Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors

PLoS ONE

Volumn 5, Issue 1, 2010, Pages

  Cencioni, Maria Teresa ^a   Chiurchiù, Valerio ^a   Catanzaro, Giuseppina ^a,b   Borsellino, Giovanna ^a   Bernardi, Giorgio ^a,c   Battistini, Luca ^a   Maccarrone, Mauro ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF TERAMO   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACEBUTOLOL; ANANDAMIDE; CANNABINOID 2 RECEPTOR; CYTOKINE; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 2; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; TH17 CELL;

ARACHIDONIC ACIDS; BASE SEQUENCE; BORNANES; CELL PROLIFERATION; CYTOKINES; DNA PRIMERS; ENDOCANNABINOIDS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; MICROSCOPY, CONFOCAL; PIPERIDINES; POLYUNSATURATED ALKAMIDES; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 77952493930     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0008688     Document Type: Article

References (30)

1. Centonze D, Battistini L, Maccarrone M (2008) The Endocannabinoid system in peripheral lymphocytes as a mirror of neuroinflammatory diseases. Curr Pharm Des 14: 2370-42.
2. Di Marzo V (2008) Endocannabinoids: synthesis and degradation. Rev Physiol Biochem Pharmacol 160: 1-24.
3. McAllister SD, GlassM(2002) CB1 and CB2 receptor-mediated signalling: a focus on endocannabinoids. Prostaglandins Leukot Essent Fatty Acids 66: 161-171.
4. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, et al. (2002) Pharmacol Rev 54: 161-202.
5. Pertwee RG (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74: 129-80.
6. Wolf SA, Tauber S, Ullrich O (2008) CNS immune surveillance and neuroinflammation: endocannabinoids keep control. Curr PharmDes 14: 2266-78.
7. Klein TW, Newton C, Larsen K, Lu L, Perkins I, et al. (2003) The cannabinoid system and immune modulation. J Leukoc Biol 74: 486-96.
8. Nong L, Newton C, Cheng Q, Friedman H, Roth MD, et al. (2002) Altered cannabinoid receptor mRNA expression in peripheral blood mononuclear cells from marijuana smokers. J Neuroimmunol 127: 169-176.
9. Felder CC, Nielsen A, Briley EM, Palkovits M, Priller J, et al. (1996) Isolation and measurement of the endogenous cannabinoid receptor agonist, anandamide, in brain and peripheral tissues of human and rat. FEBS Lett 393: 231-235.
10. Maccarrone M, De Petrocellis L, Bari M, Fezza F, Salvati S, et al. (2001) Lipopolysaccharide downregulates fatty acid amide hydrolase levels in human peripheral lymphocytes. Arch Bioch Biophys 393: 321-328.
11. Coffey RG, Yamamoto Y, Snella E, Pross S (1996) Tetrahydrocannabinol inhibition of macrophage nitric oxide production. Biochem Pharmacol 52: 743-751.
12. Puffenbarger RA, Boothe AC, Cabral GA (2000) Cannabinoids inhibits LPSinducible cytokine mRNA expression in rat microglial cells. Glia 29: 58-69.
13. Schwarz H, Blanco FJ, Lotz M (1994) Anandamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis. J Neuroimmunol 55: 107-115.
14. Joseph J, Niggemann B, Zaenker KS, Entschladen F (2004) Anandamide is an endogenous inhibitor for the migration of tumour cells and T lymphocytes. Cancer Immunol Immunother 53: 723-728.
15. Maccarrone M, Lorenzon T, Bari M, Melino G, Finazzi-Agrò A (2000) Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem 275: 31938-31945.
16. Do Y, McKallip RJ, Nagarkatti M, Nagarkatti PS (2004) Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation. J Immunol 173: 2373-2382.
17. Iwakura Y, Nakae S, Saijo S, Ishigame H (2008) The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 226: 57-79.
18. Bari M, Spagnuolo P, Fezza F, Oddi S, Pasquariello N, et al. (2006) Effect of lipid rafts on Cb2 receptor signaling and 2-arachidonoyl-glycerol metabolism in human immune cells. J Immunol 177: 4971-80.
19. Starowicz K, Nigam S, Di Marzo V (2007) Biochemistry and pharmacology of endovanilloids. Pharmacol Ther 114: 13-33.
20. Takano F, Yamaguchi M, Takada S, Shoda S, Yahagi N, et al. (2007) Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer's patch cells ex vivo. Life Sci 80: 1553-63.
21. Benito C, Romero JP, Tolon RM, Clemente D, Docagne F, et al. (2007) Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cells subtypes in human multiple sclerosis. J Neurosci 27: 2396-402.
22. Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, et al. (2007) Direct immunosuppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 13: 492-7.
23. Ihenetu K, Molleman A, Parsons M, Whelan C (2003) Pharmacological characterization of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells. Eur J Pharmacol 464: 207-215.
24. Marriott KS, Huffman JW (2008) Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Curr Topics Med Chem 8: 187-204.
25. Hillard CJ, Manna S, Greenberg MJ, DiCamelli R, Ross RA, et al. (1999) Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J Pharmacol Exp Ther 289: 1427-33.
26. Rimmerman N, Hughes HV, Bradshaw HB, Pazos MX, Mackie K, et al. (2008) Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line. Br J Pharmacol 153: 380-9.
27. Maccarrone M (2008) Good news for CB1 receptors: endogenous agonists are in the right place. Br J Pharmacol 153: 179-81.
28. Rockwell CE, Raman P, Kaplan BL, Kaminski NE (2008) A COX-2 metabolite of the endogenous cannabinoid, 2-arachidonyl glycerol, mediates suppression of IL-2 secretion in activated Jurkat T cells. Biochem Pharmacol 76: 353-61.
29. Correa F, Docagne F, Clemente D, Mestre L, Becker C, et al. (2008) Anandamide inhibits IL-2p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2). Biochem J 409: 761-70.
30. Fouser LA, Wright JF, Dunussi-Joannopoulus K, Collins M (2008) Th17 cytokines and their emerging roles in inflammatory and autoimmunity. Immunological Reviews 226: 87-102.