Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

Molecular Aspects of Medicine

Volumn 31, Issue 1, 2010, Pages 29-59

  Ralph, Stephen J ^a   Rodríguez Enríquez, Sara ^b   Neuzil, Jiri ^a,c   Moreno Sánchez, Rafael ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^c INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

Author keywords

Anti cancer drugs; Apoptosis; Bioenergetic pathways; Bioenergetics; Cancer; Carcinogenesis; Mitocans; Mitochondria; Reactive oxygen species (ROS); Warburg effect

Indexed keywords

ACETALDEHYDE; ACETIC ACID; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; BUTYRIC ACID; CARBOXYLIC ACID; DICARBOXYLIC ACID; DIHYDROOROTATE DEHYDROGENASE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR; KETONE BODY; LACTATE DEHYDROGENASE; MALATE DEHYDROGENASE (NADP); METHYLMALONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PROLINE DEHYDROGENASE; PROPIONIC ACID; PROTEIN KINASE B; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; SUCCINATE DEHYDROGENASE; THIOCTIC ACID; UNCOUPLING PROTEIN 2; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BIOENERGY; BIOSYNTHESIS; CANCER CELL; CANCER THERAPY; CARCINOGENESIS; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CLINICAL TRIAL; DISEASE COURSE; DRUG MECHANISM; DRUG TARGETING; ENERGY METABOLISM; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; HUMAN; HYPOXIA; KETOGENESIS; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PANCREAS CANCER; REVIEW; SOLID TUMOR; TUMOR RESISTANCE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; DRUG DELIVERY SYSTEMS; HUMANS; METABOLIC NETWORKS AND PATHWAYS; MITOCHONDRIA; NEOPLASMS; REACTIVE OXYGEN SPECIES;

EID: 77649183649     PISSN: 00982997     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mam.2009.12.006     Document Type: Review

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