메뉴 건너뛰기




Volumn 30, Issue 4, 2010, Pages 1270-1287

A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; NUCLEAR RECEPTOR RELATED FACTOR 1; POLYINOSINIC POLYCYTIDYLIC ACID;

EID: 75349096497     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5408-09.2010     Document Type: Article
Times cited : (189)

References (50)
  • 1
    • 0017753875 scopus 로고
    • Correlation between tyrosine hydroxylase activity and catecholamine concentration or turnover in brain regions
    • Bacopoulos NG, Bhatnagar RK (1977) Correlation between tyrosine hydroxylase activity and catecholamine concentration or turnover in brain regions. J Neurochem 29:639-643.
    • (1977) J Neurochem , vol.29 , pp. 639-643
    • Bacopoulos, N.G.1    Bhatnagar, R.K.2
  • 2
    • 0029114373 scopus 로고
    • Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse
    • Bayer SA, Wills KV, Triarhou LC, Ghetti B (1995) Time of neuron origin and gradients of neurogenesis in midbrain dopaminergic neurons in the mouse. Exp Brain Res 105:191-199.
    • (1995) Exp Brain Res , vol.105 , pp. 191-199
    • Bayer, S.A.1    Wills, K.V.2    Triarhou, L.C.3    Ghetti, B.4
  • 3
    • 0036150201 scopus 로고    scopus 로고
    • Prenatal immune challenge disrupts sensorimotor gating in adult rats: Implications for the etiopathogenesis of schizophrenia
    • Borrell J, Vela JM, Arévalo-Martin A, Molina-Holgado E, Guaza C (2002) Prenatal immune challenge disrupts sensorimotor gating in adult rats: implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology 6:204-221.
    • (2002) Neuropsychopharmacology , vol.6 , pp. 204-221
    • Borrell, J.1    Vela, J.M.2    Arévalo-Martin, A.3    Molina-Holgado, E.4    Guaza, C.5
  • 4
    • 0034891977 scopus 로고    scopus 로고
    • Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies
    • Braff DL, Geyer MA, Swerdlow NR (2001) Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology 156:234-258.
    • (2001) Psychopharmacology , vol.156 , pp. 234-258
    • Braff, D.L.1    Geyer, M.A.2    Swerdlow, N.R.3
  • 5
    • 33645217100 scopus 로고    scopus 로고
    • Prenatal infection as a risk factor for schizophrenia
    • Brown AS (2006) Prenatal infection as a risk factor for schizophrenia. Schizophr Bull 32:200-202.
    • (2006) Schizophr Bull , vol.32 , pp. 200-202
    • Brown, A.S.1
  • 6
    • 77950023382 scopus 로고    scopus 로고
    • Dysregulation of kisspeptin and neurogenesis at adolescence link inborn immune deficits to the late onset of abnormal sensorimotor gating in congenital psychological disorders
    • in press
    • Cardon M, Ron-Harel N, Cohen H, Lewitus GM, Schwartz M (2009) Dysregulation of kisspeptin and neurogenesis at adolescence link inborn immune deficits to the late onset of abnormal sensorimotor gating in congenital psychological disorders. Mol Psychiatry, in press.
    • (2009) Mol Psychiatry
    • Cardon, M.1    Ron-Harel, N.2    Cohen, H.3    Lewitus, G.M.4    Schwartz, M.5
  • 7
    • 0035898287 scopus 로고    scopus 로고
    • Translating developmental time across mammalian species
    • Clancy B, Darlington RB, Finlay BL (2001) Translating developmental time across mammalian species. Neuroscience 105:7-17.
    • (2001) Neuroscience , vol.105 , pp. 7-17
    • Clancy, B.1    Darlington, R.B.2    Finlay, B.L.3
  • 10
    • 1542315608 scopus 로고    scopus 로고
    • Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring
    • Fortier ME, Joober R, Luheshi GN, Boksa P (2004) Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring. J Psychiatr Res 38:335-345.
    • (2004) J Psychiatr Res , vol.38 , pp. 335-345
    • Fortier, M.E.1    Joober, R.2    Luheshi, G.N.3    Boksa, P.4
  • 12
    • 0031564577 scopus 로고    scopus 로고
    • Exposure to infection and brain development: Cytokines in the pathogenesis of schizophrenia
    • Gilmore JH, Jarskog LF (1997) Exposure to infection and brain development: cytokines in the pathogenesis of schizophrenia. Schizophr Res 24:365-367.
