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Volumn 178, Issue 3, 2011, Pages 1153-1166

β-caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLGLUCOSAMINIDASE; CANNABINOID 2 RECEPTOR; CARYOPHYLLENE; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXTRAN SULFATE; FORKHEAD TRANSCRIPTION FACTOR; GAMMA INTERFERON; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 4; KERATINOCYTE DERIVED CHEMOKINE; KI 67 ANTIGEN; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYELOPEROXIDASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA;

EID: 79952752154     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2010.11.052     Document Type: Article
Times cited : (202)

References (76)
  • 1
    • 0347627790 scopus 로고    scopus 로고
    • Emerging biotherapies for inflammatory bowel disease
    • Cuzzocrea S: Emerging biotherapies for inflammatory bowel disease. Expert Opin Emerg Drugs 2003, 8:339-347
    • (2003) Expert Opin Emerg Drugs , vol.8 , pp. 339-347
    • Cuzzocrea, S.1
  • 2
    • 0036886298 scopus 로고    scopus 로고
    • The current future understanding of inflammatory bowel disease
    • Podolsky DK: The current future understanding of inflammatory bowel disease. Best Pract Res Clin Gastroenterol 2002, 16:933-943
    • (2002) Best Pract Res Clin Gastroenterol , vol.16 , pp. 933-943
    • Podolsky, D.K.1
  • 5
    • 33645832524 scopus 로고    scopus 로고
    • Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
    • DOI 10.1096/fj.05-4943fje
    • D'Argenio G, Valenti M, Scaglione G, Cosenza V, Sorrentini I, Di Marzo V: Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation. FASEB J 2006, 20:568-570 (Pubitemid 46671252)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 568-570
    • D'Argenio, G.1    Valenti, M.2    Scaglione, G.3    Cosenza, V.4    Sorrentini, I.5    Di, M.V.D.6
  • 6
    • 77954274726 scopus 로고    scopus 로고
    • Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis
    • Engel MA, Kellermann CA, Burnat G, Hahn EG, Rau T, Konturek PC: Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)- induced colitis. J Physiol Pharmacol 61:89-97
    • J Physiol Pharmacol , vol.61 , pp. 89-97
    • Engel, M.A.1    Kellermann, C.A.2    Burnat, G.3    Hahn, E.G.4    Rau, T.5    Konturek, P.C.6
  • 9
    • 54249146562 scopus 로고    scopus 로고
    • The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice
    • Bento AF, Leite DF, Claudino RF, Hara DB, Leal PC, Calixto JB: The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. J Leukoc Biol 2008, 84:1213-1221
    • (2008) J Leukoc Biol , vol.84 , pp. 1213-1221
    • Bento, A.F.1    Leite, D.F.2    Claudino, R.F.3    Hara, D.B.4    Leal, P.C.5    Calixto, J.B.6
  • 11
    • 68749110973 scopus 로고    scopus 로고
    • Functional CB2 type cannabinoid receptors at CNS synapses
    • Morgan NH, Stanford IM, Woodhall GL: Functional CB2 type cannabinoid receptors at CNS synapses. Neuropharmacology 2009, 57: 356-368
    • (2009) Neuropharmacology , vol.57 , pp. 356-368
    • Morgan, N.H.1    Stanford, I.M.2    Woodhall, G.L.3
  • 13
    • 0038745585 scopus 로고    scopus 로고
    • Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid
    • DOI 10.1124/mol.63.5.983
    • Liu J, Li H, Burstein SH, Zurier RB, Chen JD: Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. Mol Pharmacol 2003, 63:983-992 (Pubitemid 36529916)
    • (2003) Molecular Pharmacology , vol.63 , Issue.5 , pp. 983-992
    • Liu, J.1    Li, H.2    Burstein, S.H.3    Zurier, R.B.4    Chen, J.D.5
  • 16
    • 15944363392 scopus 로고    scopus 로고
    • Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor- gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms
    • DOI 10.1097/01.MIB.0000160770.94199.9b
    • Schaefer KL, Denevich S, Ma C, Cooley SR, Nakajima A, Wada K, Schlezinger J, Sherr D, Saubermann LJ: Intestinal antiinflammatory effects of thiazolidenedione peroxisome proliferator-activated receptor- gamma ligands on T helper type 1 chemokine regulation include nontranscriptional control mechanisms. Inflamm Bowel Dis 2005, 11: 244-252 (Pubitemid 40439678)
    • (2005) Inflammatory Bowel Diseases , vol.11 , Issue.3 , pp. 244-252
    • Schaefer, K.L.1    Denevich, S.2    Ma, C.3    Cooley, S.R.4    Nakajima, A.5    Wada, K.6    Schlezinger, J.7    Sherr, D.8    Saubermann, L.J.9
  • 17
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • DOI 10.1038/34184
    • Jiang C, Ting AT, Seed B: PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 1998, 391:82-86 (Pubitemid 28079219)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 18
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • DOI 10.1038/34178
    • Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK: The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998, 391:79-82 (Pubitemid 28079218)
    • (1998) Nature , vol.391 , Issue.6662 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 19
    • 43549100859 scopus 로고    scopus 로고
    • A gut feeling of the PXR, PPAR and NF-kappaB connection
    • Wahli W: A gut feeling of the PXR, PPAR and NF-kappaB connection. J Intern Med 2008, 263:613-619
    • (2008) J Intern Med , vol.263 , pp. 613-619
    • Wahli, W.1
  • 24
    • 74749094518 scopus 로고    scopus 로고
    • Anti-inflammatory cannabinoids in diet: Towards a better understanding of CB(2) receptor action?
    • Gertsch J: Anti-inflammatory cannabinoids in diet: towards a better understanding of CB(2) receptor action? Commun Integr Biol 2008, 1:26-28
    • (2008) Commun Integr Biol , vol.1 , pp. 26-28
    • Gertsch, J.1
  • 25
    • 2342517543 scopus 로고    scopus 로고
    • Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states
    • Orav A, Stulova I, Kailas T, Müürisepp M: Effect of storage on the essential oil composition of Piper nigrum L. fruits of different ripening states. J Agric Food Chem 2004, 52:2582-2586
    • (2004) J Agric Food Chem , vol.52 , pp. 2582-2586
    • Orav, A.1    Stulova, I.2    Kailas, T.3    Müürisepp, M.4
  • 27
    • 45749136704 scopus 로고    scopus 로고
    • Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
    • DOI 10.1172/JCI32849
    • Ghia JE, Blennerhassett P, Collins SM: Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression. J Clin Invest 2008, 118:2209-2218 (Pubitemid 351872339)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.6 , pp. 2209-2218
    • Ghia, J.-E.1    Blennerhassett, P.2    Collins, S.M.3
  • 28
  • 29
    • 11144255122 scopus 로고    scopus 로고
    • Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice
    • DOI 10.1111/j.1365-2982.2004.00549.x
    • Kimball ES, Wallace NH, Schneider CR, D'Andrea MR, Hornby PJ: Vanilloid receptor 1 antagonists attenuate disease severity in dextran sulphate sodium-induced colitis in mice. Neurogastroenterol Motil 2004, 16:811-818 (Pubitemid 40022788)
    • (2004) Neurogastroenterology and Motility , vol.16 , Issue.6 , pp. 811-818
    • Kimball, E.S.1    Wallace, N.H.2    Schneider, C.R.3    D'Andrea, M.R.4    Hornby, P.J.5
  • 32
    • 70350134631 scopus 로고    scopus 로고
