Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: Selective regulation of mitogen-activated protein kinase activation and Fas ligand expression

Journal of Experimental Medicine

Volumn 195, Issue 1, 2002, Pages 59-70

  Devadas, Satish ^a   Zaritskaya, Luba ^a   Rhee, Sue Goo ^b   Oberley, Larry ^c   Williams, Mark S ^a  

^a HOLLAND LABORATORY   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Genes, reporter; Oxidoreductases; Reactive oxygen species; Signal transduction; T lymphocytes

Indexed keywords

ANTIOXIDANT; FAS LIGAND; HYDROGEN PEROXIDE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CELL DEATH; CROSS LINKING; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD3; APOPTOSIS; FAS LIGAND PROTEIN; FREE RADICAL SCAVENGERS; HUMANS; HYBRIDOMAS; HYDROGEN PEROXIDE; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, IMMUNOLOGICAL; OXIDATION-REDUCTION; PEROXIDES; REACTIVE OXYGEN SPECIES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SUPEROXIDES; T-LYMPHOCYTES;

EID: 0037033433     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20010659     Document Type: Article

References (56)

1. Oxidative stress: The paradox of aerobic life
2. Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation
3. p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy
4. Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes
5. NAD(P)H oxidase: Role in cardiovascular biology and disease
6. Cell transformation by the superoxide-generating oxidase Mox1
7. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction
8. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1
9. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide generated in response to growth factors and tumor necrosis factor-alpha
10. The respiratory burst oxidase
11. The role of reactive oxygen intermediates in TcR-induced death of T cell blasts and hybridomas
12. Oxidative phenomena are implicated in human T-cell stimulation
13. Endogenous oxygen radicals modulate protein tyrosine phosphorylation and JNK-1 activation in lectin-stimulated thymocytes
14. IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase
15. A signaling pathway coupled to T cell receptor ligation by MMTV superantigen leading to transient activation and programmed cell death
16. Reactive oxygen species regulate activation-induced T cell apoptosis
17. Comparison of effects of two polymorphic variants of manganese superoxide dismutase on human breast MCF-7 cancer cell phenotype
18. Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression
19. Dominant negative mutant of c-Jun inhibits NF-AT transcriptional activity and prevents IL-2 gene transcription
20. Nitric oxide synthase plays a signaling role in TCR-triggered apoptotic death
21. Immunoreceptor tyrosine-based activation motif is required to signal pathways of receptor-mediated growth arrest and apoptosis in murine B lymphoma cells
22. Measurement of oxidant-induced signal transduction proteins using cell imaging
23. Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: Implications for intracellular measurement of reactive nitrogen and oxygen species
24. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2',7'-dichlorofluorescin
25. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
26. Bcl-2 and mitochondrial oxygen radicals. New approaches with reactive oxygen species-sensitive probes
27. Regulation of CD95 (Fas) ligand expression by TCR-mediated signaling events
28. Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation
29. Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members
30. Sequential involvement of NFAT and Egr transcription factors in FasL regulation
31. Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury
32. 5-Hydroxytryptamine1A receptor/Gibetagamma stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of src in chinese hamster ovary fibroblasts
33. Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: Dual regulation by reactive oxygen species
34. Role for mitochondrial oxidants as regulators of cellular metabolism
35. Regulation of reactive-oxygen-species generation in fibroblasts by Rac1
36. Novel homologs of gp91phox
37. NADPH oxidase activity and cytochrome b558 content of human Epstein-Barr-virus-transformed B lymphocytes correlate with expression of genes encoding components of the oxidase system
38. Impact of oxidative stress on signal transduction control by phosphotyrosine phosphatases
39. An essential role for free radicals and derived species in signal transduction
40. Regulation of JNK signaling by GSTp
41. Redox regulation of the mitogen-activated protein kinase pathway during lymphocyte activation
42. Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1-regulated response element in the Fas ligand promoter
43. Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression
44. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells
45. Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor kappaB
46. Identification of two NF-kappa B sites in mouse CD95 ligand (Fas ligand) promoter: Functional analysis in T cell hybridoma
47. A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs
48. Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase
49. Role of Egr-2 in Up-regulation of Fas ligand in normal T cells and aberrant double-negative lpr and gld T cells
50. Production of hydrogen peroxide by transforming growth factor-beta 1 and its involvement in induction of egr-1 in mouse osteoblastic cells
51. Iron-sulfur clusters as biosensors of oxidants and iron
52. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical
53. Superoxide and hydrogen peroxide-dependent inhibition of iron regulatory protein activity: A protective stratagem against oxidative injury
54. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
55. Enhancement of T cell receptor signaling by a mild oxidative shift in the intracellular thiol pool
56. Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis