Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes

Annals of the New York Academy of Sciences

Volumn 1261, Issue 1, 2012, Pages 1-6

  Kraus, Jürgen ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Cannabinoid; CB1; Immunomodulation; Opioid; T lymphocytes; opioid receptors

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR; CYCLIC AMP; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MU OPIATE RECEPTOR; RECOMBINANT INTERLEUKIN 4; STAT6 PROTEIN; TETRAHYDROCANNABINOL; TRANSCRIPTION FACTOR NFAT; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL FUNCTION; EPIGENETICS; HUMAN; LEUKEMIA CELL LINE; MULTIPLE SCLEROSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

EID: 84864079270     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06524.x     Document Type: Article

References (49)

1. Kieffer, B.L. & C.J. Evans. 2009. Opioid receptors: from binding sites to visible molecules in vivo. Neuropharmacology 56 (Suppl 1): 205-212.
2. Di Marzo, V. 2008. CB(1) receptor antagonism: biological basis for metabolic effects. Drug Discov. Today 13: 1026-1041.
3. Lutz, B. 2009. Endocannabinoid signals in the control of emotion. Curr. Opin. Pharmacol. 9: 46-52.
4. Sacerdote, P. 2008. Opioid-induced immunosuppression. Curr. Opin. Support. Palliat. Care 2: 14-18.
5. Roy, S. et al. 2006. Modulation of immune function by morphine: implications for susceptibility to infection. J. Neuroimmune Pharmacol. 1: 77-89.
6. Bisogno, T. & V. Di Marzo. 2010. Cannabinoid receptors and endocannabinoids: role in neuroinflammatory and neurodegenerative disorders. CNS Neurol. Disord. Drug Targets 5: 564-573.
7. Roy, S. et al. 2004. Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J. Neuroimmunol. 147: 78-81.
8. Sacerdote, P. et al. 1998. Endogenous opioids modulate allograft rejection time in mice: possible relation with Th1/Th2 cytokines. Clin. Exp. Immunol. 113: 465-469.
9. Klein, T.W. et al. 2004. Cannabinoid receptors and T helper cells. J. Neuroimmunol. 147: 91-94.
10. Roy, S. et al. 1997. Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes. Cell. Immunol. 179: 1-9.
11. Thomas, P.T., R.V. House & H.N. Bhargava. 1995. Direct cellular immunomodulation produced by diacetylmorphine (heroin) or methadone. Gen. Pharmacol. 26: 123-130.
12. Börner, C. et al. 2009. Mechanisms of opioid-mediated inhibition of human T cell receptor signaling. J. Immunol. 183: 882-889.
13. Kaplan, B.L. et al. 2005. Inhibition of leukocyte function and interleukin-2 gene expression by 2-methylarachidonyl-(2′-fluoroethyl)amide, a stable congener of the endogenous cannabinoid receptor ligand anandamide. Toxicol. Appl. Pharmacol. 205: 107-115.
14. Klein, T.W. et al. 1995. Delta 9-tetrahydrocannabinol, cytokines, and immunity to legionella pneumophila. Proc. Soc. Exp. Biol. Med. 209: 205-212.
15. Börner, C. et al. 2009. Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. J. Biol. Chem. 284: 35450-35460.
16. Gaveriaux-Ruff, C. et al. 1998. Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene. Proc. Natl. Acad. Sci. USA 95: 6326-6330.
17. Roy, S., R.A. Barke & H.H. Loh. 1998. MU-opioid receptor-knockout mice: role of mu-opioid receptor in morphine mediated immune functions. Brain Res. Mol. Brain Res. 61: 190-194.
18. Kraus, J. et al. 2001. Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276: 43901-43908.
19. Howlett, A.C. et al. 2002. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 54: 161-202.
20. Börner, C., V. Hollt & J. Kraus. 2007. Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription. Neuroimmunomodulation 14: 281-286.
21. Börner, C. et al. 2008. Analysis of promoter regions regulating basal and interleukin-4-inducible expression of the human CB1 receptor gene in T lymphocytes. Mol. Pharmacol. 73: 1013-1019.