    • Preventive and therapeutic anti-inflammatory properties of the sesquiterpene alpha-humulene in experimental airways allergic inflammation
    • Rogerio AP, Andrade EL, Leite DF, Figueiredo CP, Calixto JB: Preventive and therapeutic anti-inflammatory properties of the sesquiterpene alpha-humulene in experimental airways allergic inflammation. Br J Pharmacol 2009, 158:1074-1087
    • (2009) Br J Pharmacol , vol.158 , pp. 1074-1087
    • Rogerio, A.P.1    Andrade, E.L.2    Leite, D.F.3    Figueiredo, C.P.4    Calixto, J.B.5
  • 33
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 34
    • 0030628362 scopus 로고    scopus 로고
    • Murine bone marrow-derived macrophages
    • Stanley ER: Murine bone marrow-derived macrophages. Methods Mol Biol 1997, 75:301-304
    • (1997) Methods Mol Biol , vol.75 , pp. 301-304
    • Stanley, E.R.1
  • 35
    • 70350339816 scopus 로고    scopus 로고
    • Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis
    • Vitor CE, Figueiredo CP, Hara DB, Bento AF, Mazzuco TL, Calixto JB: Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis. Br J Pharmacol 2009, 157:1034-1044
    • (2009) Br J Pharmacol , vol.157 , pp. 1034-1044
    • Vitor, C.E.1    Figueiredo, C.P.2    Hara, D.B.3    Bento, A.F.4    Mazzuco, T.L.5    Calixto, J.B.6
  • 36
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • DOI 10.1016/S0140-6736(07)60750-8, PII S0140673607607508
    • Baumgart DC, Carding SR: Inflammatory bowel disease: cause and immunobiology. Lancet 2007, 369:1627-1640 (Pubitemid 46722636)
    • (2007) Lancet , vol.369 , Issue.9573 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 38
    • 0036278518 scopus 로고    scopus 로고
    • Uncoupling the p38 MAPK kinase in IBD: A double edged sword?
    • Arulampalam V, Pettersson S: Uncoupling the p38 MAPK kinase in IBD: a double edged sword? Gut 2002, 50:446-447
    • (2002) Gut , vol.50 , pp. 446-447
    • Arulampalam, V.1    Pettersson, S.2
  • 39
    • 65349119888 scopus 로고    scopus 로고
    • Construction and analysis of a modular model of caspase activation in apoptosis
    • Harrington HA, Ho KL, Ghosh S, Tung KC: Construction and analysis of a modular model of caspase activation in apoptosis. Theor Biol Med Model 2008, 5:26
    • (2008) Theor Biol Med Model , vol.5 , pp. 26
    • Harrington, H.A.1    Ho, K.L.2    Ghosh, S.3    Tung, K.C.4
  • 40
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, Stein H: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 1984, 133:1710-1715 (Pubitemid 14035254)
    • (1984) Journal of Immunology , vol.133 , Issue.4 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3
  • 41
    • 0034524084 scopus 로고    scopus 로고
    • The structure and function of claudins, cell adhesion molecules at tight junctions
    • Tsukita S, Furuse M: The structure and function of claudins, cell adhesion molecules at tight junctions. Ann N Y Acad Sci 2000, 915:129-135 (Pubitemid 32059373)
    • (2000) Annals of the New York Academy of Sciences , vol.915 , pp. 129-135
    • Tsukita, S.1    Furuse, M.2
  • 42
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein TW: Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005, 5:400-411
    • (2005) Nat Rev Immunol , vol.5 , pp. 400-411
    • Klein, T.W.1
  • 44
    • 23044475561 scopus 로고    scopus 로고
    • PPAR-gamma: A nuclear receptor with affinity for cannabinoids
    • Burstein S: PPAR-gamma: a nuclear receptor with affinity for cannabinoids. Life Sci 2005, 77:1674-1684
    • (2005) Life Sci , vol.77 , pp. 1674-1684
    • Burstein, S.1
  • 46
