TNF-Induced Activation of the Nox1 NADPH Oxidase and Its Role in the Induction of Necrotic Cell Death

Molecular Cell

Volumn 26, Issue 5, 2007, Pages 675-687

  Kim, You Sun ^a   Morgan, Michael J ^a   Choksi, Swati ^a   Liu, Zheng gang ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

CELLCYCLE; SIGNALING

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEIN NOX1; RAC1 PROTEIN; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN 140; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SMALL INTERFERING RNA; SUPEROXIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; COMPLEX FORMATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNITY; INFLAMMATION; MOUSE; NONHUMAN; PHAGOCYTE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; BUTYLATED HYDROXYANISOLE; CELL DEATH; CELL LINE; GTPASE-ACTIVATING PROTEINS; HUMANS; MICE; MULTIPROTEIN COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NECROSIS; NEUROPEPTIDES; RAC GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUPEROXIDES; TNF RECEPTOR-ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34249820757     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2007.04.021     Document Type: Article

References (35)

1. Chamseddine A.H., and Miller Jr. F.J. Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 285 (2003) H2284-H2289
2. Chen G., and Goeddel D.V. TNF-R1 signaling: a beautiful pathway. Science 296 (2002) 1634-1635
3. Cheng G., and Lambeth J.D. NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J. Biol. Chem. 279 (2004) 4737-4742
4. Cheng G., Diebold B.A., Hughes Y., and Lambeth J.D. Nox1-dependent reactive oxygen generation is regulated by Rac1. J. Biol. Chem. 281 (2006) 17718-17726
5. Dang P.M., Stensballe A., Boussetta T., Raad H., Dewas C., Kroviarski Y., Hayem G., Jensen O.N., Gougerot-Pocidalo M.A., and El-Benna J. A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites. J. Clin. Invest. 116 (2006) 2033-2043
6. Dewas C., Dang P.M., Gougerot-Pocidalo M.A., and El-Benna J. TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor. J. Immunol. 171 (2003) 4392-4398
7. Fiers W., Beyaert R., Declercq W., and Vandenabeele P. More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 18 (1999) 7719-7730
8. Frey R.S., Rahman A., Kefer J.C., Minshall R.D., and Malik A.B. PKCzeta regulates TNF-alpha-induced activation of NADPH oxidase in endothelial cells. Circ. Res. 90 (2002) 1012-1019
9. Geiszt M., Lekstrom K., Witta J., and Leto T.L. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J. Biol. Chem. 278 (2003) 20006-20012
10. Gorlach A., Brandes R.P., Nguyen K., Amidi M., Dehghani F., and Busse R. A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ. Res. 87 (2000) 26-32
11. Heyworth P.G., Cross A.R., and Curnutte J.T. Chronic granulomatous disease. Curr. Opin. Immunol. 15 (2003) 578-584
12. Hilenski L.L., Clempus R.E., Quinn M.T., Lambeth J.D., and Griendling K.K. Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 677-683
13. Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.L., Schneider P., Seed B., and Tschopp J. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat. Immunol. 1 (2000) 489-495
14. Kamata H., Honda S., Maeda S., Chang L., Hirata H., and Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120 (2005) 649-661
15. Karin M., and Lin A. NF-kappaB at the crossroads of life and death. Nat. Immunol. 3 (2002) 221-227
16. Lambeth J.D. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4 (2004) 181-189
17. Legler D.F., Micheau O., Doucey M.A., Tschopp J., and Bron C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity 18 (2003) 655-664
18. Lin Y., Devin A., Rodriguez Y., and Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13 (1999) 2514-2526
19. Lin Y., Choksi S., Shen H.M., Yang Q.F., Hur G.M., Kim Y.S., Tran J.H., Nedospasov S.A., and Liu Z.G. Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J. Biol. Chem. 279 (2004) 10822-10828
20. Liu H., Nishitoh H., Ichijo H., and Kyriakis J.M. Activation of apoptosis signal-regulating kinase 1 (ASK1) by tumor necrosis factor receptor-associated factor 2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol. Cell. Biol. 20 (2000) 2198-2208
21. Martyn K.D., Frederick L.M., von Loehneysen K., Dinauer M.C., and Knaus U.G. Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell. Signal. 18 (2006) 69-82
22. Micheau O., and Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114 (2003) 181-190
23. Miyano K., Ueno N., Takeya R., and Sumimoto H. Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. J. Biol. Chem. 281 (2006) 21857-21868
24. Nguyen H.X., and Tidball J.G. Null mutation of gp91phox reduces muscle membrane lysis during muscle inflammation in mice. J. Physiol. 553 (2003) 833-841
25. Sakon S., Xue X., Takekawa M., Sasazuki T., Okazaki T., Kojima Y., Piao J.H., Yagita H., Okumura K., Doi T., and Nakano H. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J. 22 (2003) 3898-3909
26. Saran M. To what end does nature produce superoxide? NADPH oxidase as an autocrine modifier of membrane phospholipids generating paracrine lipid messengers. Free Radic. Res. 37 (2003) 1045-1059
27. Suh Y.A., Arnold R.S., Lassegue B., Shi J., Xu X., Sorescu D., Chung A.B., Griendling K.K., and Lambeth J.D. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401 (1999) 79-82
28. Takeya R., Ueno N., Kami K., Taura M., Kohjima M., Izaki T., Nunoi H., and Sumimoto H. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J. Biol. Chem. 278 (2003) 25234-25246
29. Tang G., Minemoto Y., Dibling B., Purcell N.H., Li Z., Karin M., and Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature 414 (2001) 313-317
30. Teixeira M.M., Cunha F.Q., Noronha-Dutra A., and Hothersall J. Production of singlet oxygen by eosinophils activated in vitro by C5a and leukotriene B4. FEBS Lett. 453 (1999) 265-268
31. Tobiume K., Matsuzawa A., Takahashi T., Nishitoh H., Morita K., Takeda K., Minowa O., Miyazono K., Noda T., and Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2 (2001) 222-228
32. Ueyama T., Geiszt M., and Leto T.L. Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Mol. Cell. Biol. 26 (2006) 2160-2174
33. Ventura J.J., Hubner A., Zhang C., Flavell R.A., Shokat K.M., and Davis R.J. Chemical genetic analysis of the time course of signal transduction by JNK. Mol. Cell 21 (2006) 701-710
34. Wajant H., Pfizenmaier K., and Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 10 (2003) 45-65
35. Yu L., DeLeo F.R., Biberstine-Kinkade K.J., Renee J., Nauseef W.M., and Dinauer M.C. Biosynthesis of flavocytochrome b558. gp91(phox) is synthesized as a 65-kDa precursor (p65) in the endoplasmic reticulum. J. Biol. Chem. 274 (1999) 4364-4369