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Volumn 38, Issue 13, 2013, Pages 2568-2577

Peripheral endocannabinoid system dysregulation in first-episode psychosis

Author keywords

biomarker; cannabis; endocannabinoid system; first episode of psychosis; schizophrenia

Indexed keywords

ACYLGLYCEROL LIPASE; ARIPIPRAZOLE; BIOLOGICAL MARKER; CANNABIS; CHLORPROMAZINE; CLOZAPINE; ENDOCANNABINOID; FATTY ACID AMIDASE; LIPOPROTEIN LIPASE; N ACYL PHOSPHATIDYLETHANOLAMINE PHOSPHOLIPASE; OLANZAPINE; PALIPERIDONE; PHOSPHOLIPASE; QUETIAPINE; RISPERIDONE; UNCLASSIFIED DRUG; ZIPRASIDONE;

EID: 84887989932     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.165     Document Type: Article
Times cited : (67)

References (65)
  • 1
    • 0037639116 scopus 로고    scopus 로고
    • Sex differences in the risk of schizophrenia: Evidence from meta-analysis
    • Aleman A, Kahn RS, Selten JP (2003). Sex differences in the risk of schizophrenia: evidence from meta-analysis. Arch Gen Psychiatry 60: 565-571.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 565-571
    • Aleman, A.1    Kahn, R.S.2    Selten, J.P.3
  • 3
    • 39149145495 scopus 로고    scopus 로고
    • Cannabis use and brain structural alterations in first episode schizophrenia - A region of interest, voxel based morphometric study
    • Bangalore SS, Prasad KM, Montrose DM, Goradia DD, Diwadkar VA, Keshavan MS (2008). Cannabis use and brain structural alterations in first episode schizophrenia-a region of interest, voxel based morphometric study. Schizophr Res 99: 1-6.
    • (2008) Schizophr Res , vol.99 , pp. 1-6
    • Bangalore, S.S.1    Prasad, K.M.2    Montrose, D.M.3    Goradia, D.D.4    Diwadkar, V.A.5    Keshavan, M.S.6
  • 6
    • 84859567021 scopus 로고    scopus 로고
    • Schizophrenia: From neurobiology to nosology of mental disorders
    • Bernardo M, Bioque M (2010). Schizophrenia: from neurobiology to nosology of mental disorders. Actas Esp Psiquiatr 38(Suppl 3): 15-17.
    • (2010) Actas Esp Psiquiatr , vol.38 , Issue.SUPPL. 3 , pp. 15-17
    • Bernardo, M.1    Bioque, M.2
  • 7
    • 84873300364 scopus 로고    scopus 로고
    • Assessing clinical and functional outcomes in a gene-environment interaction study in first episode of psychosis (PEPs)
    • Bernardo M, Bioque M, Parellada M, Saiz Ruiz J, Cuesta MJ, Llerena A et al (2013). Assessing clinical and functional outcomes in a gene-environment interaction study in first episode of psychosis (PEPs). Rev Psiquiatr Salud Ment 6: 4-16.
    • (2013) Rev Psiquiatr Salud Ment , vol.6 , pp. 4-16
    • Bernardo, M.1    Bioque, M.2    Parellada, M.3    Saiz Ruiz, J.4    Cuesta, M.J.5    Llerena, A.6
  • 8
    • 84868131884 scopus 로고    scopus 로고
    • The endocannabinoid system in normal and pathological brain ageing
    • Bilkei-Gorzo A (2012). The endocannabinoid system in normal and pathological brain ageing. Philos Trans R Soc Lond B Biol Sci 367: 3326-3341.
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 3326-3341
    • Bilkei-Gorzo, A.1
  • 9
    • 84856265805 scopus 로고    scopus 로고
    • Rimonabant for neurocognition in schizophrenia: A 16-week double blind randomized placebo controlled trial
    • Boggs DL, Kelly DL, McMahon RP, Gold JM, Gorelick DA, Linthicum J et al (2012). Rimonabant for neurocognition in schizophrenia: a 16-week double blind randomized placebo controlled trial. Schizophr Res 134: 207-210.