    • 0036924470 scopus 로고    scopus 로고
    • Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade
    • DOI 10.1179/135100002125000802
    • Takagi T, Naito Y, Tomatsuri N, Handa O, Ichikawa H, Yoshida N, Yoshikawa T: Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade. Redox Rep 2002, 7:283-289 (Pubitemid 36032915)
    • (2002) Redox Report , vol.7 , Issue.5 , pp. 283-289
    • Takagi, T.1    Naito, Y.2    Tomatsuri, N.3    Handa, O.4    Ichikawa, H.5    Yoshida, N.6    Yoshikawa, T.7
  • 47
    • 34147176714 scopus 로고    scopus 로고
    • Rosiglitazone, a PPARgamma ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats
    • DOI 10.1016/j.ejphar.2007.01.047, PII S0014299907000957
    • Sánchez-Hidalgo M, Martín AR, Villegas I, de la Lastra CA.: Rosiglitazone, a PPARgamma ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats. Eur J Pharmacol 2007, 562:247-258 (Pubitemid 46560498)
    • (2007) European Journal of Pharmacology , vol.562 , Issue.3 , pp. 247-258
    • Sanchez-Hidalgo, M.1    Martin, A.R.2    Villegas, I.3    De La Alarcon, L.C.4
  • 50
    • 35348922829 scopus 로고    scopus 로고
    • Bioactive constituents of the roots of Polyalthia cerasoides
    • DOI 10.1021/np070293a
    • Kanokmedhakul S, Kanokmedhakul K, Lekphrom R: Bioactive constituents of the roots of Polyalthia cerasoides. J Nat Prod 2007, 70:1536-1538 (Pubitemid 47584608)
    • (2007) Journal of Natural Products , vol.70 , Issue.9 , pp. 1536-1538
    • Kanokmedhakul, S.1    Kanokmedhakul, K.2    Lekphrom, R.3
  • 52
    • 34347352040 scopus 로고    scopus 로고
    • Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw
    • DOI 10.1038/sj.bjp.0707270, PII 0707270
    • Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB: Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol 2007, 151:618-627 (Pubitemid 47016295)
    • (2007) British Journal of Pharmacology , vol.151 , Issue.5 , pp. 618-627
    • Medeiros, R.1    Passos, G.F.2    Vitor, C.E.3    Koepp, J.4    Mazzuco, T.L.5    Pianowski, L.F.6    Campos, M.M.7    Calixto, J.B.8
  • 53
    • 33846841180 scopus 로고    scopus 로고
    • Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene
    • DOI 10.1016/j.lfs.2006.11.038, PII S0024320506009106
    • Cho JY, Chang HJ, Lee SK, Kim HJ, Hwang JK, Chun HS: Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene. Life Sci 2007, 80: 932-939 (Pubitemid 46206052)
    • (2007) Life Sciences , vol.80 , Issue.10 , pp. 932-939
    • Cho, J.Y.1    Chang, H.-J.2    Lee, S.-K.3    Kim, H.-J.4    Hwang, J.-K.5    Chun, H.S.6
  • 54
    • 0036307628 scopus 로고    scopus 로고
    • Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice
    • DOI 10.1053/gast.2002.34236
    • Ohkawara T, Nishihira J, Takeda H, Hige S, Kato M, Sugiyama T, Iwanaga T, Nakamura H, Mizue Y, Asaka M: Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice. Gastroenterology 2002, 123:256-270 (Pubitemid 34747546)
    • (2002) Gastroenterology , vol.123 , Issue.1 , pp. 256-270
    • Ohkawara, T.1    Nishihira, J.2    Takeda, H.3    Hige, S.4    Kato, M.5    Sugiyama, T.6    Iwanaga, T.7    Nakamura, H.8    Mizue, Y.9    Asaka, M.10
  • 56
    • 33751549013 scopus 로고    scopus 로고
    • Suppression of experimental colitis by intestinal mononuclear phagocytes
    • DOI 10.1189/jlb.1205734
    • Qualls JE, Kaplan AM, van Rooijen N, Cohen DA: Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol 2006, 80:802-815 (Pubitemid 44835899)
    • (2006) Journal of Leukocyte Biology , vol.80 , Issue.4 , pp. 802-815
