The schizophrenia envirome

Current Opinion in Psychiatry

Volumn 18, Issue 2, 2005, Pages 141-145

  Van Os, Jim ^a,b   Krabbendam, Lydia ^a   Myin Germeys, Inez ^a   Delespaul, Philippe ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Environment; Gene environment interaction; Genetics; Psychosis; Risk factors; Schizophrenia

Indexed keywords

CANNABIS; DOPAMINE;

ADULT; COGNITION; EMOTION; ENVIRONMENTAL FACTOR; GENETIC RISK; GENOTYPE ENVIRONMENT INTERACTION; HIGH BIRTH WEIGHT; HUMAN; LONG TERM EXPOSURE; LOW BIRTH WEIGHT; PRENATAL PERIOD; PSYCHOSIS; PSYCHOTRAUMA; REVIEW; RISK FACTOR; SCHIZOPHRENIA; SENSITIZATION; SOCIAL INTERACTION; URBAN AREA; VIRUS INFECTION; VITAMIN D DEFICIENCY;

EID: 20444452820     PISSN: 09517367     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001504-200503000-00006     Document Type: Review

References (57)

1. Harrison G. Trajectories of psychosis: towards a new social biology of schizophrenia. Epidemiol Psychiatr Soc 2004; 13:152-157.
2. Van Os J, McGuffin P. Can the social environment cause schizophrenia? Br J Psychiatry 2003; 182:291-292.
3. McGrath J, Saha S, Welham J, et al. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2004; 2:13. This is a methodologically superior review of the incidence of schizophrenia that uses the meta-analytic method to show important variation in the incidence of schizophrenia as a function of a wide range of factors. It uses nearly 200 studies from 33 countries. Published in free-access journal of BMC series.
4. Scully PJ, Owens JM, Kinsella A, Waddington JL. Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: small area variation in rate. Schizophr Res 2004; 67:143-155. This is an interesting study that made use of the unusual homogeneity of the study area to discover micro-variation in incidence.
5. Boydell J, Van Os J, Lambri M, et al. Incidence of schizophrenia in south-east London between 1965 and 1997. Br J Psychiatry 2003; 182:45-49.
6. Zal'Tsman GI, Lenskii GP. [On the effect of hashish on the psyche]. Zdravookhranenie Kazakhstana 1962; 22(9):30-35.
7. Fergusson DM, Horwood LJ, Swain-Campbell NR. Cannabis dependence and psychotic symptoms in young people. Psychol Med 2003; 33:15-21.
8. Verdoux H, Sorbara F, Gindre C, et al. Cannabis use and dimensions of psychosis in a nonclinical population of female subjects. Schizophr Res 2003; 59:77-84.
9. Johns LC, Cannon M, Singleton N, et al. Prevalence and correlates of self-reported psychotic symptoms in the British population. Br J Psychiatry 2004; 185:298-305.
10. Degenhardt L. The link between cannabis use and psychosis: furthering the debate. Psychol Med 2003; 33:3-6.
11. Arseneault L, Cannon M, Witton J, Murray RM. Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry 2004; 184:110-117.
12. Smit F, Bolier L, Cuijpers P. Cannabis use and the risk of later schizophrenia: a review. Addiction 2004; 99:425-430.
13. Atakan Z. Cannabis and psychosis: how important is the link? Addiction 2004; 99:513-515; author reply 515.
14. Arseneault L, Cannon M, Poulton R, et al. Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. BMJ 2002; 325:1212-1213.
15. Veen ND, Selten JP, van der Tweel I, et al. Cannabis use and age at onset of schizophrenia. Am J Psychiatry 2004; 161:501-506.
16. Stefanis NC, Delespaul P, Henquet C, et al. Early adolescent cannabis exposure and positive and negative dimensions of psychosis. Addiction 2004; 99:1333-1341.
17. Rey JM, Martin A, Krabman P. Is the party over? Cannabis and juvenile psychiatric disorder: the past 10 years. J Am Acad Child Adolesc Psychiatry 2004; 43:1194-1205.
18. D'Souza DC, Perry E, MacDougall L, et al. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology 2004; 29:1558-1572. This is an important study, as it makes use of an experimental cannabis paradigm - a useful method that can increase our understanding of cannabis-induced psychosis.
