메뉴 건너뛰기




Volumn 40, Issue , 2014, Pages 269-282

Immune system: A possible nexus between cannabinoids and psychosis

Author keywords

Cytokines; Endocannabinoid system; First episode psychosis; Immunology; Infection; Microglia; Schizophrenia

Indexed keywords

CANNABINOID; CANNABINOID RECEPTOR; CYTOKINE; ENDOCANNABINOID; LIGAND; CANNABINOID RECEPTOR AFFECTING AGENT;

EID: 84904101669     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.01.018     Document Type: Review
Times cited : (51)

References (193)
  • 1
    • 84868535926 scopus 로고    scopus 로고
    • Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression
    • Adhikary S., Kocieda V.P., Yen J.H., Tuma R.F., Ganea D. Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression. Blood 2012, 120(18):3741-3749.
    • (2012) Blood , vol.120 , Issue.18 , pp. 3741-3749
    • Adhikary, S.1    Kocieda, V.P.2    Yen, J.H.3    Tuma, R.F.4    Ganea, D.5
  • 2
    • 38949203366 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes
    • Agudelo M., Newton C., Widen R., Sherwood T., Nong L., Friedman H., et al. Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes. J. Neuroimmune Pharmacol. 2008, 3(1):35-42.
    • (2008) J. Neuroimmune Pharmacol. , vol.3 , Issue.1 , pp. 35-42
    • Agudelo, M.1    Newton, C.2    Widen, R.3    Sherwood, T.4    Nong, L.5    Friedman, H.6
  • 4
    • 77952601644 scopus 로고    scopus 로고
    • Regulation of Fas receptor/Fas-associated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain
    • Alvaro-Bartolome M., Esteban S., Garcia-Gutierrez M.S., Manzanares J., Valverde O., Garcia-Sevilla J.A. Regulation of Fas receptor/Fas-associated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain. Br. J. Pharmacol. 2010, 160(3):643-656.
    • (2010) Br. J. Pharmacol. , vol.160 , Issue.3 , pp. 643-656
    • Alvaro-Bartolome, M.1    Esteban, S.2    Garcia-Gutierrez, M.S.3    Manzanares, J.4    Valverde, O.5    Garcia-Sevilla, J.A.6
  • 5
    • 84867744820 scopus 로고    scopus 로고
    • A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury
    • Amenta P.S., Jallo J.I., Tuma R.F., Elliott M.B. A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury. J. Neurosci. Res. 2012, 90(12):2293-2305.
    • (2012) J. Neurosci. Res. , vol.90 , Issue.12 , pp. 2293-2305
    • Amenta, P.S.1    Jallo, J.I.2    Tuma, R.F.3    Elliott, M.B.4
  • 6
    • 84862021462 scopus 로고    scopus 로고
    • A CB(1)/CB(2) receptor agonist, WIN 55,212-2, exerts its therapeutic effect in a viral autoimmune model of multiple sclerosis by restoring self-tolerance to myelin
    • Arevalo-Martin A., Molina-Holgado E., Guaza C. A CB(1)/CB(2) receptor agonist, WIN 55,212-2, exerts its therapeutic effect in a viral autoimmune model of multiple sclerosis by restoring self-tolerance to myelin. Neuropharmacology 2012, 63(3):385-393.
    • (2012) Neuropharmacology , vol.63 , Issue.3 , pp. 385-393
    • Arevalo-Martin, A.1    Molina-Holgado, E.2    Guaza, C.3
  • 7
    • 0034044078 scopus 로고    scopus 로고
    • Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons
    • Auclair N., Otani S., Soubrie P., Crepel F. Cannabinoids modulate synaptic strength and plasticity at glutamatergic synapses of rat prefrontal cortex pyramidal neurons. J. Neurophysiol. 2000, 83(6):3287-3293.
    • (2000) J. Neurophysiol. , vol.83 , Issue.6 , pp. 3287-3293
    • Auclair, N.1    Otani, S.2    Soubrie, P.3    Crepel, F.4
  • 9
    • 84866372949 scopus 로고    scopus 로고
    • Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
    • Ayalew M., Le-Niculescu H., Levey D.F., Jain N., Changala B., Patel S.D., et al. Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Mol. Psychiatry 2012, 17(9):887-905.
    • (2012) Mol. Psychiatry , vol.17 , Issue.9 , pp. 887-905
    • Ayalew, M.1    Le-Niculescu, H.2    Levey, D.F.3    Jain, N.4    Changala, B.5    Patel, S.D.6
  • 10
    • 80053652832 scopus 로고    scopus 로고
    • GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils
    • Balenga N.A., Aflaki E., Kargl J., Platzer W., Schroder R., Blattermann S., et al. GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res. 2011, 21(10):1452-1469.
    • (2011) Cell Res. , vol.21 , Issue.10 , pp. 1452-1469
    • Balenga, N.A.1    Aflaki, E.2    Kargl, J.3    Platzer, W.4    Schroder, R.5    Blattermann, S.6
  • 11
    • 84879518676 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 (CB2) plays a role in the generation of germinal center and memory B cells, but not in the production of antigen-specific IgG and IgM, in response to T-dependent antigens
    • Basu S., Ray A., Dittel B.N. Cannabinoid receptor 2 (CB2) plays a role in the generation of germinal center and memory B cells, but not in the production of antigen-specific IgG and IgM, in response to T-dependent antigens. PLoS ONE 2013, 8(6):e67587.
    • (2013) PLoS ONE , vol.8 , Issue.6
    • Basu, S.1    Ray, A.2    Dittel, B.N.3
  • 12
    • 79952752154 scopus 로고    scopus 로고
    • Beta-caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway
    • Bento A.F., Marcon R., Dutra R.C., Claudino R.F., Cola M., Leite D.F., et al. Beta-caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway. Am. J. Pathol. 2011, 178(3):1153-1166.
    • (2011) Am. J. Pathol. , vol.178 , Issue.3 , pp. 1153-1166
    • Bento, A.F.1    Marcon, R.2    Dutra, R.C.3    Claudino, R.F.4    Cola, M.5    Leite, D.F.6
  • 13
    • 67651055423 scopus 로고    scopus 로고
    • Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy
    • Bernstein H.G., Steiner J., Bogerts B. Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy. Expert Rev. Neurother. 2009, 9(7):1059-1071.
    • (2009) Expert Rev. Neurother. , vol.9 , Issue.7 , pp. 1059-1071
    • Bernstein, H.G.1    Steiner, J.2    Bogerts, B.3
  • 15
    • 72149116426 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling
    • Borner C., Smida M., Hollt V., Schraven B., Kraus J. Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. J. Biol. Chem. 2009, 284(51):35450-35460.
    • (2009) J. Biol. Chem. , vol.284 , Issue.51 , pp. 35450-35460
    • Borner, C.1    Smida, M.2    Hollt, V.3    Schraven, B.4    Kraus, J.5
  • 17
    • 79952191254 scopus 로고    scopus 로고
    • Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1/CB2 receptors
    • Braun A., Engel T., Aguilar-Pimentel J.A., Zimmer A., Jakob T., Behrendt H., et al. Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1/CB2 receptors. Immunobiology 2011, 216(4):466-476.
    • (2011) Immunobiology , vol.216 , Issue.4 , pp. 466-476
    • Braun, A.1    Engel, T.2    Aguilar-Pimentel, J.A.3    Zimmer, A.4    Jakob, T.5    Behrendt, H.6
  • 18
    • 35548986657 scopus 로고    scopus 로고
    • Modulation of airway responses to influenza A/PR/8/34 by Delta9-tetrahydrocannabinol in C57BL/6 mice
    • Buchweitz J.P., Karmaus P.W., Harkema J.R., Williams K.J., Kaminski N.E. Modulation of airway responses to influenza A/PR/8/34 by Delta9-tetrahydrocannabinol in C57BL/6 mice. J. Pharmacol. Exp. Ther. 2007, 323(2):675-683.
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , Issue.2 , pp. 675-683
    • Buchweitz, J.P.1    Karmaus, P.W.2    Harkema, J.R.3    Williams, K.J.4    Kaminski, N.E.5
  • 19
    • 0034685707 scopus 로고    scopus 로고
    • Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor
    • Buckley N.E., McCoy K.L., Mezey E., Bonner T., Zimmer A., Felder C.C., et al. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. Eur. J. Pharmacol. 2000, 396(2-3):141-149.
    • (2000) Eur. J. Pharmacol. , vol.396 , Issue.2-3 , pp. 141-149
    • Buckley, N.E.1    McCoy, K.L.2    Mezey, E.3    Bonner, T.4    Zimmer, A.5    Felder, C.C.6
  • 20
    • 33646839061 scopus 로고    scopus 로고
    • Experimental methods to study the role of the peripheral cannabinoid receptor in immune function
    • Buckley N.E., Burbridge D., Buranapramest M., Ferguson T., Paau R.Y. Experimental methods to study the role of the peripheral cannabinoid receptor in immune function. Methods Mol. Med. 2006, 123:19-40.
    • (2006) Methods Mol. Med. , vol.123 , pp. 19-40
    • Buckley, N.E.1    Burbridge, D.2    Buranapramest, M.3    Ferguson, T.4    Paau, R.Y.5
  • 21
    • 84867191600 scopus 로고    scopus 로고
    • Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?
    • Busse S., Busse M., Schiltz K., Bielau H., Gos T., Brisch R., et al. Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?. Brain Behav. Immun. 2012, 26(8):1273-1279.
    • (2012) Brain Behav. Immun. , vol.26 , Issue.8 , pp. 1273-1279
    • Busse, S.1    Busse, M.2    Schiltz, K.3    Bielau, H.4    Gos, T.5    Brisch, R.6
  • 22
    • 53049094391 scopus 로고    scopus 로고
    • Cannabinoids as therapeutic agents for ablating neuroinflammatory disease
    • Cabral G.A., Griffin-Thomas L. Cannabinoids as therapeutic agents for ablating neuroinflammatory disease. Endocr. Metab. Immune Disord. Drug Targets 2008, 8(3):159-172.
    • (2008) Endocr. Metab. Immune Disord. Drug Targets , vol.8 , Issue.3 , pp. 159-172
    • Cabral, G.A.1    Griffin-Thomas, L.2
  • 23
    • 1642493025 scopus 로고    scopus 로고
    • Cannabinoid-mediated exacerbation of brain infection by opportunistic amebae
    • Cabral G.A., Marciano-Cabral F. Cannabinoid-mediated exacerbation of brain infection by opportunistic amebae. J. Neuroimmunol. 2004, 147(1-2):127-130.
