메뉴 건너뛰기




Volumn 71, Issue 13, 2014, Pages 2383-2402

Transcriptional control of mammalian pancreas organogenesis

Author keywords

Embryonic pancreas; GATA factors; Multipotent pancreatic progenitor cells; Transcriptional regulation

Indexed keywords

ARISTALESS RELATED HOMEOBOX; GLIS FAMILY ZINC FINGER 3; HEPATOCYTE NUCLEAR FACTOR 1BETA; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 6; MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN; NEUROGENIN 3; NEUROGENIN DIFFERENTIATION FACTOR 1; PANCREAS SPECIFIC TRANSCRIPTION FACTOR 1A; PROSPERO RELATED HOMEOBOX TRANSCRIPTION FACTOR1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR PAX4; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX9; UNCLASSIFIED DRUG;

EID: 84903279001     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-013-1510-2     Document Type: Review
Times cited : (51)

References (195)
  • 1
    • 0015446766 scopus 로고
    • An ultrastructural analysis of the developing embryonic pancreas
    • Pictet RL, Clark WR, Williams RH, Rutter WJ (1972) An ultrastructural analysis of the developing embryonic pancreas. Dev Biol 29(4):436-467
    • (1972) Dev Biol , vol.29 , Issue.4 , pp. 436-467
    • Pictet, R.L.1    Clark, W.R.2    Williams, R.H.3    Rutter, W.J.4
  • 2
    • 34250893048 scopus 로고    scopus 로고
    • A Multipotent Progenitor Domain Guides Pancreatic Organogenesis
    • DOI 10.1016/j.devcel.2007.06.001, PII S1534580707002316
    • Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA (2007) A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell 13(1):103-114 (Pubitemid 46972038)
    • (2007) Developmental Cell , vol.13 , Issue.1 , pp. 103-114
    • Zhou, Q.1    Law, A.C.2    Rajagopal, J.3    Anderson, W.J.4    Gray, P.A.5    Melton, D.A.6
  • 3
    • 58549093915 scopus 로고    scopus 로고
    • Developmental biology of the pancreas: A comprehensive review
    • doi:10.1016/j.ydbio.2008.10.024
    • Gittes GK (2009) Developmental biology of the pancreas: a comprehensive review. Dev Biol 326(1):4-35. doi:10.1016/j.ydbio.2008.10.024
    • (2009) Dev Biol , vol.326 , Issue.1 , pp. 4-35
    • Gittes, G.K.1
  • 4
    • 84865164998 scopus 로고    scopus 로고
    • Signaling pathways regulating murine pancreatic development
    • doi:10.1016/j.semcdb.2012.06.004
    • Serup P (2012) Signaling pathways regulating murine pancreatic development. Semin Cell Dev Biol 23(6):663-672. doi:10.1016/j.semcdb.2012.06.004
    • (2012) Semin Cell Dev Biol , vol.23 , Issue.6 , pp. 663-672
    • Serup, P.1
  • 5
    • 79551576112 scopus 로고    scopus 로고
    • Historical perspective: Beginnings of the beta-cell: Current perspectives in beta-cell development
    • doi:10.2337/db10-1068
    • Seymour PA, Sander M (2011) Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development. Diabetes 60(2):364-376. doi:10.2337/db10-1068
    • (2011) Diabetes , vol.60 , Issue.2 , pp. 364-376
    • Seymour, P.A.1    Sander, M.2
  • 6
    • 65649109022 scopus 로고    scopus 로고
    • Stem cells to pancreatic beta-cells: New sources for diabetes cell therapy
    • doi:10.1210/er.2009-0004
    • Guo T, Hebrok M (2009) Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy. Endocr Rev 30(3):214-227. doi:10.1210/er.2009-0004
    • (2009) Endocr Rev , vol.30 , Issue.3 , pp. 214-227
    • Guo, T.1    Hebrok, M.2
  • 7
    • 79951648873 scopus 로고    scopus 로고
    • Pancreas organogenesis: From bud to plexus to gland
    • doi:10.1002/dvdy.22584
    • Pan FC, Wright C (2011) Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 240(3):530-565. doi:10.1002/dvdy.22584
    • (2011) Dev Dyn , vol.240 , Issue.3 , pp. 530-565
    • Pan, F.C.1    Wright, C.2
  • 8
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • DOI 10.1126/science.1064344
    • Lammert E, Cleaver O, Melton D (2001) Induction of pancreatic differentiation by signals from blood vessels. Science V294(N5542):564-567 (Pubitemid 32999547)
    • (2001) Science , vol.294 , Issue.5542 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 9
    • 84865156321 scopus 로고    scopus 로고
    • Molecular pathways controlling pancreas induction
    • doi:10.1016/j.semcdb.2012.06.009
    • McCracken KW, Wells JM (2012) Molecular pathways controlling pancreas induction. Semin Cell Dev Biol 23(6):656-662. doi:10.1016/j.semcdb.2012.06.009
    • (2012) Semin Cell Dev Biol , vol.23 , Issue.6 , pp. 656-662
    • McCracken, K.W.1    Wells, J.M.2
  • 10
    • 70350225535 scopus 로고    scopus 로고
    • Vertebrate endoderm development and organ formation
    • doi:10.1146/annurev.cellbio.042308.113344
    • Zorn AM, Wells JM (2009) Vertebrate endoderm development and organ formation. Annu Rev Cell Dev Biol 25:221-251. doi:10.1146/annurev.cellbio. 042308.113344
    • (2009) Annu Rev Cell Dev Biol , vol.25 , pp. 221-251
    • Zorn, A.M.1    Wells, J.M.2
  • 11
    • 0037343917 scopus 로고    scopus 로고
    • Single-cell transcript analysis of pancreas development
    • Chiang MK, Melton DA (2003) Single-cell transcript analysis of pancreas development. Dev Cell 4(3):383-393
    • (2003) Dev Cell , vol.4 , Issue.3 , pp. 383-393
    • Chiang, M.K.1    Melton, D.A.2
  • 12
    • 0036730427 scopus 로고    scopus 로고
    • The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    • DOI 10.1038/ng959
    • Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV (2002) The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32(1):128-134 (Pubitemid 34977207)
    • (2002) Nature Genetics , vol.32 , Issue.1 , pp. 128-134
    • Kawaguchi, Y.1    Cooper, B.2    Gannon, M.3    Ray, M.4    MacDonald, R.J.5    Wright, C.V.E.6
  • 13
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CVE, Teitelman G (1995) Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121:149-161
    • (1995) Development , vol.121 , pp. 149-161
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3    Leonard, J.4    Gamer, L.W.5    Wright, C.V.E.6    Teitelman, G.7
  • 15
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • DOI 10.1038/371606a0
    • Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609 (Pubitemid 24315741)
    • (1994) Nature , vol.371 , Issue.6498 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 16
    • 0033303666 scopus 로고    scopus 로고
    • Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter
    • Stoffers DA, Heller RS, Miller CP, Habener JF (1999) Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology 140(11):5374-5381
    • (1999) Endocrinology , vol.140 , Issue.11 , pp. 5374-5381
    • Stoffers, D.A.1    Heller, R.S.2    Miller, C.P.3    Habener, J.F.4
  • 17
    • 0030448129 scopus 로고    scopus 로고
    • Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning
    • DOI 10.1016/S0925-4773(96)00609-0, PII S0925477396006090
    • Larsson LI, Madsen OD, Serup P, Jonsson J, Edlund H (1996) Pancreatic-duodenal homeobox 1 -role in gastric endocrine patterning. Mech Dev 60(2):175-184 (Pubitemid 27067071)
    • (1996) Mechanisms of Development , vol.60 , Issue.2 , pp. 175-184
    • Larsson, L.-I.1    Madsen, O.D.2    Serup, P.3    Jonsson, J.4    Edlund, H.5
  • 18
    • 0029950724 scopus 로고    scopus 로고
    • The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    • Ahlgren U, Jonsson J, Edlund H (1996) The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1- deficient mice. Development 122:1409-1416 (Pubitemid 26159631)
    • (1996) Development , vol.122 , Issue.5 , pp. 1409-1416
    • Ahlgren, U.1    Jonsson, J.2    Edlund, H.3
  • 19
    • 70350310991 scopus 로고    scopus 로고
    • Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes
    • Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y, Pascal SM (2009) Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes. Diabetes Obes Metab 11(Suppl 4):65-81
    • (2009) Diabetes Obes Metab , vol.11 , Issue.SUPPL. 4 , pp. 65-81
    • Jonas, J.C.1    Bensellam, M.2    Duprez, J.3    Elouil, H.4    Guiot, Y.5    Pascal, S.M.6
  • 20
    • 40949099880 scopus 로고    scopus 로고
    • Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells
    • doi:10.1016/j.ydbio.2008.01.011
    • Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA (2008) Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol 316(1):74-86. doi:10.1016/j.ydbio.2008.01.011
    • (2008) Dev Biol , vol.316 , Issue.1 , pp. 74-86
    • Burlison, J.S.1    Long, Q.2    Fujitani, Y.3    Wright, C.V.4    Magnuson, M.A.5
  • 21
    • 0035476437 scopus 로고    scopus 로고
    • Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1
    • DOI 10.1006/dbio.2001.0359
    • Gannon M, Gamer LW, Wright CV (2001) Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1. Dev Biol 238(1):185-201. doi:10.1006/dbio.2001.0359 (Pubitemid 32939295)
    • (2001) Developmental Biology , vol.238 , Issue.1 , pp. 185-201
    • Gannon, M.1    Gamer, L.W.2    Wright, C.V.E.3
  • 22
    • 34347345036 scopus 로고    scopus 로고
    • Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression
    • DOI 10.1128/MCB.01978-06
    • Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M (2007) Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol 27(11):4093-4104. doi:10.1128/MCB.01978-06 (Pubitemid 47011006)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.11 , pp. 4093-4104
    • Wiebe, P.O.1    Kormish, J.D.2    Roper, V.T.3    Fujitani, Y.4    Alston, N.I.5    Zaret, K.S.6    Wright, C.V.E.7    Stein, R.W.8    Gannon, M.9
  • 23
    • 0034114786 scopus 로고    scopus 로고
    • Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter
    • DOI 10.1002/(SICI)1526-968X(200002)26:2<143::AID-G
    • Gannon M, Herrera PL, Wright CV (2000) Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis 26(2):143-144 (Pubitemid 30158101)
    • (2000) Genesis , vol.26 , Issue.2 , pp. 143-144
    • Gannon, M.1    Herrera, P.-L.2    Wright, C.V.E.3
  • 24
    • 0038360823 scopus 로고    scopus 로고
    • The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    • DOI 10.1016/S0012-1606(03)00115-5
    • Jacquemin P, Lemaigre FP, Rousseau GG (2003) The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade. Dev Biol 258(1):105-116 (Pubitemid 36627659)
    • (2003) Developmental Biology , vol.258 , Issue.1 , pp. 105-116
    • Jacquemin, P.1    Lemaigre, F.P.2    Rousseau, G.G.3
  • 25
    • 12944336527 scopus 로고    scopus 로고
    • Foxa2 is required for the differentiation of pancreatic alpha-cells
    • DOI 10.1016/j.ydbio.2004.10.012, PII S0012160604007456
    • Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH (2005) Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol 278(2):484-495 (Pubitemid 40175044)
    • (2005) Developmental Biology , vol.278 , Issue.2 , pp. 484-495
    • Lee, C.S.1    Sund, N.J.2    Behr, R.3    Herrera, P.L.4    Kaestner, K.H.5
  • 26
    • 84867152330 scopus 로고    scopus 로고
    • GATA4 and GATA6 control mouse pancreas organogenesis
    • doi:10.1172/JCI63240
    • Carrasco M, Delgado I, Soria B, Martin F, Rojas A (2012) GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Investig 122(10):3504-3515. doi:10.1172/JCI63240
    • (2012) J Clin Investig , vol.122 , Issue.10 , pp. 3504-3515
    • Carrasco, M.1    Delgado, I.2    Soria, B.3    Martin, F.4    Rojas, A.5
  • 28
    • 58149262961 scopus 로고    scopus 로고
    • Transcriptional dynamics of endodermal organ formation
    • Sherwood RI, Chen TY, Melton DA (2009) Transcriptional dynamics of endodermal organ formation. Dev Dyn 238(1):29-42
    • (2009) Dev Dyn , vol.238 , Issue.1 , pp. 29-42
    • Sherwood, R.I.1    Chen, T.Y.2    Melton, D.A.3
  • 29
    • 67650246360 scopus 로고    scopus 로고
    • Sox17 regulates organ lineage segregation of ventral foregut progenitor cells
    • doi:10.1016/j.devcel.2009.05.012
    • Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM (2009) Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 17(1):62-74. doi:10.1016/j.devcel.2009.05.012
    • (2009) Dev Cell , vol.17 , Issue.1 , pp. 62-74
    • Spence, J.R.1    Lange, A.W.2    Lin, S.C.3    Kaestner, K.H.4    Lowy, A.M.5    Kim, I.6    Whitsett, J.A.7    Wells, J.M.8
  • 31
    • 84873111871 scopus 로고    scopus 로고
    • Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration
    • doi:10.1242/dev.090159
    • Pan FC, Bankaitis ED, Boyer D, Xu X, Van de Casteele M, Magnuson MA, Heimberg H, Wright CV (2013) Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration. Development 140(4):751-764. doi:10.1242/dev.090159
    • (2013) Development , vol.140 , Issue.4 , pp. 751-764
    • Pan, F.C.1    Bankaitis, E.D.2    Boyer, D.3    Xu, X.4    Van De Casteele, M.5    Magnuson, M.A.6    Heimberg, H.7    Wright, C.V.8
  • 32
    • 79956326274 scopus 로고    scopus 로고
    • Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas
    • doi:10.1126/science.1202845
    • Xu CR, Cole PA, Meyers DJ, Kormish J, Dent S, Zaret KS (2011) Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas. Science 332(6032):963-966. doi:10.1126/science.1202845
    • (2011) Science , vol.332 , Issue.6032 , pp. 963-966
    • Xu, C.R.1    Cole, P.A.2    Meyers, D.J.3    Kormish, J.4    Dent, S.5    Zaret, K.S.6
  • 34
    • 78650219917 scopus 로고    scopus 로고
    • Epithelial dynamics of pancreatic branching morphogenesis
    • doi:10.1242/dev.052993
    • Villasenor A, Chong DC, Henkemeyer M, Cleaver O (2010) Epithelial dynamics of pancreatic branching morphogenesis. Development 137(24):4295-4305. doi:10.1242/dev.052993
    • (2010) Development , vol.137 , Issue.24 , pp. 4295-4305
    • Villasenor, A.1    Chong, D.C.2    Henkemeyer, M.3    Cleaver, O.4
  • 35
  • 36
    • 77955978501 scopus 로고    scopus 로고
    • Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    • doi:10.1016/j.devcel.2010.05.015
    • Schaffer AE, Freude KK, Nelson SB, Sander M (2010) Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell 18(6):1022-1029. doi:10.1016/j.devcel.2010.05. 015
    • (2010) Dev Cell , vol.18 , Issue.6 , pp. 1022-1029
    • Schaffer, A.E.1    Freude, K.K.2    Nelson, S.B.3    Sander, M.4
  • 38
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA (2002) Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129(10):2447-2457 (Pubitemid 34863851)
    • (2002) Development , vol.129 , Issue.10 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 39
    • 71649092364 scopus 로고    scopus 로고
    • Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth
    • doi:10.1016/j.devcel.2009.11.003
    • Solar M, Cardalda C, Houbracken I, Martin M, Maestro MA, De Medts N, Xu X, Grau V, Heimberg H, Bouwens L, Ferrer J (2009) Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell 17(6):849-860. doi:10.1016/j.devcel.2009.11.003
    • (2009) Dev Cell , vol.17 , Issue.6 , pp. 849-860
    • Solar, M.1    Cardalda, C.2    Houbracken, I.3    Martin, M.4    Maestro, M.A.5    De Medts, N.6    Xu, X.7    Grau, V.8    Heimberg, H.9    Bouwens, L.10    Ferrer, J.11
  • 40
    • 77950681696 scopus 로고    scopus 로고
    • Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas
    • doi:10.1186/1471-213X-10-38
    • Kopinke D, Murtaugh LC (2010) Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas. BMC Dev Biol 10:38. doi:10.1186/1471-213X-10-38
    • (2010) BMC Dev Biol , vol.10 , pp. 38
    • Kopinke, D.1    Murtaugh, L.C.2
  • 41
    • 78751515624 scopus 로고    scopus 로고
    • Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas
    • doi:10.1242/dev.053843
    • Kopinke D, Brailsford M, Shea JE, Leavitt R, Scaife CL, Murtaugh LC (2011) Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development 138(3):431-441. doi:10.1242/dev. 053843
    • (2011) Development , vol.138 , Issue.3 , pp. 431-441
    • Kopinke, D.1    Brailsford, M.2    Shea, J.E.3    Leavitt, R.4    Scaife, C.L.5    Murtaugh, L.C.6
  • 42
    • 79951539242 scopus 로고    scopus 로고
    • Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • doi:10.1242/dev.056499
    • Kopp JL, Dubois CL, Schaffer AE, Hao E, Shih HP, Seymour PA, Ma J, Sander M (2011) Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138(4):653-665. doi:10.1242/dev.056499