19. Henquet C, Krabbendam L, Spauwen J, et al. Prospective cohort study of cannabis use, predisposition for psychosis and psychotic symptoms in young people. BMJ 2005; 330:11. In 2437 young people (aged 14-24 years) with and without liability to psychosis, the rate of psychotic symptoms at follow-up as a function of cannabis use and psychosis liability at baseline was investigated. Not only did cannabis use at baseline increase the cumulative incidence of psychotic symptoms at follow-up adjusted for age, sex, socio-economic status, urbanicity, childhood trauma, baseline psychosis liability and use of other drugs, tobacco and alcohol, but the effect of cannabis was much stronger in those with expression of liability to psychosis at baseline. In addition, expression of psychosis liability at baseline did not significantly predict cannabis use 4 years later (adjusted odds ratio 1.42, 95% CI = 0.88-2.31).
20. Byrne M, Clafferty BA, Cosway R, et al. Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia. J Abnorm Psychol 2003; 112:38-48.
21. Verdoux H, Gindre C, Sorbara F, et al. Effects of cannabis and psychosis vulnerability in daily life: an experience sampling test study. Psychol Med 2003; 33:23-32. A most elegant study, making use of the so-called experience sampling method (ESM) - a structured diary momentary assessment method to measure experiences and exposures in the flow of daily life. No clinical individuals with high levels of psychosis proneness at baseline had more psychosis-like reactions to cannabis in the flow of daily life. The ESM method is very suitable to investigate the effects of drugs of abuse in daily life.
22. Chen CK, Lin SK, Sham PC, et al. Pre-morbid characteristics and comorbidity of methamphetamine users with and without psychosis. Psychol Med 2003; 33:1407-1414.
23. Van Os J. Does the urban environment cause psychosis? Br J Psychiatry 2004; 184:287-288.
24. Sundquist K, Frank G, Sundquist J. Urbanisation and incidence of psychosis and depression: follow-up study of 4.4 million women and men in Sweden. Br J Psychiatry 2004; 184:293-298.
25. Spauwen J, Krabbendam L, Lieb R, et al. Does urbanicity shift the population expression of psychosis? J Psychiatr Res 2004; 38:613-618.
26. Stefanis NC, Delespaul P, Smyrnis N, et al. Is the excess risk of psychosis-like experiences in urban areas attributable to altered cognitive development? Soc Psychiatry Psychiatr Epidemiol 2004; 39:364-368.
27. Harrison G, Fouskakis D, Rasmussen F, et al. Association between psychotic disorder and urban place of birth is not mediated by obstetric complications or childhood socio-economic position: a cohort study. Psychol Med 2003; 33:723-731.
28. Pedersen CB, Raaschou-Nielsen O, Hertel O, Mortensen PB. Air pollution from traffic and schizophrenia risk. Schizophr Res 2004; 66:83-85.
29. Van Os J, Hanssen M, Bak M, et al. Do urbanicity and familial liability coparticipate in causing psychosis? Am J Psychiatry 2003; 160:477-482.
30. Van Os J, Pedersen CB, Mortensen PB. Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. Am J Psychiatry 2004; 161:2312-2314. This study uses data from the Danish national case register, showing that the effect of the urban environment on later schizophrenia was synergistically increased if, additionally, there was a family history of schizophrenia in a first-degree relative.
31. Hutchinson G, Haasen C. Migration and schizophrenia: the challenges for European psychiatry and implications for the future. Soc Psychiatry Psychiatr Epidemiol 2004; 39:350-357.
32. Whaley AL, Geller PA. Ethnic/racial differences in psychiatric disorders: a test of four hypotheses. Ethn Dis 2003; 13:499-512.
