메뉴 건너뛰기




Volumn 8, Issue 5, 2013, Pages 1239-1250

Cannabinoids inhibit T-cells via cannabinoid receptor 2 in an in vitro assay for graft rejection, the mixed lymphocyte reaction

Author keywords

Cannabinoid receptor 2; Cannabinoids; Immunosuppression; Mixed lymphocyte reaction; T cells

Indexed keywords

2 METHYL 3 (1 NAPHTHOYL) 1 PROPYLINDOLE; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CD3 ANTIBODY; DRONABINOL; INTERLEUKIN 2; O 1966; UNCLASSIFIED DRUG;

EID: 84891371881     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-013-9485-1     Document Type: Article
Times cited : (49)

References (69)
  • 1
    • 83455201005 scopus 로고    scopus 로고
    • Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury
    • 10.1089/neu.2011.1853 10.1089/neu.2010.1578
    • Adhikary S, Li H, Heller J, Skarica M, Zhang M, Ganea D, Tuma RF (2011) Modulation of inflammatory responses by a cannabinoid-2-selective agonist after spinal cord injury. J Neurotrauma 28:1-11. doi: 10.1089/neu.2011.1853
    • (2011) J Neurotrauma , vol.28 , pp. 1-11
    • Adhikary, S.1    Li, H.2    Heller, J.3    Skarica, M.4    Zhang, M.5    Ganea, D.6    Tuma, R.F.7
  • 2
    • 84868535926 scopus 로고    scopus 로고
    • Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression
    • 10.1182/blood-2012-06-435362 22972984 10.1182/blood-2012-06-435362 1:CAS:528:DC%2BC38Xhs12gsr3P 3488886
    • Adhikary S, Kocieda VP, Yen JH, Tuma RF, Ganea D (2012) Signaling through cannabinoid receptor 2 suppresses murine dendritic cell migration by inhibiting matrix metalloproteinase 9 expression. Blood 120:3741-3749. doi: 10.1182/blood-2012-06-435362
    • (2012) Blood , vol.120 , pp. 3741-3749
    • Adhikary, S.1    Kocieda, V.P.2    Yen, J.H.3    Tuma, R.F.4    Ganea, D.5
  • 3
    • 65349186523 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury
    • 10.1227/01.neu.0000279910.45183.15 19248685
    • Baty DE, Zhang M, Li H, Erb CJ, Adler MW, Ganea D, Loftus CM, Jallo JI, Tuma RF (2008) Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury. Clin Neurosurg 55:172-177. doi: 10.1227/01.neu.0000279910.45183.15
    • (2008) Clin Neurosurg , vol.55 , pp. 172-177
    • Baty, D.E.1    Zhang, M.2    Li, H.3    Erb, C.J.4    Adler, M.W.5    Ganea, D.6    Loftus, C.M.7    Jallo, J.I.8    Tuma, R.F.9
  • 4
    • 72149116426 scopus 로고    scopus 로고
    • Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling
    • 10.1074/jbc.M109.006338 19858202 10.1074/jbc.M109.006338 2790974
    • Borner C, Smida M, Hollt V, Schraven B, Kraus J (2009) Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling. J Biol Chem 284:35450-35460. doi: 10.1074/jbc.M109.006338
    • (2009) J Biol Chem , vol.284 , pp. 35450-35460
    • Borner, C.1    Smida, M.2    Hollt, V.3    Schraven, B.4    Kraus, J.5
  • 5
    • 77952493930 scopus 로고    scopus 로고
    • Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors
    • 10.1371/journal.pone.0008688 20098669 10.1371/journal.pone.0008688 2809084 Electronic Resource
    • Cencioni MT, Chiurchiu V, Catanzaro G, Borsellino G, Bernardi G, Battistini L, Maccarrone M (2010) Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors. PLoS ONE 5:e8688. doi: 10.1371/journal.pone.0008688, Electronic Resource
    • (2010) PLoS ONE , vol.5 , pp. 8688
    • Cencioni, M.T.1    Chiurchiu, V.2    Catanzaro, G.3    Borsellino, G.4    Bernardi, G.5    Battistini, L.6    MacCarrone, M.7
  • 7
    • 33846583671 scopus 로고    scopus 로고
    • Temporal variation in CB2R levels following T lymphocyte activation: Evidence that cannabinoids modulate CXCL12-induced chemotaxis
    • 10.1016/j.intimp.2006.11.008 10.1016/j.intimp.2006.11.008 1:CAS:528:DC%2BD2sXhtlSltLc%3D
    • Coopman K, Smith LD, Wright KL, Ward SG (2007) Temporal variation in CB2R levels following T lymphocyte activation: evidence that cannabinoids modulate CXCL12-induced chemotaxis. Int Immunopharm 7:360-371. doi: 10.1016/j.intimp. 2006.11.008
    • (2007) Int Immunopharm , vol.7 , pp. 360-371
    • Coopman, K.1    Smith, L.D.2    Wright, K.L.3    Ward, S.G.4
  • 8
    • 23044486763 scopus 로고    scopus 로고
    • Cannabinoids and the immune system: Potential for the treatment of inflammatory diseases?
