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Volumn 76, Issue 6, 2008, Pages 726-737

The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT)

Author keywords

AP 1; Cannabinoid; Interferon gamma; Interleukin 2; NFAT

Indexed keywords

CALCIUM IONOPHORE; CANNABIDIOL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID DERIVATIVE; CANNABIS; CORN OIL; GAMMA INTERFERON; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; PHORBOL ESTER; TETRAHYDROCANNABINOL; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

EID: 50549105058     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.06.022     Document Type: Article
Times cited : (104)

References (43)
  • 1
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Gaoni Y., and Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 86 8 (1964) 1646-1647
    • (1964) J Am Chem Soc , vol.86 , Issue.8 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 2
  • 3
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S., Thomas K.L., and Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature (London) 365 (1993) 61-65
    • (1993) Nature (London) , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 4
    • 0031593692 scopus 로고    scopus 로고
    • Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells
    • Srivastava M.D., Srivastava B.I., and Brouhard B. Delta9 tetrahydrocannabinol and cannabidiol alter cytokine production by human immune cells. Immunopharmacology 40 3 (1998) 179-185
    • (1998) Immunopharmacology , vol.40 , Issue.3 , pp. 179-185
    • Srivastava, M.D.1    Srivastava, B.I.2    Brouhard, B.3
  • 5
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait A.M., Gallily R., Sumariwalla P.F., Malik A.S., Andreakos E., Mechoulam R., et al. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 97 17 (2000) 9561-9566
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.17 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3    Malik, A.S.4    Andreakos, E.5    Mechoulam, R.6
  • 6
    • 1642268380 scopus 로고    scopus 로고
    • Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw
    • Costa B., Colleoni M., Conti S., Parolaro D., Franke C., Trovato A.E., et al. Oral anti-inflammatory activity of cannabidiol, a non-psychoactive constituent of cannabis, in acute carrageenan-induced inflammation in the rat paw. Naunyn Schmiedebergs Arch Pharmacol 369 3 (2004) 294-299
    • (2004) Naunyn Schmiedebergs Arch Pharmacol , vol.369 , Issue.3 , pp. 294-299
    • Costa, B.1    Colleoni, M.2    Conti, S.3    Parolaro, D.4    Franke, C.5    Trovato, A.E.6
  • 7
    • 4344571664 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
    • Vaney C., Heinzel-Gutenbrunner M., Jobin P., Tschopp F., Gattlen B., Hagen U., et al. Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study. Mult Scler 10 4 (2004) 417-424
    • (2004) Mult Scler , vol.10 , Issue.4 , pp. 417-424
    • Vaney, C.1    Heinzel-Gutenbrunner, M.2    Jobin, P.3    Tschopp, F.4    Gattlen, B.5    Hagen, U.6
  • 8
    • 4344582253 scopus 로고    scopus 로고
    • Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients
    • Wade D.T., Makela P., Robson P., House H., and Bateman C. Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Mult Scler 10 4 (2004) 434-441
    • (2004) Mult Scler , vol.10 , Issue.4 , pp. 434-441
    • Wade, D.T.1    Makela, P.2    Robson, P.3    House, H.4    Bateman, C.5
  • 9
    • 0042934012 scopus 로고    scopus 로고
    • Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes
