Psychoneuroimmunology and the cytokine action in the CNS: Implications for psychiatric disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 22, Issue 1, 1998, Pages 1-33

  Müller, Norbert ^a   Ackenheil, Manfred ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Central nervous system; Cytokines; Depression; Neurotransmitter; Psychiatric disorders; Psychoneuroimmunology; Schizophrenia

Indexed keywords

CHLORPROMAZINE; CLOZAPINE; DOPAMINE; FLUOXETINE; FLUPHENAZINE; HALOPERIDOL; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 6; NERVE GROWTH FACTOR; NEUROLEPTIC AGENT; NORADRENALIN; ROLIPRAM; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; ZIMELDINE;

AMNESIA; BEHAVIOR; BLOOD BRAIN BARRIER; CELLULAR IMMUNITY; CYTOKINE RELEASE; DEPRESSION; GLIA CELL; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOMODULATION; MENTAL DISEASE; NEUROCHEMISTRY; NEUROIMMUNOLOGY; NEUROTRANSMISSION; PATHOPHYSIOLOGY; REVIEW; SCHIZOPHRENIA; SLEEP DISORDER; STRESS;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CYTOKINES; DEPRESSIVE DISORDER; HUMANS; MENTAL DISORDERS; NEUROTRANSMITTER AGENTS; PSYCHONEUROIMMUNOLOGY; SCHIZOPHRENIA;

EID: 0031950741     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(97)00179-6     Document Type: Review

References (190)

1. ADER, R. and COHEN, N. (1975) Behaviorally conditioned immunosuppression. Psychosom. Med. 37: 333-340.
2. ADER, R., FELTEN, D.L. and COHEN, N. (1991) Psychoneuroimmunology. Second Edition Academic Press, San Diego, NY, Toronto.
3. AKIYOSHI, M., SHIMIZU, Y. and SAITO, M. (1990) Interleukin-1 increases norepinephrine turnover in the spleen and lung in rats. Biochem. Biophys. Res. Comm. 173: 1266-1270.
4. AISEN, P.S. and DAVIS, K.L. (1994) Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am. J. Psychiatry 151: 1105-1113.
5. ALOISI, F., BORSELLINO, G., CARÉ, A., TESTA, U., GALLO, P., RUSSO, G., PESCHLE, C. and LEVI, G. (1995) Cytokine regulation of astrocyte function: In-vitro studies using cells from the human brain. Int. J. Devl. Neurosci. 13: 265-274.
6. ALONSO, R., CHAUDIEU, I., DIORIO, J., KRISHNAMURTHY, A., QUIRION, R. and BOKSA, P. (1993) Interleukin-2 modulates evoked release of [3H]dopamine in rat cultured mesencephalic cells. J Neurochem 61.: 1284-1290.
7. ANGRIST, B., PESELOW, E., RUBISTEIN, M., CORWIN, J. and ROTROSEN, J. (1982) Partial improvement in negative schizophrenic symptoms after amphetamine. Psychopharmacol. 72: 128-130.
8. ARAUJO, D.M., LAPCHAK, P.A., COLLIER, B. and QUIRION R. (1989a) Localization of interleukin-2 immunoreactivity and interleukin-2 receptors in the rat brain: interaction with the cholinergic system. Brain Res. 498:257-266.
9. ARAUJO, D.M., LAPCHAK, P.A., CHABOT, J.G., NAIR, N.P. and QUIRION, R. (1989b) Characterization and possible role of growth factor and lymphokine receptors in the regulation of cholinergic function in the mammalian brain. Prog. Clin. Biol. Res. 317: 423-436.
10. AWATSUJI, H., FURUKAWA, Y., NAKAJIMA, M., FURUKAWA, S. and HAYASHI, K. (1993) Interleukin-2 as a neurotrophic factor for supporting the survival of neurons cultured from various regions of fetal rat brain. J. Neurosci. Res. 35: 305-311.
11. BAKER, G.A., SYNTALO, R. and BLUMENSTEIN, J. (1977) Effects of psychotropic agents upon the blastogenic response on human T-lymphocytes. Biol. Psychiatry 12: 159-169.
12. BANKS, W.A. and KASTIN, A.J. (1992) The interleukins-1 alpha, -1 beta, and -2 do not acutely disrupt the murine blood-brain barrier. Int. J. Immunopharmacol. 14: 629-636.
13. BANKS, W.A., KASTIN, A.J. and GUTIERREZ EG (1993) Interleukin-1 alpha in blood has direct access to cortical brain cells. Neurosci. Lett. 163: 41-44.
14. BARTROP, R.W., LAZARUS, L., LUCKHURST, E., KILCH, L.G. and PENNY, R. (1977) Depressed lymphocyte function after bereavement. Lancet I: 834-836.
15. BENGTSSON B-O, ZHU J, THORELL L-H, OLSSON T., LINK H. and WALINDER J. (1992) Effects of zimeldine and its metabolites, clomipramine, imipramine and maprotiline in experimental allergig neuritis in Lewis rats. J. Neuroimmunol. 39: 109-122.
16. BENVENISTE, E.N. (1992) Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am. J. Physiol. 263 (Cell Physiol 32): C1-C16.
17. BERKENBOSCH, F., VAN OERS, J., DEL RAY, A., TIDERS, F. and BESEDOVSKY, H.O. (1987) Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science 238: 524-526.
18. BERTINI, S., BIANCHI, M., MENGOZZI, M., and GHEZZI, P. (1989) Protective effect of chlorpromazine against the lethality of interleukin 1 in adrenalectomized or actinomycin D-sensitizrd mice. Biochem. Biophys. Res. Comm. 165: 942-947.