    • 10.1016/j.jneuroim.2005.04.023 16023222 10.1016/j.jneuroim.2005.04.023 1:CAS:528:DC%2BD2MXntVCrurw%3D
    • Croxford JL, Yamamura T (2005) Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? J Neuroimmunol 166:3-18. doi: 10.1016/j.jneuroim.2005.04.023
    • (2005) J Neuroimmunol , vol.166 , pp. 3-18
    • Croxford, J.L.1    Yamamura, T.2
  • 9
    • 0030087688 scopus 로고    scopus 로고
    • Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation
    • 8632350 1:CAS:528:DyaK28XhtFaktb4%3D
    • Daaka Y, Friedman H, Klein TW (1996) Cannabinoid receptor proteins are increased in Jurkat, human T-cell line after mitogen activation. J Pharmacol Exp Ther 276:776-783
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 776-783
    • Daaka, Y.1    Friedman, H.2    Klein, T.W.3
  • 10
    • 34548488484 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors
    • 10.1016/j.jneuroim.2007.06.001 17640739 10.1016/j.jneuroim.2007.06.001 1:CAS:528:DC%2BD2sXhtVWitL%2FK 2083705
    • 9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors. J Neuroimmunol 189:17-22. doi: 10.1016/j.jneuroim.2007.06.001
    • (2007) J Neuroimmunol , vol.189 , pp. 17-22
    • Eisenstein, T.K.1    Meissler, J.J.2    Wilson, Q.3    Gaughan, J.P.4    Adler, M.W.5
  • 11
    • 81355147645 scopus 로고    scopus 로고
    • Cannabinoids inhibit migration of microglial-like cells to the HIV protein Tat
    • 10.1007/s11481-011-9291-6 21735070 10.1007/s11481-011-9291-6
    • Fraga D, Raborn ES, Ferreira GA, Cabral GA (2011) Cannabinoids inhibit migration of microglial-like cells to the HIV protein Tat. J Neuroimmune Pharmacol 6:566-577. doi: 10.1007/s11481-011-9291-6
    • (2011) J Neuroimmune Pharmacol , vol.6 , pp. 566-577
    • Fraga, D.1    Raborn, E.S.2    Ferreira, G.A.3    Cabral, G.A.4
  • 12
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • 10.1111/j.1432-1033.1995.tb20780.x 7556170 10.1111/j.1432-1033.1995. tb20780.x 1:CAS:528:DyaK2MXnvVKksL8%3D
    • Galiegue S, Mary S, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, Le Fur G, Casellas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232:54-61. doi: 10.1111/j.1432-1033.1995.tb20780.x
    • (1995) Eur J Biochem , vol.232 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3    Dussossoy, D.4    Carriere, D.5    Carayon, P.6    Bouaboula, M.7    Shire, D.8    Le Fur, G.9    Casellas, P.10
  • 13
    • 33744827120 scopus 로고    scopus 로고
    • Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes
    • 10.1016/j.molimm.2006.01.005 16503355 10.1016/j.molimm.2006.01.005 1:CAS:528:DC%2BD28XlsFCns7c%3D
    • Ghosh S, Preet A, Groopman JE, Ganju RK (2006) Cannabinoid receptor CB2 modulates the CXCL12/CXCR4-mediated chemotaxis of T lymphocytes. Mol Immunol 43:2169-2179. doi: 10.1016/j.molimm.2006.01.005
    • (2006) Mol Immunol , vol.43 , pp. 2169-2179
    • Ghosh, S.1    Preet, A.2    Groopman, J.E.3    Ganju, R.K.4
  • 14
    • 32844465920 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain
    • 10.1016/j.brainres.2005.11.035 16472786 10.1016/j.brainres.2005.11.035 1:CAS:528:DC%2BD28XhvVWmtbg%3D
    • Gong JP, Onaivi ES, Ishiguro H, Liu QR, Tagliaferro PA, Brusco A, Uhl GR (2006) Cannabinoid CB2 receptors: immunohistochemical localization in rat brain. Brain Res 1071:10-23. doi: 10.1016/j.brainres.2005.11.035
    • (2006) Brain Res , vol.1071 , pp. 10-23