    • (2004) J. Neuroimmunol. , vol.147 , Issue.1-2 , pp. 127-130
    • Cabral, G.A.1    Marciano-Cabral, F.2
  • 25
    • 0031939076 scopus 로고    scopus 로고
    • The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study
    • Cannon T.D., Kaprio J., Lonnqvist J., Huttunen M., Koskenvuo M. The genetic epidemiology of schizophrenia in a Finnish twin cohort. A population-based modeling study. Arch. Gen. Psychiatry 1998, 55(1):67-74.
    • (1998) Arch. Gen. Psychiatry , vol.55 , Issue.1 , pp. 67-74
    • Cannon, T.D.1    Kaprio, J.2    Lonnqvist, J.3    Huttunen, M.4    Koskenvuo, M.5
  • 26
    • 67650272779 scopus 로고    scopus 로고
    • Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia
    • Caraceni P., Pertosa A.M., Giannone F., Domenicali M., Grattagliano I., Principe A., et al. Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia. Gut 2009, 58(8):1135-1143.
    • (2009) Gut , vol.58 , Issue.8 , pp. 1135-1143
    • Caraceni, P.1    Pertosa, A.M.2    Giannone, F.3    Domenicali, M.4    Grattagliano, I.5    Principe, A.6
  • 27
    • 33646534846 scopus 로고    scopus 로고
    • Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines
    • Catts V.S., Catts S.V., McGrath J.J., Feron F., McLean D., Coulson E.J., et al. Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophr. Res. 2006, 84(1):20-28.
    • (2006) Schizophr. Res. , vol.84 , Issue.1 , pp. 20-28
    • Catts, V.S.1    Catts, S.V.2    McGrath, J.J.3    Feron, F.4    McLean, D.5    Coulson, E.J.6
  • 29
    • 77952493930 scopus 로고    scopus 로고
    • Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors
    • Cencioni M.T., Chiurchiu V., Catanzaro G., Borsellino G., Bernardi G., Battistini L., et al. Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS ONE 2010, 5(1):e8688.
    • (2010) PLoS ONE , vol.5 , Issue.1
    • Cencioni, M.T.1    Chiurchiu, V.2    Catanzaro, G.3    Borsellino, G.4    Bernardi, G.5    Battistini, L.6
  • 30
    • 52949125632 scopus 로고    scopus 로고
    • The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases
    • Centonze D., Battistini L., Maccarrone M. The endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases. Curr. Pharm. Des. 2008, 14(23):2370-2382.
    • (2008) Curr. Pharm. Des. , vol.14 , Issue.23 , pp. 2370-2382
    • Centonze, D.1    Battistini, L.2    Maccarrone, M.3
  • 31
    • 84856098970 scopus 로고    scopus 로고
    • Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-alpha-directed cell apoptosis in neutrophils
    • Chen M.L., Tsai T.C., Wang L.K., Lin Y.Y., Tsai Y.M., Lee M.C., et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-alpha-directed cell apoptosis in neutrophils. Int. Immunopharmacol. 2012, 12(1):197-204.
    • (2012) Int. Immunopharmacol. , vol.12 , Issue.1 , pp. 197-204
    • Chen, M.L.1    Tsai, T.C.2    Wang, L.K.3    Lin, Y.Y.4    Tsai, Y.M.5    Lee, M.C.6
  • 33
    • 84880209405 scopus 로고    scopus 로고
    • Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia
    • Chew L.J., Fusar-Poli P., Schmitz T. Oligodendroglial alterations and the role of microglia in white matter injury: relevance to schizophrenia. Dev. Neurosci. 2013, 35(2-3):102-129.
    • (2013) Dev. Neurosci. , vol.35 , Issue.2-3 , pp. 102-129
    • Chew, L.J.1    Fusar-Poli, P.2    Schmitz, T.3
  • 34
    • 67349209561 scopus 로고    scopus 로고
    • Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts
    • Chicca A., Raduner S., Pellati F., Strompen T., Altmann K.H., Schoop R., et al. Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. Int. Immunopharmacol. 2009, 9(7-8):850-858.
    • (2009) Int. Immunopharmacol. , vol.9 , Issue.7-8 , pp. 850-858
    • Chicca, A.1    Raduner, S.2    Pellati, F.3    Strompen, T.4    Altmann, K.H.5    Schoop, R.6
  • 36
    • 33846583671 scopus 로고    scopus 로고
    • Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis
    • Coopman K., Smith L.D., Wright K.L., Ward S.G. Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. Int. Immunopharmacol. 2007, 7(3):360-371.
    • (2007) Int. Immunopharmacol. , vol.7 , Issue.3 , pp. 360-371
    • Coopman, K.1    Smith, L.D.2    Wright, K.L.3    Ward, S.G.4
  • 37
    • 56649092813 scopus 로고    scopus 로고
    • A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells
    • Correa F., Docagne F., Mestre L., Clemente D., Hernangomez M., Loria F., et al. A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells. Biochem. Pharmacol. 2009, 77(1):86-100.
    • (2009) Biochem. Pharmacol. , vol.77 , Issue.1 , pp. 86-100
    • Correa, F.1    Docagne, F.2    Mestre, L.3    Clemente, D.4    Hernangomez, M.5    Loria, F.6
  • 38
    • 73149113054 scopus 로고    scopus 로고
    • Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: roles of ERK1/2, JNK, and NF-kappaB
    • Correa F., Hernangomez M., Mestre L., Loria F., Spagnolo A., Docagne F., et al. Anandamide enhances IL-10 production in activated microglia by targeting CB(2) receptors: roles of ERK1/2, JNK, and NF-kappaB. Glia 2010, 58(2):135-147.
    • (2010) Glia , vol.58 , Issue.2 , pp. 135-147
    • Correa, F.1    Hernangomez, M.2    Mestre, L.3    Loria, F.4    Spagnolo, A.5    Docagne, F.6
  • 40
    • 27244437435 scopus 로고    scopus 로고
    • Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression
    • Croxford J.L., Wang K., Miller S.D., Engman D.M., Tyler K.M. Effects of cannabinoid treatment on Chagas disease pathogenesis: balancing inhibition of parasite invasion and immunosuppression. Cell. Microbiol. 2005, 7(11):1592-1602.
    • (2005) Cell. Microbiol. , vol.7 , Issue.11 , pp. 1592-1602
    • Croxford, J.L.1    Wang, K.2    Miller, S.D.3    Engman, D.M.4    Tyler, K.M.5
  • 42
    • 84876436206 scopus 로고    scopus 로고
    • Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the "Two Hit" hypothesis for the development of schizophrenia
    • Dalton V.S., Verdurand M., Walker A., Hodgson D.M., Zavitsanou K. Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT1A receptor binding in the hippocampus: testing the "Two Hit" hypothesis for the development of schizophrenia. ISRN Psychiatr. 2012, 2012:451865.
    • (2012) ISRN Psychiatr. , vol.2012 , pp. 451865
    • Dalton, V.S.1    Verdurand, M.2    Walker, A.3    Hodgson, D.M.4    Zavitsanou, K.5
  • 44
    • 0026753733 scopus 로고
    • The significance of age of onset for schizophrenia
    • DeLisi L.E. The significance of age of onset for schizophrenia. Schizophr. Bull. 1992, 18(2):209-215.
    • (1992) Schizophr. Bull. , vol.18 , Issue.2 , pp. 209-215
    • DeLisi, L.E.1
  • 45
    • 0142043839 scopus 로고    scopus 로고
    • No evidence for direct modulatory effects of delta 9-tetrahydrocannabinol on human polymorphonuclear leukocytes
    • Deusch E., Kraft B., Nahlik G., Weigl L., Hohenegger M., Kress H.G. No evidence for direct modulatory effects of delta 9-tetrahydrocannabinol on human polymorphonuclear leukocytes. J. Neuroimmunol. 2003, 141(1-2):99-103.
    • (2003) J. Neuroimmunol. , vol.141 , Issue.1-2 , pp. 99-103
    • Deusch, E.1    Kraft, B.2    Nahlik, G.3    Weigl, L.4    Hohenegger, M.5    Kress, H.G.6
  • 46
    • 0027078685 scopus 로고
    • Isolation and structure of a brain constituent that binds to the cannabinoid receptor
    • Devane W.A., Hanus L., Breuer A., Pertwee R.G., Stevenson L.A., Griffin G., et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1992, 258(5090):1946-1949.
    • (1992) Science , vol.258 , Issue.5090 , pp. 1946-1949
    • Devane, W.A.1    Hanus, L.2    Breuer, A.3    Pertwee, R.G.4    Stevenson, L.A.5    Griffin, G.6
  • 47
    • 4043179097 scopus 로고    scopus 로고
    • Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation
    • Do Y., McKallip R.J., Nagarkatti M., Nagarkatti P.S. Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. J. Immunol. 2004, 173(4):2373-2382.
    • (2004) J. Immunol. , vol.173 , Issue.4 , pp. 2373-2382
    • Do, Y.1    McKallip, R.J.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 48
    • 79953215626 scopus 로고    scopus 로고
    • Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis
    • Downer E.J., Clifford E., Gran B., Nel H.J., Fallon P.G., Moynagh P.N. Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis. J. Biol. Chem. 2011, 286(12):10316-10328.
    • (2011) J. Biol. Chem. , vol.286 , Issue.12 , pp. 10316-10328
    • Downer, E.J.1    Clifford, E.2    Gran, B.3    Nel, H.J.4    Fallon, P.G.5    Moynagh, P.N.6
  • 49
    • 84863612439 scopus 로고    scopus 로고
    • Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system
    • Dutra R.C., Simao da Silva K.A., Bento A.F., Marcon R., Paszcuk A.F., Meotti F.C., et al. Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system. Neuropharmacology 2012, 63(4):593-605.
    • (2012) Neuropharmacology , vol.63 , Issue.4 , pp. 593-605
    • Dutra, R.C.1    Simao da Silva, K.A.2    Bento, A.F.3    Marcon, R.4    Paszcuk, A.F.5    Meotti, F.C.6
  • 50
    • 77957129261 scopus 로고    scopus 로고
    • Autoimmune diseases, bipolar disorder, and non-affective psychosis
    • Eaton W.W., Pedersen M.G., Nielsen P.R., Mortensen P.B. Autoimmune diseases, bipolar disorder, and non-affective psychosis. Bipolar Disord. 2010, 12(6):638-646.