33. Cantor-Graae E, Selten JP. Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry 2005; 162:12-24. This is an important and long-awaited meta-analysis of the relationship between schizophrenia and minority status. The authors propose the social defeat hypothesis as an underlying mechanism.
34. Bhugra D, Hutchinson G, Hilwig M, et al. Pregnancy and birth complications in patients with schizophrenia in Trinidad and London. West Indian Med J 2003; 52:124-126.
35. Janssen I, Hanssen M, Bak M, et al. Discrimination and delusional ideation. Br J Psychiatry 2003; 182:71-76.
36. Morrison AP, Frame L, Larkin W. Relationships between trauma and psychosis: a review and integration. Br J Clin Psychol 2003; 42:331-353.
37. Read J, Ross CA. Psychological trauma and psychosis: another reason why people diagnosed schizophrenic must be offered psychological therapies. J Am Acad Psychoanal Dyn Psychiatry 2003; 31:247-268.
38. Janssen I, Krabbendam L, Bak M, et al. Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatr Scand 2004; 109:38-45.
39. Spataro J, Mullen PE, Burgess PM, et al. Impact of child sexual abuse on mental health: prospective study in males and females. Br J Psychiatry 2004; 184:416-421.
40. Bebbington PE, Bhugra D, Brugha T, et al. Psychosis, victimisation and childhood disadvantage: evidence from the second British National Survey of Psychiatric Morbidity. Br J Psychiatry 2004; 185:220-226.
41. Smits L, Pedersen C, Mortensen P, van Os J. Association between short birth intervals and schizophrenia in the offspring. Schizophr Res 2004; 70:49-56.
42. Selten JP, Cantor-Graae E, Nahon D, et al. No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel. Schizophr Res 2003; 63:131-135.
43. Spauwen J, Krabbendam L, Lieb R, et al. Early maternal stress and health behaviours and offspring expression of psychosis in adolescence. Acta Psychiatr Scand 2004; 110:356-364.
44. Brown AS, Hooton J, Schaefer CA, et al. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry 2004; 161(5): 889-895.
45. Brown AS, Begg MD, Gravenstein S, et al. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 2004; 61(8):774-780.
46. Gunnell D, Rasmussen F, Fouskakis D, et al. Patterns of fetal and childhood growth and the development of psychosis in young males: a cohort study. Am J Epidemiol 2003; 158:291-300.
47. Mackay-Sim A, Feron F, Eyles D, et al. Schizophrenia, vitamin D, and brain development. Int Rev Neurobiol 2004; 59:351-380.
48. McGrath J, Eyles D, Mowry B, et al. Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera. Schizophr Res 2003; 63:73-78.
49. Birchwood M. Pathways to emotional dysfunction in first-episode psychosis. Br J Psychiatry 2003; 182:373-375.
50. Myin-Germeys I, Krabbendam L, Delespaul PA, van Os J. Do life events have their effect on psychosis by influencing the emotional reactivity to daily life stress? Psychol Med 2003; 33:327-333.
51. Myin-Germeys I, Krabbendam L, Delespaul P, van Os J. Can cognitive deficits explain differential sensitivity to life events in psychosis? Soc Psychiatry Psychiatr Epidemiol 2003; 38:262-268.
52. Freeman D, Garety PA. Connecting neurosis and psychosis: the direct influence of emotion on delusions and hallucinations. Behav Res Ther 2003; 41:923-947.
53. Verdoux H, Husky M, Tournier M, et al. Social environments and daily life occurrence of psychotic symptoms: an experience sampling test in a non-clinical population. Soc Psychiatry Psychiatr Epidemiol 2003; 38: 654-661.
54. Howes OD, McDonald C, Cannon M, et al. Pathways to schizophrenia: the impact of environmental factors. Int J Neuropsychopharmacol 2004; 7(Suppl 1):S7-S13.
55. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003; 160:13-23.
56. ••].
57. 1 respectively. These reports need to be replicated but are the first credible findings in psychiatry that the effects of environmental exposures are modified by actual functional polymorphisms.