    • Gong, J.P.1    Onaivi, E.S.2    Ishiguro, H.3    Liu, Q.R.4    Tagliaferro, P.A.5    Brusco, A.6    Uhl, G.R.7
  • 15
    • 0016224595 scopus 로고
    • Impairment of rosette-forming T lymphocytes in chronic marihuana smokers
    • 10.1056/NEJM197410242911704 4547225 10.1056/NEJM197410242911704 1:STN:280:DyaE2M%2FhtV2htw%3D%3D
    • Gupta S, Grieco MH, Cushman P (1974) Impairment of rosette-forming T lymphocytes in chronic marihuana smokers. N Engl J Med 291:874-877. doi: 10.1056/NEJM197410242911704
    • (1974) N Engl J Med , vol.291 , pp. 874-877
    • Gupta, S.1    Grieco, M.H.2    Cushman, P.3
  • 16
    • 0038585154 scopus 로고    scopus 로고
    • T-cell allorecognition and transplant rejection: A summary and update
    • 10.1034/j.1600-6143.2003.00123.x 12752308 10.1034/j.1600-6143.2003.00123. x 1:CAS:528:DC%2BD3sXkvFGrsrs%3D
    • Heeger PS (2003) T-cell allorecognition and transplant rejection: a summary and update. Am J Transplant 3:525-533. doi: 10.1034/j.1600-6143.2003. 00123.x
    • (2003) Am J Transplant , vol.3 , pp. 525-533
    • Heeger, P.S.1
  • 17
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
    • 1992016 1:CAS:528:DyaK3MXhtlGqtro%3D
    • Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11:563-583
    • (1991) J Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    De Costa, B.R.5    Rice, K.C.6
  • 19
    • 80055107075 scopus 로고    scopus 로고
    • Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo
    • 10.1016/j.yjmcc.2011.08.008 21884703 10.1016/j.yjmcc.2011.08.008 1:CAS:528:DC%2BC3MXhsVaqtLnP
    • Hoyer FF, Steinmetz M, Zimmer S, Becker A, Lutjohann D, Buchalla R, Zimmer A, Nickenig G (2011) Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J Mol Cell Cardiol 51:1007-1014. doi: 10.1016/j.yjmcc.2011.08.008
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 1007-1014
    • Hoyer, F.F.1    Steinmetz, M.2    Zimmer, S.3    Becker, A.4    Lutjohann, D.5    Buchalla, R.6    Zimmer, A.7    Nickenig, G.8
  • 20
    • 0029846519 scopus 로고    scopus 로고
    • Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor
    • 10.1021/jm960394y 8831752 10.1021/jm960394y 1:CAS:528:DyaK28XlsVCisLg%3D
    • Huffman JW, Yu S, Showalter V, Abood ME, Wiley JL, Compton DR, Martin BR, Bramblett RD, Reggio PH (1996) Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. J Med Chem 39:3875-3877. doi: 10.1021/jm960394y
    • (1996) J Med Chem , vol.39 , pp. 3875-3877
    • Huffman, J.W.1    Yu, S.2    Showalter, V.3    Abood, M.E.4    Wiley, J.L.5    Compton, D.R.6    Martin, B.R.7    Bramblett, R.D.8    Reggio, P.H.9
  • 21
    • 0033381793 scopus 로고    scopus 로고
    • 8-THC and related compounds: Synthesis of selective ligands for the CB2 receptor
    • 10.1016/S0968-0896(99)00219-9 10658595 10.1016/S0968-0896(99)00219-9 1:CAS:528:DC%2BD3cXntFCnsA%3D%3D
    • 8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorg Med Chem 7:2905-2914. doi: 10.1016/S0968-0896(99)00219-9
    • (1999) Bioorg Med Chem , vol.7 , pp. 2905-2914
    • Huffman, J.W.1    Liddle, J.2    Yu, S.3    Aung, M.M.4    Abood, M.E.5    Wiley, J.L.6    Martin, B.R.7
  • 22
    • 9644281057 scopus 로고    scopus 로고
    • Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists
    • 10.1016/j.bmc.2004.09.050 15582455 10.1016/j.bmc.2004.09.050 1:CAS:528:DC%2BD2cXhtVCgsbrL
    • Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR (2005) Structure-activity relationships for 1-alkyl-3-(1-naphthoyl) indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists. Bioorg Med Chem 13:89-112. doi: 10.1016/j.bmc.2004.09.050
    • (2005) Bioorg Med Chem , vol.13 , pp. 89-112
    • Huffman, J.W.1    Zengin, G.2    Wu, M.J.3    Lu, J.4    Hynd, G.5    Bushell, K.6    Thompson, A.L.7    Bushell, S.8    Tartal, C.9    Hurst, D.P.10    Reggio, P.H.11    Selley, D.E.12    Cassidy, M.P.13    Wiley, J.L.14    Martin, B.R.15
  • 23
    • 0037219120 scopus 로고    scopus 로고
    • Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells
    • 10.1016/S0014-2999(03)01379-7 12620515 10.1016/S0014-2999(03)01379-7 1:CAS:528:DC%2BD3sXhs1CksLo%3D
    • Ihenetu K, Molleman A, Parsons M, Whelan C (2003) Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells. Eur J Pharmacol 464:207-215. doi: 10.1016/S0014-2999(03)01379-7
    • (2003) Eur J Pharmacol , vol.464 , pp. 207-215
    • Ihenetu, K.1    Molleman, A.2    Parsons, M.3    Whelan, C.4
  • 27
    • 33747373548 scopus 로고    scopus 로고
    • Cannabinoid-induced immune suppression and modulation of antigen-presenting cells
    • 10.1007/s11481-005-9007-x 10.1007/s11481-005-9007-x
    • Klein TW, Cabral GA (2006) Cannabinoid-induced immune suppression and modulation of antigen-presenting cells. J Neuroimm Pharmacol 1:50-64. doi: 10.1007/s11481-005-9007-x
    • (2006) J Neuroimm Pharmacol , vol.1 , pp. 50-64
    • Klein, T.W.1    Cabral, G.A.2
  • 28
    • 84907112385 scopus 로고
    • The effect of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9- tetrahydrocannabinol on T-lymphocyte and B-lymphocyte mitogen responses
    • 10.3109/08923978509026487 10.3109/08923978509026487 1:CAS:528: DyaL28XotlWrsA%3D%3D
    • Klein TW, Newton CA, Widen R, Friedman H (1985) The effect of delta-9-tetrahydrocannabinol and 11-hydroxy-delta-9-tetrahydrocannabinol on T-lymphocyte and B-lymphocyte mitogen responses. J Immunopharmac 7:451-466. doi: 10.3109/08923978509026487
    • (1985) J Immunopharmac , vol.7 , pp. 451-466
    • Klein, T.W.1    Newton, C.A.2    Widen, R.3    Friedman, H.4
  • 29
    • 0346350327 scopus 로고    scopus 로고
    • The cannabinoid system and immune modulation
    • 10.1189/jlb.0303101 12960289 10.1189/jlb.0303101 1:CAS:528: DC%2BD3sXotlGktLo%3D
    • Klein TW, Newton C, Larsen K, Lu L, Perkins I, Nong L, Friedman H (2003) The cannabinoid system and immune modulation. J Leukoc Biol 74:486-496. doi: 10.1189/jlb.0303101
    • (2003) J Leukoc Biol , vol.74 , pp. 486-496
    • Klein, T.W.1    Newton, C.2    Larsen, K.3    Lu, L.4    Perkins, I.5    Nong, L.6    Friedman, H.7
  • 30
    • 33846828655 scopus 로고    scopus 로고
    • CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: Potential role for CB2-selective ligands as immunosuppressive agents
    • 10.1016/j.clim.2006.11.002 17185040 10.1016/j.clim.2006.11.002 1:CAS:528:DC%2BD2sXhs1Chu7k%3D 1864948
    • Lombard C, Nagarkatti M, Nagarkatti P (2007) CB2 cannabinoid receptor agonist, JWH-015, triggers apoptosis in immune cells: potential role for CB2-selective ligands as immunosuppressive agents. Clin Immunol 122:259-270. doi: 10.1016/j.clim.2006.11.002
    • (2007) Clin Immunol , vol.122 , pp. 259-270
    • Lombard, C.1    Nagarkatti, M.2    Nagarkatti, P.3
  • 32
    • 32844458669 scopus 로고    scopus 로고