    • (2010) Bipolar Disord. , vol.12 , Issue.6 , pp. 638-646
    • Eaton, W.W.1    Pedersen, M.G.2    Nielsen, P.R.3    Mortensen, P.B.4
  • 51
    • 46849111394 scopus 로고    scopus 로고
    • Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
    • Eggan S.M., Hashimoto T., Lewis D.A. Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch. Gen. Psychiatry 2008, 65(7):772-784.
    • (2008) Arch. Gen. Psychiatry , vol.65 , Issue.7 , pp. 772-784
    • Eggan, S.M.1    Hashimoto, T.2    Lewis, D.A.3
  • 52
    • 29244478635 scopus 로고    scopus 로고
    • Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
    • Ehrhart J., Obregon D., Mori T., Hou H., Sun N., Bai Y., et al. Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation. J. Neuroinflamm. 2005, 2:29.
    • (2005) J. Neuroinflamm. , vol.2 , pp. 29
    • Ehrhart, J.1    Obregon, D.2    Mori, T.3    Hou, H.4    Sun, N.5    Bai, Y.6
  • 53
    • 34548488484 scopus 로고    scopus 로고
    • Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors
    • Eisenstein T.K., Meissler J.J., Wilson Q., Gaughan J.P., Adler M.W. Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. J. Neuroimmunol. 2007, 189(1-2):17-22.
    • (2007) J. Neuroimmunol. , vol.189 , Issue.1-2 , pp. 17-22
    • Eisenstein, T.K.1    Meissler, J.J.2    Wilson, Q.3    Gaughan, J.P.4    Adler, M.W.5
  • 54
    • 8444244202 scopus 로고    scopus 로고
    • Effect of cannabinoid ingestion (in the form of bhang) on the immune system of high school and university students
    • El-Gohary M., Eid M.A. Effect of cannabinoid ingestion (in the form of bhang) on the immune system of high school and university students. Hum. Exp. Toxicol. 2004, 23(3):149-156.
    • (2004) Hum. Exp. Toxicol. , vol.23 , Issue.3 , pp. 149-156
    • El-Gohary, M.1    Eid, M.A.2
  • 55
    • 29544446576 scopus 로고    scopus 로고
    • The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells
    • Eljaschewitsch E., Witting A., Mawrin C., Lee T., Schmidt P.M., Wolf S., et al. The endocannabinoid anandamide protects neurons during CNS inflammation by induction of MKP-1 in microglial cells. Neuron 2006, 49(1):67-79.
    • (2006) Neuron , vol.49 , Issue.1 , pp. 67-79
    • Eljaschewitsch, E.1    Witting, A.2    Mawrin, C.3    Lee, T.4    Schmidt, P.M.5    Wolf, S.6
  • 56
    • 79960209448 scopus 로고    scopus 로고
    • Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury
    • Esposito E., Paterniti I., Mazzon E., Genovese T., Di Paola R., Galuppo M., et al. Effects of palmitoylethanolamide on release of mast cell peptidases and neurotrophic factors after spinal cord injury. Brain Behav. Immun. 2011, 25(6):1099-1112.
    • (2011) Brain Behav. Immun. , vol.25 , Issue.6 , pp. 1099-1112
    • Esposito, E.1    Paterniti, I.2    Mazzon, E.3    Genovese, T.4    Di Paola, R.5    Galuppo, M.6
  • 57
    • 0041926531 scopus 로고    scopus 로고
    • Cannabinoids inhibit the activation of ERK MAPK in PMA/Io-stimulated mouse splenocytes
    • Faubert Kaplan BL B.L., Kaminski N.E. Cannabinoids inhibit the activation of ERK MAPK in PMA/Io-stimulated mouse splenocytes. Int. Immunopharmacol. 2003, 3(10-11):1503-1510.
    • (2003) Int. Immunopharmacol. , vol.3 , Issue.10-11 , pp. 1503-1510
    • Faubert Kaplan BL, B.L.1    Kaminski, N.E.2
  • 59
    • 0029057882 scopus 로고
    • Linked regularities in the development and evolution of mammalian brains
    • Finlay B.L., Darlington R.B. Linked regularities in the development and evolution of mammalian brains. Science 1995, 268(5217):1578-1584.
    • (1995) Science , vol.268 , Issue.5217 , pp. 1578-1584
    • Finlay, B.L.1    Darlington, R.B.2
  • 60
    • 0142038864 scopus 로고    scopus 로고
    • Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors
    • Franklin A., Stella N. Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors. Eur. J. Pharmacol. 2003, 474(2-3):195-198.
    • (2003) Eur. J. Pharmacol. , vol.474 , Issue.2-3 , pp. 195-198
    • Franklin, A.1    Stella, N.2
  • 61
    • 0042320663 scopus 로고    scopus 로고
    • Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility
    • Franklin A., Parmentier-Batteur S., Walter L., Greenberg D.A., Stella N. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. J. Neurosci. 2003, 23(21):7767-7775.
    • (2003) J. Neurosci. , vol.23 , Issue.21 , pp. 7767-7775
    • Franklin, A.1    Parmentier-Batteur, S.2    Walter, L.3    Greenberg, D.A.4    Stella, N.5
  • 62
    • 3242813912 scopus 로고    scopus 로고
    • The endocannabinoid-CB receptor system: importance for development and in pediatric disease
    • Fride E. The endocannabinoid-CB receptor system: importance for development and in pediatric disease. Neuro. Endocrinol. Lett. 2004, 25(1-2):24-30.
    • (2004) Neuro. Endocrinol. Lett. , vol.25 , Issue.1-2 , pp. 24-30
    • Fride, E.1
  • 63
    • 84883149080 scopus 로고    scopus 로고
    • Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
    • Gaffal E., Cron M., Glodde N., Tuting T. Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors. Allergy 2013, 68(8):994-1000.
    • (2013) Allergy , vol.68 , Issue.8 , pp. 994-1000
    • Gaffal, E.1    Cron, M.2    Glodde, N.3    Tuting, T.4
  • 64
    • 0029157792 scopus 로고
    • Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. The influence of age at onset and negative symptoms
    • Ganguli R., Brar J.S., Chengappa K.R., DeLeo M., Yang Z.W., Shurin G., et al. Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. The influence of age at onset and negative symptoms. Arch. Gen. Psychiatry 1995, 52(8):668-672.
    • (1995) Arch. Gen. Psychiatry , vol.52 , Issue.8 , pp. 668-672
    • Ganguli, R.1    Brar, J.S.2    Chengappa, K.R.3    DeLeo, M.4    Yang, Z.W.5    Shurin, G.6
  • 65
    • 84895756733 scopus 로고    scopus 로고
    • Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia
    • Garcia-Bueno B., Bioque M., Mac-Dowell K.S., Barcones M.F., Martinez-Cengotitabengoa M., Pina-Camacho L., et al. Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr. Bull. 2013, http://dx.doi.org/10.1093/schbul/sbt001.
    • (2013) Schizophr. Bull.
    • Garcia-Bueno, B.1    Bioque, M.2    Mac-Dowell, K.S.3    Barcones, M.F.4    Martinez-Cengotitabengoa, M.5    Pina-Camacho, L.6
  • 66
    • 84862135381 scopus 로고    scopus 로고
    • Dysequilibrium of neuronal proliferation and apoptosis in a pharmacological animal model of psychosis
    • Genius J., Benninghoff J., Reuter N., Braun I., Giegling I., Hartmann A., et al. Dysequilibrium of neuronal proliferation and apoptosis in a pharmacological animal model of psychosis. Methods 2012, 56(4):519-527.
    • (2012) Methods , vol.56 , Issue.4 , pp. 519-527
    • Genius, J.1    Benninghoff, J.2    Reuter, N.3    Braun, I.4    Giegling, I.5    Hartmann, A.6
  • 67
    • 33744827120 scopus 로고    scopus 로고
    • Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes
    • Ghosh S., Preet A., Groopman J.E., Ganju R.K. Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes. Mol. Immunol. 2006, 43(14):2169-2179.
    • (2006) Mol. Immunol. , vol.43 , Issue.14 , pp. 2169-2179
    • Ghosh, S.1    Preet, A.2    Groopman, J.E.3    Ganju, R.K.4
  • 68
    • 34447129568 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells
    • Gokoh M., Kishimoto S., Oka S., Sugiura T. 2-Arachidonoylglycerol enhances the phagocytosis of opsonized zymosan by HL-60 cells differentiated into macrophage-like cells. Biol. Pharm. Bull. 2007, 30(7):1199-1205.
    • (2007) Biol. Pharm. Bull. , vol.30 , Issue.7 , pp. 1199-1205
    • Gokoh, M.1    Kishimoto, S.2    Oka, S.3    Sugiura, T.4
  • 69
    • 0742306865 scopus 로고    scopus 로고
    • Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940
    • Gongora C., Hose S., O'Brien T.P., Sinha D. Downregulation of class II transactivator (CIITA) expression by synthetic cannabinoid CP55,940. Immunol. Lett. 2004, 91(1):11-16.
    • (2004) Immunol. Lett. , vol.91 , Issue.1 , pp. 11-16
    • Gongora, C.1    Hose, S.2    O'Brien, T.P.3    Sinha, D.4
  • 72
    • 84879004090 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability
    • Harvey B.S., Nicotra L.L., Vu M., Smid S.D. Cannabinoid CB2 receptor activation attenuates cytokine-evoked mucosal damage in a human colonic explant model without changing epithelial permeability. Cytokine 2013, 63(2):209-217.
    • (2013) Cytokine , vol.63 , Issue.2 , pp. 209-217
    • Harvey, B.S.1    Nicotra, L.L.2    Vu, M.3    Smid, S.D.4
  • 73
    • 45749086074 scopus 로고    scopus 로고
    • Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells
    • Hegde V.L., Hegde S., Cravatt B.F., Hofseth L.J., Nagarkatti M., Nagarkatti P.S. Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Mol. Pharmacol. 2008, 74(1):20-33.
    • (2008) Mol. Pharmacol. , vol.74 , Issue.1 , pp. 20-33
    • Hegde, V.L.1    Hegde, S.2    Cravatt, B.F.3    Hofseth, L.J.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 74
    • 78649605467 scopus 로고    scopus 로고
    • Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
    • Hegde V.L., Nagarkatti M., Nagarkatti P.S. Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties. Eur. J. Immunol. 2010, 40(12):3358-3371.
