Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 1, 2012, Pages

  Chatterjee, Shampa ^a   Browning, Elizabeth A ^a   Hong, Nankang ^a   Debolt, Kris ^a   Sorokina, Elena M ^a   Liu, Weidong ^a   Birnbaum, Morris J ^b   Fisher, Aron B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Endothelium; Mechanotransduction; Membrane potential; NADPH oxidase; Phosphoinositide 3 kinase; Phosphorylation; Protein kinase C; Reactive oxygen species

Indexed keywords

ADENOSINE TRIPHOSPHATE; CROMAKALIM; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENDOTHELIUM CELL; HEART MUSCLE ISCHEMIA; IN VITRO STUDY; LUNG PERFUSION; MALE; MEMBRANE DEPOLARIZATION; MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SHEAR STRESS; WILD TYPE;

EID: 84255167151     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00298.2011     Document Type: Article

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