메뉴 건너뛰기




Volumn 160, Issue 3, 2010, Pages 643-656

Regulation of Fas receptor/Fas-asssociated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain

Author keywords

Akt PEA 15; Apoptosis; CB 1 and CB 2 receptor deficient mice; FADD adaptor; Fas receptor; JWH133; MAPKs; Mouse brain; WIN55,212 2

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN KINASE B; RIMONABANT; STRESS ACTIVATED PROTEIN KINASE; 1,1-DIMETHYLBUTYL-1-DEOXY-DELTA(9)-THC; APOPTOSIS REGULATORY PROTEIN; BENZOXAZINE DERIVATIVE; CANNABINOID; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE;

EID: 77952601644     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00710.x     Document Type: Article
Times cited : (23)

References (54)
  • 2
    • 23044462592 scopus 로고    scopus 로고
    • Phosphorylation of FADD at serine 194 by CKIα regulates its nonapoptotic activities
    • Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE et al 2005). Phosphorylation of FADD at serine 194 by CKIα regulates its nonapoptotic activities. Mol Cell 19 : 321 332.
    • (2005) Mol Cell , vol.19 , pp. 321-332
    • Alappat, E.C.1    Feig, C.2    Boyerinas, B.3    Volkland, J.4    Samuels, M.5    Murmann, A.E.6
  • 3
    • 72149097863 scopus 로고    scopus 로고
    • Guide to receptors and channels (GRAC), 4th edn
    • Suppl
    • Alexander SPH, Mathie A, Peters JA (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1 S1 S254.
    • (2009) Br J Pharmacol , vol.158 , Issue.1
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 6
    • 67549144921 scopus 로고    scopus 로고
    • Blood, adipose tissue and brain levels of the cannabinoid ligands WIN-55,212 and SR-141716A after their intraperitoneal injection in mice: Compound-specific and area-specific distribution within the brain
    • Barna I, Till I, Haller J (2009). Blood, adipose tissue and brain levels of the cannabinoid ligands WIN-55,212 and SR-141716A after their intraperitoneal injection in mice: compound-specific and area-specific distribution within the brain. Eur Neuropsychopharmacol 19 : 533 541.
    • (2009) Eur Neuropsychopharmacol , vol.19 , pp. 533-541
    • Barna, I.1    Till, I.2    Haller, J.3
  • 7
    • 0035192385 scopus 로고    scopus 로고
    • Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain
    • Boronat MA, García-Fuster MJ, García-Sevilla JA 2001). Chronic morphine induces up-regulation of the pro-apoptotic Fas receptor and down-regulation of the anti-apoptotic Bcl-2 oncoprotein in rat brain. Br J Pharmacol 134 : 1263 1270.
    • (2001) Br J Pharmacol , vol.134 , pp. 1263-1270
    • Boronat, M.A.1    García-Fuster, M.J.2    García-Sevilla, J.A.3
  • 9
    • 45549109545 scopus 로고    scopus 로고
    • Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed mu opioid receptors
    • Canals M, Milligan G (2008). Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed mu opioid receptors. J Biol Chem 283 : 11424 11434.
    • (2008) J Biol Chem , vol.283 , pp. 11424-11434
    • Canals, M.1    Milligan, G.2
  • 10
    • 38349117232 scopus 로고    scopus 로고
    • Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI
    • Chin C-L, Tovcimak AE, Hradil VP, Seifert TR, Hollingsworth PR, Chandran P et al 2008). Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI. Br J Pharmacol 153 : 367 379.
    • (2008) Br J Pharmacol , vol.153 , pp. 367-379
    • Chin, C.-L.1    Tovcimak, A.E.2    Hradil, V.P.3    Seifert, T.R.4    Hollingsworth, P.R.5    Chandran, P.6
  • 11
    • 0029026548 scopus 로고
    • FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
    • Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM (1995). FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81 : 505 512.
    • (1995) Cell , vol.81 , pp. 505-512
    • Chinnaiyan, A.M.1    O'Rourke, K.2    Tewari, M.3    Dixit, V.M.4
  • 12
    • 0001169515 scopus 로고
    • Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins
    • Costa T, Herz A (1989). Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. Proc Natl Acad Sci USA 86 : 7321 7325.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 7321-7325
    • Costa, T.1    Herz, A.2
  • 13
    • 28944453205 scopus 로고    scopus 로고
    • Cannabinoid signalling
    • Demuth DG, Molleman A (2006). Cannabinoid signalling. Life Sci 78 : 549 563.
    • (2006) Life Sci , vol.78 , pp. 549-563
    • Demuth, D.G.1    Molleman, A.2
  • 14
