Cannabinoid Receptor 2 (CB2) Plays a Role in the Generation of Germinal Center and Memory B Cells, but Not in the Production of Antigen-Specific IgG and IgM, in Response to T-dependent Antigens

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Basu, Sreemanti ^a,b   Ray, Avijit ^a   Dittel, Bonnie N ^a,b  

^a BLOOD RESEARCH INSTITUTE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXY 3 NITROPHENYLACETYL CHICKEN GAMMA GLOBULIN; ANTIGEN; CANNABINOID 2 RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL TYPE; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GENE REARRANGEMENT; GERMINAL CENTER; IMMUNIZATION; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN PRODUCTION; LYMPHOCYTE FUNCTION; LYMPHOCYTE HOMING; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MALE; MEMORY CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PLASMA CELL; SPLEEN CELL; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL PROLIFERATION; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; SHEEP;

MUS; OVIS ARIES;

ANIMALS; ANTIGENS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; GERMINAL CENTER; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTOR, CANNABINOID, CB2; SHEEP;

EID: 84879518676     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0067587     Document Type: Article

References (27)

1. Munro S, Thomas KL, Abu-Shaar M, (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365: 61-65.
2. Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, et al. (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232: 54-61.
3. Sugiura T, Kondo S, Kishimoto S, Miyashita T, Nakane S, et al. (2000) Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. J Biol Chem 275: 605-612.
4. Basu S, Dittel BN, (2011) Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulaton in health and disease. Immunol Res. 51: 26-38.
5. Derocq JM, Segui M, Marchand J, Le Fur G, Casellas P, (1995) Cannabinoids enhance human B-cell growth at low nanomolar concentrations. FEBS Lett 369: 177-182.
6. Tanikawa T, Kurohane K, Imai Y, (2007) Induction of preferential chemotaxis of unstimulated B-lymphocytes by 2-arachidonoylglycerol in immunized mice. Microbiol Immunol 51: 1013-1019.
7. Ziring D, Wei B, Velazquez P, Schrage M, Buckley NE, et al. (2006) Formation of B and T cell subsets require the cannabinoid receptor CB2. Immunogenetics 58: 714-725.
8. Muppidi JR, Arnon TI, Bronevetsky Y, Veerapen N, Tanaka M, et al. (2011) Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone. J Exp Med 208: 1941-1948.
9. Basu S, Ray A, Dittel BN, (2011) Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. J Immunol 187: 5720-5732.
10. Garside P, Ingulli E, Merica RR, Johnson JG, Noelle RJ, et al. (1998) Visualization of specific B and T lymphocyte interactions in the lymph node. Science 281: 96-99.
11. Okada T, Miller MJ, Parker I, Krummel MF, Neighbors M, et al. (2005) Antigen-engaged B cells undergo chemotaxis toward the T zone and form motile conjugates with helper T cells. PLoS Biol 3: e150.
12. Jacob J, Kassir R, Kelsoe G, (1991) In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med 173: 1165-1175.
13. Liu YJ, Zhang J, Lane PJ, Chan EY, MacLennan IC, (1991) Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur J Immunol 21: 2951-2962.
14. Stavnezer J, Guikema JE, Schrader CE, (2008) Mechanism and regulation of class switch recombination. Annu Rev Immunol 26: 261-292.
15. Berek C, Berger A, Apel M, (1991) Maturation of the immune response in germinal centers. Cell 67: 1121-1129.
16. Jacob J, Kelsoe G, Rajewsky K, Weiss U, (1991) Intraclonal generation of antibody mutants in germinal centres. Nature 354: 389-392.
17. Slifka MK, Matloubian M, Ahmed R, (1995) Bone marrow is a major site of long-term antibody production after acute viral infection. J Virol 69: 1895-1902.
18. Hargreaves DC, Hyman PL, Lu TT, Ngo VN, Bidgol A, et al. (2001) A coordinated change in chemokine responsiveness guides plasma cell movements. J Exp Med 194: 45-56.
19. Manz RA, Hauser AE, Hiepe F, Radbruch A, (2005) Maintenance of serum antibody levels. Annu Rev Immunol 23: 367-386.
20. Koganei A, Tsuchiya T, Samura K, Nishikibe M, (2007) Use of whole sheep red blood cells in ELISA to assess immunosuppression in vivo. J Immunotoxicol 4: 77-82.
21. Newton CA, Klein TW, (2012) Cannabinoid 2 (CB2) receptor involvement in the down-regulation but not up-regulation of serum IgE levels in immunized mice. J Neuroimmune Pharmacol 7: 591-598.
22. Agudelo M, Newton C, Widen R, Sherwood T, Nong L, et al. (2008) Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes. J Neuroimmune Pharmacol 3: 35-42.
23. Song H, Cerny J, (2003) Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen. J Exp Med 198: 1923-1935.
24. Attanavanich K, Kearney JF, (2004) Marginal zone, but not follicular B cells, are potent activators of naive CD4 T cells. J Immunol 172: 803-811.
25. Rubtsov AV, Swanson CL, Troy S, Strauch P, Pelanda R, et al. (2008) TLR agonists promote marginal zone B cell activation and facilitate T-dependent IgM responses. J Immunol 180: 3882-3888.
26. Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, et al. (2010) PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol 11: 535-542.
27. Springs AE, Karmaus PW, Crawford RB, Kaplan BL, Kaminski NE, (2008) Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by Delta9-tetrahydrocannabinol. J Leukoc Biol 84: 1574-1584.