19. BERTINI, S., GARATTINI, R., DELGADO, P. and GHEZZI, P. (1993) Pharmacological activities of chlorpromazine invilved in the inhibition of tumour necrosis factor production in vivo in mice. Immunology 79: 217-219
20. BESEDOVSKY, H.O., DEL RAY, A., SORKIN, E. and DINARELLO, C.A. (1986) Immunregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233: 652-654.
21. BONNET, M., LESPINATS, G., and BURTIN, C. (1984) Histamin and serotonin suppression of lymphocyte response to phythemagglutinin and antigen. Cell. Immunol. 1984; 83: 280-291.
22. BOUKHRIS, W., KOUASSI, E. and REVILLARD, J.P. (1988) Differential effect of mixed D1/D2 and selective D2 dopaminergic antagonists on mouse T and B lymphocyte proliferation and interleukin production in vitro. Immunopharmacol. Immunotoxicol. 10: 501-512.
23. BREDER, C.D., DINARELLO, C.A. and SABER, C.B. (1988) Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240: 321-324.
24. BRUCE, L.C. and PEEBLES, A.M.S. (1903) Clinical and experimental observations on catatonia. J. Mental. Sci. 49: 614-628.
25. BUDKA, H. and MAJDIC, O. (1985) Shared antigenic determinants between human hemopoietic cells and nervous tissues and tumors. Acta Neuropathol. (Berl.) 67: 58-66
26. CACABELOS, R., ALVAREZ, X.A., FRANCO-MASIDE, A., FERNÁNDEZ-NOVOA, L. and CAAMAÑO, J. (1994) Serum tumor necrosis factor (TNF) in Alzheimer's disease and multi-infarct dementia. Meth. Find. Exp. Clin. Pharmacol. 16: 29-35.
27. CANCILLA, P.A. and DEBAULT, L.E. (1983) Neutral amino acid transport properties of cerebral endothelial cells in vitro. J. Neuropathol. Expl. Neurol. 42: 191-199.
28. CARLSSON, A. and LINDQUIST, M. (1963) Effect of chlorpromazine and haloperidole on the formation of 3-methoxytyramine and normetanophrine in mouse brain. Acta Pharmacologica (Copenhagen) 20: 140-144.
29. CARUSO, C., CANDORE, G., CIGNA, D., COLUCCl, A.T. and MODICA, M.A. (1993) Biological significance of soluble IL-2 receptor. Med. Inflamm. 2: 3-21.
30. COPPEN, A. and SWADE, C. (1988) 5-HT and depression: the present position. In New concepts in depression. Edited by Briley M, Fillion G. Pierre Fabre Monograph Series. London, MacMillan Press, 2: 120-136.
31. DAMESHEK, W. (1930) White blood cells in dementia praecox and dementia paralytica. Arch. Neurol. Psychiatry 24: 855.
32. DAMLE, R.N., ADVANI, S.H. and GANGAL, S.G. (1992) Analysis of regulation of T-cell responses by soluble inhibitory factors from the sera of patients with Hodgkin's disease. Int. J. Cancer 50: 192-196.
33. DELISI, L.E., GOODMAN, S., NECKERS, L.M. and WYATT, R.J. (1982) An analysis of lymphocyte subpopulations in schizophrenic patients. Biol. Psychiatry 17: 1003-1009.
34. DENICOFF, K.D., RUBINOFF, D.R., PAPA, M.Z., SIMPSON, C., SEIPP, C.A., LOTZE, M.T., CHANG, A.E., ROSENSTEIN, D. and ROSENBERG, SA. (1987) The neuropsychiatric effects of treatment with Interleukin-2 and lymphokine-activated killer cells. Ann. Internal. Med. 107: 293-300.
35. DE SOUZA, E.B. (1994) Identification, localisation and modulation of Interleukin-1 receptors in the central nervous system. Neuropsychopharmacol. 10/1: 830.
36. DEVOINO, L.V., EVEMINA, O.F.M. and ILYUTCHENOK, R.I. (1970) The role of the hypothalamopituitary system in the mechanism of action of reserpine and 5-hydroxytryptophan on antibody production. Neuropharmacol. 9: 67-72.
37. DUNN, A.J. (1992) Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: comparison with interleukin-1. J. Pharmacol. Exp. Ther. 261: 964-969.
38. DUNN, A.J. (1994) Pituitary-adrenal Activation and behavioral activity of Interleukin-1. Neuropsychopharmacol. 10/1: 833.
39. EBBESEN, F. and KNUDSEN, A. (1992) The possible risk of bilirubin encephalopathy as predicted by plasma parameters in neonates with previous severe asphyxia. Eur. J. Pediatrics 151: 910-912.
40. EGGERT, F., LUSZYK, D., WESTPHAL., E., MÜLLER-RUCHHOLZ, W. and FERSTL, R. (1990) Vom Gen zum Geruch zum Verhalten; über immunogenetische Grundlagen der chemosensorischen Identität und ihre psychobiologischen Effekte. T.W. Neurol. Psychiatrie 3: 889-892.
41. ELLISON, M.D., POVLISHOCK, J.T. and MERCHANT, R.E. (1987) Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion. Cancer Res. 47: 5765-5770.
42. ELLISON, M.D., KRIEG, R.J. and POVLISHOCK, J.T. (1990) Differential central nervous responses following single and multiple recombinant interleukin-2 infusions. J. Neuroimmunol. 28: 259-260.
43. ENGEL, R.R., MÜLLER, F., MÜNCH, U. and ACKENHEIL, M. (1980) Plasma catecholamine response and autonomic function during short-time psychological stress. In: Catecholamines and stress. Recent advances. E. Usdin, R. Kyetnansky and J. Kopin (Eds.), pp 461-466, Elsevier, NY.
44. FABRY, Z., WALDSCHMIDT, M.M., HENDRICKSON, D., KEINER, J., LOVEHOMANN, L., TAKEI, F. and HART, M.N. (1992) Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55. J. Neuroimmunol. 36: 1-11.
