ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

Autophagy

Volumn 8, Issue 10, 2012, Pages 1462-1476

  Wang, Yuqing ^a,b   Nartiss, Yulia ^a,b   Steipe, Boris ^b   McQuibban, G Angus ^b   Kim, Peter K ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

KillerRed; Live cell imaging; Mitochondrial morphology; Mitophagy; Neurodegenerative disorders; PARK2 PARKIN; PINK1; Reactive oxygen species; SOD2

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL PROTEIN; PARKIN; PARKINSON PROTEIN 2; PHOTOSENSITIZING AGENT; PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; BIODEGRADATION; CELL DAMAGE; CELL MEMBRANE DEPOLARIZATION; CELL STRUCTURE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; HYPOTHESIS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOPHAGY; PROTEIN EXPRESSION;

EID: 84867273800     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.21211     Document Type: Article

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