    • (1997) Schizophr Res , vol.24 , pp. 365-367
    • Gilmore, J.H.1    Jarskog, L.F.2
  • 13
    • 0030071106 scopus 로고    scopus 로고
    • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
    • Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606-612.
    • (1996) Nature , vol.379 , pp. 606-612
    • Giros, B.1    Jaber, M.2    Jones, S.R.3    Wightman, R.M.4    Caron, M.G.5
  • 17
    • 65349120160 scopus 로고    scopus 로고
    • The dopamine hypothesis of schizophrenia: Version III-the final common pathway
    • Howes OD, Kapur S (2009) The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr Bull 35:549-562.
    • (2009) Schizophr Bull , vol.35 , pp. 549-562
    • Howes, O.D.1    Kapur, S.2
  • 18
    • 37249083413 scopus 로고    scopus 로고
    • Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis
    • Howes OD, Montgomery AJ, Asselin MC, Murray RM, Grasby PM, McGuire PK (2007) Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis. Br J Psychiatry 51:s13-18.
    • (2007) Br J Psychiatry , vol.51
    • Howes, O.D.1    Montgomery, A.J.2    Asselin, M.C.3    Murray, R.M.4    Grasby, P.M.5    McGuire, P.K.6
  • 19
    • 0032966607 scopus 로고    scopus 로고
    • Specification of dopaminergic and serotonergic neurons in the vertebrate CNS
    • Hynes M, Rosenthal A (1999) Specification of dopaminergic and serotonergic neurons in the vertebrate CNS. Curr Opin Neurobiol 9:26-36.
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 26-36
    • Hynes, M.1    Rosenthal, A.2
  • 20
    • 3242671794 scopus 로고    scopus 로고
    • Sex-specific, postpuberty changes in mouse brain structures revealed by three-dimensional magnetic resonance microscopy
    • Koshibu K, Levitt P, Ahrens ET (2004) Sex-specific, postpuberty changes in mouse brain structures revealed by three-dimensional magnetic resonance microscopy. Neuroimage 22:1636-1645.
    • (2004) Neuroimage , vol.22 , pp. 1636-1645
    • Koshibu, K.1    Levitt, P.2    Ahrens, E.T.3
  • 21
    • 0031791214 scopus 로고    scopus 로고
    • Imaging dopamine transmission in schizophrenia. A review and meta-analysis
    • Laruelle M (1998) Imaging dopamine transmission in schizophrenia. A review and meta-analysis. Q J Nucl Med 42:211-221.
    • (1998) Q J Nucl Med , vol.42 , pp. 211-221
    • Laruelle, M.1
  • 22
    • 0032987267 scopus 로고    scopus 로고
    • Increased dopamine transmission in schizophrenia: Relationship to illness phases
    • Laruelle M, Abi-Dargham A, Gil R, Kegeles L, Innis R (1999) Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol Psychiatry 46:56-72.
    • (1999) Biol Psychiatry , vol.46 , pp. 56-72
    • Laruelle, M.1    Abi-Dargham, A.2    Gil, R.3    Kegeles, L.4    Innis, R.5
  • 23
    • 0032852641 scopus 로고    scopus 로고
    • Neurotransmitter transporters in the central nervous system
    • Masson J, Sagné C, Hamon M, El Mestikawy S (1999) Neurotransmitter transporters in the central nervous system. Pharmacol Rev 51:439-464.
    • (1999) Pharmacol Rev , vol.51 , pp. 439-464
    • Masson, J.1    Sagné, C.2    Hamon, M.3    El Mestikawy, S.4
  • 24
    • 70349652131 scopus 로고    scopus 로고
    • Prenatal exposure to infection: A primary mechanism for abnormal dopaminergic development in schizophrenia
    • Meyer U, Feldon J (2009) Prenatal exposure to infection: a primary mechanism for abnormal dopaminergic development in schizophrenia. Psychopharmacology 206:587-602.
    • (2009) Psychopharmacology , vol.206 , pp. 587-602
    • Meyer, U.1    Feldon, J.2
  • 25
    • 23244437953 scopus 로고    scopus 로고
    • Towards an immunoprecipitated neurodevelopmental animal model of schizophrenia
    • Meyer U, Feldon J, Schedlowski M, Yee BK (2005) Towards an immunoprecipitated neurodevelopmental animal model of schizophrenia. Neurosci Biobehav Rev 29:913-947.