    • (2012) Schizophr Res , vol.134 , pp. 207-210
    • Boggs, D.L.1    Kelly, D.L.2    McMahon, R.P.3    Gold, J.M.4    Gorelick, D.A.5    Linthicum, J.6
  • 10
    • 20944446077 scopus 로고    scopus 로고
    • Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction
    • Caspi A, Moffitt TE, Cannon M, McClay J, Murray R, Harrington H et al (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 57: 1117-1127.
    • (2005) Biol Psychiatry , vol.57 , pp. 1117-1127
    • Caspi, A.1    Moffitt, T.E.2    Cannon, M.3    McClay, J.4    Murray, R.5    Harrington, H.6
  • 12
    • 52949125632 scopus 로고    scopus 로고
    • The endocanna-binoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases
    • Centonze D, Battistini L, Maccarrone M (2008). The endocanna-binoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases. Curr Pharm Des 14: 2370-2442.
    • (2008) Curr Pharm des , vol.14 , pp. 2370-2442
    • Centonze, D.1    Battistini, L.2    MacCarrone, M.3
  • 13
    • 78649924956 scopus 로고    scopus 로고
    • Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system
    • Chanda PK, Gao Y, Mark L, Btesh J, Strassle BW, Lu P et al (2010). Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol 78: 996-1003.
    • (2010) Mol Pharmacol , vol.78 , pp. 996-1003
    • Chanda, P.K.1    Gao, Y.2    Mark, L.3    Btesh, J.4    Strassle, B.W.5    Lu, P.6
  • 16
    • 84867130956 scopus 로고    scopus 로고
    • Plasma endocannabinoid alterations in individuals with substance use disorder are dependent on the Mirror Effect of schizophrenia
    • Desfosses J, Stip E, Bentaleb LA, Lipp O, Chiasson JP, Furtos A et al (2012). Plasma endocannabinoid alterations in individuals with substance use disorder are dependent on the "Mirror Effect" of schizophrenia. Front Psychiatry 3: 85.
    • (2012) Front Psychiatry , vol.3 , pp. 85
    • Desfosses, J.1    Stip, E.2    Bentaleb, L.A.3    Lipp, O.4    Chiasson, J.P.5    Furtos, A.6
  • 17
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocannabinoids are involved in maintaining food intake
    • Di Marzo V, Goparaju SK, Wang L, Liu J, Batkai S, Jarai Z et al (2001). Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410: 822-825.
    • (2001) Nature , vol.410 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3    Liu, J.4    Batkai, S.5    Jarai, Z.6
  • 18
    • 46849111394 scopus 로고    scopus 로고
    • Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia
    • Eggan SM, Hashimoto T, Lewis DA (2008). Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. Arch Gen Psychiatry 65: 772-784.
    • (2008) Arch Gen Psychiatry , vol.65 , pp. 772-784
    • Eggan, S.M.1    Hashimoto, T.2    Lewis, D.A.3
  • 19
    • 0016970988 scopus 로고
    • The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance
    • Endicott J, Spitzer RL, Fleiss JL, Cohen J (1976). The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry 33: 766-771.
    • (1976) Arch Gen Psychiatry , vol.33 , pp. 766-771
    • Endicott, J.1    Spitzer, R.L.2    Fleiss, J.L.3    Cohen, J.4
  • 21
    • 84889097583 scopus 로고    scopus 로고
    • Is there an association between peripheral immune markers and structural/functional neuro-imaging findings?
    • Frodl T, Amico F (2013). Is there an association between peripheral immune markers and structural/functional neuro-imaging findings? Prog Neuropsychopharmacol Biol Psychiatry (http://dx.doi.org/10.1016/j.pnpbp.2012.12. 013).
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry (
    • Frodl, T.1    Amico, F.2
  • 22
    • 84873112468 scopus 로고    scopus 로고
    • Stronger evidence is needed before accepting that cannabis plays an important role in the aetiology of schizophrenia in the population
    • Gage SH, Zammit S, Hickman M (2013). Stronger evidence is needed before accepting that cannabis plays an important role in the aetiology of schizophrenia in the population. F1000 Med Rep 5: 2.
