Mutant neurogenin-3 in congenital malabsorptive diarrhea [5]

New England Journal of Medicine

Volumn 356, Issue 17, 2007, Pages 1781-1782

  Jensen, Jan N ^a   Rosenberg, Louise C ^a   Hecksher Sørensen, Jacob ^a   Serup, Palle ^a  

^a HAGEDORN RESEARCH INSTITUTE   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROTEIN NEUROGENIN 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

CHICK EMBRYO; DIARRHEA; EMBRYO DEVELOPMENT; ENTEROENDOCRINE CELL; GENE MUTATION; HUMAN; INSULIN SYNTHESIS; INSULINOMA; LETTER; MALABSORPTION; NONHUMAN; ORGANOGENESIS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 34247519644     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc063247     Document Type: Letter

References (4)

1. Wang J, Cortina G, Wu SV, et al. Mutant neurogenin-3 in congenital malabsorptive diarrhea. N Engl J Med 2006;355:270-80.
2. Gradwohl G, Dierich A, LeMeur M, Guillemot F. Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A 2000;97:1607-11.
3. Grapin-Botton A, Majithia AR, Melton DA. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes Dev 2001;15:444-54.
4. Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 2004;114:828-36.