    • 0142184948 scopus 로고    scopus 로고
    • 1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons
    • 1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons. Br J Pharmacol 140 : 547 557.
    • (2003) Br J Pharmacol , vol.140 , pp. 547-557
    • Downer, E.J.1    Fogarty, M.P.2    Campbell, V.A.3
  • 15
    • 34848875379 scopus 로고    scopus 로고
    • 9- tetrahydrocannabinol in the neonatal and adult rat cerebral cortex
    • 9-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex. Brain Res 1175 : 39 47.
    • (2007) Brain Res , vol.1175 , pp. 39-47
    • Downer, E.J.1    Gowran, A.2    Campbell, V.A.3
  • 16
    • 67649460932 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in neuronal injury
    • Galluzzi L, Blomgren K, Kroemer G (2009). Mitochondrial membrane permeabilization in neuronal injury. Nat Rev Neurosci 10 : 481 494.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 481-494
    • Galluzzi, L.1    Blomgren, K.2    Kroemer, G.3
  • 17
    • 52949118833 scopus 로고    scopus 로고
    • Mechanisms of control of neuron survival by the endocannabinoid system
    • Galve-Roperh I, Aguado T, Palazuelos J, Guzmán M (2008). Mechanisms of control of neuron survival by the endocannabinoid system. Curr Pharm Des 14 : 2279 2288.
    • (2008) Curr Pharm des , vol.14 , pp. 2279-2288
    • Galve-Roperh, I.1    Aguado, T.2    Palazuelos, J.3    Guzmán, M.4
  • 18
    • 33846188103 scopus 로고    scopus 로고
    • Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: Regulation by the ERK1/2 MAP kinase pathway
    • García-Fuster MJ, Miralles A, García-Sevilla JA (2007a). Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Neuropsychopharmacology 32 : 399 411.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 399-411
    • García-Fuster, M.J.1    Miralles, A.2    García-Sevilla, J.A.3
  • 19
    • 33847179518 scopus 로고    scopus 로고
    • Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: A Δ-opioid tone inhibits FADD
    • García-Fuster MJ, Ferrer-Alcón M, Martín M, Kieffer BL, Maldonado R, García-Sevilla JA (2007b). Effects of constitutive deletion of opioid receptors on the basal densities of Fas and Fas-associated protein with death domain (FADD) in the mouse brain: a Δ-opioid tone inhibits FADD. Eur Neuropsychopharmacol 17 : 366 374.
    • (2007) Eur Neuropsychopharmacol , vol.17 , pp. 366-374
    • García-Fuster, M.J.1    Ferrer-Alcón, M.2    Martín, M.3    Kieffer, B.L.4    Maldonado, R.5    García-Sevilla, J.A.6
  • 20
    • 51049121781 scopus 로고    scopus 로고
    • Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: Functional interactions with casein kinase Iα, Gαi proteins, and ERK1/2 signaling
    • García-Fuster MJ, Ramos-Miguel A, Miralles A, García- Sevilla JA (2008a). Opioid receptor agonists enhance the phosphorylation state of Fas-associated death domain (FADD) protein in the rat brain: functional interactions with casein kinase Iα, Gαi proteins, and ERK1/2 signaling. Neuropharmacology 55 : 886 899.
    • (2008) Neuropharmacology , vol.55 , pp. 886-899
    • García-Fuster, M.J.1    Ramos-Miguel, A.2    Miralles, A.3    García-Sevilla, J.A.4
  • 21
    • 54549124411 scopus 로고    scopus 로고
    • Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers
    • García-Fuster MJ, Ramos-Miguel A, Rivero G, La Harpe R, Meana JJ, García-Sevilla JA (2008b). Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers. Neuroscience 157 : 105 119.
    • (2008) Neuroscience , vol.157 , pp. 105-119
    • García-Fuster, M.J.1    Ramos-Miguel, A.2    Rivero, G.3    La Harpe, R.4    Meana, J.J.5    García-Sevilla, J.A.6
  • 22
    • 62349090510 scopus 로고    scopus 로고
    • Effect of cocaine on Fas-associated protein with death domain in the rat brain: Individual differences in a model of differential vulnerability to drug abuse
    • García-Fuster MJ, Clinton SM, Watson SJ, Akil H (2009). Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse. Neuropsychopharmacology 34 : 1123 1134.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1123-1134
    • García-Fuster, M.J.1    Clinton, S.M.2    Watson, S.J.3    Akil, H.4
  • 23
    • 0030441132 scopus 로고    scopus 로고
    • Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN
    • 552122-2, and is potentiated by the cannabinoid antagonist, SR 141716A