    • Synthesis and pharmacology of 11-nor-1-methoxy-9- hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: New selective ligands for the cannabinoid CB2 receptor
    • 10.1016/j.bmc.2005.11.023 16321538 10.1016/j.bmc.2005.11.023 1:CAS:528:DC%2BD28XhsFKqtrY%3D
    • Marriott KS, Huffman JW, Wiley JL, Martin BR (2006) Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor. Bioorg Med Chem 14:2386-2397. doi: 10.1016/j.bmc.2005.11.023
    • (2006) Bioorg Med Chem , vol.14 , pp. 2386-2397
    • Marriott, K.S.1    Huffman, J.W.2    Wiley, J.L.3    Martin, B.R.4
  • 33
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • 10.1038/346561a0 2165569 10.1038/346561a0 1:CAS:528:DyaK3cXls1Ghu7w%3D
    • Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564. doi: 10.1038/346561a0
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 34
    • 0033057247 scopus 로고    scopus 로고
    • Cannabinoid inhibition of the processing of intact lysozyme by macrophages: Evidence for CB2 receptor participation
    • 10336560 1:CAS:528:DyaK1MXjtlGnt78%3D
    • McCoy KL, Matveyeva M, Carlisle SJ, Cabral GA (1999) Cannabinoid inhibition of the processing of intact lysozyme by macrophages: evidence for CB2 receptor participation. J Pharmacol Exp Ther 289:1620-1625
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1620-1625
    • McCoy, K.L.1    Matveyeva, M.2    Carlisle, S.J.3    Cabral, G.A.4
  • 35
    • 0036074054 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo
    • 10.1124/jpet.102.033506 12130702 10.1124/jpet.102.033506 1:CAS:528:DC%2BD38Xls1OgsLc%3D
    • 9-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo. J Pharmacol Exp Ther 302:451-465. doi: 10.1124/jpet.102.033506
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 451-465
    • McKallip, R.J.1    Lombard, C.2    Martin, B.R.3    Nagarkatti, M.4    Nagarkatti, P.S.5
  • 36
    • 16444362802 scopus 로고    scopus 로고
    • Combating chronic renal allograft dysfunction: Optimal immunosuppressive regimens
    • 10.2165/00003495-200565050-00004 15748097 10.2165/00003495-200565050- 00004 1:CAS:528:DC%2BD2MXjsV2rtLg%3D
    • Merville P (2005) Combating chronic renal allograft dysfunction: optimal immunosuppressive regimens. Drugs 65:615-631. doi: 10.2165/00003495-200565050- 00004
    • (2005) Drugs , vol.65 , pp. 615-631
    • Merville, P.1
  • 37
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • 10.1038/365061a0 7689702 10.1038/365061a0 1:CAS:528:DyaK3sXmsVWiurk%3D
    • Munro S, Thomas KK, Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature 365:61-65. doi: 10.1038/365061a0
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.K.2    Abu-Shaar, M.3
  • 38
    • 77952302634 scopus 로고    scopus 로고
    • Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment
    • 10.1096/fj.09-141275 19884325 10.1096/fj.09-141275 1:CAS:528: DC%2BC3cXjtFagsbo%3D
    • Murikinati S, Jüttler E, Keinert T, Ridder DA, Muhammad S, Waibler Z, Ledent C, Zimmer A, Kalinke U, Schwaninger M (2010) Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment. FASEB J 24:788-798. doi: 10.1096/fj.09-141275
    • (2010) FASEB J , vol.24 , pp. 788-798
    • Murikinati, S.1    Jüttler, E.2    Keinert, T.3    Ridder, D.A.4    Muhammad, S.5    Waibler, Z.6    Ledent, C.7    Zimmer, A.8    Kalinke, U.9    Schwaninger, M.10
  • 39
    • 77955266826 scopus 로고    scopus 로고
    • Do cannabinoids have a therapeutic role in transplantation?