    • (2011) Development , vol.138 , Issue.4 , pp. 653-665
    • Kopp, J.L.1    Dubois, C.L.2    Schaffer, A.E.3    Hao, E.4    Shih, H.P.5    Seymour, P.A.6    Ma, J.7    Sander, M.8
  • 43
    • 33847210675 scopus 로고    scopus 로고
    • Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    • doi:10.1038/nature05537
    • Stanger BZ, Tanaka AJ, Melton DA (2007) Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445(7130):886-891. doi:10.1038/nature05537
    • (2007) Nature , vol.445 , Issue.7130 , pp. 886-891
    • Stanger, B.Z.1    Tanaka, A.J.2    Melton, D.A.3
  • 44
    • 0035694459 scopus 로고    scopus 로고
    • Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    • Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R (2001) Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128(24):5109-5117 (Pubitemid 34083036)
    • (2001) Development , vol.128 , Issue.24 , pp. 5109-5117
    • Bhushan, A.1    Itoh, N.2    Kato, S.3    Thiery, J.P.4    Czernichow, P.5    Bellusci, S.6    Scharfmann, R.7
  • 45
    • 28044449357 scopus 로고    scopus 로고
    • Beta-Catenin is essential for pancreatic acinar but not islet development
    • DOI 10.1242/dev.02063
    • Murtaugh LC, Law AC, Dor Y, Melton DA (2005) Beta-catenin is essential for pancreatic acinar but not islet development. Development 132(21):4663-4674. doi:10.1242/dev.02063 (Pubitemid 41685277)
    • (2005) Development , vol.132 , Issue.21 , pp. 4663-4674
    • Murtaugh, L.C.1    Law, A.C.2    Dor, Y.3    Melton, D.A.4
  • 47
    • 0037125977 scopus 로고    scopus 로고
    • Experimental control of pancreatic development and maintenance
    • doi:10.1073/pnas.192255099
    • Holland AM, Hale MA, Kagami H, Hammer RE, MacDonald RJ (2002) Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci USA 99(19):12236-12241. doi:10.1073/pnas.192255099
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.19 , pp. 12236-12241
    • Holland, A.M.1    Hale, M.A.2    Kagami, H.3    Hammer, R.E.4    MacDonald, R.J.5
  • 48
    • 25844522522 scopus 로고    scopus 로고
    • The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas
    • DOI 10.1016/j.ydbio.2005.07.026, PII S0012160605005075
    • Hale MA, Kagami H, Shi L, Holland AM, Elsasser HP, Hammer RE, MacDonald RJ (2005) The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas. Dev Biol 286(1):225-237. doi:10.1016/j.ydbio.2005.07.026 (Pubitemid 41394060)
    • (2005) Developmental Biology , vol.286 , Issue.1 , pp. 225-237
    • Hale, M.A.1    Kagami, H.2    Shi, L.3    Holland, A.M.4    Elsasser, H.-P.5    Hammer, R.E.6    MacDonald, R.J.7
  • 49
    • 38649133142 scopus 로고    scopus 로고
    • Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells
    • doi:10.1186/1471-213X-7-129
    • Svensson P, Williams C, Lundeberg J, Ryden P, Bergqvist I, Edlund H (2007) Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells. BMC Dev Biol 7:129. doi:10.1186/1471-213X-7-129
    • (2007) BMC Dev Biol , vol.7 , pp. 129
    • Svensson, P.1    Williams, C.2    Lundeberg, J.3    Ryden, P.4    Bergqvist, I.5    Edlund, H.6
  • 50
    • 84865277434 scopus 로고    scopus 로고
    • A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
    • doi:10.1242/dev.078733
    • Seymour PA, Shih HP, Patel NA, Freude KK, Xie R, Lim CJ, Sander M (2012) A Sox9/Fgf feed-forward loop maintains pancreatic organ identity. Development 139(18):3363-3372. doi:10.1242/dev.078733
    • (2012) Development , vol.139 , Issue.18 , pp. 3363-3372
    • Seymour, P.A.1    Shih, H.P.2    Patel, N.A.3    Freude, K.K.4    Xie, R.5    Lim, C.J.6    Sander, M.7
  • 51
    • 74049127312 scopus 로고    scopus 로고
    • An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo
    • doi:10.1002/dvdy.22091
    • Rojas A, Schachterle W, Xu SM, Black BL (2009) An endoderm-specific transcriptional enhancer from the mouse Gata4 gene requires GATA and homeodomain protein-binding sites for function in vivo. Dev Dyn 238(10):2588-2598. doi:10.1002/dvdy.22091
    • (2009) Dev Dyn , vol.238 , Issue.10 , pp. 2588-2598
    • Rojas, A.1    Schachterle, W.2    Xu, S.M.3    Black, B.L.4
  • 52
    • 68849091103 scopus 로고    scopus 로고
    • The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    • doi:10.1172/JCI37028
    • Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA (2009) The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest 119(7):1888-1898. doi:10.1172/JCI37028
    • (2009) J Clin Invest , vol.119 , Issue.7 , pp. 1888-1898
    • Oliver-Krasinski, J.M.1    Kasner, M.T.2    Yang, J.3    Crutchlow, M.F.4    Rustgi, A.K.5    Kaestner, K.H.6    Stoffers, D.A.7
  • 53
    • 30544438811 scopus 로고    scopus 로고
    • An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
    • DOI 10.1016/j.ydbio.2005.11.023, PII S001216060500816X
    • Jacquemin P, Yoshitomi H, Kashima Y, Rousseau GG, Lemaigre FP, Zaret KS (2006) An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol 290(1):189-199. doi:10.1016/j.ydbio.2005.11.023 (Pubitemid 43083614)
    • (2006) Developmental Biology , vol.290 , Issue.1 , pp. 189-199
    • Jacquemin, P.1    Yoshitomi, H.2    Kashima, Y.3    Rousseau, G.G.4    Lemaigre, F.P.5    Zaret, K.S.6
  • 54
    • 33645236232 scopus 로고    scopus 로고
    • PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L
    • doi:10.1128/MCB.26.1.117-130.2006
    • Beres TM, Masui T, Swift GH, Shi L, Henke RM, MacDonald RJ (2006) PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L. Mol Cell Biol 26(1):117-130. doi:10.1128/MCB.26.1.117-130.2006
    • (2006) Mol Cell Biol , vol.26 , Issue.1 , pp. 117-130
    • Beres, T.M.1    Masui, T.2    Swift, G.H.3    Shi, L.4    Henke, R.M.5    MacDonald, R.J.6
  • 55
    • 35348985382 scopus 로고    scopus 로고
    • Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex
    • DOI 10.1101/gad.1575207
    • Masui T, Long Q, Beres TM, Magnuson MA, MacDonald RJ (2007) Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex. Genes Dev 21(20):2629-2643. doi:10.1101/gad.1575207 (Pubitemid 47607672)
    • (2007) Genes and Development , vol.21 , Issue.20 , pp. 2629-2643
    • Masui, T.1    Long, Q.2    Beres, T.M.3    Magnuson, M.A.4    MacDonald, R.J.5
  • 56
    • 84857846185 scopus 로고    scopus 로고
    • RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors
    • doi:10.1128/MCB.06318-11
    • Thompson N, Gesina E, Scheinert P, Bucher P, Grapin-Botton A (2012) RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors. Mol Cell Biol 32(6):1189-1199. doi:10.1128/MCB.06318-11
    • (2012) Mol Cell Biol , vol.32 , Issue.6 , pp. 1189-1199
    • Thompson, N.1    Gesina, E.2    Scheinert, P.3    Bucher, P.4    Grapin-Botton, A.5
  • 57
    • 50249106419 scopus 로고    scopus 로고
    • Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood
    • doi:10.1128/MCB.00549-08
    • Masui T, Swift GH, Hale MA, Meredith DM, Johnson JE, Macdonald RJ (2008) Transcriptional autoregulation controls pancreatic Ptf1a expression during development and adulthood. Mol Cell Biol 28(17):5458-5468. doi:10.1128/MCB. 00549-08
    • (2008) Mol Cell Biol , vol.28 , Issue.17 , pp. 5458-5468
    • Masui, T.1    Swift, G.H.2    Hale, M.A.3    Meredith, D.M.4    Johnson, J.E.5    Macdonald, R.J.6
  • 60
    • 0027450889 scopus 로고
    • Mouse GATA-4: A retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart
    • Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB (1993) Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol 13(4):2235-2246 (Pubitemid 23097702)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.4 , pp. 2235-2246
    • Arceci, R.J.1    King, A.A.J.2    Simon, M.C.3    Orkin, S.H.4    Wilson, D.B.5
  • 61
    • 0034671733 scopus 로고    scopus 로고
    • The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression
    • Molkentin JD (2000) The zinc finger-containing transcription factors GATA-4, -5, and -6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem 275(50):38949-38952
