Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 304, Issue 2, 2013, Pages

  Michler, Thomas ^a   Storr, Martin ^a   Kramer, Johannes ^a   Ochs, Stefanie ^a   Malo, Antje ^a   Reu, Simone ^a   Göke, Burkhard ^a   Schäfer, Claus ^a,b  

^a UNIVERSITY OF MUNICH   (Germany)

^b Klinikum Neumarkt   (Germany)

Author keywords

Cannabinoids; CB2; Experimental pancreatitis; MK2; P38

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; AMYLASE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DEXANABINOL; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; STRESS ACTIVATED PROTEIN KINASE; TRYPSINOGEN;

ACUTE PANCREATITIS; AMYLASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ATTENUATION; CELL LYSATE; CONTROLLED STUDY; DISEASE SEVERITY; EDEMA; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; UPREGULATION; WESTERN BLOTTING;

AMYLASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; BLOTTING, WESTERN; CAERULEIN; CANNABINOIDS; DISEASE MODELS, ANIMAL; EDEMA; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANCREAS, EXOCRINE; PANCREATITIS; PEROXIDASE; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; TETRAHYDROCANNABINOL; TRYPSINOGEN;

EID: 84872387809     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00133.2012     Document Type: Article

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