45. FABRY, Z., RAINE, C.S. and HART, M.N. (1994) Nervous tissue as an immune compartment: the dialect of the immune response in the CNS. Immunol. Today 15:218-224.
46. FERNSTROM, J.D. and FALLER, D.V. (1977) Neutral amino acids in the brain: changes in response to food ingestion. J. Neurochem. 30: 1511-1538.
47. FESSEL, W.J. (1963) The 'antibrain' factors in psychiatric patients' sera. Arch. Gen. Psychiatry 8: 614-621.
48. FREI, K., MALIPIERO, U.V., LEIST, T.P., ZINKERNAGEL, R.M., SCHWAB, M.E. and FONTANA, A. (1989) On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases. Eur. J. Immunol. 19: 689-694.
49. FRENZEL, K.H., MÜLLER, N., HEIDMANN, D., HAMPEL, H., KRETZSCHMAR, H.A., PENNING, R. and ACKENHEIL, M. (1995) Expression of T cell receptor γδ antigens in human brain tissue. NeuroImmunomodulation 2: 115-120.
50. FUNKE, I., HAHN, A., RIEBER, E.P., WEISS, E. and RIETHMÜLLER, G. (1987) The cellular receptor (CD4) on the human deficiency virus is expressed on neurons and glia cells in human brain. J. Exp. Med. 165: 1230-1235.
51. GADINA, M., BERTINI, R., MENGOZZI, M., ZANDALASINI, M., MANTOVANI, A. and GHEZZI, P. (1991) Protective effects of chlorpromazine on endotoxin toxicity and TNF production in glucocoticoid-sensitive and glucocorticoid-resistant models of endotoxin shock. J. Exp. Med. 173: 1305-1310.
52. GALLIEN, M., SCHNETZLER, J.P. and MORIN, J. (1977) Antinuclear antibodies and lupus cells in 600 hospitalized phenothiazine treated patients. Ann. Med. Psychol. Med. 1: 237-248.
53. GANGULI, R., RABIN, B.S., KELLY, R.H., LYTE, M. and RAGU, U. (1987) Clinical and laboratory evidence of autoimmunity in acute schizophrenia. Ann. N.Y. Acad. Sci. 496: 676-685.
54. GANGULI, R. and RABIN, B.S. (1989) Increased serum Interleukin 2 receptor levels in schizophrenic and brain damaged subjects. Arch. Gen. Psychiat. 46: 292.
55. GANGULI, R., YANG, Z., SHURIN, G., CHENGAPPA, R., BRAR, J.S., GUBBI, A.V. and RABIN, B.S. (1994) Serum Interleukin-6 concentration in schizophrenia: elevation associated with duration of illness. Psychiatry Res. 51: 1-10.
56. GANGULI, R., BRAR, J.S., CHENGAPPA, K.R., DELEO, M., YANG, Z.W., SHURIN, G. and RABIN B. (1995a) Mitogen-stimulated interleukin 2 production in never-medicated, first episode schizophrenics - the influence of age of onset and negative symptoms. Arch. Gen. Psychiat. 52: 668-672.
57. GANGULI, R., BRAR, J.S. and Rabin, B. S. (1995b) Reply on: Pollmächer, T., Hinze-Seich, D., Mullington, J. and Holsboer, F.: Clozapine-induced increase in plasma levels of soluble Interleukin-2 receptors. Arch. Gen. Psychiatry 52: 878.
58. GATTAZ, W.F., DALGALARRADO, P. and SCHRÖDER, H.C. (1992) Abnormalities in serum concentrations of interleukin-2, inferon γ and interferon γ in schizophrenia not detected. Schizophr. Res. 6: 237-241.
59. GERMAIN, R. (1994) MHC dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation. Cell 76: 287-299
60. GLASER, R., KIECOLT-GLASER, J.K., GEORGE, J.M., SPEICHER, C.E. and HOLLIDAY, J.E. (1985) Stress, loneliness and change in herpes virus latency. J. Behav. Med. 8: 249-260.
61. GLASS, J.D., WESSELINGH, S.L., SELNES, O.A. and MCARTHUR, J.C. (1993) Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 43: 2230-2237.
62. GUTIERREZ, E.G., BANKS, W.A. and KASTIN A.J. (1993) Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47: 169-176.
63. HAMA, T., KUSHIMA, Y., MIYAMOTO, M., KUBOTA, M., TAKEI, N. and HATANAKA, H. (1991) Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal., two-week-old rats in cultures. Neurosci. 40: 445-452
64. HAMPEL, H. and MÜLLER, N. (1995) Inflammatory and immunological mechanisms in Alzheimer's disease. Drug News & Perspect. 8: 599-608.
65. HANISCH, U.K., SETO, D. and QUIRION, R (1993) Modulation of hippocampal acetylcholine release: a potent central action of interleukin-2. J. Neurosci. 13: 3368-3374.
66. HASHIMOTO, M., ISHIKAWA, Y., YOKOTA, S., GOTO, F., BANDO, T., SAKAKIBARA, Y. and IRIKI, M. (1991) Action side of circulating interleukin-1 on the rabbit brain. Brain Res. 540: 217-223.
67. HEATH, R.G. and KRUPP, I.M. (1967) Schizophrenia as an immunologic disorder. I. Demonstration of antibrain globulins by fluorescent antibody techniques. Arch. Gen. Psychiatry 39: 82-87.
68. HENNEBERG, A., RIEDL, B., DUMKE, H.O. and KORNHUBER, H.H. (1990) T-lymphocyte subpopulations in schizophrenic patients. Eur. Arch. Psychiat. Neurol. Sci. 239: 283-284.
69. HICKEY, W. and KIMURA, H. (1988) Perivascular microglial cells of the CNS are bone-marrow derived and present antigen in vivo. Science 238: 290-292.