    • (2000) J Biol Chem , vol.275 , Issue.50 , pp. 38949-38952
    • Molkentin, J.D.1
  • 64
    • 0344771681 scopus 로고    scopus 로고
    • Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation
    • Coffinier C, Thepot D, Babinet C, Yaniv M, Barra J (1999) Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development 126(21):4785-4794
    • (1999) Development , vol.126 , Issue.21 , pp. 4785-4794
    • Coffinier, C.1    Thepot, D.2    Babinet, C.3    Yaniv, M.4    Barra, J.5
  • 68
    • 33644772578 scopus 로고    scopus 로고
    • A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
    • DOI 10.2337/diabetes.55.1.61
    • Poll AV, Pierreux CE, Lokmane L, Haumaitre C, Achouri Y, Jacquemin P, Rousseau GG, Cereghini S, Lemaigre FP (2006) A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells. Diabetes 55(1):61-69 (Pubitemid 43343299)
    • (2006) Diabetes , vol.55 , Issue.1 , pp. 61-69
    • Poll, A.V.1    Pierreux, C.E.2    Lokmane, L.3    Haumaitre, C.4    Achouri, Y.5    Jacquemin, P.6    Rousseau, G.G.7    Cereghini, S.8    Lemaigre, F.P.9
  • 69
    • 0032844643 scopus 로고    scopus 로고
    • Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    • DOI 10.1038/12669
    • Li H, Arber S, Jessell TM, Edlund H (1999) Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 23(1):67-70 (Pubitemid 29418790)
    • (1999) Nature Genetics , vol.23 , Issue.1 , pp. 67-70
    • Li, H.1    Arber, S.2    Jessell, T.M.3    Edlund, H.4
  • 70
    • 0032860478 scopus 로고    scopus 로고
    • Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
    • DOI 10.1038/12674
    • Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH (1999) Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23(1):71-75 (Pubitemid 29418791)
    • (1999) Nature Genetics , vol.23 , Issue.1 , pp. 71-75
    • Harrison, K.A.1    Thaler, J.2    Pfaff, S.L.3    Gu, H.4    Kehrl, J.H.5
  • 72
    • 25844446995 scopus 로고    scopus 로고
    • Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells
    • DOI 10.1016/j.ydbio.2005.07.021, PII S001216060500477X
    • Wang J, Kilic G, Aydin M, Burke Z, Oliver G, Sosa-Pineda B (2005) Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells. Dev Biol 286(1):182-194. doi:10.1016/j.ydbio.2005.07.021 (Pubitemid 41394056)
    • (2005) Developmental Biology , vol.286 , Issue.1 , pp. 182-194
    • Wang, J.1    Kilic, G.2    Aydin, M.3    Burke, Z.4    Oliver, G.5    Sosa-Pineda, B.6
  • 73
    • 84859439941 scopus 로고    scopus 로고
    • Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas
    • doi:10.1053/j.gastro.2011.12.007
    • Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B (2012) Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Gastroenterology 142 (4):999-1009 e1006. doi:10.1053/j.gastro.2011.12.007
    • (2012) Gastroenterology , vol.142 , Issue.4
    • Westmoreland, J.J.1    Kilic, G.2    Sartain, C.3    Sirma, S.4    Blain, J.5    Rehg, J.6    Harvey, N.7    Sosa-Pineda, B.8
  • 74
    • 58049204234 scopus 로고    scopus 로고
    • Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    • doi:10.1101/gad.1752608
    • Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH (2008) Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev 22(24):3435-3448. doi:10.1101/gad.1752608
    • (2008) Genes Dev , vol.22 , Issue.24 , pp. 3435-3448
    • Gao, N.1    LeLay, J.2    Vatamaniuk, M.Z.3    Rieck, S.4    Friedman, J.R.5    Kaestner, K.H.6
  • 75
    • 2442666735 scopus 로고    scopus 로고
    • Transcriptional networks controlling pancreatic development and beta cell function
    • DOI 10.1007/s00125-004-1368-9
    • Servitja JM, Ferrer J (2004) Transcriptional networks controlling pancreatic development and beta cell function. Diabetologia 47(4):597-613. doi:10.1007/s00125-004-1368-9 (Pubitemid 38658361)
    • (2004) Diabetologia , vol.47 , Issue.4 , pp. 597-613
    • Servitja, J.M.1    Ferrer, J.2
  • 76
    • 84876351067 scopus 로고    scopus 로고
    • Gene regulatory networks governing pancreas development
    • doi:10.1016/j.devcel.2013.03.016
    • Arda HE, Benitez CM, Kim SK (2013) Gene regulatory networks governing pancreas development. Dev Cell 25(1):5-13. doi:10.1016/j.devcel.2013.03.016
    • (2013) Dev Cell , vol.25 , Issue.1 , pp. 5-13
    • Arda, H.E.1    Benitez, C.M.2    Kim, S.K.3
  • 77
    • 0002923914 scopus 로고
    • Development of the embryonic endocrine pancreas
    • Greep RO, Astwood EB, Steiner DF, Freinkel N, Geiger SR (eds) American Physiological Society, Washington, DC
    • Pictet R, Rutter WJ (1972) Development of the embryonic endocrine pancreas. In: Greep RO, Astwood EB, Steiner DF, Freinkel N, Geiger SR (eds) Handbook of physiology, vol I. American Physiological Society, Washington, DC, pp 25-76
    • (1972) Handbook of Physiology , vol.1 , pp. 25-76
    • Pictet, R.1    Rutter, W.J.2
  • 78
    • 43949111010 scopus 로고    scopus 로고
    • Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development
    • DOI 10.1369/jhc.2008.950675
    • Hald J, Sprinkel AE, Ray M, Serup P, Wright C, Madsen OD (2008) Generation and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development. J Histochem Cytochem 56(6):587-595. doi:10.1369/jhc.2008.950675 (Pubitemid 351702303)
    • (2008) Journal of Histochemistry and Cytochemistry , vol.56 , Issue.6 , pp. 587-595
    • Hald, J.1    Sprinkel, A.E.2    Ray, M.3    Serup, P.4    Wright, C.5    Madsen, O.D.6
  • 84
    • 33846619189 scopus 로고    scopus 로고
    • Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas
    • DOI 10.1016/j.modgep.2006.11.001, PII S1567133X06001931
    • Rukstalis JM, Habener JF (2007) Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas. Gene Expr Patterns 7(4):471-479. doi:10.1016/j.modgep.2006.11.001 (Pubitemid 46172933)
    • (2007) Gene Expression Patterns , vol.7 , Issue.4 , pp. 471-479
    • Rukstalis, J.M.1    Habener, J.F.2
  • 85
    • 70349778139 scopus 로고    scopus 로고
    • One process for pancreatic beta-cell coalescence into islets involves an epithelial-mesenchymal transition
    • doi:10.1677/JOE-09-0072
    • Cole L, Anderson M, Antin PB, Limesand SW (2009) One process for pancreatic beta-cell coalescence into islets involves an epithelial-mesenchymal transition. J Endocrinol 203(1):19-31. doi:10.1677/JOE-09-0072
    • (2009) J Endocrinol , vol.203 , Issue.1 , pp. 19-31
    • Cole, L.1    Anderson, M.2    Antin, P.B.3    Limesand, S.W.4
  • 86
    • 84858841326 scopus 로고    scopus 로고
    • The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and beta-cell differentiation
    • doi:10.1242/dev.072892
    • Metzger DE, Gasperowicz M, Otto F, Cross JC, Gradwohl G, Zaret KS (2012) The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and beta-cell differentiation. Development 139(8):1447-1456. doi:10.1242/dev.072892
    • (2012) Development , vol.139 , Issue.8 , pp. 1447-1456
    • Metzger, D.E.1    Gasperowicz, M.2    Otto, F.3    Cross, J.C.4    Gradwohl, G.5    Zaret, K.S.6
  • 87
    • 80053602993 scopus 로고    scopus 로고
    • Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium
    • doi:10.1016/j.ydbio.2011.08.006
    • Magenheim J, Klein AM, Stanger BZ, Ashery-Padan R, Sosa-Pineda B, Gu G, Dor Y (2011) Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol 359(1):26-36. doi:10.1016/j.ydbio.2011.08.006
    • (2011) Dev Biol , vol.359 , Issue.1 , pp. 26-36
    • Magenheim, J.1    Klein, A.M.2    Stanger, B.Z.3    Ashery-Padan, R.4    Sosa-Pineda, B.5    Gu, G.6    Dor, Y.7
  • 88
    • 84355162838 scopus 로고    scopus 로고
    • Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development
    • doi:10.1016/j.ydbio.2011.10.025
    • Beucher A, Martin M, Spenle C, Poulet M, Collin C, Gradwohl G (2012) Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development. Dev Biol 361(2):277-285. doi:10.1016/j.ydbio.2011.10.025
    • (2012) Dev Biol , vol.361 , Issue.2 , pp. 277-285
    • Beucher, A.1    Martin, M.2    Spenle, C.3    Poulet, M.4    Collin, C.5    Gradwohl, G.6