    • Kaplan B.L., Rockwell C.E., and Kaminski N.E. Evidence for cannabinoid receptor-dependent and -independent mechanisms of action in leukocytes. J Pharmacol Exp Ther 306 3 (2003) 1077-1085
    • (2003) J Pharmacol Exp Ther , vol.306 , Issue.3 , pp. 1077-1085
    • Kaplan, B.L.1    Rockwell, C.E.2    Kaminski, N.E.3
  • 11
    • 30344476972 scopus 로고    scopus 로고
    • In silico patent searching reveals a new cannabinoid receptor
    • Baker D., Pryce G., Davies W.L., and Hiley C.R. In silico patent searching reveals a new cannabinoid receptor. Trends Pharmacol Sci 27 1 (2006) 1-4
    • (2006) Trends Pharmacol Sci , vol.27 , Issue.1 , pp. 1-4
    • Baker, D.1    Pryce, G.2    Davies, W.L.3    Hiley, C.R.4
  • 12
    • 6344293648 scopus 로고    scopus 로고
    • A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes
    • Rockwell C.E., and Kaminski N.E. A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes. J Pharmacol Exp Ther 311 2 (2004) 683-690
    • (2004) J Pharmacol Exp Ther , vol.311 , Issue.2 , pp. 683-690
    • Rockwell, C.E.1    Kaminski, N.E.2
  • 13
    • 33745280979 scopus 로고    scopus 로고
    • Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2
    • Rockwell C.E., Snider N.T., Thompson J., Vanden Heuvel J., and Kaminski N.E. Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. Mol Pharmacol 70 1 (2006) 101-111
    • (2006) Mol Pharmacol , vol.70 , Issue.1 , pp. 101-111
    • Rockwell, C.E.1    Snider, N.T.2    Thompson, J.3    Vanden Heuvel, J.4    Kaminski, N.E.5
  • 14
    • 0038845604 scopus 로고    scopus 로고
    • Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
    • Jarai Z., Wagner J.A., Varga K., Lake K.D., Compton D.R., Martin B.R., et al. Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. Proc Natl Acad Sci USA 96 24 (1999) 14136-14141
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.24 , pp. 14136-14141
    • Jarai, Z.1    Wagner, J.A.2    Varga, K.3    Lake, K.D.4    Compton, D.R.5    Martin, B.R.6
  • 15
    • 12344250051 scopus 로고    scopus 로고
    • The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro
    • Sacerdote P., Martucci C., Vaccani A., Bariselli F., Panerai A.E., Colombo A., et al. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol 159 1-2 (2005) 97-105
    • (2005) J Neuroimmunol , vol.159 , Issue.1-2 , pp. 97-105
    • Sacerdote, P.1    Martucci, C.2    Vaccani, A.3    Bariselli, F.4    Panerai, A.E.5    Colombo, A.6
  • 16
    • 0023229590 scopus 로고
    • Inhibition of macrophage accessory cell function in casein-treated B6C3F1 mice
    • Kaminski N.E., and Holsapple M.P. Inhibition of macrophage accessory cell function in casein-treated B6C3F1 mice. J Immunol 139 6 (1987) 1804-1810
    • (1987) J Immunol , vol.139 , Issue.6 , pp. 1804-1810
    • Kaminski, N.E.1    Holsapple, M.P.2
  • 17
    • 37049240329 scopus 로고
    • Plaque formation in agar by single antibody-producing cells
    • Jerne N.K., and Nordin A.A. Plaque formation in agar by single antibody-producing cells. Science 140 (1963) 405
    • (1963) Science , vol.140 , pp. 405
    • Jerne, N.K.1    Nordin, A.A.2
  • 18
    • 0032055664 scopus 로고    scopus 로고
    • Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid
    • Herring A.C., Koh W.S., and Kaminski N.E. Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid. Biochem Pharmacol 55 7 (1998) 1013-1023
    • (1998) Biochem Pharmacol , vol.55 , Issue.7 , pp. 1013-1023
    • Herring, A.C.1    Koh, W.S.2    Kaminski, N.E.3
  • 19
    • 0027166278 scopus 로고