    • (2010) Eur. J. Immunol. , vol.40 , Issue.12 , pp. 3358-3371
    • Hegde, V.L.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 75
    • 79953658580 scopus 로고    scopus 로고
    • Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
    • Hegde V.L., Nagarkatti P.S., Nagarkatti M. Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. PLoS ONE 2011, 6(4):e18281.
    • (2011) PLoS ONE , vol.6 , Issue.4
    • Hegde, V.L.1    Nagarkatti, P.S.2    Nagarkatti, M.3
  • 76
    • 61849156712 scopus 로고    scopus 로고
    • Are common childhood or adolescent infections risk factors for schizophrenia and other psychotic disorders?
    • Hickie I.B., Banati R., Stewart C.H., Lloyd A.R. Are common childhood or adolescent infections risk factors for schizophrenia and other psychotic disorders?. Med. J. Aust. 2009, 190(4 Suppl):S17-S21.
    • (2009) Med. J. Aust. , vol.190 , Issue.4 SUPPL
    • Hickie, I.B.1    Banati, R.2    Stewart, C.H.3    Lloyd, A.R.4
  • 77
    • 21644464904 scopus 로고    scopus 로고
    • CB2 receptor ligands
    • Huffman J.W. CB2 receptor ligands. Mini Rev. Med. Chem. 2005, 5(7):641-649.
    • (2005) Mini Rev. Med. Chem. , vol.5 , Issue.7 , pp. 641-649
    • Huffman, J.W.1
  • 79
    • 34247359068 scopus 로고    scopus 로고
    • Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice
    • Jan T.R., Su S.T., Wu H.Y., Liao M.H. Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice. Int. Immunopharmacol. 2007, 7(6):773-780.
    • (2007) Int. Immunopharmacol. , vol.7 , Issue.6 , pp. 773-780
    • Jan, T.R.1    Su, S.T.2    Wu, H.Y.3    Liao, M.H.4
  • 80
    • 3242724820 scopus 로고    scopus 로고
    • Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes
    • Joseph J., Niggemann B., Zaenker K.S., Entschladen F. Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes. Cancer Immunol. Immunother. 2004, 53(8):723-728.
    • (2004) Cancer Immunol. Immunother. , vol.53 , Issue.8 , pp. 723-728
    • Joseph, J.1    Niggemann, B.2    Zaenker, K.S.3    Entschladen, F.4
  • 81
    • 50549105058 scopus 로고    scopus 로고
    • The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT)
    • Kaplan B.L., Springs A.E., Kaminski N.E. The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT). Biochem. Pharmacol. 2008, 76(6):726-737.
    • (2008) Biochem. Pharmacol. , vol.76 , Issue.6 , pp. 726-737
    • Kaplan, B.L.1    Springs, A.E.2    Kaminski, N.E.3
  • 82
    • 80055070153 scopus 로고    scopus 로고
    • Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection
    • Karmaus P.W., Chen W., Crawford R.B., Harkema J.R., Kaplan B.L., Kaminski N.E. Deletion of cannabinoid receptors 1 and 2 exacerbates APC function to increase inflammation and cellular immunity during influenza infection. J. Leukoc. Biol. 2011, 90(5):983-995.
    • (2011) J. Leukoc. Biol. , vol.90 , Issue.5 , pp. 983-995
    • Karmaus, P.W.1    Chen, W.2    Crawford, R.B.3    Harkema, J.R.4    Kaplan, B.L.5    Kaminski, N.E.6
  • 83
    • 84873845159 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2
    • Karmaus P.W., Chen W., Crawford R., Kaplan B.L., Kaminski N.E. Delta9-tetrahydrocannabinol impairs the inflammatory response to influenza infection: role of antigen-presenting cells and the cannabinoid receptors 1 and 2. Toxicol. Sci. 2013, 131(2):419-433.
    • (2013) Toxicol. Sci. , vol.131 , Issue.2 , pp. 419-433
    • Karmaus, P.W.1    Chen, W.2    Crawford, R.3    Kaplan, B.L.4    Kaminski, N.E.5
  • 86
    • 77649271275 scopus 로고    scopus 로고
    • A unifying hypothesis of schizophrenia: abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction
    • Kinney D.K., Hintz K., Shearer E.M., Barch D.H., Riffin C., Whitley K., et al. A unifying hypothesis of schizophrenia: abnormal immune system development may help explain roles of prenatal hazards, post-pubertal onset, stress, genes, climate, infections, and brain dysfunction. Med. Hypotheses 2010, 74(3):555-563.
    • (2010) Med. Hypotheses , vol.74 , Issue.3 , pp. 555-563
    • Kinney, D.K.1    Hintz, K.2    Shearer, E.M.3    Barch, D.H.4    Riffin, C.5    Whitley, K.6
  • 87
    • 84885997463 scopus 로고    scopus 로고
    • Inflammation and schizophrenia
    • Kirkpatrick B., Miller B.J. Inflammation and schizophrenia. Schizophr. Bull. 2013, 39(6):1174-1179.
    • (2013) Schizophr. Bull. , vol.39 , Issue.6 , pp. 1174-1179
    • Kirkpatrick, B.1    Miller, B.J.2
  • 88
    • 2442706289 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells
    • Kishimoto S., Kobayashi Y., Oka S., Gokoh M., Waku K., Sugiura T. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. J. Biochem. 2004, 135(4):517-524.
    • (2004) J. Biochem. , vol.135 , Issue.4 , pp. 517-524
    • Kishimoto, S.1    Kobayashi, Y.2    Oka, S.3    Gokoh, M.4    Waku, K.5    Sugiura, T.6
  • 89
    • 0026576232 scopus 로고
    • Can autoimmune mechanisms account for the genetic predisposition to schizophrenia?
    • Knight J., Knight A., Ungvari G. Can autoimmune mechanisms account for the genetic predisposition to schizophrenia?. Br. J. Psychiatry 1992, 160:533-540.
    • (1992) Br. J. Psychiatry , vol.160 , pp. 533-540
    • Knight, J.1    Knight, A.2    Ungvari, G.3
  • 90
    • 2942560977 scopus 로고    scopus 로고
    • Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide
    • Kraft B., Wintersberger W., Kress H.G. Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide. Life Sci. 2004, 75(8):969-977.
    • (2004) Life Sci. , vol.75 , Issue.8 , pp. 969-977
    • Kraft, B.1    Wintersberger, W.2    Kress, H.G.3
  • 91
    • 84864079270 scopus 로고    scopus 로고
    • Expression and functions of mu-opioid receptors and cannabinoid receptors type 1 in T lymphocytes
    • Kraus J. Expression and functions of mu-opioid receptors and cannabinoid receptors type 1 in T lymphocytes. Ann. N. Y. Acad. Sci. 2012, 1261:1-6.
    • (2012) Ann. N. Y. Acad. Sci. , vol.1261 , pp. 1-6
    • Kraus, J.1
  • 92
    • 0034097718 scopus 로고    scopus 로고
    • Twin studies in schizophrenia with special emphasis on concordance figures
    • Kringlen E. Twin studies in schizophrenia with special emphasis on concordance figures. Am. J. Med. Genet. 2000, 97(1):4-11.
    • (2000) Am. J. Med. Genet. , vol.97 , Issue.1 , pp. 4-11
    • Kringlen, E.1
  • 93
    • 84865843840 scopus 로고    scopus 로고
    • Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation
    • Krishnan G., Chatterjee N. Endocannabinoids alleviate proinflammatory conditions by modulating innate immune response in muller glia during inflammation. Glia 2012, 60(11):1629-1645.
    • (2012) Glia , vol.60 , Issue.11 , pp. 1629-1645
    • Krishnan, G.1    Chatterjee, N.2
  • 94
    • 0034062158 scopus 로고    scopus 로고
    • Cytokines and the brain: implications for clinical psychiatry
    • Kronfol Z., Remick D.G. Cytokines and the brain: implications for clinical psychiatry. Am. J. Psychiatry 2000, 157(5):683-694.
    • (2000) Am. J. Psychiatry , vol.157 , Issue.5 , pp. 683-694
    • Kronfol, Z.1    Remick, D.G.2
  • 95
    • 43749091232 scopus 로고    scopus 로고
    • Cannabis and psychiatric disorders: it is not only addiction
    • Leweke F.M., Koethe D. Cannabis and psychiatric disorders: it is not only addiction. Addict. Biol. 2008, 13(2):264-275.
    • (2008) Addict. Biol. , vol.13 , Issue.2 , pp. 264-275
    • Leweke, F.M.1    Koethe, D.2
  • 96
    • 34447106643 scopus 로고    scopus 로고
    • Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use
    • Leweke F.M., Giuffrida A., Koethe D., Schreiber D., Nolden B.M., Kranaster L., et al. Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. Schizophr. Res. 2007, 94(1-3):29-36.
    • (2007) Schizophr. Res. , vol.94 , Issue.1-3 , pp. 29-36
    • Leweke, F.M.1    Giuffrida, A.2    Koethe, D.3    Schreiber, D.4    Nolden, B.M.5    Kranaster, L.6
  • 97
    • 84858391237 scopus 로고    scopus 로고
    • Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
    • Leweke F.M., Piomelli D., Pahlisch F., Muhl D., Gerth C.W., Hoyer C., et al. Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Transl. Psychiatry 2012, 2:e94.
    • (2012) Transl. Psychiatry , vol.2
    • Leweke, F.M.1    Piomelli, D.2    Pahlisch, F.3    Muhl, D.4    Gerth, C.W.5    Hoyer, C.6
  • 98
    • 20544444202 scopus 로고    scopus 로고
    • Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells
    • Lombard C., Nagarkatti M., Nagarkatti P.S. Targeting cannabinoid receptors to treat leukemia: role of cross-talk between extrinsic and intrinsic pathways in Delta9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells. Leuk. Res. 2005, 29(8):915-922.
    • (2005) Leuk. Res. , vol.29 , Issue.8 , pp. 915-922
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 99
    • 80054782506 scopus 로고    scopus 로고
    • Perinatal exposure to Delta9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens
    • Lombard C., Hegde V.L., Nagarkatti M., Nagarkatti P.S. Perinatal exposure to Delta9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens. J. Pharmacol. Exp. Ther. 2011, 339(2):607-617.
