-
1
-
-
2342466734
-
Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
-
Wild S, Roglic G, Green A, Sicree R, King H 2004 Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-1053
-
(2004)
Diabetes Care
, vol.27
, pp. 1047-1053
-
-
Wild, S.1
Roglic, G.2
Green, A.3
Sicree, R.4
King, H.5
-
2
-
-
0037219411
-
β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC 2003 β-Cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes 52:102-110
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
3
-
-
48849088546
-
Diabetes mellitus: An opportunity for therapy with stem cells?
-
Sordi V, Bertuzzi F, Piemonti L 2008 Diabetes mellitus: an opportunity for therapy with stem cells? Regen Med 3:377-397
-
(2008)
Regen Med
, vol.3
, pp. 377-397
-
-
Sordi, V.1
Bertuzzi, F.2
Piemonti, L.3
-
4
-
-
0000197284
-
Pancreatic extracts in the treatment of diabetes mellitus: Preliminary report
-
Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA 1922 Pancreatic extracts in the treatment of diabetes mellitus: preliminary report. Can Med Assoc J 12:141-146
-
(1922)
Can Med Assoc J
, vol.12
, pp. 141-146
-
-
Banting, F.G.1
Best, C.H.2
Collip, J.B.3
Campbell, W.R.4
Fletcher, A.A.5
-
5
-
-
24944591025
-
New sources of pancreatic β-cells
-
Bonner-Weir S, Weir GC 2005 New sources of pancreatic β-cells. Nat Biotechnol 23:857-861
-
(2005)
Nat Biotechnol
, vol.23
, pp. 857-861
-
-
Bonner-Weir, S.1
Weir, G.C.2
-
6
-
-
0034721255
-
Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen
-
Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV 2000 Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238
-
(2000)
N Engl J Med
, vol.343
, pp. 230-238
-
-
Shapiro, A.M.1
Lakey, J.R.2
Ryan, E.A.3
Korbutt, G.S.4
Toth, E.5
Warnock, G.L.6
Kneteman, N.M.7
Rajotte, R.V.8
-
7
-
-
33749070784
-
International trial of the Edmonton protocol for islet transplantation
-
Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, Polonsky KS, Reems JA, Bretzel RG, Bertuzzi F, Froud T, Kandaswamy R, Sutherland DE, Eisenbarth G, Segal M, Preiksaitis J, Korbutt GS, Barton FB, Viviano L, Seyfert-Margolis V, Bluestone J, Lakey JR 2006 International trial of the Edmonton protocol for islet transplantation. N Engl J Med 355:1318-1330
-
(2006)
N Engl J Med
, vol.355
, pp. 1318-1330
-
-
Shapiro, A.M.1
Ricordi, C.2
Hering, B.J.3
Auchincloss, H.4
Lindblad, R.5
Robertson, R.P.6
Secchi, A.7
Brendel, M.D.8
Berney, T.9
Brennan, D.C.10
Cagliero, E.11
Alejandro, R.12
Ryan, E.A.13
DiMercurio, B.14
Morel, P.15
Polonsky, K.S.16
Reems, J.A.17
Bretzel, R.G.18
Bertuzzi, F.19
Froud, T.20
Kandaswamy, R.21
Sutherland, D.E.22
Eisenbarth, G.23
Segal, M.24
Preiksaitis, J.25
Korbutt, G.S.26
Barton, F.B.27
Viviano, L.28
Seyfert-Margolis, V.29
Bluestone, J.30
Lakey, J.R.31
more..
-
8
-
-
21344462346
-
Five-year follow-up after clinical islet transplantation
-
Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JR, Shapiro AM 2005 Five-year follow-up after clinical islet transplantation. Diabetes 54:2060-2069
-
(2005)
Diabetes
, vol.54
, pp. 2060-2069
-
-
Ryan, E.A.1
Paty, B.W.2
Senior, P.A.3
Bigam, D.4
Alfadhli, E.5
Kneteman, N.M.6
Lakey, J.R.7
Shapiro, A.M.8
-
9
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
-
Martin GR 1981 Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA 78:7634-7638
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 7634-7638
-
-
Martin, G.R.1
-
10
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM 1998 Embryonic stem cell lines derived from human blastocysts. Science 282:1145-1147
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
Itskovitz-Eldor, J.2
Shapiro, S.S.3
Waknitz, M.A.4
Swiergiel, J.J.5
Marshall, V.S.6
Jones, J.M.7
-
11
-
-
0345687862
-
Genes, signals, and lineages in pancreas development
-
Murtaugh LC, Melton DA 2003 Genes, signals, and lineages in pancreas development. Annu Rev Cell Dev Biol 19:71-89
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 71-89
-
-
Murtaugh, L.C.1
Melton, D.A.2
-
12
-
-
0015446766
-
An ultrastructural analysis of the developing embryonic pancreas
-
Pictet RL, Clark WR, Williams RH, Rutter WJ 1972 An ultrastructural analysis of the developing embryonic pancreas. Dev Biol 29:436-467
-
(1972)
Dev Biol
, vol.29
, pp. 436-467
-
-
Pictet, R.L.1
Clark, W.R.2
Williams, R.H.3
Rutter, W.J.4
-
14
-
-
33144467088
-
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
-
