
-
Anti- and pro-tumor functions of autophagy
-
Morselli E, Galluzzi L, Kepp O, Vicencio JM, Criollo A, Maiuri MC and Kroemer G: Anti- and pro-tumor functions of autophagy. Biochim Biophys Acta 1793: 1524-1532, 2009.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 1524-1532
-
-
Morselli, E.1
Galluzzi, L.2
Kepp, O.3
Vicencio, J.M.4
Criollo, A.5
Maiuri, M.C.6
Kroemer, G.7
-
18
-
-
77957656802
-
A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy
-
Gibson SB: A matter of balance between life and death: targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy. Autophagy 6: 835-837, 2010.
-
(2010)
Autophagy
, vol.6
, pp. 835-837
-
-
Gibson, S.B.1
-
19
-
-
69949106925
-
The double-edged sword of autophagy modulation in cancer
-
White E and DiPaola RS: The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 15: 5308-5316, 2009.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5308-5316
-
-
White, E.1
DiPaola, R.S.2
-
20
-
-
60249088344
-
Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defence
-
Olovnikova IA, Kravchenkoa JE and Chumakov PM: Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defence. Sem Can Biol 19: 32-41, 2009.
-
(2009)
Sem Can Biol
, vol.19
, pp. 32-41
-
-
Olovnikova, I.A.1
Kravchenkoa, J.E.2
Chumakov, P.M.3
-
21
-
-
77958108351
-
Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts
-
Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR and Halldén G: Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts. Hum Gene Ther 21: 1311-1325, 2010.
-
(2010)
Hum Gene Ther
, vol.21
, pp. 1311-1325
-
-
Radhakrishnan, S.1
Miranda, E.2
Ekblad, M.3
Holford, A.4
Pizarro, M.T.5
Lemoine, N.R.6
Halldén, G.7
-
22
-
-
0035931568
-
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore
-
DOI 10.1016/S0960-894X(00)00614-4, PII S0960894X00006144
-
McNulty J, Mao J, Gibe R, Mo R, Wolf S, Pettit GR, Herald DL and Boyd MR: Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore. Bioorg Med Chem Lett 11: 169-172, 2001. (Pubitemid 32099633)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.2
, pp. 169-172
-
-
McNulty, J.1
Mao, J.2
Gibe, R.3
Mo, R.4
Wolf, S.5
Pettit, G.R.6
Herald, D.L.7
Boyd, M.R.8
-
23
-
-
54049099288
-
Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo
-
Hu H, Lee HJ, Jiang C, Zhang J, Wang L, Zhao Y, Xiang Q, Lee EO, Kim SH and Lü J: Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Mol Cancer Ther 7: 2681-2691, 2008.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2681-2691
-
-
Hu, H.1
Lee, H.J.2
Jiang, C.3
Zhang, J.4
Wang, L.5
Zhao, Y.6
Xiang, Q.7
Lee, E.O.8
Kim, S.H.9
Lü, J.10
-
24
-
-
0026498292
-
Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances
-
Gabrielsen B, Monath TP, Huggins JW, Kefauver DF, Pettit GR, Groszek G, Hollingshead M, Kirsi JJ, Shannon WM and Schubert EM: Antiviral (RNA) activity of selected Amaryllidaceae isoquinoline constituents and synthesis of related substances. J Nat Prod 55: 1569-1581, 1992.
-
(1992)
J Nat Prod
, vol.55
, pp. 1569-1581
-
-
Gabrielsen, B.1
Monath, T.P.2
Huggins, J.W.3
Kefauver, D.F.4
Pettit, G.R.5
Groszek, G.6
Hollingshead, M.7
Kirsi, J.J.8
Shannon, W.M.9
Schubert, E.M.10
-
25
-
-
68149123651
-
Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer
-
Shah MR, Kriedt CL, Lents NH, Hoyer MK, Jamaluddin N, Klein C and Baldassare J: Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer. J Exp Clin Cancer Res 28: 84, 2009.
-
(2009)
J Exp Clin Cancer Res
, vol.28
, pp. 84
-
-
Shah, M.R.1
Kriedt, C.L.2
Lents, N.H.3
Hoyer, M.K.4
Jamaluddin, N.5
Klein, C.6
Baldassare, J.7
-
26
-
-
78751503441
-
Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells
-
Griffin C, Hamm C, McNulty J and Pandey S: Pancratistatin induces apoptosis in clinical leukemia samples with minimal effect on non-cancerous peripheral blood mononuclear cells. Cancer Cell Int 10: 6, 2010.
-
(2010)
Cancer Cell Int
, vol.10
, pp. 6
-
-
Griffin, C.1
Hamm, C.2
McNulty, J.3
Pandey, S.4
-
27
-
-
77649188789
-
Small mitochondria-targeting molecules as anti-cancer agents
-
Wang F, Ogasawara MA and Huang P: Small mitochondria-targeting molecules as anti-cancer agents. Mol Asp Med 31: 75-92, 2010.
-
(2010)
Mol Asp Med
, vol.31
, pp. 75-92
-
-
Wang, F.1
Ogasawara, M.A.2
Huang, P.3
-
28
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000. (Pubitemid 30046295)
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
29
-
-
34147193472
-
Cell biology: Autophagy and cancer
-
Levine B: Cell biology: Autophagy and cancer. Nature Q&A 446: 745-747, 2007.
-
(2007)
Nature Q&A
, vol.446
, pp. 745-747
-
-
Levine, B.1
-
30
-
-
79955751141
-
Mitochondrial liaisons of p53
-
In press
-
Galluzzi L, Morselli E, Kepp O, Vitale I, Pinti M and Kroemer G: Mitochondrial liaisons of p53. Antioxid Redox Signal (In press).
-
Antioxid Redox Signal
-
-
Galluzzi, L.1
Morselli, E.2
Kepp, O.3
Vitale, I.4
Pinti, M.5
Kroemer, G.6
-
31
-
-
65949083750
-
Cytoplasmic functions of the tumour suppressor p53
-
Green DR and Kroemer G: Cytoplasmic functions of the tumour suppressor p53. Nature 458: 1127-1130, 2009.
-
(2009)
Nature
, vol.458
, pp. 1127-1130
-
-
Green, D.R.1
Kroemer, G.2
-
32
-
-
33746872880
-
Mitochondria and cancer: Is there a morphological connection?
-
Alirol E and Martinou JC: Mitochondria and cancer: is there a morphological connection? Oncogene 25: 4706-4716, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 4706-4716
-
-
Alirol, E.1
Martinou, J.C.2
|