    • 10.1016/j.tips.2010.05.006 20591510 10.1016/j.tips.2010.05.006 1:CAS:528:DC%2BC3cXpsFKrsLw%3D 2923447
    • Nagarkatti M, Rieder SA, Hegde VL, Kanada S, Nagarkatti P (2010) Do cannabinoids have a therapeutic role in transplantation? Trends Pharmacol Sci 31:345-350. doi: 10.1016/j.tips.2010.05.006
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 345-350
    • Nagarkatti, M.1    Rieder, S.A.2    Hegde, V.L.3    Kanada, S.4    Nagarkatti, P.5
  • 40
    • 0015988672 scopus 로고
    • Inhibition of cellular mediated immunity in marihuana smokers
    • 10.1126/science.183.4123.419 4271816 10.1126/science.183.4123.419 1:CAS:528:DyaE2cXks1Wqt70%3D
    • Nahas GG, Suciu-Foca N, Armand JP, Morishima A (1974) Inhibition of cellular mediated immunity in marihuana smokers. Science 183:419-420. doi: 10.1126/science.183.4123.419
    • (1974) Science , vol.183 , pp. 419-420
    • Nahas, G.G.1    Suciu-Foca, N.2    Armand, J.P.3    Morishima, A.4
  • 41
    • 0017577341 scopus 로고
    • Effects of cannabinoids on macromolecular synthesis and replication of cultured lymphocytes
    • 844617 1:CAS:528:DyaE2sXktVSitLg%3D
    • Nahas GG, Morishima A, Desoize B (1977) Effects of cannabinoids on macromolecular synthesis and replication of cultured lymphocytes. Fed Proc 36:1748-1752
    • (1977) Fed Proc , vol.36 , pp. 1748-1752
    • Nahas, G.G.1    Morishima, A.2    Desoize, B.3
  • 43
    • 60549114334 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection
    • 10.1007/s11481-008-9126-2 10.1007/s11481-008-9126-2
    • 9-tetrahydrocannabinol (THC)-induced T helper cell shift following immune activation by Legionella pneumophila infection. J Neuroimm Pharmacol 4:92-102. doi: 10.1007/s11481-008- 9126-2
    • (2009) J Neuroimm Pharmacol , vol.4 , pp. 92-102
    • Newton, C.A.1    Chou, J.P.2    Perkins, I.3    Klein, T.W.4
  • 44
    • 84875841520 scopus 로고    scopus 로고
    • 9-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cells
    • 10.1007/s11481-012-9390-z 22851303 10.1007/s11481-012-9390-z 3657729
    • 9-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cells. J Neuroimmune Pharmacol 7:969-980. doi: 10.1007/s11481-012-9390-z
    • (2012) J Neuroimmune Pharmacol , vol.7 , pp. 969-980
    • Ngaotepprutaram, T.1    Kaplan, B.L.2    Crawford, R.B.3    Kaminski, N.E.4
  • 45
    • 16544377251 scopus 로고    scopus 로고
    • Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis mode
    • 10.1191/1352458504ms1009oa 15124761 10.1191/1352458504ms1009oa 1:CAS:528:DC%2BD2cXktlKgt70%3D
    • Ni X, Geller EB, Eppihimer MJ, Eisenstein TK, Adler MW, Tuma RF (2004) Win 55212-2, a cannabinoid receptor agonist, attenuates leukocyte/endothelial interactions in an experimental autoimmune encephalomyelitis mode. Mult Scler 10:158-164. doi: 10.1191/1352458504ms1009oa
    • (2004) Mult Scler , vol.10 , pp. 158-164
    • Ni, X.1    Geller, E.B.2    Eppihimer, M.J.3    Eisenstein, T.K.4    Adler, M.W.5    Tuma, R.F.6
  • 48
    • 35348946336 scopus 로고    scopus 로고
    • CB2-receptor stimulation attenuates TNF-α-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion
    • 10.1152/ajpheart.00688.2007 1:CAS:528:DC%2BD2sXht1WlurnO
    • Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Huffman JW, Csiszar A, Ungvari Z, Mackie K, Chatterjee S, Pacher P (2007) CB2-receptor stimulation attenuates TNF-α-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. Am J Physiol 293:H2210-H2218. doi: 10.1152/ajpheart.00688.2007
    • (2007) Am J Physiol , vol.293
    • Rajesh, M.1    Mukhopadhyay, P.2    Bátkai, S.3    Haskó, G.4    Liaudet, L.5    Huffman, J.W.6    Csiszar, A.7    Ungvari, Z.8    MacKie, K.9    Chatterjee, S.10    Pacher, P.11
  • 49
    • 84863380403 scopus 로고    scopus 로고
    • Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions
    • 10.1523/JNEUROSCI.4628-11.201 22442067 10.1523/JNEUROSCI.4628-11.2012 1:CAS:528:DC%2BC38XkslCmtrs%3D 3325902