22. Kraus, J., C. Borner & V. Hollt. 2003. Distinct palindromic extensions of the 5′-TTC...GAA-3′ motif allow STAT6 binding in vivo. FASEB J. 17: 304-306.
23. Börner, C. et al. 2004. STAT6 transcription factor binding sites with mismatches within the canonical 5′-TTC...GAA-3′ motif involved in regulation of delta- and mu-opioid receptors. J. Neurochem. 91: 1493-1500.
24. Börner, C., V. Hollt & J. Kraus. 2006. Cannabinoid receptor type 2 agonists induce transcription of the μ-opioid receptor gene in jurkat T cells. Mol. Pharmacol. 69: 1486-1491.
25. Börner, C. et al. 2007. Comparative analysis of mu-opioid receptor expression in immune and neuronal cells. J. Neuroimmunol. 188: 56-63.
26. Börner, C. et al. 2007. Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids. J. Leukoc. Biol. 81: 336-343.
27. Roy, S. et al. 2005. Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway. J. Immunol. 175: 6361-6367.
28. Yuan, M. et al. 2002. Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J. Neuroimmunol. 133: 124-131.
29. Curfs, J.H., J.F. Meis & J.A. Hoogkamp-Korstanje. 1997. A primer on cytokines: sources, receptors, effects, and inducers. Clin. Microbiol. Rev. 10: 742-780.
30. Takeba, Y. et al. 2001. Endorphin and enkephalin ameliorate excessive synovial cell functions in patients with rheumatoid arthritis. J. Rheumatol. 28: 2176-2183.
31. Philippe, D. et al. 2003. Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. J. Clin. Invest. 111: 1329-1338.
32. Molina-Holgado, F. et al. 2003. Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia. J. Neurosci. 23: 6470-6474.
33. Nakajima, Y. et al. 2006. Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-κB pathway inhibition. FEBS Lett. 580: 613-619.
34. Panikashvili, D. et al. 2005. CB1 cannabinoid receptors are involved in neuroprotection via NF-κ B inhibition. J. Cereb. Blood Flow Metab. 25: 477-484.
35. Mormina, M.E. et al. 2006. Cannabinoid signalling in TNF-alpha induced IL-8 release. Eur. J. Pharmacol. 540: 183-190.
36. Berger, S.L. 2007. The complex language of chromatin regulation during transcription. Nature 447: 407-412.
37. Jenuwein, T. & C.D. Allis. 2001. Translating the histone code. Science 293: 1074-1080.
38. Wolffe, A.P. & M.A. Matzke. 1999. Epigenetics: regulation through repression. Science 286: 481-486.
39. Karpf, A.R. & D.A. Jones. 2002. Reactivating the expression of methylation silenced genes in human cancer. Oncogene 21: 5496-5503.
40. Jones, P.A. 1986. DNA methylation and cancer. Cancer Res. 46: 461-466.
41. Kraus, J. et al. 2010. Epigenetic mechanisms involved in the induction of the mu opioid receptor gene in Jurkat T cells in response to interleukin-4. Mol. Immunol. 48: 257-263.
42. Koretzky, G.A. & P.S. Myung. 2001. Positive and negative regulation of T-cell activation by adaptor proteins. Nat. Rev. Immunol. 1: 95-107.
43. Horejsi, V., W. Zhang & B. Schraven. 2004. Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat. Rev. Immunol. 4: 603-616.
44. Torgersen, K.M. et al. 2001. Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts. J. Biol. Chem. 276: 29313-29318.
45. Börner, C. et al. 2008. T cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional {micro}-opioid receptors. Mol. Pharmacol. 74: 496-504.
46. Börner, C., V. Hollt & J. Kraus. 2002. Involvement of activator protein-1 in transcriptional regulation of the human mu-opioid receptor gene. Mol. Pharmacol. 61: 800-805.
47. Kraus, J. et al. 2003. The Role of nuclear factor {κ}B in tumor necrosis factor-regulated transcription of the human {micro}-opioid receptor gene. Mol. Pharmacol. 64: 876-884.
48. Graul, R.C. & W. Sadee. 2001. Evolutionary relationships among G protein-coupled receptors using a clustered database approach. AAPS PharmSci. 3: E12.
49. Beltran, J.A., A. Pallur & S.L. Chang. 2006. HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells. Int. Immunopharmacol. 6: 1459-1467.