70. HORNBERG, M., AROLT, V., WILKE, I., KRUSE, A. and KIRCHNER, H. (1995) Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia. Schizophrenia Res. 15: 237-242.
71. JOYCE, P.R., HAWES, C.R., MULDER, R.T., SELLMAN, J.D., WILSON, D.A. and BOSWELL, D.R. (1992) Elevated levels of acute phase plasma proteins in major depression. Biol. Psychiatry 32: 713-718.
72. KENT, S., BLUTHE, R.M., KELLEY, K.W. and DANTZER, R. (1992) Sickness behavior and drug development. TIPS 13: 24-28.
73. KIECOLT-GLASER, J.K. and GLASER, R. (1987) Psychosocial influences on herpes virus latency. In Viruses, Immunity, and mental disorders. Edited by Kurstak E, Lipowski ZJ, Morozov PV. London, NY, Plenum press 403-412.
74. KIRCH, D.G., KAUFMANN, C.A., PAPADOPOULOS, N.M., MARTIN, B. and WEINBERGER, D.R. (1985) Abnormal cerebrospinal fluid protein indices in schizophrenia. Biol. Psychiatry 20: 1039-1046.
75. KNIGHT, J.G. (1982) Dopamine-receptor-stimulating autoantibodies, a possible cause of schizophrenia. Lancet i: 1073-1076.
76. KRÜGER, K.W. (1984) Lupus erythematodes und Zentralnervensystem. Nervenarzt 55: 165-172.
77. KURTZ, G. and MÜLLER, N. (1994) The antiphospholipid syndrome and psychosis. Am. J. Psychiatry 151:1841-1842.
78. LAPCHAK, P.A. (1992) A role for Interleukin-2 in the regulation of striatal dopaminergic function. Neuroreport 1: 165-168.
79. LAUDENSLAGER, M.L. (1987) Psychosociul stress and susceptibility to infections disease. In: Viruses, Immunity, and mental disorders. E. Kurstak, E.J. Lipowski and P. V. Morozov (Eds.), pp 391-402, Plenum press, London, NY.
80. LECHAN, R.M., TONI, R., CLARK, B.D., CANNON, L.G., SHAW, A.R., DINARELLO, C.A. and REICHLIN, S. (1990) Immunoreactive interleukin-1 beta localization in the rat forebrain. Brain Res. 514: 135-140.
81. LEHMANN-FACIUS, H. (1939) Serologisch-analytische Versuche mit Liquores und Seren von Schizophrenen. Allg. Z. Psychiatrie 110: 232-243.
82. LEWANDOWSKI, G., HOBBS, M.V. and BLOMOM, F.E. (1994) Alteration of intracerebral cytokine production in mice infected with herpes simplex virus types 1 and 2. J* Neuroimmunol. 55: 23-34.
83. LICINIO, J., SEIBYL, J.P., ALTEMUS, M., CHARNEY, D.S and, KRYSTAL., J.H. (1993) Elevated levels of Interleukin-2 in neuroleptic-free schizophrenics. Am. J. Psychiat. 150: 1408-1410.
84. LICINIO, J. and WONG, M.L. (1994) Lokalizations of Interleukin-1 and Interleukin-1 mRNA in brain: pathophysiological implications. Neuropsychopharmacol. 10/1: 834.
85. LIEBERMAN, A.P., PITHA, P.M., SHIN, H.S. and SHIN, M.L. (1989) Produktion of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc. Natl. Acad. Sci. USA 86: 6348-6352.
86. LINDHOLM, D., HEUMANN, R., MEYER, M. and THOENEN, H. (1987) Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330: 658-659
87. MACKIEWICZ, A., SCHOOLTINK, H., HEINRICH, P.C. and ROSE-JOHN, S. (1992) Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins. J. Immunol. 49: 2021-2027.
88. MADDON, P.I., DALGLEISH, A.G., MCDOUGAL., E.S., CLAPHAM, P.R., WEISS, A.R. and AXEL, R. (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and in the brain. Cell. 47: 333-348.
89. MAES M (1995) Evidence for an immune response in major depression: A review and hypothesis. Prog. Neuro-Psychopharmacol. & Biol. Psychiatry 19: 11-38.
90. MAES, M., BOSMANS, E., SUY, E., VANDERVORST, C., DEJONCKHEERE, C., MINNER, B. and RAUS, J. (1991a) Depression-related disturbances in mitogen-induced lymphocyte responses, interleukin-1ß, and soluble interleukin-2-receprtor production. Acta Psychiat. Scand. 84: 379-386.
91. MAES, M., BOSMANS, E., SUY, E., VANDERVORST, C., DEJONCKHEERE, C. and RAUS, J. (1991b) Antiphospholipid, anti-nuclear, Epstein-Barr and cytomegalovirus antibodies, and soluble interleukin-2 receptors in depressive patients. J. Affect. Dis. 21: 133-140.
92. MAES, M., MELTZER, H.Y., SCHARPÉ, S., BOSMANS, E., SUY, E., DE MEESTER, I., CALABRESE, J. and COSYNS, P. (1993a) Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res. 49: 11-27.
93. MAES, M., SCHARPÉ, S., MELTZER, H.Y., BOSMANS, E., SUY, E., CALABRESE, J. and COSYNS, P. (1993b) Relationships between lower plasma L-Tryptophan levels and immune-inflammatory variables in depression. Psychiatry Res. 49: 151-165.
94. MAES, M., MELTZER, H.Y. and BOSMANS, E. (1994) Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine. Acta Psychiatr. Scand. 89: 346-351.
95. MAES, M., SMITH, R. and SCHARPE, S. (1995a) The monocyte-T-lymphocyte hypothesis of major depression. Psychoneuroendocrinol. 20: 111-116.