    • (2011) J. Pharmacol. Exp. Ther. , vol.339 , Issue.2 , pp. 607-617
    • Lombard, C.1    Hegde, V.L.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 100
    • 81955164773 scopus 로고    scopus 로고
    • Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis
    • Lou Z.Y., Chen C., He Q., Zhao C.B., Xiao B.G. Targeting CB(2) receptor as a neuroinflammatory modulator in experimental autoimmune encephalomyelitis. Mol. Immunol. 2011, 49(3):453-461.
    • (2011) Mol. Immunol. , vol.49 , Issue.3 , pp. 453-461
    • Lou, Z.Y.1    Chen, C.2    He, Q.3    Zhao, C.B.4    Xiao, B.G.5
  • 101
    • 81255152003 scopus 로고    scopus 로고
    • Immunoregulation of experimental autoimmune encephalomyelitis by the selective CB1 receptor antagonist
    • Lou Z.Y., Zhao C.B., Xiao B.G. Immunoregulation of experimental autoimmune encephalomyelitis by the selective CB1 receptor antagonist. J. Neurosci. Res. 2012, 90(1):84-95.
    • (2012) J. Neurosci. Res. , vol.90 , Issue.1 , pp. 84-95
    • Lou, Z.Y.1    Zhao, C.B.2    Xiao, B.G.3
  • 102
    • 79955610081 scopus 로고    scopus 로고
    • Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis
    • Lourbopoulos A., Grigoriadis N., Lagoudaki R., Touloumi O., Polyzoidou E., Mavromatis I., et al. Administration of 2-arachidonoylglycerol ameliorates both acute and chronic experimental autoimmune encephalomyelitis. Brain Res. 2011, 16(1390):126-141.
    • (2011) Brain Res. , vol.16 , Issue.1390 , pp. 126-141
    • Lourbopoulos, A.1    Grigoriadis, N.2    Lagoudaki, R.3    Touloumi, O.4    Polyzoidou, E.5    Mavromatis, I.6
  • 103
    • 58749088580 scopus 로고    scopus 로고
    • Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells
    • Lu T.S., Avraham H.K., Seng S., Tachado S.D., Koziel H., Makriyannis A., et al. Cannabinoids inhibit HIV-1 Gp120-mediated insults in brain microvascular endothelial cells. J. Immunol. 2008, 181(9):6406-6416.
    • (2008) J. Immunol. , vol.181 , Issue.9 , pp. 6406-6416
    • Lu, T.S.1    Avraham, H.K.2    Seng, S.3    Tachado, S.D.4    Koziel, H.5    Makriyannis, A.6
  • 104
    • 59649122396 scopus 로고    scopus 로고
    • Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol
    • Lu H., Kaplan B.L., Ngaotepprutaram T., Kaminski N.E. Suppression of T cell costimulator ICOS by Delta9-tetrahydrocannabinol. J. Leukoc. Biol. 2009, 85(2):322-329.
    • (2009) J. Leukoc. Biol. , vol.85 , Issue.2 , pp. 322-329
    • Lu, H.1    Kaplan, B.L.2    Ngaotepprutaram, T.3    Kaminski, N.E.4
  • 105
    • 31144468211 scopus 로고    scopus 로고
    • A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo
    • Lunn C.A., Fine J.S., Rojas-Triana A., Jackson J.V., Fan X., Kung T.T., et al. A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J. Pharmacol. Exp. Ther. 2006, 316(2):780-788.
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , Issue.2 , pp. 780-788
    • Lunn, C.A.1    Fine, J.S.2    Rojas-Triana, A.3    Jackson, J.V.4    Fan, X.5    Kung, T.T.6
  • 106
    • 10044257545 scopus 로고    scopus 로고
    • The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein
    • Maestroni G.J. The endogenous cannabinoid 2-arachidonoyl glycerol as in vivo chemoattractant for dendritic cells and adjuvant for Th1 response to a soluble protein. FASEB J. 2004, 18(15):1914-1916.
    • (2004) FASEB J. , vol.18 , Issue.15 , pp. 1914-1916
    • Maestroni, G.J.1
  • 107
    • 84877045028 scopus 로고    scopus 로고
    • Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis
    • Malfitano A.M., Laezza C., D'Alessandro A., Procaccini C., Saccomanni G., Tuccinardi T., et al. Effects on immune cells of a new 1,8-naphthyridin-2-one derivative and its analogues as selective CB2 agonists: implications in multiple sclerosis. PLoS ONE 2013, 8(5):e62511.
    • (2013) PLoS ONE , vol.8 , Issue.5
    • Malfitano, A.M.1    Laezza, C.2    D'Alessandro, A.3    Procaccini, C.4    Saccomanni, G.5    Tuccinardi, T.6
  • 108
    • 80054839677 scopus 로고    scopus 로고
    • Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis
    • Marazzi J., Kleyer J., Paredes J.M., Gertsch J. Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. J. Immunol. Methods 2011, 373(1-2):219-228.
    • (2011) J. Immunol. Methods , vol.373 , Issue.1-2 , pp. 219-228
    • Marazzi, J.1    Kleyer, J.2    Paredes, J.M.3    Gertsch, J.4
  • 109
    • 78249233276 scopus 로고    scopus 로고
    • Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis
    • Marquart S., Zerr P., Akhmetshina A., Palumbo K., Reich N., Tomcik M., et al. Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis. Arthritis Rheum. 2010, 62(11):3467-3476.
    • (2010) Arthritis Rheum. , vol.62 , Issue.11 , pp. 3467-3476
    • Marquart, S.1    Zerr, P.2    Akhmetshina, A.3    Palumbo, K.4    Reich, N.5    Tomcik, M.6
  • 110
    • 81955164808 scopus 로고    scopus 로고
    • A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia
    • Matheson S.L., Shepherd A.M., Laurens K.R., Carr V.J. A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr. Res. 2011, 133(1-3):133-142.
    • (2011) Schizophr. Res. , vol.133 , Issue.1-3 , pp. 133-142
    • Matheson, S.L.1    Shepherd, A.M.2    Laurens, K.R.3    Carr, V.J.4
  • 112
    • 77952731052 scopus 로고    scopus 로고
    • N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor
    • McHugh D., Hu S.S., Rimmerman N., Juknat A., Vogel Z., Walker J.M., et al. N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor. BMC Neurosci. 2010, 11:44.
    • (2010) BMC Neurosci. , vol.11 , pp. 44
    • McHugh, D.1    Hu, S.S.2    Rimmerman, N.3    Juknat, A.4    Vogel, Z.5    Walker, J.M.6
  • 113
    • 14844362003 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response
    • McKallip R.J., Nagarkatti M., Nagarkatti P.S. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the antitumor immune response. J. Immunol. 2005, 174(6):3281-3289.
    • (2005) J. Immunol. , vol.174 , Issue.6 , pp. 3281-3289
    • McKallip, R.J.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 114
    • 80052334860 scopus 로고    scopus 로고
    • Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype
    • McKernan D.P., Dennison U., Gaszner G., Cryan J.F., Dinan T.G. Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype. Transl. Psychiatry 2011, 1:e36.
    • (2011) Transl. Psychiatry , vol.1
    • McKernan, D.P.1    Dennison, U.2    Gaszner, G.3    Cryan, J.F.4    Dinan, T.G.5
  • 115
    • 84882783935 scopus 로고    scopus 로고
    • Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors
    • Mecha M., Feliu A., Inigo P.M., Mestre L., Carrillo-Salinas F.J., Guaza C. Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors. Neurobiol. Dis. 2013, 59:141-150.
    • (2013) Neurobiol. Dis. , vol.59 , pp. 141-150
    • Mecha, M.1    Feliu, A.2    Inigo, P.M.3    Mestre, L.4    Carrillo-Salinas, F.J.5    Guaza, C.6
  • 116
    • 84857514914 scopus 로고    scopus 로고
    • Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide
    • Merighi S., Gessi S., Varani K., Simioni C., Fazzi D., Mirandola P., et al. Cannabinoid CB(2) receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide. Br. J. Pharmacol. 2012, 165(6):1773-1788.
    • (2012) Br. J. Pharmacol. , vol.165 , Issue.6 , pp. 1773-1788
    • Merighi, S.1    Gessi, S.2    Varani, K.3    Simioni, C.4    Fazzi, D.5    Mirandola, P.6
  • 117
    • 15244359387 scopus 로고    scopus 로고
    • Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis
    • Mestre L., Correa F., Arevalo-Martin A., Molina-Holgado E., Valenti M., Ortar G., et al. Pharmacological modulation of the endocannabinoid system in a viral model of multiple sclerosis. J. Neurochem. 2005, 92(6):1327-1339.
    • (2005) J. Neurochem. , vol.92 , Issue.6 , pp. 1327-1339
    • Mestre, L.1    Correa, F.2    Arevalo-Martin, A.3    Molina-Holgado, E.4    Valenti, M.5    Ortar, G.6
  • 118
    • 84872387809 scopus 로고    scopus 로고
    • Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms
    • Michler T., Storr M., Kramer J., Ochs S., Malo A., Reu S., et al. Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms. Am. J. Physiol. Gastrointest. Liver Physiol. 2013, 304(2):G181-G192.
    • (2013) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.304 , Issue.2
    • Michler, T.1    Storr, M.2    Kramer, J.3    Ochs, S.4    Malo, A.5    Reu, S.6
  • 119
    • 80052853015 scopus 로고    scopus 로고
    • Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects
    • Miller B.J., Buckley P., Seabolt W., Mellor A., Kirkpatrick B. Meta-analysis of cytokine alterations in schizophrenia: clinical status and antipsychotic effects. Biol. Psychiatry 2011, 70(7):663-671.
    • (2011) Biol. Psychiatry , vol.70 , Issue.7 , pp. 663-671
    • Miller, B.J.1    Buckley, P.2    Seabolt, W.3    Mellor, A.4    Kirkpatrick, B.5
  • 121
    • 77951036863 scopus 로고    scopus 로고
    • Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors
    • Mnich S.J., Hiebsch R.R., Huff R.M., Muthian S. Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors. J. Pharmacol. Exp. Ther. 2010, 333(2):445-453.
    • (2010) J. Pharmacol. Exp. Ther. , vol.333 , Issue.2 , pp. 445-453
    • Mnich, S.J.1    Hiebsch, R.R.2    Huff, R.M.3    Muthian, S.4
  • 122
    • 0031950741 scopus 로고    scopus 로고
    • Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders
    • Muller N., Ackenheil M. Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry 1998, 22(1):1-33.