    • Gifford AN, Ashby CR Jr. (1996). Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 552122-2, and is potentiated by the cannabinoid antagonist, SR 141716A. J Pharmacol Exp Ther 277 : 1431 1436.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1431-1436
    • Gifford, A.N.1    Ashby Jr., C.R.2
  • 24
    • 32844465920 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain
    • DOI 10.1016/j.brainres.2005.11.035, PII S0006899305016239
    • Gong J-P, Onaivi ES, Ishiguro H, Liu Q-R, Tagliaferro PA, Brusco A et al 2006). Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 1071 : 10 23. (Pubitemid 43255471)
    • (2006) Brain Research , vol.1071 , Issue.1 , pp. 10-23
    • Gong, J.-P.1    Onaivi, E.S.2    Ishiguro, H.3    Liu, Q.-R.4    Tagliaferro, P.A.5    Brusco, A.6    Uhl, G.R.7
  • 27
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
    • Herkenham M, Lynn AB, Johnson MR, Melvin LS, De Costa BR, Rice KC (1991). Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11 : 563 583.
    • (1991) J Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    De Costa, B.R.5    Rice, K.C.6
  • 29
    • 0345621691 scopus 로고    scopus 로고
    • Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurones
    • Katona I, Sperlágh B, Sík A, Käfalvi A, Vizi ES, Mackie K et al 1999). Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurones. J Neurosci 19 : 4544 4558.
    • (1999) J Neurosci , vol.19 , pp. 4544-4558
    • Katona, I.1    Sperlágh, B.2    Sík, A.3    Käfalvi, A.4    Vizi, E.S.5    MacKie, K.6
  • 30
    • 33845480548 scopus 로고    scopus 로고
    • Caspase function in programmed cell death
    • Kumar S (2007). Caspase function in programmed cell death. Cell Death Differ 14 : 32 43.
    • (2007) Cell Death Differ , vol.14 , pp. 32-43
    • Kumar, S.1
  • 31
    • 0033555839 scopus 로고    scopus 로고
    • Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice
    • Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, Beslot F et al 1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283 : 401 404.
    • (1999) Science , vol.283 , pp. 401-404
    • Ledent, C.1    Valverde, O.2    Cossu, G.3    Petitet, F.4    Aubert, J.F.5    Beslot, F.6
  • 32
    • 4143087278 scopus 로고    scopus 로고
    • Constitutive endocytic cycle of the CB1 cannabinoid receptor
    • Leterrier C, Bonnard D, Carrel D, Rossier J, Lenkei Z (2004). Constitutive endocytic cycle of the CB1 cannabinoid receptor. J Biol Chem 279 : 36013 36021.
    • (2004) J Biol Chem , vol.279 , pp. 36013-36021
    • Leterrier, C.1    Bonnard, D.2    Carrel, D.3    Rossier, J.4    Lenkei, Z.5
  • 33
    • 0038012640 scopus 로고    scopus 로고
    • In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS
    • Lossi L, Merighi A (2003). In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS. Prog Neurobiol 69 : 287 312.
    • (2003) Prog Neurobiol , vol.69 , pp. 287-312
    • Lossi, L.1    Merighi, A.2
  • 34
    • 0041411118 scopus 로고    scopus 로고
    • The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis
    • Maccarrone M, Finazzi-Agró A (2003). The endocannabinoid system, anandamide and the regulation of mammalian cell apoptosis. Cell Death Differ 10 : 946 955.
    • (2003) Cell Death Differ , vol.10 , pp. 946-955
    • MacCarrone, M.1    Finazzi-Agró, A.2
  • 36
    • 33847291794 scopus 로고    scopus 로고
    • Acute, chronic and withdrawal effects of the cannabinoid receptor agonist WIN55212-2 on the sequential activation of MAPK/Raf-MEK-ERK signaling in the rat cerebral frontal cortex: Short-term regulation by intrinsic and extrinsic pathways
    • Moranta D, Esteban S, García-Sevilla JA (2007). Acute, chronic and withdrawal effects of the cannabinoid receptor agonist WIN55212-2 on the sequential activation of MAPK/Raf-MEK-ERK signaling in the rat cerebral frontal cortex: short-term regulation by intrinsic and extrinsic pathways. J Neurosci Res 85 : 656 667.
    • (2007) J Neurosci Res , vol.85 , pp. 656-667
    • Moranta, D.1    Esteban, S.2    García-Sevilla, J.A.3
  • 37
    • 33646589609 scopus 로고    scopus 로고
    • Role of Δ-opioid receptor function in neurogenesis and neuroprotection
    • Narita M, Kuzumaki N, Miyatake M, Sato F, Wachi H, Seyama Y et al 2006). Role of Δ-opioid receptor function in neurogenesis and neuroprotection. J Neurochem 97 : 1494 1505.
    • (2006) J Neurochem , vol.97 , pp. 1494-1505
    • Narita, M.1    Kuzumaki, N.2    Miyatake, M.3    Sato, F.4    Wachi, H.5    Seyama, Y.6
