Global expression analysis of gene regulatory pathways during endocrine pancreatic development

Development

Volumn 131, Issue 1, 2004, Pages 165-179

  Gu, Guoqiang ^a,c   Wells, James M ^a,d   Dombkowski, David ^b   Preffer, Fred ^b   Aronow, Bruce ^d   Melton, Douglas A ^a  

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

Endocrine; Endoderm; Islets; Microarray; Myt1; Pancreas

Indexed keywords

PROTEIN MYT1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; CELL DIFFERENTIATION; CELL FATE; CELL ISOLATION; CELL MATURATION; CELL SPECIFICITY; CONTROLLED STUDY; EMBRYO; ENDOCRINE CELL; ENDOCRINE SYSTEM; ENDODERM; GENE CONTROL; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC CODE; GENETIC IDENTIFICATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; IN SITU HYBRIDIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PANCREAS ISLET DELTA CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; IN SITU HYBRIDIZATION; ISLETS OF LANGERHANS; LUMINESCENT PROTEINS; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; PREGNANCY; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 1642474003     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.00921     Document Type: Review

References (63)

1. Abraham, E. J., Leech, C. A., Lin, J. C., Zulewski, H. and Habener, J. F. (2002). Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology 143, 3152-3161.
2. Angelastro, J. M., Ignatova, T. N., Kukekov, V. G., Steindler, D. A., Stengren, G. B., Mendelsohn, C. and Greene, L. A. (2003). Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons. J. Neurosci. 23, 4590-4600.
3. Apelqvist, A., Li, H., Sommer, L., Beatus, P., Anderson, D. J., Honjo, T., Hrabe de Angelis, M., Lendahl, U. and Edlund, H. (1999). Notch signalling controls pancreatic cell differentiation. Nature 400, 877-881.
4. Baugh, L. R., Hill, A. A., Brown, E. L. and Hunter, C. P. (2001). Quantitative analysis of mRNA amplification by in vitro transcription. Nucleic Acids Res. 29, E29.
5. Beddington, R. S. and Robertson, E. J. (1999). Axis development and early asymmetry in mammals. Cell 96, 195-209.
6. Bellefroid, E. J., Bourguignon, C., Hollemann, T., Ma, Q., Anderson, D. J., Kintner, C. and Pieler, T. (1996). X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation. Cell 87, 1191-1202.
7. Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. and De Robertis, E. M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
8. Brissova, M., Shiota, M., Nicholson, W. E., Gannon, M., Knobel, S. M., Piston, D. W., Wright, C. V. and Powers, A. C. (2002). Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J. Biol. Chem. 277, 11225-11232.
9. Chiang, M. K. and Melton, D. A. (2003). Single-cell transcript analysis of pancreas development. Dev. Cell 4, 383-393.
10. Conlon, F. L., Lyons, K. M., Takaesu, N., Barth, K. S., Kispert, A., Herrmann, B. and Robertson, E. J. (1994). A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120, 1919-1928.
11. Cornelius, J. G., Tchernev, V., Kao, K. J. and Peck, A. B. (1997). In vitro-generation of islets in long-term cultures of pluripotent stem cells from adult mouse pancreas. Horm. Metab. Res. 29, 271-277.
12. Edlund, H. (1998). Transcribing pancreas. Diabetes 47, 1817-1823.
13. Gannon, M., Herrera, P. L. and Wright, C. V. (2000). Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis 26, 143-144.
14. Godin, I., Deed, R., Cooke, J., Zsebo, K., Dexter, M. and Wylie, C. C. (1991). Effects of the steel gene product on mouse primordial germ cells in culture. Nature 352, 807-809.
15. Gradwohl, G., Dierich, A., LeMeur, M. and Guillemot, F. (2000). neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. USA 97, 1607-1611.
16. Grapin-Botton, A., Majithia, A. R. and Melton, D. A. (2001). Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev. 15, 444-454.
17. Gu, G., Dubauskaite, J. and Melton, D. A. (2002). Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129, 2447-2457.