    • Qualls, J.E.1    Kaplan, A.M.2    Van Rooijen, N.3    Cohen, D.A.4
  • 57
    • 0036314767 scopus 로고    scopus 로고
    • Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats
    • DOI 10.1023/A:1015931128583
    • Vetuschi A, Latella G, Sferra R, Caprilli R, Gaudio E: Increased proliferation and apoptosis of colonic epithelial cells in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci 2002, 47:1447-1457 (Pubitemid 34753919)
    • (2002) Digestive Diseases and Sciences , vol.47 , Issue.7 , pp. 1447-1457
    • Vetuschi, A.1    Latella, G.2    Sferra, R.3    Caprilli, R.4    Gaudio, E.5
  • 58
    • 57449095650 scopus 로고    scopus 로고
    • Changes in the expression of claudins in active ulcerative colitis
    • Oshima T, Miwa H, Joh T: Changes in the expression of claudins in active ulcerative colitis. J Gastroenterol Hepatol 2008, 23 Suppl 2:S146-S150
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.SUPPL. 2
    • Oshima, T.1    Miwa, H.2    Joh, T.3
  • 61
    • 0029052324 scopus 로고
    • Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun
    • Cippitelli M, Sica A, Viggiano V, Ye J, Ghosh P, Birrer MJ, Young HA: Negative transcriptional regulation of the interferon-gamma promoter by glucocorticoids and dominant negative mutants of c-Jun. J Biol Chem 1995, 270:12548-12556
    • (1995) J Biol Chem , vol.270 , pp. 12548-12556
    • Cippitelli, M.1    Sica, A.2    Viggiano, V.3    Ye, J.4    Ghosh, P.5    Birrer, M.J.6    Young, H.A.7
  • 63
    • 0033768784 scopus 로고    scopus 로고
    • Characterisation of acute murine dextran sodium sulphate colitis: Cytokine profile and dose dependency
    • Egger B, Bajaj-Elliott M, MacDonald TT, Inglin R, Eysselein VE, Buchler MW: Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency. Digestion 2000, 62: 240-248
    • (2000) Digestion , vol.62 , pp. 240-248
    • Egger, B.1    Bajaj-Elliott, M.2    MacDonald, T.T.3    Inglin, R.4    Eysselein, V.E.5    Buchler, M.W.6
  • 64
    • 0041929384 scopus 로고    scopus 로고
    • Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population
    • Yano S, Ghosh P, Kusaba H, Buchholz M, Longo DL: Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol 2003, 171:2510-2516 (Pubitemid 37025560)
    • (2003) Journal of Immunology , vol.171 , Issue.5 , pp. 2510-2516
    • Yano, S.1    Ghosh, P.2    Kusaba, H.3    Buchholz, M.4    Longo, D.L.5
  • 65
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • DOI 10.1016/j.it.2004.09.015, PII S1471490604002959
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M: The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 2004, 25:677-686 (Pubitemid 39457982)
    • (2004) Trends in Immunology , vol.25 , Issue.12 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 66
    • 33646259983 scopus 로고    scopus 로고
    • T regulatory cell suppression of colitis: The role of TGF-beta
    • Duchmann R, Zeitz M: T regulatory cell suppression of colitis: the role of TGF-beta. Gut 2006, 55:604-606
    • (2006) Gut , vol.55 , pp. 604-606
    • Duchmann, R.1    Zeitz, M.2
  • 67
    • 22044449933 scopus 로고    scopus 로고
    • 2 receptor negatively regulates IL-12p40 production in murine macrophages: Role of IL-10 and ERK1/2 kinase signaling
    • DOI 10.1038/sj.bjp.0706215
    • Correa F, Mestre L, Docagne F, Guaza C: Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br J Pharmacol 2005, 145:441-448 (Pubitemid 40966273)
    • (2005) British Journal of Pharmacology , vol.145 , Issue.4 , pp. 441-448
    • Correa, F.1    Mestre, L.2    Docagne, F.3    Guaza, C.4