    • (2005) Neurosci Biobehav Rev , vol.29 , pp. 913-947
    • Meyer, U.1    Feldon, J.2    Schedlowski, M.3    Yee, B.K.4
  • 26
    • 33646926705 scopus 로고    scopus 로고
    • The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology
    • Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I, Yee BK, Feldon J (2006) The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci 26:4752-4762.
    • (2006) J Neurosci , vol.26 , pp. 4752-4762
    • Meyer, U.1    Nyffeler, M.2    Engler, A.3    Urwyler, A.4    Schedlowski, M.5    Knuesel, I.6    Yee, B.K.7    Feldon, J.8
  • 27
    • 34249021752 scopus 로고    scopus 로고
    • The neurodevelopmental impact of prenatal infections at different times of pregnancy: The earlier the worse?
    • Meyer U, Yee BK, Feldon J (2007) The neurodevelopmental impact of prenatal infections at different times of pregnancy: the earlier the worse? Neuroscientist 13:241-256.
    • (2007) Neuroscientist , vol.13 , pp. 241-256
    • Meyer, U.1    Yee, B.K.2    Feldon, J.3
  • 28
    • 46549087172 scopus 로고    scopus 로고
    • Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy
    • Meyer U, Engler A, Weber L, Schedlowski M, Feldon J (2008a) Preliminary evidence for a modulation of fetal dopaminergic development by maternal immune activation during pregnancy. Neuroscience 154:701-709.
    • (2008) Neuroscience , vol.154 , pp. 701-709
    • Meyer, U.1    Engler, A.2    Weber, L.3    Schedlowski, M.4    Feldon, J.5
  • 29
    • 36949028725 scopus 로고    scopus 로고
    • Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge
    • Meyer U, Nyffeler M, Schwendener S, Knuesel I, Yee BK, Feldon J (2008b) Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge. Neuropsychopharmacology 33:441-456.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 441-456
    • Meyer, U.1    Nyffeler, M.2    Schwendener, S.3    Knuesel, I.4    Yee, B.K.5    Feldon, J.6
  • 30
    • 67649464224 scopus 로고    scopus 로고
    • In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders
    • Meyer U, Feldon J, Fatemi SH (2009a) In-vivo rodent models for the experimental investigation of prenatal immune activation effects in neurodevelopmental brain disorders. Neurosci Biobehav Rev 33:1061-1079.
    • (2009) Neurosci Biobehav Rev , vol.33 , pp. 1061-1079
    • Meyer, U.1    Feldon, J.2    Fatemi, S.H.3
  • 31
    • 69249107681 scopus 로고    scopus 로고
    • A review of the fetal brain cytokine imbalance hypothesis of schizophrenia
    • Meyer U, Feldon J, Yee BK (2009b) A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. Schizophr Bull 35:959-972.
    • (2009) Schizophr Bull , vol.35 , pp. 959-972
    • Meyer, U.1    Feldon, J.2    Yee, B.K.3
  • 32
    • 50049107823 scopus 로고    scopus 로고
    • Schizophrenia: From developmental deviance to dopamine dysregulation
    • Murray RM, Lappin J, Di Forti M (2008) Schizophrenia: from developmental deviance to dopamine dysregulation. Eur Neuropsychopharmacol 18:S129-134.
    • (2008) Eur Neuropsychopharmacol , vol.18
    • Murray, R.M.1    Lappin, J.2    Di Forti, M.3
  • 34
    • 33644610741 scopus 로고    scopus 로고
    • Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: A neurodevelopmental animal model of schizophrenia
    • Ozawa K, Hashimoto K, Kishimoto T, Shimizu E, Ishikura H, Iyo M (2006) Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry 59:546-554.
    • (2006) Biol Psychiatry , vol.59 , pp. 546-554
    • Ozawa, K.1    Hashimoto, K.2    Kishimoto, T.3    Shimizu, E.4    Ishikura, H.5    Iyo, M.6
  • 35
    • 67749114055 scopus 로고    scopus 로고
    • Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
    • Patterson PH (2009) Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 204:313-321.