    • Δ9-tetrahydrocanabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function
    • Schatz A.R., Koh W.S., and Kaminski N.E. Δ9-tetrahydrocanabinol selectively inhibits T-cell dependent humoral immune responses through direct inhibition of accessory T-cell function. Immunopharmacology 26 (1993) 129-137
    • (1993) Immunopharmacology , vol.26 , pp. 129-137
    • Schatz, A.R.1    Koh, W.S.2    Kaminski, N.E.3
  • 20
    • 0030613857 scopus 로고    scopus 로고
    • Interaction of NF-kappaB and NFAT with the interferon-gamma promoter
    • Sica A., Dorman L., Viggiano V., Cippitelli M., Ghosh P., Rice N., et al. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 272 48 (1997) 30412-30420
    • (1997) J Biol Chem , vol.272 , Issue.48 , pp. 30412-30420
    • Sica, A.1    Dorman, L.2    Viggiano, V.3    Cippitelli, M.4    Ghosh, P.5    Rice, N.6
  • 21
    • 0032567436 scopus 로고    scopus 로고
    • The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells
    • Sweetser M.T., Hoey T., Sun Y.L., Weaver W.M., Price G.A., and Wilson C.B. The roles of nuclear factor of activated T cells and ying-yang 1 in activation-induced expression of the interferon-gamma promoter in T cells. J Biol Chem 273 52 (1998) 34775-34783
    • (1998) J Biol Chem , vol.273 , Issue.52 , pp. 34775-34783
    • Sweetser, M.T.1    Hoey, T.2    Sun, Y.L.3    Weaver, W.M.4    Price, G.A.5    Wilson, C.B.6
  • 22
    • 0023821516 scopus 로고
    • Identification of a putative regulator of early T cell activation genes
    • Shaw J.P., Utz P.J., Durand D.B., Toole J.J., Emmel E.A., and Crabtree G.R. Identification of a putative regulator of early T cell activation genes. Science 241 4862 (1988) 202-205
    • (1988) Science , vol.241 , Issue.4862 , pp. 202-205
    • Shaw, J.P.1    Utz, P.J.2    Durand, D.B.3    Toole, J.J.4    Emmel, E.A.5    Crabtree, G.R.6
  • 23
    • 0027491776 scopus 로고
    • The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun
    • Jain J., McCaffrey P.G., Miner Z., Kerppola T.K., Lambert J.N., Verdine G.L., et al. The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature 365 6444 (1993) 352-355
    • (1993) Nature , vol.365 , Issue.6444 , pp. 352-355
    • Jain, J.1    McCaffrey, P.G.2    Miner, Z.3    Kerppola, T.K.4    Lambert, J.N.5    Verdine, G.L.6
  • 24
    • 0033800314 scopus 로고    scopus 로고
    • AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun
    • Faubert B.L., and Kaminski N.E. AP-1 activity is negatively regulated by cannabinol through inhibition of its protein components, c-fos and c-jun. J Leukoc Biol 67 2 (2000) 259-266
    • (2000) J Leukoc Biol , vol.67 , Issue.2 , pp. 259-266
    • Faubert, B.L.1    Kaminski, N.E.2
  • 25
    • 2642609451 scopus 로고    scopus 로고
    • Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells
    • Ouyang Y., Hwang S.G., Han S.H., and Kaminski N.E. Suppression of interleukin-2 by the putative endogenous cannabinoid 2-arachidonyl-glycerol is mediated through down-regulation of the nuclear factor of activated T cells. Mol Pharmacol 53 4 (1998) 676-683
    • (1998) Mol Pharmacol , vol.53 , Issue.4 , pp. 676-683
    • Ouyang, Y.1    Hwang, S.G.2    Han, S.H.3    Kaminski, N.E.4
  • 26
    • 0007827240 scopus 로고    scopus 로고
    • Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells
    • Yea S.S., Yang K.H., and Kaminski N.E. Role of nuclear factor of activated T-cells and activator protein-1 in the inhibition of interleukin-2 gene transcription by cannabinol in EL4 T-cells. J Pharmacol Exp Ther 292 2 (2000) 597-605
