Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes

Journal of NeuroImmune Pharmacology

Volumn 3, Issue 1, 2008, Pages 35-42

  Agudelo, Marisela ^a   Newton, Cathy ^a   Widen, Ray ^a   Sherwood, Tracy ^a   Nong, Liang ^a   Friedman, Herman ^a   Klein, Thomas W ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

B lymphocytes; Cannabinoids; CB 2; IL 4; Immunoglobulin class switching

Indexed keywords

3 (2 HYDROXY 4 (1,1 DIMETHYLHEPTYL)PHENYL) 4 (3 HYDROXYPROPYL)CYCLOHEXANOL; 3-(2-HYDROXY-4-(1,1-DIMETHYLHEPTYL)PHENYL)-4-(3-HYDROXYPROPYL)CYCLOHEXANOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; BORNANE DERIVATIVE; CANNABINOID; CANNABINOID 2 RECEPTOR; CYCLOHEXANOL DERIVATIVE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN M; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; RIMONABANT; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; B LYMPHOCYTE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE REARRANGEMENT; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOUSE; PHYSIOLOGY; TH2 CELL;

ANIMALS; B-LYMPHOCYTES; BORNANES; CANNABINOIDS; CYCLOHEXANOLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN E; IMMUNOGLOBULIN M; MICE; PIPERIDINES; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; TH2 CELLS;

EID: 38949203366     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-007-9088-9     Document Type: Article

References (16)

1. Braun MC, Kelsall BL (2001) Regulation of interleukin-12 production by G-protein-coupled receptors. Microbes Infect 3:99-107
2. Carayon P, Marchand J, Dussossoy D, Derocq JM, Jbilo O, Bord A, Bouaboula M, Galiegue S, Mondiere P, Penarier G, LeFur G, Defrance T, Casellas P (1998) Modulation and functional involvement of CB2 peripheral cannabinoid receptors during B-cell differentiation. Blood 92:3605-3615
3. Galieque S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, Le Fur G, Casellas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232:54-61
4. Kaminski N, Koh WS, Yang KH, Lee M, Kessler FK (1994) Suppression of the humoral immune response by cannabinoids is partially mediated through inhibition of adenylate cyclase by a pertussis toxin-sensitive G-protein coupled mechanism. Biochem Pharmacol 48:1899-1908
5. Klein TW (2005) Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 5:400-411
6. Klein TW, Cabral GA (2006) Cannabinoid-induced immune suppression and modulation of antigen-presenting cells. J Neuroimmune Pharmacol 1:50-64
7. Klein TW, Newton C, Larsen K, Lu L, Perkins I, Nong L, Friedman H (2003) The cannabinoid system and immune modulation. J Leukoc Biol 74:486-496
8. Lee SF, Newton C, Widen R, Friedman H, Klein TW (2001) Differential expression of cannabinoid CB2 receptor mRNA in mouse immune cell subpopulations and following B cell stimulation. Eur J Pharmacol 423:235-241
9. Lu T, Newton C, Perkins I, Friedman H, Klein TW (2006) Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. J Pharmacol Exp Ther 319:269-276. Epub 2006 Jul 2012
10. Newton CA, Klein TW, Friedman H (1994) Secondary immunity to Legionella pneumophila and Th1 activity are suppressed by delta-9-tetrahydrocannabinol injection. Infect Immun 62:4015-4020
11. Pertwee RG (2006) Cannabinoid pharmacology: the first 66 years. Br J Pharmacol 147:S163-171
12. Roper RL, Brown DM, Phipps RP (1995) Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol 154:162-170
13. Rush JS, Hasbold J, Hodgkin PD (2002) Cross-linking surface Ig delays CD40 ligand- and IL-4-induced B cell Ig class switching and reveals evidence for independent regulation of B cell proliferation and differentiation. J Immunol 168:2676-2682
14. Schroder AJ, Pavlidis P, Arimura A, Capece D, Rothman PB (2002) Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes. J Immunol 168:996-1000
15. Takeda K, Tanaka T, Shi W, Matsumoto M, Minami M, Kashiwamura S, Nakanishi K, Yoshida N, Kishimoto T, Akira S (1996) Essential role of Stat6 in IL-4 signalling. Nature 380:627-630
16. Takhar P, Smurthwaite L, Coker HA, Fear DJ, Banfield GK, Carr VA, Durham SR, Gould HJ (2005) Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis. J Immunol 174:5024-5032