96. MAES, M., BOSMANS, E. and MELTZER, H.Y. (1995b) Immunoendocrine aspects of major depression. Relationships between plasma interleukin-6 and soluble interleukin-2 receptor, prolactin and cortisol. Eur. Arch. Psychiatry Clin. Neurosci. 245: 172-178.
97. MAES, M., BOSMANS, E., RANJAN, R., VANDOOLAEGHE, B., MELTZER, H.Y., DE LEY, M., BERGHMANS, R., STANS, G. and DESNYDER, R. (1996) Lower plasma CC16, a natural anti-inflammatory protein, and increased plasma interleukin-1 receptor antagonist in schizophrenia: effects of antipsychotic drugs. Schizophrenia Res. 21: 39-50.
98. MATUSSEK, N. (1966) Neurobiologie und Depression. Med. Monatsschr. 3: 109-112.
99. + B-lymphocytes in schizophrenic patients. Arch. Gen. Psychiatry 46: 890-894.
100. MCALLISTER, C.G., RAPAPORT, M.H., PICKAR, D. and PAUL, S.M. (1989b) Effect of short term administration of antipsychotic drugs on lymphocyte subsets in schizophrenic patients. Arch. Gen. Psychiat. 46: 956-957.
101. MCALLISTER, C.G., VAN KAMMEN, D.P., REHN, T.J., MILLER, A.N., GURKLIS, J., KELLEY, M.E., YAO, J. and PETERS, J.L. (1995) Increases in CSF levels of interleukin-2 in schizophrenia: effects of recurrance of psychosis and medication status. Am. J. Psychiat. 152: 1291-1297.
102. MERILL, J.E. (1992) Tumor necrosis factor alpha, Interleukin 1 and related cytokines in brain development: normal and pathological. Dev. Neurosci. 14: 1-10.
103. MILLER, A.H. and LACKNER, C. (1989) Tricyclic antidepressants and immunity. In: Depressive disorders and immunity. A. H. Miller (Ed), pp 85-103, American Psychiatric Press, Washington.
104. MINAMI, M., KURAISHI, Y., YAMAGUCHI, T., NAKAI, S., HIRAI, Y. and SATOH, M. (1991) Immobilization stress induces interleukin-1 beta mRNA in the rat hypothalamus. Neurosci. Lett. 123: 254-256.
105. MOREAU, TH., COLES, A., WING, M., ISAAKS, J., HALE, G., WALDMANN, H. and COMPSTONE, A. (1996) Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 119: 225-237.
106. MÜLLER, N. (1995) Psychoimmunology: Implications for the drug treatment of psychiatric disorders. CNS Drugs 4: 125-140.
107. MÜLLER, N. and ACKENHEIL, M. (1995a) The immune system and schizophrenia. In: Stress, the immune system and psychiatry. B. E. Leonard, K. Miller (Eds.), pp 137-164, Wiley and sons, Chichester, NY.
108. MÜLLER, N. and ACKENHEIL, M. (1995b) Immunoglobulin and albumin contents of cerebrospinal fluid in schizophrenic patients: The relationship to negative symptomatology. Schizophr. Res. 14: 223-223.
109. MÜLLER, N., ACKENHEIL, M., ECKSTEIN, R., HOFSCHUSTER, E. and MEMPEL, W. (1987) Reduced suppressor cell function in psychiatric patients. Ann. N.Y. Acad. Sci. 496: 686-690.
110. MÜLLER, N., ACKENHEIL, M., HOFSCHUSTER, E., MEMPEL, W. and ECKSTEIN, R. (1991) Cellular immunity in schizophrenic patients before and during neuroleptic therapy. Psychiatry Res. 37: 147-160.
111. MÜLLER, N., GIZYCKI-NIENHAUS, B., GÜNTHER, W. and MEURER, M. (1992) Depression as a possible cerebral manifestation of scleroderma: immunological findings in serum and CSF. Biol. Psychiatry 31: 1151-1156.
112. MÜLLER, N., ACKENHEIL, M., HOFSCHUSTER, E., MEMPEL, W. and ECKSTEIN, R. (1993a) Cellular immunity, HLA-class I antigens, and family history of psychiatric disorder in endogenous psychoses. Psychiatry Res. 48: 201-217.
113. MÜLLER, N., ACKENHEIL, M., HOFSCHUSTER, E., MEMPEL, W. and ECKSTEIN, R. (1993b) T-cells and psychopathology in schizophrenia: relationship to the outcome of neuroleptic therapy. Acta Psychiat. Scand. 87: 66-71.
114. MÜLLER, N., ACKENHEIL, M., HOFSCHUSTER, E., MEMPEL, W. and ECKSTEIN, R. (1993c) Investigations of the cellular immunity during depression and the free interval: evidence for an immune activation in affective psychosis. Prog. Neuro-Psychopharmacol. & Biol. Psychiatry 17: 713-730.
115. MÜLLER N., SCHWARZ M., RIEDEL M. and ACKENHEIL M. (1996) Developmental processes and immunology in schizophrenia. Eur. Neuropsychopharmacol. 6: S4-44.
116. MÜLLER, N., DOBMEIER, P., EMPL, M., RIEDEL, M., SCHWARZ, M. and ACKENHEIL, M. (1997a) Soluble IL-6 receptors in the serum and cerebrospinal fluid of paranoid schizophrenic patients. Eur. Psychiatry (in press).
117. MÜLLER, N., EMPL, M., RIEDEL, M., SCHWARZ, M. and ACKENHEIL, M. (1997b) Decrease of soluble IL-6 receptor- and increase of soluble 1L-2 receptor serum levels in schizophrenic patients reflect the immunomodulatory effect of neuroleptics. Eur. Arch. Psychiatry Clin. Neurosci. (submitted).