    • (2000) J Pharmacol Exp Ther , vol.292 , Issue.2 , pp. 597-605
    • Yea, S.S.1    Yang, K.H.2    Kaminski, N.E.3
  • 27
    • 17544371574 scopus 로고    scopus 로고
    • Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and IL-2 expression in the murine T-cell line, EL4.IL-2
    • Condie R., Herring A., Koh W.S., Lee M., and Kaminski N.E. Cannabinoid inhibition of adenylate cyclase-mediated signal transduction and IL-2 expression in the murine T-cell line, EL4.IL-2. J Biol Chem 271 (1996) 13175-13183
    • (1996) J Biol Chem , vol.271 , pp. 13175-13183
    • Condie, R.1    Herring, A.2    Koh, W.S.3    Lee, M.4    Kaminski, N.E.5
  • 28
    • 18944404672 scopus 로고    scopus 로고
    • Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2′-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide
    • Kaplan B.L., Ouyang Y., Herring A., Yea S.S., Razdan R., and Kaminski N.E. Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2′-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. Toxicol Appl Pharmacol 205 2 (2005) 107-115
    • (2005) Toxicol Appl Pharmacol , vol.205 , Issue.2 , pp. 107-115
    • Kaplan, B.L.1    Ouyang, Y.2    Herring, A.3    Yea, S.S.4    Razdan, R.5    Kaminski, N.E.6
  • 29
    • 20044386146 scopus 로고    scopus 로고
    • 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2
    • Kaplan B.L., Ouyang Y., Rockwell C.E., Rao G.K., and Kaminski N.E. 2-Arachidonoyl-glycerol suppresses interferon-gamma production in phorbol ester/ionomycin-activated mouse splenocytes independent of CB1 or CB2. J Leukoc Biol 77 6 (2005) 966-974
    • (2005) J Leukoc Biol , vol.77 , Issue.6 , pp. 966-974
    • Kaplan, B.L.1    Ouyang, Y.2    Rockwell, C.E.3    Rao, G.K.4    Kaminski, N.E.5
  • 30
    • 33645239301 scopus 로고    scopus 로고
    • Cannabidiol-induced intracellular Ca(2+) elevations in hippocampal cells
    • Drysdale A.J., Ryan D., Pertwee R.G., and Platt B. Cannabidiol-induced intracellular Ca(2+) elevations in hippocampal cells. Neuropharmacology 50 5 (2006) 621-631
    • (2006) Neuropharmacology , vol.50 , Issue.5 , pp. 621-631
    • Drysdale, A.J.1    Ryan, D.2    Pertwee, R.G.3    Platt, B.4
  • 31
    • 33645858271 scopus 로고    scopus 로고
    • Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship
    • Rao G.K., and Kaminski N.E. Cannabinoid-mediated elevation of intracellular calcium: a structure-activity relationship. J Pharmacol Exp Ther 317 2 (2006) 820-829
    • (2006) J Pharmacol Exp Ther , vol.317 , Issue.2 , pp. 820-829
    • Rao, G.K.1    Kaminski, N.E.2
  • 33
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno T., Hanus L., De Petrocellis L., Tchilibon S., Ponde D.E., Brandi I., et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 134 4 (2001) 845-852
    • (2001) Br J Pharmacol , vol.134 , Issue.4 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6
  • 34
    • 18244396915 scopus 로고    scopus 로고
    • Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
    • Mishima K., Hayakawa K., Abe K., Ikeda T., Egashira N., Iwasaki K., et al. Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism. Stroke 36 5 (2005) 1077-1082
    • (2005) Stroke , vol.36 , Issue.5 , pp. 1077-1082
    • Mishima, K.1    Hayakawa, K.2    Abe, K.3    Ikeda, T.4    Egashira, N.5    Iwasaki, K.6
  • 35
    • 27644440716 scopus 로고    scopus 로고
    • Agonistic properties of cannabidiol at 5-HT1a receptors
    • Russo E.B., Burnett A., Hall B., and Parker K.K. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res 30 8 (2005) 1037-1043