    • (2013) F1000 Med Rep , vol.5 , pp. 2
    • Gage, S.H.1    Zammit, S.2    Hickman, M.3
  • 23
    • 84895756733 scopus 로고    scopus 로고
    • Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: Toward an integrative inflammatory hypothesis of schizophrenia
    • (e-pub ahead of print 13 March 2013)
    • Garcia-Bueno B, Bioque M, Mac-Dowell KS, Barcones MF, Martinez-Cengotitabengoa M, Pina-Camacho L et al (2013). Pro-/anti-inflammatory dysregulation in patients with first episode of psychosis: toward an integrative inflammatory hypothesis of schizophrenia. Schizophr Bull (e-pub ahead of print 13 March 2013).
    • (2013) Schizophr Bull
    • Garcia-Bueno, B.1    Bioque, M.2    Mac-Dowell, K.S.3    Barcones, M.F.4    Martinez-Cengotitabengoa, M.5    Pina-Camacho, L.6
  • 24
    • 84868159779 scopus 로고    scopus 로고
    • Inflammatory markers in antipsycho-tic-naive patients with nonaffective psychosis and deficit vs. Nondeficit features
    • Garcia-Rizo C, Fernandez-Egea E, Oliveira C, Justicia A, Bernardo M, Kirkpatrick B (2012). Inflammatory markers in antipsycho-tic-naive patients with nonaffective psychosis and deficit vs. nondeficit features. Psychiatry Res 198: 212-215.
    • (2012) Psychiatry Res , vol.198 , pp. 212-215
    • Garcia-Rizo, C.1    Fernandez-Egea, E.2    Oliveira, C.3    Justicia, A.4    Bernardo, M.5    Kirkpatrick, B.6
  • 26
    • 8444242207 scopus 로고    scopus 로고
    • Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms
    • Giuffrida A, Leweke FM, Gerth CW, Schreiber D, Koethe D, Faulhaber J et al (2004). Cerebrospinal anandamide levels are elevated in acute schizophrenia and are inversely correlated with psychotic symptoms. Neuropsychopharmacology 29: 2108-2114.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 2108-2114
    • Giuffrida, A.1    Leweke, F.M.2    Gerth, C.W.3    Schreiber, D.4    Koethe, D.5    Faulhaber, J.6
  • 28
    • 24344470642 scopus 로고    scopus 로고
    • The environment and schizophrenia: The role of cannabis use
    • Henquet C, Murray R, Linszen D, van Os J (2005). The environment and schizophrenia: the role of cannabis use. Schizophr Bull 31: 608-612.
    • (2005) Schizophr Bull , vol.31 , pp. 608-612
    • Henquet, C.1    Murray, R.2    Linszen, D.3    Van Os, J.4
  • 29
    • 84857125719 scopus 로고    scopus 로고
    • Contributions of endocannabinoid signaling to psychiatric disorders in humans: Genetic and biochemical evidence
    • Hillard CJ, Weinlander KM, Stuhr KL (2012). Contributions of endocannabinoid signaling to psychiatric disorders in humans: genetic and biochemical evidence. Neuroscience 204: 207-229.
    • (2012) Neuroscience , vol.204 , pp. 207-229
    • Hillard, C.J.1    Weinlander, K.M.2    Stuhr, K.L.3
  • 30
    • 79955473886 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia
    • Ho BC, Wassink TH, Ziebell S, Andreasen NC (2011). Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res 128: 66-75.
    • (2011) Schizophr Res , vol.128 , pp. 66-75
    • Ho, B.C.1    Wassink, T.H.2    Ziebell, S.3    Andreasen, N.C.4
  • 32
  • 33
    • 78149428430 scopus 로고    scopus 로고
    • Rethinking schizophrenia
    • Insel TR (2010). Rethinking schizophrenia. Nature 468: 187-193.
    • (2010) Nature , vol.468 , pp. 187-193
    • Insel, T.R.1
  • 35
    • 40949142200 scopus 로고    scopus 로고
    • Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: An open randomised clinical trial
    • Kahn RS, Fleischhacker WW, Boter H, Davidson M, Vergouwe Y, Keet IP et al (2008). Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet 371: 1085-1097.
