Cytokines production in chronic schizophrenia patients with or without paranoid behaviour

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 22, Issue 6, 1998, Pages 947-957

  Cazzullo, Carlo L ^a,b,d   Scarone, Silvio ^b   Grassi, Barbara ^d   Vismara, Chiara ^b   Trabattoni, Daria ^c   Clerici, Massimo ^b   Clerici, Mario ^c  

^a Assoc Ric sulla Schizofrenia ARS   (Italy)

^b Association for Research on Schizophrenia (ARS)   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d Fondazione Legrenzi ^*

Author keywords

Cell mediated immunity; Cytokine production; Interleukin 10; Interleukin 2; Neuroleptic drugs; Paranoia; Schizophrenia

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2;

ADULT; ARTICLE; BIOSYNTHESIS; CELLULAR IMMUNITY; FEMALE; HOSPITALIZATION; HUMAN; IMMUNOLOGY; MALE; PARANOIA; SCHIZOPHRENIA;

ADULT; FEMALE; HUMANS; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; MALE; PARANOID BEHAVIOR; SCHIZOPHRENIA; SEVERITY OF ILLNESS INDEX;

EID: 0032130477     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(98)00059-1     Document Type: Article

References (26)

1. th ed., American Psychiatric Association, Washington DC.
2. BIONDI, M.and KATZALIDIS, G.D. (1990) Human psychoneuroimmunology today. J.Clin. Lab. Anal. 4: 22-38.
3. CAZZULLO, C.L., CLERICI, MARIO, SCARONE, S., FERRANTE, P., SARESELLA, M., CLERICI, MASSIMO and DORIA, S. (1996) Immunological Biology in Schizophrenia Plenary Lecture. World Congress of WPA. Madrid, august 29, 1996. Tilesa. (In press).
4. CAZZULLO, C.L., FERRANTE, P., CLERICI, MARIO, SARESELLA, M-. RODA, K., CALVO, M.G., BERTRANDO, P., DORIA, S., and SALVAGGIO, A. (1997). Increased levels of CD8 and CD4 + 45 RA+ Lymphocytes in schizophrenic patients. Schizophrenia Research. In press.
5. CLERICI , M., HAKIM, F.T., VENZON, D.J., BLATT, S., HENDRIX, C.W., WYNN, T.A., and SHEARER, G.M. (1993) Changes in interleukin 2 and interleukin 4 production in asymptomatic HIV-seropositive individuals. J. Clin: Invest. 91: 759-765.
6. CLERICI, M., WYNN, T.A., BERZOFSKY, J.A., BLATT, S.P., HENDRIX, C.W., SHER, A., COFFMAN, R.L. and SHEARER, G.M. (1994) Role of interleukin-10 (IL-10) in T helper cell dysfunction in asymptomatic individuals infected with the immunodeficiency virus (HIV-1). J. Clin. Invest. 93: 768-775.
7. CLERICI, M., MEROLA, M., FERRARIO, A., TRABATTONI, D., VILLA, M.L., SHEARER, G.M., DE PAOLO, G. and CLERICI, E., (1996) Cytokine production patterns in cervical intraepithelial neoplasia: association with HPV infection limited to the cervix or invading other sites of the lower genital tract. JNCI 89: 245-250.
8. DELISI, L.E., ORTALDO J.R. , MALUISH , A.E. and WYATT, R. (1983) Deficient natural killer cell activity and macrophage functioning in schizophrenic patients. J. Neuro. Trans. 58: 99-106.
9. FERGUSON, R.M., SCHMIDTKE, J.R. and SIMON, R.L. (1975) Concurrent inhibition by chlorpromazine of concanavalin A induced lymphocyte aggregation and mitogens. Nature 256: 744-745.
10. GANGULI, R. and RABIN, B. S. (1989) Increased serum interleukin-2 receptor concentration in schizophrenic and brain-demagedsubjects. Arch. Gen. Psych. 46: 292.
11. GANGULI, R., RABIN, B.S., and BELLE, S.H. (1989) Decreased interleukin-2 production in schizophrenic patients. Biol. Psychiatr. 26: 424.
12. HORNBERG, M., AROLT, V., WILKE, I., KRUSE, A., and KIRCHNER, H. (1995) Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia Schiz. Res. 15: 237-242.
13. HUETTNER C., PAULMUS W. and ROGGENDORF W. (1995) Messenger RNA expression of the immunosuppressive cytokine IL-10 in human gliomas. Am. J. Pathol. 146: 317-332.
14. KATILA , H., CANTELL, K., HIRRONEN, S. and RIMON R. (1989) Production of interferon-α and -γ by leukocytes from patients with schizophrenia. Schiz. Res. 2: 361-365.
15. KING, D.J. and COOPER, S.J. (1989) Viruses, immunity and mental disorder. Brit. J. Psychiatry 154: 1-7.
16. MAES, M., MELTZER, H.Y., and BOSMANS E. (1994) Immune Inflammatory Markers in Schizophrenia: comparison to normal controls and effects of Clozapine. Acta Psych. Scand., 99: 346-351.
17. MAES , M., MELTZER, H.Y., BRECKLET, P. and BOSMANS, E. (1995) Plasma soluble Interleukin-2 and transferring receptor in schizophrenia and major depression. Eur. Arch. Psychiatry Clin. Neurose., 244: 325-329.
18. MAEURER, M.J., MARTIN, D.M. CASTELLI , C., ELDER, E., LEDER, G., STORKUS, W.J., and LOTZE, M.T. (1995) Host immune response in renal cell cancer: IL-4 and IL-10 mRNA are frequently detected in freshly collected tumor-infiltrating lymphocytes. Cancer Immunol. Immunother. 41: 111-121.
19. MASSERINI, C., VITA, A., FERRANTE, P. and CAZZULLO, C.L. (1990) Lymphocytes subsets in schizophrenic disorders. Relationship with clinical, neuromorphological and treatment variable.Schiz. Research 3: 269-275.
20. MOISES, H.W., SCHINDLER, L., LEROUX, M. and KIRCHNER H. (1985) Decreased production of interferon-α and -γ in leukocyte cultures of schizophrenic patients. Acta Psychiatr. Scand. 72: 45-50.
21. MURRAY, R.M., JONES, P., O'CALLAGHAN, E., TAKEI, N. and SHAM P. (1992) Genes, viruses and neurodevelopmental schizophrenia. J. Psychiatr. Res. 26: 225-235.
22. PERT, C.B., KNIGHT J.G., LAING P., MARKWELL M.A.K. (1988) Scenarios for viral etiology of schizophrenia. Schiz. Bull. 14: 234-247.
23. RAPAPORT M.H., MCALLISTER, C., PICKAR, D., NELSON, D.L. and PAUL S.M. (1989) Elevated levels of soluble interleukin-2 receptors in schizophrenia. Arch. Gen. Psychiatry 46: 291-292.
24. + 4.0 (1990) Base Manual. SPSS Inc., Chicago.
25. TSUANG, M.T., LYONS, M.J. and FARAONE, S.V. (1990) Heterogeneity of schizophrenia: conceptual models and analytic strategies. Brit. J. Psychiatry 156: 17-26.
26. VILLEMAIN, F., CHATENOUD, L., GALINOWSKI, A., HOMO-DELARCH, F., GINESTET, D., LOO, H. et al. (1989). Aberrant T-cell mediated immunity in untreated schizophrenic patients: deficient interleukin-2 production Am. J. Psychiatry 146: 609-618.