  • 89
    • 79951590737 scopus 로고    scopus 로고
    • Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development
    • doi:10.1002/dvdy.22544
    • Gouzi M, Kim YH, Katsumoto K, Johansson K, Grapin-Botton A (2011) Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development. Dev Dyn 240(3):589-604. doi:10.1002/dvdy.22544
    • (2011) Dev Dyn , vol.240 , Issue.3 , pp. 589-604
    • Gouzi, M.1    Kim, Y.H.2    Katsumoto, K.3    Johansson, K.4    Grapin-Botton, A.5
  • 90
    • 59649089873 scopus 로고    scopus 로고
    • Rac1 regulates pancreatic islet morphogenesis
    • doi:10.1186/1471-213X-9-2
    • Greiner TU, Kesavan G, Stahlberg A, Semb H (2009) Rac1 regulates pancreatic islet morphogenesis. BMC Dev Biol 9:2. doi:10.1186/1471-213X-9-2
    • (2009) BMC Dev Biol , vol.9 , pp. 2
    • Greiner, T.U.1    Kesavan, G.2    Stahlberg, A.3    Semb, H.4
  • 94
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • doi:10.1016/j.devcel.2007.02.010
    • Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A (2007) Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 12(3):457-465. doi:10.1016/j.devcel.2007.02.010
    • (2007) Dev Cell , vol.12 , Issue.3 , pp. 457-465
    • Johansson, K.A.1    Dursun, U.2    Jordan, N.3    Gu, G.4    Beermann, F.5    Gradwohl, G.6    Grapin-Botton, A.7
  • 95
    • 77649182245 scopus 로고    scopus 로고
    • Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
    • doi:10.1016/j.ydbio.2009.12.009
    • Wang S, Yan J, Anderson DA, Xu Y, Kanal MC, Cao Z, Wright CV, Gu G (2010) Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. Dev Biol 339(1):26-37. doi:10.1016/j.ydbio. 2009.12.009
    • (2010) Dev Biol , vol.339 , Issue.1 , pp. 26-37
    • Wang, S.1    Yan, J.2    Anderson, D.A.3    Xu, Y.4    Kanal, M.C.5    Cao, Z.6    Wright, C.V.7    Gu, G.8
  • 96
    • 84876365172 scopus 로고    scopus 로고
    • Neurogenin3 cooperates with Foxa2 to autoactivate its own expression
    • doi:10.1074/jbc.M112.388173
    • Ejarque M, Cervantes S, Pujadas G, Tutusaus A, Sanchez L, Gasa R (2013) Neurogenin3 cooperates with Foxa2 to autoactivate its own expression. J Biol Chem 288(17):11705-11717. doi:10.1074/jbc.M112.388173
    • (2013) J Biol Chem , vol.288 , Issue.17 , pp. 11705-11717
    • Ejarque, M.1    Cervantes, S.2    Pujadas, G.3    Tutusaus, A.4    Sanchez, L.5    Gasa, R.6
  • 98
    • 84860410786 scopus 로고    scopus 로고
    • Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression
    • doi:10.1101/gad.16875711
    • Yang YP, Thorel F, Boyer DF, Herrera PL, Wright CV (2011) Context-specific alpha- to-beta-cell reprogramming by forced Pdx1 expression. Genes Dev 25(16):1680-1685. doi:10.1101/gad.16875711
    • (2011) Genes Dev , vol.25 , Issue.16 , pp. 1680-1685
    • Yang, Y.P.1    Thorel, F.2    Boyer, D.F.3    Herrera, P.L.4    Wright, C.V.5
  • 100
    • 0033984886 scopus 로고    scopus 로고
    • Independent development of pancreatic and beta-cells from Neurogenin3- expressing precursors: A role for the notch pathway in repression of premature differentiation
    • Jensen J, Heller RS, Funder-Nielsen T, Pedersen E, Lindsell C, Weinmaster G, Madsen OD, Serup P (2000) Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49(2):163-176 (Pubitemid 30070993)
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 163-176
    • Jensen, J.1    Heller, R.S.2    Funder-Nielsen, T.3    Pedersen, E.E.4    Lindsell, C.5    Weinmaster, G.6    Madsen, O.D.7    Serup, P.8
  • 101
    • 84863088235 scopus 로고    scopus 로고
    • A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
    • doi:10.1242/dev.078634
    • Shih HP, Kopp JL, Sandhu M, Dubois CL, Seymour PA, Grapin-Botton A, Sander M (2012) A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation. Development 139(14):2488-2499. doi:10.1242/dev.078634
    • (2012) Development , vol.139 , Issue.14 , pp. 2488-2499
    • Shih, H.P.1    Kopp, J.L.2    Sandhu, M.3    Dubois, C.L.4    Seymour, P.A.5    Grapin-Botton, A.6    Sander, M.7
  • 102
    • 68349113777 scopus 로고    scopus 로고
    • Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas
    • doi:10.1016/j.mod.2009.05.005
    • Golson ML, Le Lay J, Gao N, Bramswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH (2009) Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mech Dev 126(8-9):687-699. doi:10.1016/j.mod.2009.05.005
    • (2009) Mech Dev , vol.126 , Issue.8-9 , pp. 687-699
    • Golson, M.L.1    Le Lay, J.2    Gao, N.3    Bramswig, N.4    Loomes, K.M.5    Oakey, R.6    May, C.L.7    White, P.8    Kaestner, K.H.9
  • 103
    • 69749084211 scopus 로고    scopus 로고
    • Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window
    • doi:10.1101/gad.1800209
    • Cras-Meneur C, Li L, Kopan R, Permutt MA (2009) Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev 23(17):2088-2101. doi:10.1101/gad.1800209
    • (2009) Genes Dev , vol.23 , Issue.17 , pp. 2088-2101
    • Cras-Meneur, C.1    Li, L.2    Kopan, R.3    Permutt, M.A.4
  • 105
    • 53549088061 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors
    • doi:10.1128/MCB.00413-08
    • Haumaitre C, Lenoir O, Scharfmann R (2008) Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol 28(20):6373-6383. doi:10.1128/MCB.00413-08
    • (2008) Mol Cell Biol , vol.28 , Issue.20 , pp. 6373-6383
    • Haumaitre, C.1    Lenoir, O.2    Scharfmann, R.3
  • 106
    • 84871684668 scopus 로고    scopus 로고
    • Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis
    • doi:10.1016/j.celrep.2012.10.016
    • Cortijo C, Gouzi M, Tissir F, Grapin-Botton A (2012) Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep 2(6):1593-1606. doi:10.1016/j.celrep.2012.10.016
    • (2012) Cell Rep , vol.2 , Issue.6 , pp. 1593-1606
    • Cortijo, C.1    Gouzi, M.2    Tissir, F.3    Grapin-Botton, A.4
  • 107
    • 70350144386 scopus 로고    scopus 로고
    • Pancreatic neurogenin 3-expressing cells are unipotent islet precursors
    • doi:10.1242/dev.039214
    • Desgraz R, Herrera PL (2009) Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development 136(21):3567-3574. doi:10.1242/dev. 039214
    • (2009) Development , vol.136 , Issue.21 , pp. 3567-3574
    • Desgraz, R.1    Herrera, P.L.2
  • 108
    • 0141643340 scopus 로고    scopus 로고
    • Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4
    • DOI 10.1074/jbc.M302229200
    • Smith SB, Gasa R, Watada H, Wang J, Griffen SC, German MS (2003) Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4. J Biol Chem 278(40):38254-38259 (Pubitemid 37221715)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.40 , pp. 38254-38259
    • Smith, S.B.1    Gasa, R.2    Watada, H.3    Wang, J.4    Griffen, S.C.5    German, M.S.6
  • 110
  • 111
    • 0037931806 scopus 로고    scopus 로고
    • Distinct gene expression programs function in progenitor and mature islet cells
    • DOI 10.1074/jbc.M213196200
    • Watada H, Scheel DW, Leung J, German MS (2003) Distinct gene expression programs function in progenitor and mature islet cells. J Biol Chem 278(19):17130-17140. doi:10.1074/jbc.M213196200 (Pubitemid 36799591)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.19 , pp. 17130-17140
    • Watada, H.1    Scheel, D.W.2    Leung, J.3    German, M.S.4
  • 113
    • 43049145766 scopus 로고    scopus 로고
    • Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation
    • doi:10.1016/j.ydbio.2008.02.052
    • Wang S, Hecksher-Sorensen J, Xu Y, Zhao A, Dor Y, Rosenberg L, Serup P, Gu G (2008) Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol 317(2):531-540. doi:10.1016/j.ydbio.2008.02.052
    • (2008) Dev Biol , vol.317 , Issue.2 , pp. 531-540
    • Wang, S.1    Hecksher-Sorensen, J.2    Xu, Y.3    Zhao, A.4    Dor, Y.5    Rosenberg, L.6    Serup, P.7    Gu, G.8
  • 117
    • 1642474003 scopus 로고    scopus 로고
    • Global expression analysis of gene regulatory pathways during endocrine pancreatic development
    • DOI 10.1242/dev.00921
    • Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA (2004) Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 131(1):165-179. doi:10.1242/dev.00921 (Pubitemid 38111424)
    • (2004) Development , vol.131 , Issue.1 , pp. 165-179
    • Gu, G.1    Wells, J.M.2    Dombkowski, D.3    Preffer, F.4    Aronow, B.5    Melton, D.A.6
  • 118
    • 40949142371 scopus 로고    scopus 로고
    • Defining pancreatic endocrine precursors and their descendants
    • doi:10.2337/db07-1362
    • White P, May CL, Lamounier RN, Brestelli JE, Kaestner KH (2008) Defining pancreatic endocrine precursors and their descendants. Diabetes 57(3):654-668. doi:10.2337/db07-1362
    • (2008) Diabetes , vol.57 , Issue.3 , pp. 654-668
    • White, P.1    May, C.L.2    Lamounier, R.N.3    Brestelli, J.E.4    Kaestner, K.H.5
  • 119
    • 58149343890 scopus 로고    scopus 로고
    • Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse
    • doi:10.2337/db07-1126
    • Juhl K, Sarkar SA, Wong R, Jensen J, Hutton JC (2008) Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes 57(10):2755-2761. doi:10.2337/db07-1126
    • (2008) Diabetes , vol.57 , Issue.10 , pp. 2755-2761
    • Juhl, K.1    Sarkar, S.A.2    Wong, R.3    Jensen, J.4    Hutton, J.C.5
  • 120
    • 48749122021 scopus 로고    scopus 로고
    • On the origin of the beta cell
    • doi:10.1101/gad.1670808
    • Oliver-Krasinski JM, Stoffers DA (2008) On the origin of the beta cell. Genes Dev 22(15):1998-2021. doi:10.1101/gad.1670808
    • (2008) Genes Dev , vol.22 , Issue.15 , pp. 1998-2021
    • Oliver-Krasinski, J.M.1    Stoffers, D.A.2
  • 121
    • 33748251457 scopus 로고    scopus 로고
    • The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells
    • DOI 10.1101/gad.381806
    • Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C (2006) The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev 20(17):2465-2478. doi:10.1101/gad.381806 (Pubitemid 44320393)
    • (2006) Genes and Development , vol.20 , Issue.17 , pp. 2465-2478
    • Gierl, M.S.1    Karoulias, N.2    Wende, H.3    Strehle, M.4    Birchmeier, C.5
  • 122
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
    • Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11(18):2323-2334 (Pubitemid 27408530)
    • (1997) Genes and Development , vol.11 , Issue.18 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.-P.2    Qiu, Y.3    Mutoh, H.4    DeMayo, F.J.5    Leiter, A.B.6    Tsai, M.-J.7
  • 123
    • 70349145464 scopus 로고    scopus 로고
    • Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    • doi:10.2337/db08-0987
    • Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL (2009) Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes 58(9):2059-2069. doi:10.2337/db08-0987
    • (2009) Diabetes , vol.58 , Issue.9 , pp. 2059-2069
    • Du, A.1    Hunter, C.S.2    Murray, J.3    Noble, D.4    Cai, C.L.5    Evans, S.M.6    Stein, R.7    May, C.L.8
  • 124
    • 0031843386 scopus 로고    scopus 로고
    • Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    • Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS (1998) Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 125(12):2213-2221 (Pubitemid 28336383)
    • (1998) Development , vol.125 , Issue.12 , pp. 2213-2221
    • Sussel, L.1    Kalamaras, J.2    Hartigan-O'Connor, D.J.3    Meneses, J.J.4    Pedersen, R.A.5    Rubenstein, J.L.R.6    German, M.S.7
  • 126
    • 23144437373 scopus 로고    scopus 로고
    • NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas
    • DOI 10.1242/dev.01875
    • Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M (2005) NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development 132(13):3139-3149. doi:10.1242/dev. 01875 (Pubitemid 41086746)
    • (2005) Development , vol.132 , Issue.13 , pp. 3139-3149
    • Henseleit, K.D.1    Nelson, S.B.2    Kuhlbrodt, K.3    Hennings, J.C.4    Ericson, J.5    Sander, M.6
  • 128
    • 36549075522 scopus 로고    scopus 로고
    • Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells
    • DOI 10.1016/j.ydbio.2007.09.057, PII S0012160607014108
    • Chao CS, Loomis ZL, Lee JE, Sussel L (2007) Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol 312(2):523-532. doi:10.1016/j.ydbio.2007.09.057 (Pubitemid 350183978)
    • (2007) Developmental Biology , vol.312 , Issue.2 , pp. 523-532
    • Chao, C.S.1    Loomis, Z.L.2    Lee, J.E.3    Sussel, L.4
  • 129
    • 84874778569 scopus 로고    scopus 로고
    • Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas
    • doi:10.1371/journal.pgen.1003278
    • Mastracci TL, Anderson KR, Papizan JB, Sussel L (2013) Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreas. PLoS Genet 9(2):e1003278. doi:10.1371/journal.pgen. 1003278
    • (2013) PLoS Genet , vol.9 , Issue.2
    • Mastracci, T.L.1    Anderson, K.R.2    Papizan, J.B.3    Sussel, L.4
  • 130
    • 80053580232 scopus 로고    scopus 로고
    • Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression
    • doi:10.1016/j.ydbio.2011.08.001
    • Mastracci TL, Wilcox CL, Arnes L, Panea C, Golden JA, May CL, Sussel L (2011) Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol 359(1):1-11. doi:10.1016/j.ydbio.2011.08.001
    • (2011) Dev Biol , vol.359 , Issue.1 , pp. 1-11
    • Mastracci, T.L.1    Wilcox, C.L.2    Arnes, L.3    Panea, C.4    Golden, J.A.5    May, C.L.6    Sussel, L.7
  • 131
    • 79961187994 scopus 로고    scopus 로고
    • Transcriptional regulation of alpha-cell differentiation
    • doi:10.1111/j.1463-1326.2011.01440.x
    • Bramswig NC, Kaestner KH (2011) Transcriptional regulation of alpha-cell differentiation. Diabetes Obes Metab 13(Suppl 1):13-20. doi:10.1111/j.1463-1326. 2011.01440.x
    • (2011) Diabetes Obes Metab , vol.13 , Issue.SUPPL. 1 , pp. 13-20
    • Bramswig, N.C.1    Kaestner, K.H.2
  • 133
    • 0030897629 scopus 로고    scopus 로고
    • The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas
    • DOI 10.1038/386399a0
    • Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Gruss P (1997) The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas. Nature 386:399-402 (Pubitemid 27154480)
    • (1997) Nature , vol.386 , Issue.6623 , pp. 399-402
    • Sosa-Pineda, B.1    Chowdhury, K.2    Torres, M.3    Oliver, G.4    Gruss, P.5
  • 134
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    • doi:10.1016/j.cell.2009.05.035
    • Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, Serup P, Heimberg H, Mansouri A (2009) The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138(3):449-462. doi:10.1016/j.cell.2009.05.035
    • (2009) Cell , vol.138 , Issue.3 , pp. 449-462
    • Collombat, P.1    Xu, X.2    Ravassard, P.3    Sosa-Pineda, B.4    Dussaud, S.5    Billestrup, N.6    Madsen, O.D.7    Serup, P.8    Heimberg, H.9    Mansouri, A.10
  • 137
    • 38949149704 scopus 로고    scopus 로고
    • pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis
    • doi:10.1016/j.ydbio.2007.10.038
    • Gannon M, Ables ET, Crawford L, Lowe D, Offield MF, Magnuson MA, Wright CV (2008) pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol 314(2):406-417. doi:10.1016/j.ydbio.2007.10.038
    • (2008) Dev Biol , vol.314 , Issue.2 , pp. 406-417
    • Gannon, M.1    Ables, E.T.2    Crawford, L.3    Lowe, D.4    Offield, M.F.5    Magnuson, M.A.6    Wright, C.V.7
  • 138
    • 80455173402 scopus 로고    scopus 로고
    • Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming
    • doi:10.1101/gad.173039.111
    • Papizan JB, Singer RA, Tschen SI, Dhawan S, Friel JM, Hipkens SB, Magnuson MA, Bhushan A, Sussel L (2011) Nkx2.2 repressor complex regulates islet beta-cell specification and prevents beta-to-alpha-cell reprogramming. Genes Dev 25(21):2291-2305. doi:10.1101/gad.173039.111
    • (2011) Genes Dev , vol.25 , Issue.21 , pp. 2291-2305
    • Papizan, J.B.1    Singer, R.A.2    Tschen, S.I.3    Dhawan, S.4    Friel, J.M.5    Hipkens, S.B.6    Magnuson, M.A.7    Bhushan, A.8    Sussel, L.9
  • 139
    • 79954563768 scopus 로고    scopus 로고
    • Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx
    • doi:10.1016/j.devcel.2011.03.012
    • Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A (2011) Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell 20(4):419-429. doi:10.1016/j.devcel.2011.03.012
    • (2011) Dev Cell , vol.20 , Issue.4 , pp. 419-429
    • Dhawan, S.1    Georgia, S.2    Tschen, S.I.3    Fan, G.4    Bhushan, A.5
  • 140
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • doi:10.1038/nature08894
    • Thorel F, Nepote V, Avril I, Kohno K, Desgraz R, Chera S, Herrera PL (2010) Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464(7292):1149-1154. doi:10.1038/nature08894
    • (2010) Nature , vol.464 , Issue.7292 , pp. 1149-1154
    • Thorel, F.1    Nepote, V.2    Avril, I.3    Kohno, K.4    Desgraz, R.5    Chera, S.6    Herrera, P.L.7
  • 142
    • 77953903417 scopus 로고    scopus 로고
    • Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells
    • doi:10.1053/j.gastro.2010.04.003
    • Masui T, Swift GH, Deering T, Shen C, Coats WS, Long Q, Elsasser HP, Magnuson MA, MacDonald RJ (2010) Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells. Gastroenterology 139(1):270-280. doi:10.1053/j.gastro.2010.04.003
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 270-280
    • Masui, T.1    Swift, G.H.2    Deering, T.3    Shen, C.4    Coats, W.S.5    Long, Q.6    Elsasser, H.P.7    Magnuson, M.A.8    MacDonald, R.J.9
  • 143
    • 33748963738 scopus 로고    scopus 로고
    • Gata6 is an important regulator of mouse pancreas development
    • DOI 10.1016/j.ydbio.2006.06.046, PII S0012160606009729
    • Decker K, Goldman DC, Grasch CL, Sussel L (2006) Gata6 is an important regulator of mouse pancreas development. Dev Biol 298(2):415-429 (Pubitemid 44441183)
    • (2006) Developmental Biology , vol.298 , Issue.2 , pp. 415-429
    • Decker, K.1    Goldman, D.C.2    L, G.C.3    Sussel, L.4
  • 144
    • 84884285309 scopus 로고    scopus 로고
    • Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice
    • doi:10.1136/gutjnl-2012-303328
    • Martinelli P, Canamero M, Del Pozo N, Madriles F, Zapata A, Real FX (2012) Gata6 is required for complete acinar differentiation and maintenance of the exocrine pancreas in adult mice. Gut. doi:10.1136/gutjnl-2012-303328
    • (2012) Gut
    • Martinelli, P.1    Canamero, M.2    Del Pozo, N.3    Madriles, F.4    Zapata, A.5    Real, F.X.6
  • 145
    • 84895442729 scopus 로고    scopus 로고
    • Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation
    • doi:10.1136/gutjnl-2012-304287
    • von Figura G, Morris JPt, Wright CV, Hebrok M (2013) Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut. doi:10.1136/gutjnl-2012-304287
    • (2013) Gut
    • Von Figura, G.1    Morris, J.Pt.2    Wright, C.V.3    Hebrok, M.4
  • 146
    • 84924133024 scopus 로고    scopus 로고
    • The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity
    • Pin CL, Rukstalis JM, Johnson C, Konieczny SF (2001) The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity. J Cell Biol 155(4):519-530. doi:10.1083/jcb.200105060 (Pubitemid 34289311)
    • (2001) Journal of Cell Biology , vol.155 , Issue.3 , pp. 519-530
    • Pin, C.L.1    Michael, R.J.2    Johnson, C.3    Konieczny, S.F.4
  • 147
    • 84860390430 scopus 로고    scopus 로고
    • LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function
    • doi:10.1101/gad.16860911
    • Holmstrom SR, Deering T, Swift GH, Poelwijk FJ, Mangelsdorf DJ, Kliewer SA, MacDonald RJ (2011) LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function. Genes Dev 25(16):1674-1679. doi:10.1101/gad.16860911
    • (2011) Genes Dev , vol.25 , Issue.16 , pp. 1674-1679
    • Holmstrom, S.R.1    Deering, T.2    Swift, G.H.3    Poelwijk, F.J.4    Mangelsdorf, D.J.5    Kliewer, S.A.6    MacDonald, R.J.7
  • 148
    • 78649303599 scopus 로고    scopus 로고
    • Transcriptional control of acinar development and homeostasis
    • doi:10.1016/B978-0-12-385233-5.00001-5
    • MacDonald RJ, Swift GH, Real FX (2010) Transcriptional control of acinar development and homeostasis. Prog Mol Biol Transl Sci 97:1-40. doi:10.1016/B978-0-12-385233-5.00001-5
    • (2010) Prog Mol Biol Transl Sci , vol.97 , pp. 1-40
    • MacDonald, R.J.1    Swift, G.H.2    Real, F.X.3
  • 149
    • 84055193971 scopus 로고    scopus 로고
    • Pancreatic ductal cells in development, regeneration, and neoplasia
    • doi:10.1172/JCI57131
    • Reichert M, Rustgi AK (2011) Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Investig 121(12):4572-4578. doi:10.1172/JCI57131
    • (2011) J Clin Investig , vol.121 , Issue.12 , pp. 4572-4578
    • Reichert, M.1    Rustgi, A.K.2
  • 150
    • 32044438892 scopus 로고    scopus 로고
    • The Transcription Factor Hepatocyte Nuclear Factor-6 Controls the Development of Pancreatic Ducts in the Mouse
    • DOI 10.1053/j.gastro.2005.12.005, PII S0016508505024340
    • Pierreux CE, Poll AV, Kemp CR, Clotman F, Maestro MA, Cordi S, Ferrer J, Leyns L, Rousseau GG, Lemaigre FP (2006) The transcription factor hepatocyte nuclear factor-6 controls the development of pancreatic ducts in the mouse. Gastroenterology 130(2):532-541. doi:10.1053/j.gastro.2005.12.005 (Pubitemid 43202049)
    • (2006) Gastroenterology , vol.130 , Issue.2 , pp. 532-541
    • Pierreux, C.E.1    Poll, A.V.2    Kemp, C.R.3    Clotman, F.4    Maestro, M.A.5    Cordi, S.6    Ferrer, J.7    Leyns, L.8    Rousseau, G.G.9    Lemaigre, F.P.10
  • 151
    • 4243144134 scopus 로고    scopus 로고
    • Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    • DOI 10.1242/dev.01189
    • Cano DA, Murcia NS, Pazour GJ, Hebrok M (2004) Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development 131(14):3457-3467 (Pubitemid 39139891)
    • (2004) Development , vol.131 , Issue.14 , pp. 3457-3467
    • Cano, D.A.1    Murcia, N.S.2    Pazour, G.J.3    Hebrok, M.4
  • 152
    • 33845661591 scopus 로고    scopus 로고
    • Primary Cilia Deletion in Pancreatic Epithelial Cells Results in Cyst Formation and Pancreatitis
    • DOI 10.1053/j.gastro.2006.10.050, PII S0016508506022840
    • Cano DA, Sekine S, Hebrok M (2006) Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology 131(6):1856-1869 (Pubitemid 44958534)
    • (2006) Gastroenterology , vol.131 , Issue.6 , pp. 1856-1869
    • Cano, D.A.1    Sekine, S.2    Hebrok, M.3
  • 155
    • 0033960256 scopus 로고    scopus 로고
    • Early pattern of differentiation in the human pancreas
    • Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P (2000) Early pattern of differentiation in the human pancreas. Diabetes 49(2):225-232 (Pubitemid 30071001)
    • (2000) Diabetes , vol.49 , Issue.2 , pp. 225-232
    • Polak, M.1    Bouchareb-Banaei, L.2    Scharfmann, R.3    Czernichow, P.4
  • 156
    • 44749087461 scopus 로고    scopus 로고
    • Transcription factor expression in the developing human fetal endocrine pancreas
    • doi:10.1007/s00125-008-1006-z
    • Lyttle BM, Li J, Krishnamurthy M, Fellows F, Wheeler MB, Goodyer CG, Wang R (2008) Transcription factor expression in the developing human fetal endocrine pancreas. Diabetologia 51(7):1169-1180. doi:10.1007/s00125-008-1006-z
    • (2008) Diabetologia , vol.51 , Issue.7 , pp. 1169-1180
    • Lyttle, B.M.1    Li, J.2    Krishnamurthy, M.3    Fellows, F.4    Wheeler, M.B.5    Goodyer, C.G.6    Wang, R.7
  • 158
    • 70249089375 scopus 로고    scopus 로고
    • Endocrine cell clustering during human pancreas development
    • doi:10.1369/jhc.2009.953307
    • Jeon J, Correa-Medina M, Ricordi C, Edlund H, Diez JA (2009) Endocrine cell clustering during human pancreas development. J Histochem Cytochem 57(9):811-824. doi:10.1369/jhc.2009.953307
    • (2009) J Histochem Cytochem , vol.57 , Issue.9 , pp. 811-824
    • Jeon, J.1    Correa-Medina, M.2    Ricordi, C.3    Edlund, H.4    Diez, J.A.5
  • 164
    • 84856715292 scopus 로고    scopus 로고
    • Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas
    • doi:10.1007/s00125-011-2344-9