    • (1998) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.22 , Issue.1 , pp. 1-33
    • Muller, N.1    Ackenheil, M.2
  • 123
    • 0034309738 scopus 로고    scopus 로고
    • Cellular and humoral immune system in schizophrenia: a conceptual re-evaluation
    • Muller N., Riedel M., Ackenheil M., Schwarz M.J. Cellular and humoral immune system in schizophrenia: a conceptual re-evaluation. World J. Biol. Psychiatry 2000, 1(4):173-179.
    • (2000) World J. Biol. Psychiatry , vol.1 , Issue.4 , pp. 173-179
    • Muller, N.1    Riedel, M.2    Ackenheil, M.3    Schwarz, M.J.4
  • 125
    • 46949099370 scopus 로고    scopus 로고
    • Cannabis and schizophrenia: towards a cannabinoid hypothesis of schizophrenia
    • Muller-Vahl K.R., Emrich H.M. Cannabis and schizophrenia: towards a cannabinoid hypothesis of schizophrenia. Expert Rev. Neurother. 2008, 8(7):1037-1048.
    • (2008) Expert Rev. Neurother. , vol.8 , Issue.7 , pp. 1037-1048
    • Muller-Vahl, K.R.1    Emrich, H.M.2
  • 126
    • 80555129348 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone
    • Muppidi J.R., Arnon T.I., Bronevetsky Y., Veerapen N., Tanaka M., Besra G.S., et al. Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J. Exp. Med. 2011, 208(10):1941-1948.
    • (2011) J. Exp. Med. , vol.208 , Issue.10 , pp. 1941-1948
    • Muppidi, J.R.1    Arnon, T.I.2    Bronevetsky, Y.3    Veerapen, N.4    Tanaka, M.5    Besra, G.S.6
  • 127
    • 4744342396 scopus 로고    scopus 로고
    • The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2
    • Newton C.A., Lu T., Nazian S.J., Perkins I., Friedman H., Klein T.W. The THC-induced suppression of Th1 polarization in response to Legionella pneumophila infection is not mediated by increases in corticosterone and PGE2. J. Leukoc. Biol. 2004, 76(4):854-861.
    • (2004) J. Leukoc. Biol. , vol.76 , Issue.4 , pp. 854-861
    • Newton, C.A.1    Lu, T.2    Nazian, S.J.3    Perkins, I.4    Friedman, H.5    Klein, T.W.6
  • 128
    • 60549114334 scopus 로고    scopus 로고
    • CB(1) and CB(2) cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection
    • Newton C.A., Chou P.J., Perkins I., Klein T.W. CB(1) and CB(2) cannabinoid receptors mediate different aspects of delta-9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection. J. Neuroimmune Pharmacol. 2009, 4(1):92-102.
    • (2009) J. Neuroimmune Pharmacol. , vol.4 , Issue.1 , pp. 92-102
    • Newton, C.A.1    Chou, P.J.2    Perkins, I.3    Klein, T.W.4
  • 129
    • 16544377251 scopus 로고    scopus 로고
    • Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model
    • Ni X., Geller E.B., Eppihimer M.J., Eisenstein T.K., Adler M.W., Tuma R.F. Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis model. Mult. Scler. 2004, 10(2):158-164.
    • (2004) Mult. Scler. , vol.10 , Issue.2 , pp. 158-164
    • Ni, X.1    Geller, E.B.2    Eppihimer, M.J.3    Eisenstein, T.K.4    Adler, M.W.5    Tuma, R.F.6
  • 130
    • 84885194908 scopus 로고    scopus 로고
    • Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials
    • Nitta M., Kishimoto T., Muller N., Weiser M., Davidson M., Kane J.M., et al. Adjunctive use of nonsteroidal anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials. Schizophr. Bull. 2013, 39(6):1230-1241.
    • (2013) Schizophr. Bull. , vol.39 , Issue.6 , pp. 1230-1241
    • Nitta, M.1    Kishimoto, T.2    Muller, N.3    Weiser, M.4    Davidson, M.5    Kane, J.M.6
  • 131
    • 70249094588 scopus 로고    scopus 로고
    • Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2
    • Olea-Herrero N., Vara D., Malagarie-Cazenave S., Diaz-Laviada I. Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2. Br. J. Cancer 2009, 101(6):940-950.
    • (2009) Br. J. Cancer , vol.101 , Issue.6 , pp. 940-950
    • Olea-Herrero, N.1    Vara, D.2    Malagarie-Cazenave, S.3    Diaz-Laviada, I.4
  • 132
    • 71749104726 scopus 로고    scopus 로고
    • Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications
    • Onaivi E.S. Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications. Int. Rev. Neurobiol. 2009, 88:335-369.
    • (2009) Int. Rev. Neurobiol. , vol.88 , pp. 335-369
    • Onaivi, E.S.1
  • 133
    • 84863011465 scopus 로고    scopus 로고
    • CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity
    • Onaivi E.S., Ishiguro H., Gu S., Liu Q.R. CNS effects of CB2 cannabinoid receptors: beyond neuro-immuno-cannabinoid activity. J. Psychopharmacol. 2012, 26(1):92-103.
    • (2012) J. Psychopharmacol. , vol.26 , Issue.1 , pp. 92-103
    • Onaivi, E.S.1    Ishiguro, H.2    Gu, S.3    Liu, Q.R.4
  • 134
    • 33845603466 scopus 로고    scopus 로고
    • Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    • Palazuelos J., Aguado T., Egia A., Mechoulam R., Guzman M., Galve-Roperh I. Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J. 2006, 20(13):2405-2407.
    • (2006) FASEB J. , vol.20 , Issue.13 , pp. 2405-2407
    • Palazuelos, J.1    Aguado, T.2    Egia, A.3    Mechoulam, R.4    Guzman, M.5    Galve-Roperh, I.6
  • 135
    • 0033850995 scopus 로고    scopus 로고
    • Natural and synthetic endocannabinoids and their structure-activity relationships
    • Palmer S.L., Khanolkar A.D., Makriyannis A. Natural and synthetic endocannabinoids and their structure-activity relationships. Curr. Pharm. Des. 2000, 6(13):1381-1397.
    • (2000) Curr. Pharm. Des. , vol.6 , Issue.13 , pp. 1381-1397
    • Palmer, S.L.1    Khanolkar, A.D.2    Makriyannis, A.3
  • 136
    • 37349130599 scopus 로고    scopus 로고
    • The effects of Morinda citrifolia L. (noni) on the immune system: its molecular mechanisms of action
    • Palu A.K., Kim A.H., West B.J., Deng S., Jensen J., White L. The effects of Morinda citrifolia L. (noni) on the immune system: its molecular mechanisms of action. J. Ethnopharmacol. 2008, 115(3):502-506.
    • (2008) J. Ethnopharmacol. , vol.115 , Issue.3 , pp. 502-506
    • Palu, A.K.1    Kim, A.H.2    West, B.J.3    Deng, S.4    Jensen, J.5    White, L.6
  • 137
    • 80052168226 scopus 로고    scopus 로고
    • Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model
    • Pandey R., Hegde V.L., Nagarkatti M., Nagarkatti P.S. Targeting cannabinoid receptors as a novel approach in the treatment of graft-versus-host disease: evidence from an experimental murine model. J. Pharmacol. Exp. Ther. 2011, 338(3):819-828.
    • (2011) J. Pharmacol. Exp. Ther. , vol.338 , Issue.3 , pp. 819-828
    • Pandey, R.1    Hegde, V.L.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 138
    • 84884266921 scopus 로고    scopus 로고
    • Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives
    • Pathmanandavel K., Starling J., Dale R.C., Brilot F. Autoantibodies and the immune hypothesis in psychotic brain diseases: challenges and perspectives. Clin. Dev. Immunol. 2013, 2013:257184.
    • (2013) Clin. Dev. Immunol. , vol.2013 , pp. 257184
    • Pathmanandavel, K.1    Starling, J.2    Dale, R.C.3    Brilot, F.4
  • 139
    • 84873322870 scopus 로고    scopus 로고
    • The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins
    • Paulsen K., Tauber S., Timm J., Goelz N., Dumrese C., Stolzing A., et al. The cannabinoid receptors agonist WIN55212-2 inhibits macrophageal differentiation and alters expression and phosphorylation of cell cycle control proteins. Cell Commun. Signal. 2011, 9:33.
    • (2011) Cell Commun. Signal. , vol.9 , pp. 33
    • Paulsen, K.1    Tauber, S.2    Timm, J.3    Goelz, N.4    Dumrese, C.5    Stolzing, A.6
  • 140
    • 77951043153 scopus 로고    scopus 로고
    • The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis
    • Pellerito O., Calvaruso G., Portanova P., De Blasio A., Santulli A., Vento R., et al. The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis. Mol. Pharmacol. 2010, 77(5):854-863.
    • (2010) Mol. Pharmacol. , vol.77 , Issue.5 , pp. 854-863
    • Pellerito, O.1    Calvaruso, G.2    Portanova, P.3    De Blasio, A.4    Santulli, A.5    Vento, R.6
  • 141
    • 0033538346 scopus 로고    scopus 로고
    • Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors
    • Pertwee R.G. Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors. Life Sci. 1999, 65(6-7):597-605.
    • (1999) Life Sci. , vol.65 , Issue.6-7 , pp. 597-605
    • Pertwee, R.G.1
  • 142
    • 0242268553 scopus 로고    scopus 로고
    • The molecular logic of endocannabinoid signalling
    • Piomelli D. The molecular logic of endocannabinoid signalling. Nat. Rev. Neurosci. 2003, 4(11):873-884.
    • (2003) Nat. Rev. Neurosci. , vol.4 , Issue.11 , pp. 873-884
    • Piomelli, D.1
  • 143
    • 0242304878 scopus 로고    scopus 로고
    • Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    • Pryce G., Ahmed Z., Hankey D.J., Jackson S.J., Croxford J.L., Pocock J.M., et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 2003, 126(Pt. 10):2191-2202.
    • (2003) Brain , vol.126 , Issue.PART. 10 , pp. 2191-2202
    • Pryce, G.1    Ahmed, Z.2    Hankey, D.J.3    Jackson, S.J.4    Croxford, J.L.5    Pocock, J.M.6
  • 144
    • 84863380403 scopus 로고    scopus 로고
    • Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions
    • Ramirez S.H., Hasko J., Skuba A., Fan S., Dykstra H., McCormick R., et al. Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J. Neurosci. 2012, 32(12):4004-4016.