    • Ramirez SH, Hasko J, Skuba A, Fan S, Dykstra H, McCormick R, Reichenbach N, Krizbai I, Mahedevan A, Zhang M, Tuma R, Son YJ, Persidsky Y (2012) Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. J Neurosci 32:4004-4016. doi: 10.1523/JNEUROSCI.4628-11.201
    • (2012) J Neurosci , vol.32 , pp. 4004-4016
    • Ramirez, S.H.1    Hasko, J.2    Skuba, A.3    Fan, S.4    Dykstra, H.5    McCormick, R.6    Reichenbach, N.7    Krizbai, I.8    Mahedevan, A.9    Zhang, M.10    Tuma, R.11    Son, Y.J.12    Persidsky, Y.13
  • 50
    • 0037207092 scopus 로고    scopus 로고
    • Effects of 9-tetrahydrocannabinol on human immune function and host defense
    • 10.1016/S0009-3084(02)00159-7 12505703 10.1016/S0009-3084(02)00159-7 1:CAS:528:DC%2BD38XpslansL8%3D
    • Roth MD (2002) Effects of 9-tetrahydrocannabinol on human immune function and host defense. Chem Phys Lipids 121:229-239. doi: 10.1016/S0009-3084(02) 00159-7
    • (2002) Chem Phys Lipids , vol.121 , pp. 229-239
    • Roth, M.D.1
  • 51
    • 77954574870 scopus 로고    scopus 로고
    • Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis
    • 10.2353/ajpath.2010.090763 20508030 10.2353/ajpath.2010.090763 2893662
    • Servettaz A, Kavian N, Nicco C, Deveaux V, Chereau C, Wang A, Zimmer A, Lotersztajn S, Weill B, Batteux F (2010) Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis. Am J Pathol 177:187-196. doi: 10.2353/ajpath.2010.090763
    • (2010) Am J Pathol , vol.177 , pp. 187-196
    • Servettaz, A.1    Kavian, N.2    Nicco, C.3    Deveaux, V.4    Chereau, C.5    Wang, A.6    Zimmer, A.7    Lotersztajn, S.8    Weill, B.9    Batteux, F.10
  • 52
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • 8819477 1:CAS:528:DyaK28XmtVSjs74%3D
    • Showalter VM, Compton DR, Martin BR, Abood ME (1996) Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J Pharmacol Exp Ther 278:989-999
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 55
    • 72549108949 scopus 로고    scopus 로고
    • Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis
    • 10.1002/ibd.20960 19408320 10.1002/ibd.20960
    • Storr MA, Keenan CM, Zhang H, Patel KD, Makriyannis A, Sharkey KA (2009) Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis. Inflamm Bowel Dis 15:1678-1685. doi: 10.1002/ibd.20960
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1678-1685
    • Storr, M.A.1    Keenan, C.M.2    Zhang, H.3    Patel, K.D.4    Makriyannis, A.5    Sharkey, K.A.6
  • 56
    • 1542283741 scopus 로고    scopus 로고
    • A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
    • 10.1002/art.20050 15022343 10.1002/art.20050 1:CAS:528: DC%2BD2cXjtVCrsLs%3D
    • Sumariwalla PF, Gallily R, Tchilibon S, Fride E, Mechoulam R, Feldmann M (2004) A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis. Arthritis Rheum 50:985-998. doi: 10.1002/art.20050
    • (2004) Arthritis Rheum , vol.50 , pp. 985-998
    • Sumariwalla, P.F.1    Gallily, R.2    Tchilibon, S.3    Fride, E.4    Mechoulam, R.5    Feldmann, M.6
  • 60
    • 0032982520 scopus 로고    scopus 로고
    • The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells
    • 10027878 1:CAS:528:DyaK1MXhs1KisLg%3D
    • Waksman Y, Olson JM, Carlisle SJ, Cabral GA (1999) The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells. J Pharmacol Exp Ther 288:1357-1366
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 1357-1366
    • Waksman, Y.1    Olson, J.M.2    Carlisle, S.J.3    Cabral, G.A.4
  • 61
    • 0036226664 scopus 로고    scopus 로고
    • Resorcinol derivatives: A novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists
    • 10.1124/jpet.301.2.679 11961073 10.1124/jpet.301.2.679 1:CAS:528:DC%2BD38XjtlKis7w%3D
    • Wiley JL, Beletskaya ID, Ng EW, Dai Z, Crocker PJ, Mahadevan A, Razdan RK, Martin BR (2002) Resorcinol derivatives: a novel template for the development of cannabinoid CB(1)/CB(2) and CB(2)-selective agonists. J Pharmacol Exp Ther 301:679-689. doi: 10.1124/jpet.301.2.679
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 679-689
    • Wiley, J.L.1    Beletskaya, I.D.2    Ng, E.W.3    Dai, Z.4    Crocker, P.J.5    Mahadevan, A.6    Razdan, R.K.7    Martin, B.R.8
  • 62
    • 80052213796 scopus 로고    scopus 로고