  • 69
    • 34249099761 scopus 로고    scopus 로고
    • The PPARgamma agonist rosiglitazone impairs colonic inflammation in mice with experimental colitis
    • DOI 10.1007/s10875-007-9074-2
    • Ramakers JD, Verstege MI, Thuijls G, Te Velde AA, Mensink RP, Plat J: The PPARgamma agonist rosiglitazone impairs colonic inflammation in mice with experimental colitis. J Clin Immunol 2007, 27:275-283 (Pubitemid 46790815)
    • (2007) Journal of Clinical Immunology , vol.27 , Issue.3 , pp. 275-283
    • Ramakers, J.D.1    Verstege, M.I.2    Thuijls, G.3    Te, V.A.A.4    Mensink, R.P.5    Plat, J.6
  • 70
    • 33749014963 scopus 로고    scopus 로고
    • Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection
    • DOI 10.1124/jpet.106.108381
    • Lu T, Newton C, Perkins I, Friedman H, Klein TW: Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection. J Pharmacol Exp Ther 2006, 319:269-276 (Pubitemid 44455132)
    • (2006) Journal of Pharmacology and Experimental Therapeutics , vol.319 , Issue.1 , pp. 269-276
    • Lu, T.1    Newton, C.2    Perkins, I.3    Friedman, H.4    Klein, T.W.5
  • 72
    • 0029821620 scopus 로고    scopus 로고
    • Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene
    • DOI 10.1055/s-2006-957942
    • Tambe Y, Tsujiuchi H, Honda G, Ikeshiro Y, Tanaka S: Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. Planta Med 1996, 62:469-470 (Pubitemid 26370345)
    • (1996) Planta Medica , vol.62 , Issue.5 , pp. 469-470
    • Tambe, Y.1    Tsujiuchi, H.2    Honda, G.3    Ikeshiro, Y.4    Tanaka, S.5
  • 73
    • 33750987072 scopus 로고    scopus 로고
    • NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: Correlation with COX-2 expression
    • Konstantinopoulos PA, Vandoros GP, Sotiropoulou-Bonikou G, Kominea A, Papavassiliou AG: NF-kappaB/PPAR gamma and/or AP- 1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression. Int J Colorectal Dis 2007, 22:57-68
    • (2007) Int J Colorectal Dis , vol.22 , pp. 57-68
    • Konstantinopoulos, P.A.1    Vandoros, G.P.2    Sotiropoulou-Bonikou, G.3    Kominea, A.4    Papavassiliou, A.G.5
  • 74
    • 0032731287 scopus 로고    scopus 로고
    • Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin-2 secretion by activated thymocytes
    • Herring AC, Kaminski NE: Cannabinol-mediated inhibition of nuclear factor-kappaB, cAMP response element-binding protein, and interleukin- 2 secretion by activated thymocytes. J Pharmacol Exp Ther 1999, 291:1156-1163
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 1156-1163
    • Herring, A.C.1    Kaminski, N.E.2
  • 75
    • 39849091923 scopus 로고    scopus 로고
    • An experimental study on the reverse mechanism of PPAR-gamma agonist rosiglitazone in rats with non-alcoholic steatohepatitis
    • Chinese
    • Zhao CY, Wang YD, Zhou JY, Jia B, Cui JF: [An experimental study on the reverse mechanism of PPAR-gamma agonist rosiglitazone in rats with non-alcoholic steatohepatitis]. Chinese. Zhonghua Gan Zang Bing Za Zhi 2007, 15:450-455
    • (2007) Zhonghua Gan Zang Bing Za Zhi , vol.15 , pp. 450-455
    • Zhao, C.Y.1    Wang, Y.D.2    Zhou, J.Y.3    Jia, B.4    Cui, J.F.5
  • 76
    • 35649008926 scopus 로고    scopus 로고
    • Cannabinoids go nuclear: Evidence for activation of peroxisome proliferator-activated receptors
    • O'Sullivan SE: Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors. Br J Pharmacol 2007, 152:576-582
    • (2007) Br J Pharmacol , vol.152 , pp. 576-582
    • O'Sullivan, S.E.1


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