118. MÜLLER. N., HADJAMU, M., RIEDEL, M., PRIMBS, J., ACKENHEIL M. and GRUBER R. (1997c) Adhesion-Molecule Receptor Expression on T-celis and the Role of the Blood-Brain-Barrier in Schizophrenia. Arch. Gen. Psychiatry (submitted).
119. MURAGUCHI, A., HIRANO, T., TANG, B., MATSUDA, T., HORH, Y., NAKAJIMA, K. and KISHIMOIO, T. (1988) The essential role of U-cell stimulating factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 167: 332-344.
120. MURRAY, R.M. and O'CALLAGHAN, E. (1991) The congenital and adult onset psychoses: Kraepelin lost - Kraepelin found. In: Concepts of mental disorders. Edited by A. Kerr, London, Gaskell Pub.
121. NABER, D., EINHÄUPL, K., STRAUß, A. and FIEDLER, S. (1986) Klinische Bedeutung pathologischer Liquor-Befunde bei schizophrenen Patienten. Psycho. 12: 364-365.
122. NÄSSBERGER, L. and TRÄKSMAN-BENDZ, L. (1993) Increased soluble interleukin-2 receptor concentrations in suicide attempters. Acta Psychiat. Scand. 88: 48-52.
123. NEMNI, R., IANNACCONE, S., QUATTRINI, A., SMIRNE, S., SESSA, M., LODI, M., ERMINIO, C. and CANAL., N. (1992) Effect of chronic treatment with recombinant interleukin-2 on the central nervous system of adult and old mice. Brain Res. 591: 248-252.
124. OPPENHEIMER-MARKS, N., DAVIS, L.S., BOGUE, D.T., RAMBERG, J. and LIPSKY, P.E. (1991) Differential utilisation of ICAM-1 and VCAM-1 during the adhesion and transendothelial migration of human T-lymphocytes. J. Immunol. 147:2913-2921.
125. NISTICÒ, G. and DE SARRO, G. (1991) Is Interleukin 2 a neuromodulator in the brain? TINS 14: 146-150.
126. NORRIS, J.G. and BENVENISTE, E.N. (1993) Interleukin-6 production by astrocytes: induction by the neurotransmitter norepinephrine. J. Neuroimmunol. 45: 137-146.
127. PANDEY, R.S., GUPTA, A.K. and CHATURVEDI, J.C. (1981) Autoimmune model of schizophrenia with special reference to antibrain antibodies. Biol. Psychiatry 16: 1123-1136.
128. PLATA-SALAMAN, C.R. (1991) Immunoregulators in the nervous system. Neurosci. Behav. Rev. 15: 185-215.
129. PLATA-SALAMAN, C.R. and FFRENCH-MULLEN, J.M. (1993) Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons, Neuroreport 4: 579-581.
130. POLLMÄCHER, T., HINZE-SELCH, D., MULLINGTON, J. and HOLSBOER, F. (1995) Clozapine-induced increase in plasma levels of soluble Interleukin-2 receptors. Arch. Gen. Psychiat. 52: 877-878.
131. RABIN, B.S., GANGULI, R., CUNNICK, J.E. and LYSLE, D.T. (1988) The central nervous system - immune system relationship. Clin. Lab. Med. 8: 253-268.
132. RADA, P., MARK, G.P. and VITEK, M.P. (1991) Interleukin-1ß decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats. Brain Res. 15: 287-290.
133. RAINE, Ç.S. (1995) Multiple sclerosis: TNF revisited, with promise. Nat. Med. 1: 211-214.
134. RANSOHOFF, R.M. and BENVENISTE, E.N. (1996) Cytokines in the CNS. CRC press, Boca Raton, NY.
135. RANSOHOFF, R.M. and BÖ, L. (1996) Cytokines in CNS inflammation: Status of experimental autoimmune encephalomyelitis and multiple sclerosis as cytokine-regulated delayed type hypersensitivity reactions. In: Cytokines in the CNS. R. M. Ransohoff and E. N. Benveniste (Eds.), pp 221-237, CRC press, Boca Raton, NY.
136. RAPAPORT, M.H., MCALLISTER, C.G., PICKAR, D., NELSON, D.M. and PAUL, S.M. (1989) Elevated levels of soluble interleukin 2 receptors in schizophrenia. Arch. Gen. Psychiatry 46: 292.
137. RAPAPORT, M.H., MCALLISTER, C.G., KIRCH, D.G. and PICKAR, D. (1990) The effects of typical and atypical neuroleptics on mitogen-induced T lymphocyte responsiveness. Biol. Psychiatry 29: 715-717.
138. RAPAPORT, M.H., DORAN, A.R., NELSON, D.M., MCALLISTER, C.G., MAGLIOZZI, J.R. and PAUL, S.M. (1991) Haloperidol and soluble Interleukin-2 Receptors. Biol. Psychiatry 10: 1063-1065.
139. RAPAPORT, M.H., TORREY, E.F., MCALLISTER, C.G., NELSON, D.M., PICKAR, D. and PAUL, S.M. (1993) Increased serum soluble interleukin-2 receptors in schizophrenic monozygotic twins. Eur. Arch. Psychiat. Clin. Neurosci. 243: 7-10.
140. RAPAPORT, M.H., MCALLISTER, C.G., KIM, V.S., HAN, J.H., PICKAR, D., NELSON, D.M., KIRCH, D.G. and PAUL, S.M. (1994) Increased soluble Interleukin-2 receptors in Caucasian and Korean schizophrenic patients. Biol. Psychiatry 35: 767-771.
141. RAPS, A., ABRAMOVICH, Y. and ASSAEL, M. (1986) Relation between schizophrenic-like psychosis and Sjögren Syndrome (SS). Isr. J Psychiatry Relat. Sci. 23: 321-324.
142. REICH, A., ERLWEIN, O., NIEWIESK, S., TER MEULEN, V. and LIEBERT, U.G. (1992) CD4+ T cells control measles virus infection of the central nervous system. Immunology 76: 185-191.