    • Brain cannabinoid CB2 receptors modulate cocaine's actions in mice
    • 10.1038/nn.2874 21785434 10.1038/nn.2874 1:CAS:528:DC%2BC3MXptlalsbo%3D 3164946
    • Xi ZX, Peng XQ, Li X, Song R, Zhang HY, Liu QR, Yang HJ, Bi GH, Li J, Gardner EL (2011) Brain cannabinoid CB2 receptors modulate cocaine's actions in mice. Nat Neurosci 14:1160-1166. doi: 10.1038/nn.2874
    • (2011) Nat Neurosci , vol.14 , pp. 1160-1166
    • Xi, Z.X.1    Peng, X.Q.2    Li, X.3    Song, R.4    Zhang, H.Y.5    Liu, Q.R.6    Yang, H.J.7    Bi, G.H.8    Li, J.9    Gardner, E.L.10
  • 63
    • 34548446421 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis
    • 10.1189/jlb.0307159 17537989 10.1189/jlb.0307159 1:CAS:528: DC%2BD2sXhtValu7rM
    • Xu H, Cheng CL, Chen M, Manivannan A, Cabay L, Pertwee RG, Coutts A, Forrester JV (2007) Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol 82:532-541. doi: 10.1189/jlb.0307159
    • (2007) J Leukoc Biol , vol.82 , pp. 532-541
    • Xu, H.1    Cheng, C.L.2    Chen, M.3    Manivannan, A.4    Cabay, L.5    Pertwee, R.G.6    Coutts, A.7    Forrester, J.V.8
  • 64
    • 0036889699 scopus 로고    scopus 로고
    • 9-tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells
    • 10.1016/S0165-5728(02)00370-3 12446015 10.1016/S0165-5728(02)00370-3 1:CAS:528:DC%2BD38Xoslant7k%3D
    • 9-tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J Neuroimmunol 133:124-131. doi: 10.1016/S0165-5728(02) 00370-3
    • (2002) J Neuroimmunol , vol.133 , pp. 124-131
    • Yuan, M.1    Kiertscher, S.M.2    Cheng, Q.3    Zoumalan, R.4    Tashkin, D.P.5    Roth, M.D.6
  • 65
    • 34250717998 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model
    • 10.1038/sj.jcbfm.9600447 17245417 10.1038/sj.jcbfm.9600447 1:CAS:528:DC%2BD2sXnvFCqsb4%3D 2637559
    • Zhang M, Martin BR, Adler MW, Razdan RK, Jallo JI, Tuma RF (2007) Cannabinoid CB2 receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model. J Cereb Blood Flow Metab 27:1387-1396. doi: 10.1038/sj.jcbfm.9600447
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1387-1396
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.K.4    Jallo, J.I.5    Tuma, R.F.6
  • 66
    • 67349193286 scopus 로고    scopus 로고
    • CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury
    • 10.1016/j.mvr.2009.03.005 19332079 10.1016/j.mvr.2009.03.005 1:CAS:528:DC%2BD1MXnt1Ggs78%3D 3319431
    • Zhang M, Adler MW, Abood ME, Ganea D, Jallo J, Tuma RF (2009a) CB2 receptor activation attenuates microcirculatory dysfunction during cerebral ischemic/reperfusion injury. Microvasc Res 78:86-94. doi: 10.1016/j.mvr.2009.03. 005
    • (2009) Microvasc Res , vol.78 , pp. 86-94
    • Zhang, M.1    Adler, M.W.2    Abood, M.E.3    Ganea, D.4    Jallo, J.5    Tuma, R.F.6
  • 67
    • 67649101330 scopus 로고    scopus 로고
    • Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke
    • 10.1007/s11481-009-9148-4 10.1007/s11481-009-9148-4
    • Zhang M, Martin BR, Adler MW, Razdan RJ, Kong W, Ganea D, Tuma RF (2009b) Modulation of cannabinoid receptor activation as a neuroprotective strategy for EAE and stroke. J Neuroimm Pharmacol 4:249-259. doi: 10.1007/s11481-009-9148-4
    • (2009) J Neuroimm Pharmacol , vol.4 , pp. 249-259
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.J.4    Kong, W.5    Ganea, D.6    Tuma, R.F.7
  • 68
    • 0027273257 scopus 로고
    • 9-tetrahydrocannabinol (THC) decreases the number of high and intermediate affinity IL-2 receptors of the IL-2 dependent cell line NKB61A2
    • 10.1016/0192-0561(93)90051-Y 8389328 10.1016/0192-0561(93)90051-Y 1:CAS:528:DyaK3sXktVSmsLo%3D
    • 9-tetrahydrocannabinol (THC) decreases the number of high and intermediate affinity IL-2 receptors of the IL-2 dependent cell line NKB61A2. Int J Immunopharmacol 15:401-408. doi: 10.1016/0192-0561(93)90051-Y
    • (1993) Int J Immunopharmacol , vol.15 , pp. 401-408
    • Zhu, W.1    Igarashi, T.2    Qi, Z.T.3    Newton, C.4    Widen, R.E.5    Friedman, H.6    Klein, T.W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.