The synthetic cannabinoid WIN 55,212-2 sensitizes hepatocellular carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by activating p8/CCAAT/enhancer binding protein homologous protein (CHOP)/death receptor 5 (DR5) axis

Molecular Pharmacology

Volumn 77, Issue 5, 2010, Pages 854-863

  Pellerito, O ^a   Calvaruso, G ^a   Portanova, P ^a   De Blasio, A ^a   Santulli, A ^a   Vento, R ^a   Tesoriere, G ^a   Giuliano, Michela ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID; CASPASE; CCAAT BINDING FACTOR; DEATH RECEPTOR 5; INHIBITOR OF APOPTOSIS PROTEIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BCL 2; SMALL INTERFERING RNA; SURVIVIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENTIATION; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING;

APOPTOSIS; BENZOXAZINES; CANNABINOIDS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DNA PRIMERS; DNA, COMPLEMENTARY; DNA, NEOPLASM; FLOW CYTOMETRY; GENE AMPLIFICATION; HUMANS; LIVER NEOPLASMS; MEMBRANE POTENTIALS; MITOCHONDRIAL MEMBRANES; MORPHOLINES; NAPHTHALENES; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR CHOP;

EID: 77951043153     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.109.062257     Document Type: Article

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