    • (2012) J. Neurosci. , vol.32 , Issue.12 , pp. 4004-4016
    • Ramirez, S.H.1    Hasko, J.2    Skuba, A.3    Fan, S.4    Dykstra, H.5    McCormick, R.6
  • 145
  • 146
    • 67449119178 scopus 로고    scopus 로고
    • Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids
    • Realini N., Rubino T., Parolaro D. Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids. Pharmacol. Res. 2009, 60(2):132-138.
    • (2009) Pharmacol. Res. , vol.60 , Issue.2 , pp. 132-138
    • Realini, N.1    Rubino, T.2    Parolaro, D.3
  • 147
    • 84863530790 scopus 로고    scopus 로고
    • Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat
    • Rettori E., De Laurentiis A., Zorrilla Zubilete M., Rettori V., Elverdin J.C. Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat. Neuroimmunomodulation 2012, 19(5):293-303.
    • (2012) Neuroimmunomodulation , vol.19 , Issue.5 , pp. 293-303
    • Rettori, E.1    De Laurentiis, A.2    Zorrilla Zubilete, M.3    Rettori, V.4    Elverdin, J.C.5
  • 148
    • 84874995599 scopus 로고    scopus 로고
    • Involvement of ERK1/2, cPLA2 and NF-kappaB in microglia suppression by cannabinoid receptor agonists and antagonists
    • Ribeiro R., Wen J., Li S., Zhang Y. Involvement of ERK1/2, cPLA2 and NF-kappaB in microglia suppression by cannabinoid receptor agonists and antagonists. Prostaglandins Other Lipid Mediat. 2013, 100-101:1-14.
    • (2013) Prostaglandins Other Lipid Mediat. , pp. 1-14
    • Ribeiro, R.1    Wen, J.2    Li, S.3    Zhang, Y.4
  • 149
    • 84891371881 scopus 로고    scopus 로고
    • Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction
    • Robinson R.H., Meissler J.J., Breslow-Deckman J.M., Gaughan J., Adler M.W., Eisenstein T.K. Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction. J. Neuroimmune Pharmacol. 2013, 8(5):1239-1250.
    • (2013) J. Neuroimmune Pharmacol. , vol.8 , Issue.5 , pp. 1239-1250
    • Robinson, R.H.1    Meissler, J.J.2    Breslow-Deckman, J.M.3    Gaughan, J.4    Adler, M.W.5    Eisenstein, T.K.6
  • 150
    • 34247489723 scopus 로고    scopus 로고
    • WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: involvement of cannabinoid receptors
    • Rock R.B., Gekker G., Hu S., Sheng W.S., Cabral G.A., Martin B.R., et al. WIN55,212-2-mediated inhibition of HIV-1 expression in microglial cells: involvement of cannabinoid receptors. J. Neuroimmune Pharmacol. 2007, 2(2):178-183.
    • (2007) J. Neuroimmune Pharmacol. , vol.2 , Issue.2 , pp. 178-183
    • Rock, R.B.1    Gekker, G.2    Hu, S.3    Sheng, W.S.4    Cabral, G.A.5    Martin, B.R.6
  • 151
    • 6344293648 scopus 로고    scopus 로고
    • A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes
    • Rockwell C.E., Kaminski N.E. A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J. Pharmacol. Exp. Ther. 2004, 311(2):683-690.
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , Issue.2 , pp. 683-690
    • Rockwell, C.E.1    Kaminski, N.E.2
  • 152
    • 84886652959 scopus 로고    scopus 로고
    • Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier
    • Rom S., Zuluaga-Ramirez V., Dykstra H., Reichenbach N.L., Pacher P., Persidsky Y. Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier. Am. J. Pathol. 2013, 183(5):1548-1558.
    • (2013) Am. J. Pathol. , vol.183 , Issue.5 , pp. 1548-1558
    • Rom, S.1    Zuluaga-Ramirez, V.2    Dykstra, H.3    Reichenbach, N.L.4    Pacher, P.5    Persidsky, Y.6
  • 153
    • 79953307429 scopus 로고    scopus 로고
    • Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism
    • Rossi B., Zenaro E., Angiari S., Ottoboni L., Bach S., Piccio L., et al. Inverse agonism of cannabinoid CB1 receptor blocks the adhesion of encephalitogenic T cells in inflamed brain venules by a protein kinase A-dependent mechanism. J. Neuroimmunol. 2011, 233(1-2):97-105.
    • (2011) J. Neuroimmunol. , vol.233 , Issue.1-2 , pp. 97-105
    • Rossi, B.1    Zenaro, E.2    Angiari, S.3    Ottoboni, L.4    Bach, S.5    Piccio, L.6
  • 154
    • 23044432045 scopus 로고    scopus 로고
    • Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse
    • Roth M.D., Tashkin D.P., Whittaker K.M., Choi R., Baldwin G.C. Tetrahydrocannabinol suppresses immune function and enhances HIV replication in the huPBL-SCID mouse. Life Sci. 2005, 77(14):1711-1722.
    • (2005) Life Sci. , vol.77 , Issue.14 , pp. 1711-1722
    • Roth, M.D.1    Tashkin, D.P.2    Whittaker, K.M.3    Choi, R.4    Baldwin, G.C.5
  • 155
    • 12344250051 scopus 로고    scopus 로고
    • The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro
    • Sacerdote P., Martucci C., Vaccani A., Bariselli F., Panerai A.E., Colombo A., et al. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J. Neuroimmunol. 2005, 159(1-2):97-105.
    • (2005) J. Neuroimmunol. , vol.159 , Issue.1-2 , pp. 97-105
    • Sacerdote, P.1    Martucci, C.2    Vaccani, A.3    Bariselli, F.4    Panerai, A.E.5    Colombo, A.6
  • 156
    • 84884672482 scopus 로고    scopus 로고
    • Inflammatory and immune response genes have significantly altered expression in schizophrenia
    • Sainz J., Mata I., Barrera J., Perez-Iglesias R., Varela I., Arranz M.J., et al. Inflammatory and immune response genes have significantly altered expression in schizophrenia. Mol. Psychiatry 2013, 18(10):1056-1057.
    • (2013) Mol. Psychiatry , vol.18 , Issue.10 , pp. 1056-1057
    • Sainz, J.1    Mata, I.2    Barrera, J.3    Perez-Iglesias, R.4    Varela, I.5    Arranz, M.J.6
  • 157
    • 70349287534 scopus 로고    scopus 로고
    • Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death
    • Saunders C.I., Fassett R.G., Geraghty D.P. Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death. Biochim. Biophys. Acta 2009, 1792(10):1019-1026.
    • (2009) Biochim. Biophys. Acta , vol.1792 , Issue.10 , pp. 1019-1026
    • Saunders, C.I.1    Fassett, R.G.2    Geraghty, D.P.3
  • 158
    • 0035042767 scopus 로고    scopus 로고
    • The Th2-hypothesis of schizophrenia: a strategy to identify a subgroup of schizophrenia caused by immune mechanisms
    • Schwarz M.J., Muller N., Riedel M., Ackenheil M. The Th2-hypothesis of schizophrenia: a strategy to identify a subgroup of schizophrenia caused by immune mechanisms. Med. Hypotheses 2001, 56(4):483-486.
    • (2001) Med. Hypotheses , vol.56 , Issue.4 , pp. 483-486
    • Schwarz, M.J.1    Muller, N.2    Riedel, M.3    Ackenheil, M.4
  • 159
    • 77954574870 scopus 로고    scopus 로고
    • Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis
    • Servettaz A., Kavian N., Nicco C., Deveaux V., Chereau C., Wang A., et al. Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. Am. J. Pathol. 2010, 177(1):187-196.
    • (2010) Am. J. Pathol. , vol.177 , Issue.1 , pp. 187-196
    • Servettaz, A.1    Kavian, N.2    Nicco, C.3    Deveaux, V.4    Chereau, C.5    Wang, A.6
  • 160
    • 39749087583 scopus 로고    scopus 로고
    • Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis
    • Shiratsuchi A., Watanabe I., Yoshida H., Nakanishi Y. Involvement of cannabinoid receptor CB2 in dectin-1-mediated macrophage phagocytosis. Immunol. Cell Biol. 2008, 86(2):179-184.
    • (2008) Immunol. Cell Biol. , vol.86 , Issue.2 , pp. 179-184
    • Shiratsuchi, A.1    Watanabe, I.2    Yoshida, H.3    Nakanishi, Y.4
  • 161
    • 84855765207 scopus 로고    scopus 로고
    • Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis
    • Singh U.P., Singh N.P., Singh B., Price R.L., Nagarkatti M., Nagarkatti P.S. Cannabinoid receptor-2 (CB2) agonist ameliorates colitis in IL-10(-/-) mice by attenuating the activation of T cells and promoting their apoptosis. Toxicol. Appl. Pharmacol. 2012, 258(2):256-267.
    • (2012) Toxicol. Appl. Pharmacol. , vol.258 , Issue.2 , pp. 256-267
    • Singh, U.P.1    Singh, N.P.2    Singh, B.3    Price, R.L.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 162
    • 84885137892 scopus 로고    scopus 로고
    • Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 Receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis
    • Sisay S., Pryce G., Jackson S.J., Tanner C., Ross R.A., Michael G.J., et al. Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 Receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis. PLoS ONE 2013, 8(10):e76907.
    • (2013) PLoS ONE , vol.8 , Issue.10
    • Sisay, S.1    Pryce, G.2    Jackson, S.J.3    Tanner, C.4    Ross, R.A.5    Michael, G.J.6
  • 163
    • 84868129085 scopus 로고    scopus 로고
    • Endocannabinoids in nervous system health and disease: the big picture in a nutshell
    • Skaper S.D., Di Marzo V. Endocannabinoids in nervous system health and disease: the big picture in a nutshell. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2012, 367(1607):3193-3200.
    • (2012) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.367 , Issue.1607 , pp. 3193-3200
    • Skaper, S.D.1    Di Marzo, V.2
  • 164
    • 84885327252 scopus 로고    scopus 로고
    • Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator
    • Skaper S.D., Facci L., Giusti P. Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator. Mol. Neurobiol. 2013, 48(2):340-352.
    • (2013) Mol. Neurobiol. , vol.48 , Issue.2 , pp. 340-352
    • Skaper, S.D.1    Facci, L.2    Giusti, P.3
  • 165
    • 57149109403 scopus 로고    scopus 로고
    • Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune compete nce and sensitivity to immune modulation by Delta9-tetrahydrocannabinol
    • Springs A.E., Karmaus P.W., Crawford R.B., Kaplan B.L., Kaminski N.E. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune compete nce and sensitivity to immune modulation by Delta9-tetrahydrocannabinol. J. Leukoc. Biol. 2008, 84(6):1574-1584.