    • (2009) Behav Brain Res , vol.204 , pp. 313-321
    • Patterson, P.H.1
  • 37
    • 0035143189 scopus 로고    scopus 로고
    • Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: Differential effects of D1 and D2 receptor antagonists
    • Ralph RJ, Paulus MP, Fumagalli F, Caron MG, Geyer MA (2001) Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J Neurosci 21:305-313.
    • (2001) J Neurosci , vol.21 , pp. 305-313
    • Ralph, R.J.1    Paulus, M.P.2    Fumagalli, F.3    Caron, M.G.4    Geyer, M.A.5
  • 38
    • 0037208934 scopus 로고    scopus 로고
    • Dopamine D1 rather than D2 receptor agonists disrupt prepulse inhibition of startle in mice
    • Ralph-Williams RJ, Lehmann-Masten V, Geyer MA (2003) Dopamine D1 rather than D2 receptor agonists disrupt prepulse inhibition of startle in mice. Neuropsychopharmacology 28:108-118.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 108-118
    • Ralph-Williams, R.J.1    Lehmann-Masten, V.2    Geyer, M.A.3
  • 39
    • 66149130688 scopus 로고    scopus 로고
    • Dopaminergic synapses in the caudate of subjects with schizophrenia: Relationship to treatment response
    • Roberts RC, Roche JK, Conley RR, Lahti AC (2009) Dopaminergic synapses in the caudate of subjects with schizophrenia: relationship to treatment response. Synapse 63:520-530.
    • (2009) Synapse , vol.63 , pp. 520-530
    • Roberts, R.C.1    Roche, J.K.2    Conley, R.R.3    Lahti, A.C.4
  • 40
    • 53149084959 scopus 로고    scopus 로고
    • Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: Implications for the etiopathology of schizophrenia
    • in press
    • Romero E, Guaza C, Castellano B, Borrell J (2008) Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia. Mol Psychiatry, in press.
    • (2008) Mol Psychiatry
    • Romero, E.1    Guaza, C.2    Castellano, B.3    Borrell, J.4
  • 42
    • 0037218688 scopus 로고    scopus 로고
    • Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
    • Shi L, Fatemi SH, Sidwell RW, Patterson PH (2003) Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci 23:297-302.
    • (2003) J Neurosci , vol.23 , pp. 297-302
    • Shi, L.1    Fatemi, S.H.2    Sidwell, R.W.3    Patterson, P.H.4
  • 43
    • 67349167781 scopus 로고    scopus 로고
    • Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour
    • Singer P, Feldon J, Yee BK (2009) Interactions between the glycine transporter 1(GlyT1) inhibitor SSR504734 and psychoactive drugs in mouse motor behaviour. Eur Neuropsychopharmacol 19:571-580.
    • (2009) Eur Neuropsychopharmacol , vol.19 , pp. 571-580
    • Singer, P.1    Feldon, J.2    Yee, B.K.3
  • 44
    • 33845746199 scopus 로고    scopus 로고
    • How to make a mesodiencephalic dopaminergic neuron
    • Smidt MP, Burbach JP (2007) How to make a mesodiencephalic dopaminergic neuron. Nat Rev Neurosci 8:21-32.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 21-32
    • Smidt, M.P.1    Burbach, J.P.2
  • 45
    • 0034056125 scopus 로고    scopus 로고
    • The adolescent brain and age-related behavioral manifestations
    • Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463.
    • (2000) Neurosci Biobehav Rev , vol.24 , pp. 417-463
    • Spear, L.P.1
  • 48
    • 0842308159 scopus 로고    scopus 로고
    • Apomorphine-induced prepulse inhibition disruption is associated with a paradoxical enhancement of prepulse stimulus reactivity
    • Yee BK, Russig H, Feldon J (2004) Apomorphine-induced prepulse inhibition disruption is associated with a paradoxical enhancement of prepulse stimulus reactivity. Neuropsychopharmacology 29:240-248.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 240-248
    • Yee, B.K.1    Russig, H.2    Feldon, J.3
  • 50
    • 0642369566 scopus 로고    scopus 로고
    • Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: A novel neurodevelopmental model of schizophrenia
    • Zuckerman L, Rehavi M, Nachman R, Weiner I (2003) Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. Neuropsychopharmacology 28:1778-1789.
    • (2003) Neuropsychopharmacology , vol.28 , pp. 1778-1789
    • Zuckerman, L.1    Rehavi, M.2    Nachman, R.3    Weiner, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.