143. REICHLIN, S. (1993) Neuroendocrine-immune interactions. N. Engl. J. Med. 329: 1246-1253.
144. ROSENSTEIN, M., ETTINGHAUSEN, S.E. and ROSENBERG, S.A. (1986) Extravasation of intravascular fluid mediated by the systemic administration on recombinant interleukin-2. J. Immunol. 137: 1735-1742.
145. SARIS, S.C., ROSENBERG, S.A., FRIEDMAN, R.B., RUBIN, J.T., BARBA, D. and OLDFIELD, E.H. (1988) Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier. J. Neurosurgery 69: 29-34.
146. SAUNDERS, J.C. and MUCHMORE, E. (1964) Phenothiazine effect on human antibody synthesis. Br. J. Psychiatry 110: 84-89.
147. SAWADA, M., SUZUMURA, A. and MARUNOUCHI, T. (1992) TNF-alpha induces IL-6 production by astrocytes, but not by microglia. Brain Res. 583: 296-299.
148. SCHILDKRAUT, J.J. (1965) The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am. J. Psychiatry 122: 509.
149. SCHLEUNING, M.J., DUGGAN, A., and REEM, G.H. (1989) Inhibition by chlorpromazine of lymphokine-specific m-RNA expression in human thymocytes. Eur J Immunol 19: 1491-1496.
150. SCHLEUNING, M., BRUMME, V. and WILMANNS, W. (1994) Inhibition of cyclosporin A/FK 506 resistant, lymphokine-induced T-cell activation by phenothiazine derivates. Naunyn-Schmiedeberg's Arch. Pharmacol. 350: 100-103.
151. SCHNEIDER-SCHAULIES, J., SCHNEIDER-SCHAULIES, S. and TER MEULEN, V. (1993) Differential induction of cytokines by primary and persistant measles virus infections in human glial cells. Virology 195: 219-228.
152. SCHÖBITZ, B., PEZESHKI G., POHL, T., HERMANN, U., HEINRICH, P.C., HOLSBOER, F. and REUL, J.M. (1995) Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo. FASEB J. 9: 659-664.
153. SCOTT, A.I.F., PERINI, A.F., SHERING, P.A. and WHALLEY L.J. (1991) Inpatient major depression: is rolipram as effective as amitriptylin? Eur. J. Clin. Pharmacol. 40: 127-129.
154. SELMAJ, K.W. and RAINE, C.S. (1988) Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann. Neurol. 23: 339-346.
155. SELMAJ, K.W., RAINE, C.S., FAROOQ, M., NORTON, W.T. and BROSNAN, C.F. (1991) Cytokine cytotoxicity against oligodendrocytes: apoptosis induced by lymphotoxin. J. Immunol. 147: 1522-1529.
156. SHANKAR, V., KAO, M., HAMIR, A.N., SHENG, H., KOPROWSKI, H. and DIETZSCHOLD, B. (1992) Kinetics of virus spread and changes in levels of several cytokine mRNAs in the brain after intranasal infections of rats with Borna sisease virus. J. Virol. 66: 992-998.
157. SHARIEF, M.K. and THOMPSON, E.J. (1992) In vivo relationship of tumor necrosis factor alpha to blood-brain barrier damage in patients with active multiple sclerosis. J. Neuroimmunol. 38: 27-34.
158. SHARIEF, M.K. and HENTGES, R. (1991) Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N. Engl. J. Medicine 325: 467-472.
159. SHIMOJO, M., IMAY, Y., NAKAJIAMA, K., MIZUSHIMA, S., UEMURA, A. and KOHSAKA, A. (1993) Interleukin enhances the viability of primary cultured rat neocortical neurons. Neurosci. Lett. 151: 170-173.
160. SHINTANI, F., KANBA, S., NAKAKI, T., NIBUYA, M., KINOSHlTA, N., SUZUKI, E., YAGI, G., KATO, R. and ASAI, M. (1993) Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. J. Neurosci. 13: 3574-3581.
161. SLUZEWSKA, A., RYBAKOWSKI, J.K., LACIAK, M., MACKIEWICZ, A., SOBIESKA, M. and WIKTOROWICZ, K (1995) Interleukiti-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann. N.Y. Acad. Sci. 762: 474-476.
162. SMITH, R.S. (1991) Is schizophrenia caused by excessive production of Interleukin-2 and Interleukin-2 receptors by gastrointestinal lymphocytes? Med. Hypotheses 34:225-229.
163. SMITH, R.S. (1992) A comprehensive macrophage-T-lymphocyte theory of schizophrenia. Med. Hypotheses 39: 248-257.
164. SOLIVEN, B. and ALBERT, J. (1992) Tumor necrosis factor modulates the inactivation of catecholamine secretion in cultured sympathetic neurons. J. Neurochem. 58: 1073-1078.
165. SOLOMON, G.F. (1981) Emotional and personality factors in the onset and course of autoimmune disease, particularly rheumatoid arthritis. In: Psychoneuroimmunology. R. Ader (Ed.), pp 159-182, Academic press, N.Y.
166. SOMMER, N., LÖSCHMANN, P.-A., NORTHOFF, G.H., WELLER, M., STEINBRECHER, A., STEINBACH, J.P., LICHTENFELS, R., MEYERMANN, R., RIETHMÜLLER, A., FONTANA, A., DICHGANS, J. and MARTIN, R. (1995) The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis. Nat. Med. 1: 244-248.
167. SONG, C. and LEONARD, B.E. (1994) An acute phase protein response in the olfactory bulbectomised rat: effect of sertraline treatment. Med. Sci. Res. 22: 313-314.
168. SPANGELO, B.L., JUDD, A.M., ISAKSON, P.C. and MACLEOD, R.M. (1989) Interleukin-6 stimulates anterior pituitary hormone release in vitro. Endocrinology 125: 575-577.