    • Riedel MJ, Asadi A, Wang R, Ao Z, Warnock GL, Kieffer TJ (2012) Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas. Diabetologia 55(2):372-381. doi:10.1007/s00125-011-2344-9
    • (2012) Diabetologia , vol.55 , Issue.2 , pp. 372-381
    • Riedel, M.J.1    Asadi, A.2    Wang, R.3    Ao, Z.4    Warnock, G.L.5    Kieffer, T.J.6
  • 165
    • 84856689283 scopus 로고    scopus 로고
    • Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
    • doi:10.1007/s00125-011-2369-0
    • Dai C, Brissova M, Hang Y, Thompson C, Poffenberger G, Shostak A, Chen Z, Stein R, Powers AC (2012) Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets. Diabetologia 55(3):707-718. doi:10.1007/s00125-011-2369-0
    • (2012) Diabetologia , vol.55 , Issue.3 , pp. 707-718
    • Dai, C.1    Brissova, M.2    Hang, Y.3    Thompson, C.4    Poffenberger, G.5    Shostak, A.6    Chen, Z.7    Stein, R.8    Powers, A.C.9
  • 167
    • 77949910139 scopus 로고    scopus 로고
    • Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells
    • doi:10.1016/j.stem.2010.03.003
    • McKnight KD, Wang P, Kim SK (2010) Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell 6(4):300-308. doi:10.1016/j.stem.2010.03.003
    • (2010) Cell Stem Cell , vol.6 , Issue.4 , pp. 300-308
    • McKnight, K.D.1    Wang, P.2    Kim, S.K.3
  • 168
    • 0035199577 scopus 로고    scopus 로고
    • Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice
    • DOI 10.1007/s001250100012
    • Castaing M, Peault B, Basmaciogullari A, Casal I, Czernichow P, Scharfmann R (2001) Blood glucose normalization upon transplantation of human embryonic pancreas into beta-cell-deficient SCID mice. Diabetologia 44(11):2066-2076. doi:10.1007/s001250100012 (Pubitemid 33124053)
    • (2001) Diabetologia , vol.44 , Issue.11 , pp. 2066-2076
    • Castaing, M.1    Peault, B.2    Basmaciogullari, A.3    Casal, I.4    Czernichow, P.5    Scharfmann, R.6
  • 169
    • 75749109851 scopus 로고    scopus 로고
    • Converting human pluripotent stem cells into beta-cells: Recent advances and future challenges
    • doi:10.1097/MOT.0b013e3283337e1c
    • Mayhew CN, Wells JM (2010) Converting human pluripotent stem cells into beta-cells: recent advances and future challenges. Curr Opin Organ Transplant 15(1):54-60. doi:10.1097/MOT.0b013e3283337e1c
    • (2010) Curr Opin Organ Transplant , vol.15 , Issue.1 , pp. 54-60
    • Mayhew, C.N.1    Wells, J.M.2
  • 170
    • 84865157730 scopus 로고    scopus 로고
    • Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine
    • doi:10.1016/j.semcdb.2012.06.010
    • Nostro MC, Keller G (2012) Generation of beta cells from human pluripotent stem cells: potential for regenerative medicine. Semin Cell Dev Biol 23(6):701-710. doi:10.1016/j.semcdb.2012.06.010
    • (2012) Semin Cell Dev Biol , vol.23 , Issue.6 , pp. 701-710
    • Nostro, M.C.1    Keller, G.2
  • 174
    • 79952153009 scopus 로고    scopus 로고
    • Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm
    • doi:10.1016/j.stem.2011.01.017
    • Wang P, Rodriguez RT, Wang J, Ghodasara A, Kim SK (2011) Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell 8(3):335-346. doi:10.1016/j.stem. 2011.01.017
    • (2011) Cell Stem Cell , vol.8 , Issue.3 , pp. 335-346
    • Wang, P.1    Rodriguez, R.T.2    Wang, J.3    Ghodasara, A.4    Kim, S.K.5
  • 175
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • DOI 10.1038/ng0197-106
    • Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF (1997) Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15(1):106-110 (Pubitemid 27014961)
    • (1997) Nature Genetics , vol.15 , Issue.1 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, J.F.5
  • 177
    • 77956373682 scopus 로고    scopus 로고
    • Homozygous mutations in NEUROD1 are responsible for a novel syndrome of permanent neonatal diabetes and neurological abnormalities
    • doi:10.2337/db10-0011
    • Rubio-Cabezas O, Minton JA, Kantor I, Williams D, Ellard S, Hattersley AT (2010) Homozygous mutations in NEUROD1 are responsible for a novel syndrome of permanent neonatal diabetes and neurological abnormalities. Diabetes 59(9):2326-2331. doi:10.2337/db10-0011
    • (2010) Diabetes , vol.59 , Issue.9 , pp. 2326-2331
    • Rubio-Cabezas, O.1    Minton, J.A.2    Kantor, I.3    Williams, D.4    Ellard, S.5    Hattersley, A.T.6
  • 179
    • 79953219761 scopus 로고    scopus 로고
    • Permanent neonatal diabetes and enteric anendocrinosis associated with biallelic mutations in NEUROG3
    • doi:10.2337/db10-1008
    • Rubio-Cabezas O, Jensen JN, Hodgson MI, Codner E, Ellard S, Serup P, Hattersley AT (2011) Permanent neonatal diabetes and enteric anendocrinosis associated with biallelic mutations in NEUROG3. Diabetes 60(4):1349-1353. doi:10.2337/db10-1008
    • (2011) Diabetes , vol.60 , Issue.4 , pp. 1349-1353
    • Rubio-Cabezas, O.1    Jensen, J.N.2    Hodgson, M.I.3    Codner, E.4    Ellard, S.5    Serup, P.6    Hattersley, A.T.7
  • 180
  • 183
    • 84867162947 scopus 로고    scopus 로고
    • GATA believe it: New essential regulators of pancreas development
    • doi:10.1172/JCI65751
    • Rodriguez-Segui S, Akerman I, Ferrer J (2012) GATA believe it: new essential regulators of pancreas development. J Clin Investig 122(10):3469-3471. doi:10.1172/JCI65751
    • (2012) J Clin Investig , vol.122 , Issue.10 , pp. 3469-3471
    • Rodriguez-Segui, S.1    Akerman, I.2    Ferrer, J.3
  • 185
    • 77957320355 scopus 로고    scopus 로고
    • Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation
    • doi:10.1016/j.diff.2010.05.003
    • Itoh M, Takizawa Y, Hanai S, Okazaki S, Miyata R, Inoue T, Akashi T, Hayashi M, Goto Y (2010) Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: consideration of pancreas differentiation. Differentiation 80(2-3):118-122. doi:10.1016/j.diff.2010.05.003
    • (2010) Differentiation , vol.80 , Issue.2-3 , pp. 118-122
    • Itoh, M.1    Takizawa, Y.2    Hanai, S.3    Okazaki, S.4    Miyata, R.5    Inoue, T.6    Akashi, T.7    Hayashi, M.8    Goto, Y.9
  • 187
    • 84874432333 scopus 로고    scopus 로고
    • GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency
    • doi:10.2337/db12-0885
    • De Franco E, Shaw-Smith C, Flanagan SE, Shepherd MH, Hattersley AT, Ellard S (2013) GATA6 mutations cause a broad phenotypic spectrum of diabetes from pancreatic agenesis to adult-onset diabetes without exocrine insufficiency. Diabetes 62(3):993-997. doi:10.2337/db12-0885
    • (2013) Diabetes , vol.62 , Issue.3 , pp. 993-997
    • De Franco, E.1    Shaw-Smith, C.2    Flanagan, S.E.3    Shepherd, M.H.4    Hattersley, A.T.5    Ellard, S.6
  • 191
    • 34247519644 scopus 로고    scopus 로고
    • Mutant neurogenin-3 in congenital malabsorptive diarrhea
    • doi:10.1056/NEJMc063247 (author reply 1782)
    • Jensen JN, Rosenberg LC, Hecksher-Sorensen J, Serup P (2007) Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med 356(17):1781-1782. doi:10.1056/NEJMc063247 (author reply 1782)
    • (2007) N Engl J Med , vol.356 , Issue.17 , pp. 1781-1782
    • Jensen, J.N.1    Rosenberg, L.C.2    Hecksher-Sorensen, J.3    Serup, P.4
  • 194
    • 0031253820 scopus 로고    scopus 로고
    • Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
    • Stoffers DA, Ferrer J, Clarke WL, Habener JF (1997) Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet 17(2):138-139
    • (1997) Nat Genet , vol.17 , Issue.2 , pp. 138-139
    • Stoffers, D.A.1    Ferrer, J.2    Clarke, W.L.3    Habener, J.F.4
  • 195
    • 0035996994 scopus 로고    scopus 로고
    • Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia
    • DOI 10.1016/S0925-4773(02)00145-4, PII S0925477302001454
    • Piper K, Ball SG, Keeling JW, Mansoor S, Wilson DI, Hanley NA (2002) Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia. Mech Dev 116(1-2):223-226 (Pubitemid 34786431)
    • (2002) Mechanisms of Development , vol.116 , Issue.1-2 , pp. 223-226
    • Piper, K.1    Ball, S.G.2    Keeling, J.W.3    Mansoor, S.4    Wilson, D.I.5    Hanley, N.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.