    • (2005) Neurochem Res , vol.30 , Issue.8 , pp. 1037-1043
    • Russo, E.B.1    Burnett, A.2    Hall, B.3    Parker, K.K.4
  • 36
    • 33646734889 scopus 로고    scopus 로고
    • Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression
    • Carrier E.J., Auchampach J.A., and Hillard C.J. Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression. Proc Natl Acad Sci USA 103 20 (2006) 7895-7900
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.20 , pp. 7895-7900
    • Carrier, E.J.1    Auchampach, J.A.2    Hillard, C.J.3
  • 37
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: key regulators of T-cell development and function
    • Macian F. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol 5 6 (2005) 472-484
    • (2005) Nat Rev Immunol , vol.5 , Issue.6 , pp. 472-484
    • Macian, F.1
  • 38
    • 0032487527 scopus 로고    scopus 로고
    • The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells
    • Schuh K., Twardzik T., Kneitz B., Heyer J., Schimpl A., and Serfling E. The interleukin 2 receptor alpha chain/CD25 promoter is a target for nuclear factor of activated T cells. J Exp Med 188 7 (1998) 1369-1373
    • (1998) J Exp Med , vol.188 , Issue.7 , pp. 1369-1373
    • Schuh, K.1    Twardzik, T.2    Kneitz, B.3    Heyer, J.4    Schimpl, A.5    Serfling, E.6
  • 39
    • 0034651637 scopus 로고    scopus 로고
    • Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes
    • Matsuguchi T., Takagi K., Musikacharoen T., and Yoshikai Y. Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes. Blood 95 4 (2000) 1378-1385
    • (2000) Blood , vol.95 , Issue.4 , pp. 1378-1385
    • Matsuguchi, T.1    Takagi, K.2    Musikacharoen, T.3    Yoshikai, Y.4
  • 40
    • 0034597604 scopus 로고    scopus 로고
    • Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide (LPS)
    • Ulmer A.J., Flad H., Rietschel T., and Mattern T. Induction of proliferation and cytokine production in human T lymphocytes by lipopolysaccharide (LPS). Toxicology 152 1-3 (2000) 37-45
    • (2000) Toxicology , vol.152 , Issue.1-3 , pp. 37-45
    • Ulmer, A.J.1    Flad, H.2    Rietschel, T.3    Mattern, T.4
  • 41
    • 0017367815 scopus 로고
    • delta1-tetrahydrocannabinol, cannabidiol and cannabinol effects on the immune response of mice
    • Zimmerman S., Zimmerman A.M., Cameron I.L., and Laurence H.L. delta1-tetrahydrocannabinol, cannabidiol and cannabinol effects on the immune response of mice. Pharmacology 15 1 (1977) 10-23
    • (1977) Pharmacology , vol.15 , Issue.1 , pp. 10-23
    • Zimmerman, S.1    Zimmerman, A.M.2    Cameron, I.L.3    Laurence, H.L.4
  • 42
    • 34247359068 scopus 로고    scopus 로고
    • Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice
    • Jan T.R., Su S.T., Wu H.Y., and Liao M.H. Suppressive effects of cannabidiol on antigen-specific antibody production and functional activity of splenocytes in ovalbumin-sensitized BALB/c mice. Int Immunopharmacol 7 6 (2007) 773-780
    • (2007) Int Immunopharmacol , vol.7 , Issue.6 , pp. 773-780
    • Jan, T.R.1    Su, S.T.2    Wu, H.Y.3    Liao, M.H.4
  • 43
    • 57149109403 scopus 로고    scopus 로고
    • Springs AE, Karmaus PW, Crawford RB, Kaplan BL, Kaminski NE. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Δ9-tetrahydrocannabinol. J Leukoc Biol 2008; in press.
    • Springs AE, Karmaus PW, Crawford RB, Kaplan BL, Kaminski NE. Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Δ9-tetrahydrocannabinol. J Leukoc Biol 2008; in press.


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