18. Gu, G., Brown, J. R. and Melton, D. A. (2003). Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech. Dev. 120, 35-43.
19. Guz, Y., Montminy, M. R., Stein, R., Leonard, J., Gamer, L. W., Wright, C. V. and Teltelman, G. (1995). Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121, 11-18.
20. Harrison, S. M., Dunwoodie, S. L., Arkell, R. M., Lehrach, H. and Beddington, R. S. (1995). Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development 121, 2479-2489.
21. Heanue, T. A., Reshef, R., Davis, R. J., Mardon, G., Oliver, G., Tomarev, S., Lassar, A. B. and Tabin, C. J. (1999). Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation. Genes Dev. 13, 3231-3243.
22. Hebrok, M., Kim, S. K. and Melton, D. A. (1998). Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12, 1705-1713.
23. Herrera, P. L. (2000). Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127, 2317-2322.
24. Herrera, P. L., Orci, L. and Vassalli, J. D. (1998). Two transgenic approaches to define the cell lineages in endocrine pancreas development. Mol. Cell Endocrinol. 140, 45-50.
25. Hori, Y., Rulifson, I. C., Tsai, B. C., Heit, J. J., Cahoy, J. D. and Kim, S. K. (2002). Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc. Natl. Acad. Sci. USA 99, 16105-16110.
26. Johansson, B. M. and Wiles, M. V. (1995). Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development. Mol. Cell Biol. 15, 141-151.
27. Johnston, S. H., Rauskolb, C., Wilson, R., Prabhakaran, B., Irvine, K. D. and Vogt, T. F. (1997). A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development 124, 2245-2254.
28. Jonsson, J., Carlsson, L., Edlund, T. and Edlund, H. (1994). Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371, 606-609.
29. Kim, J. G., Armstrong, R. C., v Agoston, D., Robinsky, A., Wiese, C., Nagle, J. and Hudson, L. D. (1997a). Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J. Neurosci. Res. 50, 272-290.
30. Kim, S. K. and Hebrok, M. (2001). Intercellular signals regulating pancreas development and function. Genes Dev. 15, 111-127.
31. Kim, S. K., Hebrok, M. and Melton, D. A. (1997b). Pancreas development in the chick embryo. Cold Spring Harb. Symp. Quant. Biol. 62, 377-383.
32. Lammert, E., Cleaver, O. and Melton, D. (2001). Induction of pancreatic differentiation by signals from blood vessels. Science 294, 564-567.
33. Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R. and McKay, R. (2001). Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292, 1389-1394.
34. Mathis, D., Vence, L. and Benoist, C. (2001). beta-Cell death during progression to diabetes. Nature 414, 792-798.
35. Matsushita, F., Kameyama, T. and Marunouchi, T. (2002). NZF-2b is a novel predominant form of mouse NZF-2/MyT1, expressed in differentiated neurons especially at higher levels in newly generated ones. Mech. Dev. 118, 209-213.
36. Miralles, F., Battelino, T., Czernichow, P. and Scharfmann, R. (1998a). TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2. J. Cell Biol. 143, 827-836.
37. Miralles, F., Czernichow, P. and Scharfmann, R. (1998b). Follistatin regulates the relative proportions of endocrine versus exocrine tissue during pancreatic development. Development 125, 1017-1024.
38. Motro, B., van der Kooy, D., Rossant, J., Reith, A. and Bernstein, A. (1991). Contiguous patterns of c-kit and steel expression: analysis of mutations at the W and S1 loci. Development 113, 1207-1221.
39. Mukhopadhyay, M., Shtrom, S., Rodriguez-Esteban, C., Chen, L., Tsukui, T., Gomer, L., Dorward, D. W., Glinka, A., Grinberg, A., Huang, S. P. et al. (2001). Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev. Cell 1, 423-434.
40. Offield, M. F., Jetton, T. L., Labosky, P. A., Ray, M., Stein, R. W., Magnuson, M. A., Hogan, B. L. and Wright, C. V. (1996). PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122, 983-995.