169. SPERNER-UNTERWEGER, B., BARNAS, C., FUCHS, D., KEMMLER, G., WACHTER, H., HINTERHUBER, H. and FLEISCHHACKER, W.W. (1992) Neopterin production in acute schizophrenic patients: an indicator of alterations of cell mediated immunity. Psychiatry Res. 42: 121-128.
170. SPERNER-UNTERWEGER, B., GAGGL, S., FLEISCHHACKER, W., BARNAS, C., HEROLD, M. and GEISLER, D. (1993) Effects of clozapine on hematopoesis and the cytokine system. Biol. Psychiatry 34: 536-543.
171. STERNBERG, F.M., WEDNER, H.J. and LEUNG, M.K. (1987) Effect of serotonin (5-HT) and other monoamines on murine macrophages: modulation of interferon-γ induced phagocytosis. J. Immunol. 138: 4360-4365.
172. ST. PIERRE, B.A., MERILL, J.E. and DOPP, J.M. (1996) Effects of cytokines on CNS cells: Glia. In: Cytokines in the CNS. R. M. Ransohoff and E. N. Benveniste (Eds.), pp 151-168, CRC press, Boca Raton, NY.
173. SUNDAR, S.K., CIERPIAL., M.A., KILTS, C., RITCHIE, J.C. and WEISS, M. (1990) Brain IL-1 induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin-releasing factor. J. Neurosci. 10: 3701-3706.
174. SYVÄLATHI, E., ESKOLA, J., RUNSKANEN, O. and LAINE, T. (1985) Nonsuppression of cortisol in depression and immune function. Progr. Neuro-Psychopharmacol. & Biol. Psychiatry 9: 413-422.
175. THOMAS, K. (1989) Immunomodulation in mice induced by the antidepressant drug zimeldine. Thesis, Utrecht, University of Utrecht.
176. TYOR, W.R., GLASS, J.D., GRIFFIN, J.W., BECKER, P.S., MCARTHUR, J.C., BEZMAN, L. and GRIFFIN, D.E. (1992) Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31: 349-360.
177. VARGAS F., TOLOSA E., SOSPEDRA M., CATALFAMO M., LUCAS-MARTIN A., OBIOLS G. and PUJOL-BORELL R. (1994) Characterization of neuronal adhesion molecule (NCAM) expression in thyroid follicular cells: induction by cytokines and overexpression in autoimmune glands. Clin. Exp. Immunol. 98: 478-488
178. VILLEMAIN, F., CHATENOUD, L., GALINOWSKI, A., HOMO-DELARCHE, F., GENESTET, D., LOO, H., ZARIFARAIN, E. and BACH, J.F. (1989) Aberrant T-cell-mediated immunity in untreated schizophrenic patients: Deficient Interleukin-2 production. Am. J. Psychiatry 146: 609-616.
179. WACHTEL, H. and SCHNEIDER, H.H. (1986) Rolipram, a novel antidepressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by a action beyond postsynaptic monoamine receptors. Neuropharmacology 25: 1119-1126.
180. WALTRIP, II R.W., CARRIGAN, D.R, and CARPENTER, W.T. JR. (1990) Immunopathology and viral reactivation. A general theory of schizophrenia. J. Nerv. Ment. Dis. 178: 729-738.
181. WATTS, R.G., WRIGHT, J.L., ATKINSON, L.L. and MERCHANT, R.E. (1989) Histopathological and blood-brain barrier changes in rats induced by an intracerebral injection of human recombinant interleukin-2. Neurosurgery 25: 202-208.
182. WEISS, J.M., QUAN, N. and SUNDAR, S.K. (1994) Immunological consequences of Interleukin-1 in the brain. Neuropsychopharmacol. 10: 833S.
183. WILKE, I., AROLT, V., ROTHERMUNDT, M., WEITZSCH, C.H., HORNBERG, M., and KIRCHNER, H. (1996) Investigations of cytokine production in whole blood cultures of paranoid and residual schizophrenic patients. Eur Arch Psychiatry Clin Ncurosci 246: 279-284.
184. YOLKEN, R.H. and TORREY, E.F. (1995) Viruses, schizophrenia, and bipolar disorder. Clin. Microbiol. Rev. 8: 131-145.
185. ZALCMAN, S., GREEN-JOHNSON, J.M., MURRAY, L., NANCE, D.M., DYCK, D., ANISMAN, H. and GREENBERG, A.M. (1994) Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Res. 643: 40-49.
186. ZARRABI, M.H., ZUCKER, S., MILLER, F., DERMAN, R.M., ROMANO, G.S., HARTNETT, J.A. and VARMA, A.O. (1979) Immunologic and coagulation disorders in chlorpromazine-treated patients. Ann. Int. Med. 91: 194-199.
187. ZHU, J., BENGTSSON, B.-O., MIX, E., THORELL, L.H., OLSSON, T. and LINK, H. (1994) Effect of monoamine reuptake inhibiting antidepressants on major istocompatibility complex expression on macrophages in normal rats and rats with experimental allergic neuritis (EAN). Immunopharmacology 22-225-244.
188. ZISOOK, S., SHUCHTER, S.R., IRWIN, M., DARKO, D.F., SLEDGE, P. and RESOVSKY, K. (1994) Bereavment, depression, and immune function. Psychiatry Res. 52: 1-10.
189. ZORILLA, E.P., REDEL, E. and DERUBEIS, R.J. (1994) Reduced cytokine levels and T-cell function in healthy controls: relation to individual differences in subclinical anxiety. Brain, Behav. Immun. 8:293-312.
190. ZUBIN. J. and SPRING, B. (1977) Vulnerability - A new view of schizophrenia. J. Abnorm. Psychol. 86: 103-126.