    • (2008) Lancet , vol.371 , pp. 1085-1097
    • Kahn, R.S.1    Fleischhacker, W.W.2    Boter, H.3    Davidson, M.4    Vergouwe, Y.5    Keet, I.P.6
  • 36
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay SR, Fiszbein A, Opler LA (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 13: 261-276.
    • (1987) Schizophr Bull , vol.13 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 37
  • 40
    • 0000262577 scopus 로고
    • EuropASI: European adaptation of a multidimensional assessment instrument for drug and alcohol dependence
    • Kokkevi A, Hartgers C (1995). EuropASI: European adaptation of a multidimensional assessment instrument for drug and alcohol dependence. Eur Addict Res 1: 208-210.
    • (1995) Eur Addict Res , vol.1 , pp. 208-210
    • Kokkevi, A.1    Hartgers, C.2
  • 41
    • 78650154703 scopus 로고    scopus 로고
    • Rate of cannabis use disorders in clinical samples of patients with schizophrenia: A meta-analysis
    • Koskinen J, Lohonen J, Koponen H, Isohanni M, Miettunen J (2009). Rate of cannabis use disorders in clinical samples of patients with schizophrenia: a meta-analysis. Schizophr Bull 36: 1115-1130.
    • (2009) Schizophr Bull , vol.36 , pp. 1115-1130
    • Koskinen, J.1    Lohonen, J.2    Koponen, H.3    Isohanni, M.4    Miettunen, J.5
  • 42
    • 84874657739 scopus 로고    scopus 로고
    • Brain regional differences in CB1 receptor adaptation and regulation of transcription
    • Lazenka MF, Selley DE, Sim-Selley LJ (2012). Brain regional differences in CB1 receptor adaptation and regulation of transcription. Life Sci 92: 446-452.
    • (2012) Life Sci , vol.92 , pp. 446-452
    • Lazenka, M.F.1    Selley, D.E.2    Sim-Selley, L.J.3
  • 43
    • 1942473118 scopus 로고    scopus 로고
    • Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle
    • Lazzarin N, Valensise H, Bari M, Ubaldi F, Battista N, Finazzi-Agro A et al (2004). Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle. Gynecol Endocrinol 18: 212-218.
    • (2004) Gynecol Endocrinol , vol.18 , pp. 212-218
    • Lazzarin, N.1    Valensise, H.2    Bari, M.3    Ubaldi, F.4    Battista, N.5    Finazzi-Agro, A.6
  • 44
    • 34447106643 scopus 로고    scopus 로고
    • Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: Impact of cannabis use
    • Leweke FM, Giuffrida A, Koethe D, Schreiber D, Nolden BM, Kranaster L et al (2007). Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. Schizophr Res 94: 29-36.
    • (2007) Schizophr Res , vol.94 , pp. 29-36
    • Leweke, F.M.1    Giuffrida, A.2    Koethe, D.3    Schreiber, D.4    Nolden, B.M.5    Kranaster, L.6
  • 47
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • McGeer PL, Itagaki S, Akiyama H, McGeer EG (1988). Rate of cell death in parkinsonism indicates active neuropathological process. Ann Neurol 24: 574-576.
    • (1988) Ann Neurol , vol.24 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    McGeer, E.G.4
  • 48
    • 4243057297 scopus 로고    scopus 로고
    • A systematic review of the incidence of schizophrenia: The distribution of rates and the influence of sex, urbanicity, migrant status and methodology
    • McGrath J, Saha S, Welham J, El Saadi O, MacCauley C, Chant D (2004). A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2: 13.
    • (2004) BMC Med , vol.2 , pp. 13
    • McGrath, J.1    Saha, S.2    Welham, J.3    El Saadi, O.4    MacCauley, C.5    Chant, D.6
  • 49
    • 79960608289 scopus 로고    scopus 로고
    • Inflammatory processes in schizophrenia: A promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond
    • Meyer U, Schwarz MJ, Muller N (2011). Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond. Pharmacol Ther 132: 96-110.
    • (2011) Pharmacol Ther , vol.132 , pp. 96-110
    • Meyer, U.1    Schwarz, M.J.2    Muller, N.3
  • 50
    • 0018425438 scopus 로고
    • A new depression scale designed to be sensitive to change
    • Montgomery SA, Asberg M (1979). A new depression scale designed to be sensitive to change. Br J Psychiatry 134: 382-389.
