δ8-Tetrahydrocannabinol induces cytotoxicity in macrophage J774-1 cells: Involvement of cannabinoid receptor 2 and p38 MAPK

Toxicology

Volumn 314, Issue 2-3, 2013, Pages 254-261

  Yamaori, Satoshi ^a,c   Ishii, Hirosuke ^a   Chiba, Kenzo ^a   Yamamoto, Ikuo ^b   Watanabe, Kazuhito ^a  

^a HOKURIKU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^c SHINSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

CB2 receptor; Cytotoxicity; JNK; Macrophage; P38 MAPK; Tetrahydrocannabinol

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ALPHA TOCOPHEROL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CANNABINOID 2 RECEPTOR; DELTA8 TETRAHYDROCANNABINOL; MITOGEN ACTIVATED PROTEIN KINASE P38; PERTUSSIS TOXIN; STRESS ACTIVATED PROTEIN KINASE; DRONABINOL; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; DIMETHYL SULFOXIDE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; TETRAHYDROCANNABINOL;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL SWELLING; CELL VACUOLE; CHROMATIN CONDENSATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; FRAGMENTATION REACTION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; TOXICITY; 3-(4,5-DIMETHYL-2-THIAZOLYL)-2,5-DIPHENYL-2H-TETRAZOLIUM BROMIDE; C-JUN N-TERMINAL KINASE; CB(2) RECEPTOR; DRUG ANTAGONISM; DRUG EFFECT; JNK; MAPK; MITOGEN-ACTIVATED PROTEIN KINASE; MTT; P38 MAPK; PBS; PCR; PHOSPHATE-BUFFERED SALINE; POLYMERASE CHAIN REACTION; ROS; THC;

ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRONABINOL; ENZYME INHIBITORS; IMIDAZOLES; MACROPHAGES; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RECEPTOR, CANNABINOID, CB2;

3-(4,5-DIMETHYL-2-THIAZOLYL)-2,5-DIPHENYL-2H-TETRAZOLIUM BROMIDE; C-JUN N-TERMINAL KINASE; CB(2) RECEPTOR; CYTOTOXICITY; DIMETHYL SULFOXIDE; DMSO; JNK; LACTATE DEHYDROGENASE; LDH; MACROPHAGE; MAPK; MITOGEN-ACTIVATED PROTEIN KINASE; MTT; P38 MAPK; PBS; PCR; PHOSPHATE-BUFFERED SALINE; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; ROS; TETRAHYDROCANNABINOL; THC;

EID: 84888062313     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.10.007     Document Type: Article

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