  • 38
    • 34547484379 scopus 로고    scopus 로고
    • Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain
    • Ozaita A, Puighermanal E, Maldonado R (2007). Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain. J Neurochem 102 : 1105 1114.
    • (2007) J Neurochem , vol.102 , pp. 1105-1114
    • Ozaita, A.1    Puighermanal, E.2    Maldonado, R.3
  • 40
    • 12744258029 scopus 로고    scopus 로고
    • 1 receptors
    • 1 receptors. Life Sci 76 : 1307 1324.
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 42
    • 66449132820 scopus 로고    scopus 로고
    • WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • Price DA, Martinez AA, Seillier A, Koek W, Acosta Y, Fernandez E et al 2009). WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Eur J Neurosci 29 : 2177 2186.
    • (2009) Eur J Neurosci , vol.29 , pp. 2177-2186
    • Price, D.A.1    Martinez, A.A.2    Seillier, A.3    Koek, W.4    Acosta, Y.5    Fernandez, E.6
  • 43
    • 12344324970 scopus 로고    scopus 로고
    • Direct quantitation of poly(ADP-ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples
    • Putt KS, Beilman GJ, Hergenrother PJ (2005). Direct quantitation of poly(ADP-ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples. Chembiochem 6 : 53 55.
    • (2005) Chembiochem , vol.6 , pp. 53-55
    • Putt, K.S.1    Beilman, G.J.2    Hergenrother, P.J.3
  • 44
    • 67349168682 scopus 로고    scopus 로고
    • Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: Relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity
    • Ramos-Miguel A, García-Fuster MJ, Callado LF, La Harpe R, Meana JJ, García-Sevilla JA (2009). Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity. Neuroscience 161 : 23 38.
    • (2009) Neuroscience , vol.161 , pp. 23-38
    • Ramos-Miguel, A.1    García-Fuster, M.J.2    Callado, L.F.3    La Harpe, R.4    Meana, J.J.5    García-Sevilla, J.A.6
  • 45
    • 71849119173 scopus 로고    scopus 로고
    • The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: Role of PEA-15 as a FADD-ERK binding partner in striatal plasticity
    • Ramos-Miguel A, Esteban S, García-Sevilla JA (2010). The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity. Eur Neuropsychopharmacol 20 : 49 64.
    • (2010) Eur Neuropsychopharmacol , vol.20 , pp. 49-64
    • Ramos-Miguel, A.1    Esteban, S.2    García-Sevilla, J.A.3
  • 47
    • 60549106191 scopus 로고    scopus 로고
    • The Fas-FADD death domain complex structure unravels signalling by receptor clustering
    • Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E et al 2009). The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature 457 : 1019 1022.
    • (2009) Nature , vol.457 , pp. 1019-1022
    • Scott, F.L.1    Stec, B.2    Pop, C.3    Dobaczewska, M.K.4    Lee, J.J.5    Monosov, E.6
  • 48
    • 0742271034 scopus 로고    scopus 로고
    • 1 receptors in the central nervous system by chronic cannabinoids
    • 1 receptors in the central nervous system by chronic cannabinoids. Crit Rev Neurobiol 15 : 91 119.
    • (2003) Crit Rev Neurobiol , vol.15 , pp. 91-119
    • Sim-Selley, L.J.1
  • 51
    • 0034889428 scopus 로고    scopus 로고
    • Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission
    • Valjent E, Pagès C, Rogard M, Besson MJ, Maldonado R, Caboche J (2001). Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. Eur J Neurosci 14 : 342 352.
    • (2001) Eur J Neurosci , vol.14 , pp. 342-352
    • Valjent, E.1    Pagès, C.2    Rogard, M.3    Besson, M.J.4    Maldonado, R.5    Caboche, J.6
  • 53
    • 65549125084 scopus 로고    scopus 로고
    • Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K/Akt pathway
    • Viscomi MT, Oddi S, Latini L, Pasquariello N, Florenzano F, Bernardi G et al 2009). Selective CB2 receptor agonism protects central neurons from remote axotomy-induced apoptosis through the PI3K/Akt pathway. J Neurosci 29 : 4564 4570.
    • (2009) J Neurosci , vol.29 , pp. 4564-4570
    • Viscomi, M.T.1    Oddi, S.2    Latini, L.3    Pasquariello, N.4    Florenzano, F.5    Bernardi, G.6
  • 54
    • 9444233897 scopus 로고    scopus 로고
    • FADD and its phosphorylation
    • Zhang J, Zhang D, Hua Z (2004). FADD and its phosphorylation. IUBMB Life 56 : 395 401.
    • (2004) IUBMB Life , vol.56 , pp. 395-401
    • Zhang, J.1    Zhang, D.2    Hua, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.