    • (1979) Br J Psychiatry , vol.134 , pp. 382-389
    • Montgomery, S.A.1    Asberg, M.2
  • 51
    • 34447619511 scopus 로고    scopus 로고
    • Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review
    • Moore TH, Zammit S, Lingford-Hughes A, Barnes TR, Jones PB, Burke M et al (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370: 319-328.
    • (2007) Lancet , vol.370 , pp. 319-328
    • Moore, T.H.1    Zammit, S.2    Lingford-Hughes, A.3    Barnes, T.R.4    Jones, P.B.5    Burke, M.6
  • 52
    • 0036270406 scopus 로고    scopus 로고
    • Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers
    • Nong L, Newton C, Cheng Q, Friedman H, Roth MD, Klein TW (2002). Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J Neuroimmunol 127: 169-176.
    • (2002) J Neuroimmunol , vol.127 , pp. 169-176
    • Nong, L.1    Newton, C.2    Cheng, Q.3    Friedman, H.4    Roth, M.D.5    Klein, T.W.6
  • 54
    • 33846585119 scopus 로고    scopus 로고
    • Systemic infections and inflammation affect chronic neurodegeneration
    • Perry VH, Cunningham C, Holmes C (2007). Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol 7: 161-167.
    • (2007) Nat Rev Immunol , vol.7 , pp. 161-167
    • Perry, V.H.1    Cunningham, C.2    Holmes, C.3
  • 57
    • 77952882862 scopus 로고    scopus 로고
    • Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats
    • Seillier A, Advani T, Cassano T, Hensler JG, Giuffrida A (2010). Inhibition of fatty-acid amide hydrolase and CB1 receptor antagonism differentially affect behavioural responses in normal and PCP-treated rats. Int J Neuropsychopharmacol 13: 373-386.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 373-386
    • Seillier, A.1    Advani, T.2    Cassano, T.3    Hensler, J.G.4    Giuffrida, A.5
  • 60
    • 84860152544 scopus 로고    scopus 로고
    • Toxoplasma gondii and other risk factors for schizophrenia: An update
    • Torrey EF, Bartko JJ, Yolken RH (2012). Toxoplasma gondii and other risk factors for schizophrenia: an update. Schizophr Bull 38: 642-647.
    • (2012) Schizophr Bull , vol.38 , pp. 642-647
    • Torrey, E.F.1    Bartko, J.J.2    Yolken, R.H.3
  • 61
    • 65349174015 scopus 로고    scopus 로고
    • Substance use disorders in schizophrenia-clinical implications of comorbidity
    • Volkow ND (2009). Substance use disorders in schizophrenia-clinical implications of comorbidity. Schizophr Bull 35: 469-472.
    • (2009) Schizophr Bull , vol.35 , pp. 469-472
    • Volkow, N.D.1
  • 62
    • 52949090419 scopus 로고    scopus 로고
    • CNS immune surveillance and neuroinflammation: Endocannabinoids keep control
    • Wolf SA, Tauber S, Ullrich O (2008). CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Curr Pharm Des 14: 2266-2278.
    • (2008) Curr Pharm des , vol.14 , pp. 2266-2278
    • Wolf, S.A.1    Tauber, S.2    Ullrich, O.3
  • 63
    • 0018175277 scopus 로고
    • A rating scale for mania: Reliability, validity and sensitivity
    • Young RC, Biggs JT, Ziegler VE, Meyer DA (1978). A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133: 429-435.
    • (1978) Br J Psychiatry , vol.133 , pp. 429-435
    • Young, R.C.1    Biggs, J.T.2    Ziegler, V.E.3    Meyer, D.A.4
  • 64
    • 84873411255 scopus 로고    scopus 로고
    • The endocannabinoid system and schizophrenia: Integration of evidence
    • Zamberletti E, Rubino T, Parolaro D (2012). The endocannabinoid system and schizophrenia: integration of evidence. Curr Pharm Des 18: 4980-4990.
    • (2012) Curr Pharm des , vol.18 , pp. 4980-4990
    • Zamberletti, E.1    Rubino, T.2    Parolaro, D.3


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