41. Perfetti, V., Vignarelli, M. C., Casarini, S., Ascari, E. and Merlini, G. (2001). Biological features of the clone involved in primary amyloidosis (AL). Leukemia 15, 195-202.
42. Pictet, R. L., Clark, W. R., Williams, R. H. and Rutter, W. J. (1972). An ultrastructural analysis of the developing embryonic pancreas. Dev. Biol. 29, 436-467.
43. Pignoni, F., Hu, B., Zavitz, K. H., Xiao, J., Garrity, P. A. and Zipursky, S. L. (1997). The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell 91, 881-891.
44. Ramalho-Santos, M., Melton, D. A. and McMahon, A. P. (2000). Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127, 2763-2772.
45. Ramiya, V. K., Maraist, M., Arfors, K. E., Schatz, D. A., Peck, A. B. and Cornelius, J. G. (2000). Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat. Med. 6, 278-282.
46. Ridgeway, A. G. and Skerjanc, I. S. (2001). Pax3 is essential for skeletal myogenesis and the expression of Six1 and Eya2. J. Biol. Chem. 276, 19033-19039.
47. Scearce, L. M., Brestelli, J. E., McWeeney, S. K., Lee, C. S., Mazzarelli, J., Pinney, D. F., Pizarro, A., Stoeckert, C. J., Jr, Clifton, S. W., Permutt, M. A. et al. (2002). Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes 51, 1997-2004.
48. Schwitzgebel, V. M., Scheel, D. W., Conners, J. R., Kalamaras, J., Lee, J. E., Anderson, D. J., Sussel, L., Johnson, J. D. and German, M. S. (2000). Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127, 3533-3542.
49. Sharma, A., Zangen, D. H., Reitz, P., Taneja, M., Lissauer, M. E., Miller, C. P., Weir, G. C., Habener, J. F. and Bonner-Weir, S. (1999). The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48, 507-513.
50. Shimizu, K., Chiba, S., Saito, T., Kumano, K., Takahashi, T. and Hirai, H. (2001). Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation. J. Biol. Chem. 276, 25753-25758.
51. Slack, J. M. (1995). Developmental biology of the pancreas. Development 121, 1569-1580.
52. Stride, A. and Hattersley, A. T. (2002). Different genes, different diabetes: lessons from maturity-onset diabetes of the young. Ann. Med. 34, 207-216.
53. Tisch, R. and McDevitt, H. (1996). Insulin-dependent diabetes mellitus. Cell 85, 291-297.
54. Ueda, S., Mizuki, M., Ikeda, H., Tsujimura, T., Matsumura, I., Nakano, K., Daino, H., Honda Zi, Z., Sonoyama, J., Shibayama, H. et al. (2002). Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Blood 99, 3342-3349.
55. van Schaick, H. S., Smidt, M. P., Rovescalli, A. C., Luijten, M., van der Kleij, A. A., Asoh, S., Kozak, C. A., Nirenberg, M. and Burbach, J. P. (1997). Homeobox gene Prx3 expression in rodent brain and extraneural tissues. Proc. Natl. Acad. Sci. USA 94, 12993-12998.
56. Warnock, G. L., Kneteman, N. M., Evans, M. G. and Rajotte, R. V. (1990). Isolation of purified large mammal and human islets of Langerhans. Horm. Metab. Res. Supplement 25, 37-44.
57. Wells, J. M. (2003). Genes expressed in the developing endocrine pancreas and their importance for stem cell and diabetes research. Diabetes Metab. Res. Rev. 19, 191-201.
58. Wells, J. M. and Melton, D. A. (1999). Vertebrate endoderm development. Annu. Rev. Cell. Dev. Biol. 15, 393-410.
59. Wells, J. M. and Melton, D. A. (2000). Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 127, 1563-1572.
60. Wilkinson, D. G. and Nieto, M. A. (1993). Detection of messenger RNA by ISH to tissue sections and whole mounts. Methods Enzymol. 225, 361-373.
61. Wu, K. L., Gannon, M., Peshavaria, M., Offield, M. F., Henderson, E., Ray, M., Marks, A., Gamer, L. W., Wright, C. V. and Stein, R. (1997). Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene. Mol. Cell Biol. 17, 6002-6013.
62. Xu, P. X., Woo, I., Her, H., Beier, D. R. and Maas, R. L. (1997). Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development 124, 219-231.
63. Zulewski, H., Abraham, E. J., Gerlach, M. J., Daniel, P. B., Moritz, W., Muller, B., Vallejo, M., Thomas, M. K. and Habener, J. E (2001). Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521-533.