    • (2008) J. Leukoc. Biol. , vol.84 , Issue.6 , pp. 1574-1584
    • Springs, A.E.1    Karmaus, P.W.2    Crawford, R.B.3    Kaplan, B.L.4    Kaminski, N.E.5
  • 167
    • 33747759704 scopus 로고    scopus 로고
    • Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization
    • Steiner J., Mawrin C., Ziegeler A., Bielau H., Ullrich O., Bernstein H.G., et al. Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathol. 2006, 112(3):305-316.
    • (2006) Acta Neuropathol. , vol.112 , Issue.3 , pp. 305-316
    • Steiner, J.1    Mawrin, C.2    Ziegeler, A.3    Bielau, H.4    Ullrich, O.5    Bernstein, H.G.6
  • 168
    • 58049170379 scopus 로고    scopus 로고
    • Endocannabinoid signaling in microglial cells
    • Stella N. Endocannabinoid signaling in microglial cells. Neuropharmacology 2009, 56(Suppl. 1):244-253.
    • (2009) Neuropharmacology , vol.56 , Issue.SUPPL. 1 , pp. 244-253
    • Stella, N.1
  • 169
    • 77954177664 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: an overview
    • Tanasescu R., Constantinescu C.S. Cannabinoids and the immune system: an overview. Immunobiology 2010, 215(8):588-597.
    • (2010) Immunobiology , vol.215 , Issue.8 , pp. 588-597
    • Tanasescu, R.1    Constantinescu, C.S.2
  • 170
    • 35448940523 scopus 로고    scopus 로고
    • Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice
    • Tanikawa T., Kurohane K., Imai Y. Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice. Microbiol. Immunol. 2007, 51(10):1013-1019.
    • (2007) Microbiol. Immunol. , vol.51 , Issue.10 , pp. 1013-1019
    • Tanikawa, T.1    Kurohane, K.2    Imai, Y.3
  • 171
    • 79960327022 scopus 로고    scopus 로고
    • Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis
    • Tanikawa T., Kurohane K., Imai Y. Regulatory effect of cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. Biol. Pharm. Bull. 2011, 34(7):1090-1093.
    • (2011) Biol. Pharm. Bull. , vol.34 , Issue.7 , pp. 1090-1093
    • Tanikawa, T.1    Kurohane, K.2    Imai, Y.3
  • 172
    • 67651121672 scopus 로고    scopus 로고
    • The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages
    • Tolon R.M., Nunez E., Pazos M.R., Benito C., Castillo A.I., Martinez-Orgado J.A., et al. The activation of cannabinoid CB2 receptors stimulates in situ and in vitro beta-amyloid removal by human macrophages. Brain Res. 2009, 4(1283):148-154.
    • (2009) Brain Res. , vol.4 , Issue.1283 , pp. 148-154
    • Tolon, R.M.1    Nunez, E.2    Pazos, M.R.3    Benito, C.4    Castillo, A.I.5    Martinez-Orgado, J.A.6
  • 173
    • 77749264923 scopus 로고    scopus 로고
    • Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain
    • Torres E., Gutierrez-Lopez M.D., Borcel E., Peraile I., Mayado A., O'Shea E., et al. Evidence that MDMA ('ecstasy') increases cannabinoid CB2 receptor expression in microglial cells: role in the neuroinflammatory response in rat brain. J. Neurochem. 2010, 113(1):67-78.
    • (2010) J. Neurochem. , vol.113 , Issue.1 , pp. 67-78
    • Torres, E.1    Gutierrez-Lopez, M.D.2    Borcel, E.3    Peraile, I.4    Mayado, A.5    O'Shea, E.6
  • 175
    • 84860152544 scopus 로고    scopus 로고
    • Toxoplasma gondii and other risk factors for schizophrenia: an update
    • Torrey E.F., Bartko J.J., Yolken R.H. Toxoplasma gondii and other risk factors for schizophrenia: an update. Schizophr. Bull. 2012, 38(3):642-647.
    • (2012) Schizophr. Bull. , vol.38 , Issue.3 , pp. 642-647
    • Torrey, E.F.1    Bartko, J.J.2    Yolken, R.H.3
  • 179
    • 4644254057 scopus 로고    scopus 로고
    • The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids
    • Vannacci A., Giannini L., Passani M.B., Di Felice A., Pierpaoli S., Zagli G., et al. The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids. J. Pharmacol. Exp. Ther. 2004, 311(1):256-264.
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , Issue.1 , pp. 256-264
    • Vannacci, A.1    Giannini, L.2    Passani, M.B.3    Di Felice, A.4    Pierpaoli, S.5    Zagli, G.6
  • 181
    • 84884945604 scopus 로고    scopus 로고
    • HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity
    • Vicente-Sanchez A., Sanchez-Blazquez P., Rodriguez-Munoz M., Garzon J. HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity. Mol. Brain 2013, 6(1):42.
    • (2013) Mol. Brain , vol.6 , Issue.1 , pp. 42
    • Vicente-Sanchez, A.1    Sanchez-Blazquez, P.2    Rodriguez-Munoz, M.3    Garzon, J.4
  • 182
    • 75349096497 scopus 로고    scopus 로고
    • A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia
    • Vuillermot S., Weber L., Feldon J., Meyer U. A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia. J. Neurosci. 2010, 30(4):1270-1287.
    • (2010) J. Neurosci. , vol.30 , Issue.4 , pp. 1270-1287
    • Vuillermot, S.1    Weber, L.2    Feldon, J.3    Meyer, U.4
  • 183
    • 51549090440 scopus 로고    scopus 로고
    • Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity
    • Wacnik P.W., Luhr K.M., Hill R.H., Ljunggren H.G., Kristensson K., Svensson M. Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity. J. Immunol. 2008, 181(5):3057-3066.
    • (2008) J. Immunol. , vol.181 , Issue.5 , pp. 3057-3066
    • Wacnik, P.W.1    Luhr, K.M.2    Hill, R.H.3    Ljunggren, H.G.4    Kristensson, K.5    Svensson, M.6
  • 184
    • 0037442829 scopus 로고    scopus 로고
    • Nonpsychotropic cannabinoid receptors regulate microglial cell migration
    • Walter L., Franklin A., Witting A., Wade C., Xie Y., Kunos G., et al. Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J. Neurosci. 2003, 23(4):1398-1405.
    • (2003) J. Neurosci. , vol.23 , Issue.4 , pp. 1398-1405
    • Walter, L.1    Franklin, A.2    Witting, A.3    Wade, C.4    Xie, Y.5    Kunos, G.6
  • 185
    • 24744433317 scopus 로고    scopus 로고
    • Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis
    • Wang H., Xu H., Dyck L.E., Li X.M. Olanzapine and quetiapine protect PC12 cells from beta-amyloid peptide(25-35)-induced oxidative stress and the ensuing apoptosis. J. Neurosci. Res. 2005, 81(4):572-580.
    • (2005) J. Neurosci. Res. , vol.81 , Issue.4 , pp. 572-580
    • Wang, H.1    Xu, H.2    Dyck, L.E.3    Li, X.M.4
  • 186
    • 57049106235 scopus 로고    scopus 로고
    • High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells
    • Widmer M., Hanemann C.O., Zajicek J. High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells. J. Neurosci. Res. 2008, 86(14):3212-3220.
    • (2008) J. Neurosci. Res. , vol.86 , Issue.14 , pp. 3212-3220
    • Widmer, M.1    Hanemann, C.O.2    Zajicek, J.3
  • 188
    • 34548446421 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis
    • Xu H., Cheng C.L., Chen M., Manivannan A., Cabay L., Pertwee R.G., et al. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J. Leukoc. Biol. 2007, 82(3):532-541.
    • (2007) J. Leukoc. Biol. , vol.82 , Issue.3 , pp. 532-541
    • Xu, H.1    Cheng, C.L.2    Chen, M.3    Manivannan, A.4    Cabay, L.5    Pertwee, R.G.6
  • 189
    • 84888062313 scopus 로고    scopus 로고
    • Delta(8)-tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: Involvement of cannabinoid receptor 2 and p38 MAPK
    • Yamaori S., Ishii H., Chiba K., Yamamoto I., Watanabe K. Delta(8)-tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: Involvement of cannabinoid receptor 2 and p38 MAPK. Toxicology 2013, 314(2-3):254-261.
    • (2013) Toxicology , vol.314 , Issue.2-3 , pp. 254-261
    • Yamaori, S.1    Ishii, H.2    Chiba, K.3    Yamamoto, I.4    Watanabe, K.5
  • 190
    • 84870669755 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury
    • Yang Y., Yang H., Wang Z., Varadaraj K., Kumari S.S., Mergler S., et al. Cannabinoid receptor 1 suppresses transient receptor potential vanilloid 1-induced inflammatory responses to corneal injury. Cell. Signal. 2013, 25(2):501-511.
    • (2013) Cell. Signal. , vol.25 , Issue.2 , pp. 501-511
    • Yang, Y.1    Yang, H.2    Wang, Z.3    Varadaraj, K.4    Kumari, S.S.5    Mergler, S.6
  • 191
    • 0028205758 scopus 로고
    • Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6
    • Zalcman S., Green-Johnson J.M., Murray L., Nance D.M., Dyck D., Anisman H., et al. Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res. 1994, 643(1-2):40-49.
    • (1994) Brain Res. , vol.643 , Issue.1-2 , pp. 40-49
    • Zalcman, S.1    Green-Johnson, J.M.2    Murray, L.3    Nance, D.M.4    Dyck, D.5    Anisman, H.6
  • 192
    • 84876434618 scopus 로고    scopus 로고
    • Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat
    • Zavitsanou K., Dalton V.S., Walker A.K., Weickert C.S., Sominsky L., Hodgson D.M. Neonatal lipopolysaccharide treatment has long-term effects on monoaminergic and cannabinoid receptors in the rat. Synapse 2013, 67(6):290-299.
    • (2013) Synapse , vol.67 , Issue.6 , pp. 290-299
    • Zavitsanou, K.1    Dalton, V.S.2    Walker, A.K.3    Weickert, C.S.4    Sominsky, L.5    Hodgson, D.M.6
  • 193


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.