Cabrera O, Berman DM, Kenyon NS, Ricordi C, Berggren PO, Caicedo A 2006 The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci USA 103:2334-2339
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 2334-2339
-
-
Cabrera, O.1
Berman, D.M.2
Kenyon, N.S.3
Ricordi, C.4
Berggren, P.O.5
Caicedo, A.6
-
15
-
-
35349020015
-
An illustrated review of early pancreas development in the mouse
-
Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher-Sørensen J 2007 An illustrated review of early pancreas development in the mouse. Endocr Rev 28:685-705
-
(2007)
Endocr Rev
, vol.28
, pp. 685-705
-
-
Jørgensen, M.C.1
Ahnfelt-Rønne, J.2
Hald, J.3
Madsen, O.D.4
Serup, P.5
Hecksher-Sørensen, J.6
-
16
-
-
0035863135
-
Intercellular signals regulating pancreas development and function
-
Kim SK, Hebrok M 2001 Intercellular signals regulating pancreas development and function. Genes Dev 15:111-127
-
(2001)
Genes Dev
, vol.15
, pp. 111-127
-
-
Kim, S.K.1
Hebrok, M.2
-
18
-
-
0035913986
-
Induction of pancreatic differentiation by signals from blood vessels
-
Lammert E, Cleaver O, Melton D 2001 Induction of pancreatic differentiation by signals from blood vessels. Science 294:564-567
-
(2001)
Science
, vol.294
, pp. 564-567
-
-
Lammert, E.1
Cleaver, O.2
Melton, D.3
-
19
-
-
14244266611
-
Minireview: Transcriptional regulation in pancreatic development
-
Habener JF, Kemp DM, Thomas MK 2005 Minireview: transcriptional regulation in pancreatic development. Endocrinology 146:1025-1034
-
(2005)
Endocrinology
, vol.146
, pp. 1025-1034
-
-
Habener, J.F.1
Kemp, D.M.2
Thomas, M.K.3
-
20
-
-
0023949396
-
Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons
-
Alpert S, Hanahan D, Teitelman G 1988 Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53:295-308
-
(1988)
Cell
, vol.53
, pp. 295-308
-
-
Alpert, S.1
Hanahan, D.2
Teitelman, G.3
-
21
-
-
0023682658
-
Transient coappearance of glucagon and insulin in the progenitor cells of the rat pancreatic islets
-
(Berl)
-
Hashimoto T, Kawano H, Daikoku S, Shima K, Taniguchi H, Baba S 1988 Transient coappearance of glucagon and insulin in the progenitor cells of the rat pancreatic islets. Anat Embryol (Berl) 178:489-497
-
(1988)
Anat Embryol
, vol.178
, pp. 489-497
-
-
Hashimoto, T.1
Kawano, H.2
Daikoku, S.3
Shima, K.4
Taniguchi, H.5
Baba, S.6
-
22
-
-
0034524101
-
Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas
-
Sander M, Sussel L, Conners J, Scheel D, Kalamaras J, Dela Cruz F, Schwitzgebel V, Hayes-Jordan A, German M 2000 Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of β-cell formation in the pancreas. Development 127:5533-5540
-
(2000)
Development
, vol.127
, pp. 5533-5540
-
-
Sander, M.1
Sussel, L.2
Conners, J.3
Scheel, D.4
Kalamaras, J.5
Dela Cruz, F.6
Schwitzgebel, V.7
Hayes-Jordan, A.8
German, M.9
-
23
-
-
84984087075
-
Regulation of specific protein synthesis in cytodifferentiation
-
Rutter WJ, Kemp JD, Bradshaw WS, Clark WR, Ronzio RA, Sanders TG1968 Regulation of specific protein synthesis in cytodifferentiation. J Cell Physiol 72(Suppl 1):1-18
-
(1968)
J Cell Physiol
, vol.72
, Issue.SUPPL. 1
, pp. 1-18
-
-
Rutter, W.J.1
Kemp, J.D.2
Bradshaw, W.S.3
Clark, W.R.4
Ronzio, R.A.5
Sanders, T.G.6
-
24
-
-
33847210675
-
Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
-
Stanger BZ, Tanaka AJ, Melton DA 2007 Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445:886-891
-
(2007)
Nature
, vol.445
, pp. 886-891
-
-
Stanger, B.Z.1
Tanaka, A.J.2
Melton, D.A.3
-
25
-
-
34250893048
-
A multipotent progenitor domain guides pancreatic organogenesis
-
Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA 2007 A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell 13:103-114
-
(2007)
Dev Cell
, vol.13
, pp. 103-114
-
-
Zhou, Q.1
Law, A.C.2
Rajagopal, J.3
Anderson, W.J.4
Gray, P.A.5
Melton, D.A.6
-
26
-
-
0029027780
-
Developmental biology of the pancreas
-
Slack JM 1995 Developmental biology of the pancreas. Development 121:1569-1580
-
(1995)
Development
, vol.121
, pp. 1569-1580
-
-
Slack, J.M.1
-
27
-
-
36649003358
-
Pancreatic innervation in mouse development and β-cell regeneration
-
Burris RE, Hebrok M 2007 Pancreatic innervation in mouse development and β-cell regeneration. Neuroscience 150:592-602
-
(2007)
Neuroscience
, vol.150
, pp. 592-602
-
-
Burris, R.E.1
Hebrok, M.2
-
28
-
-
0037665295
-
Role of VEGF-A in vascularization of pancreatic islets
-
Lammert E, Gu G, McLaughlin M, Brown D, Brekken R, Murtaugh LC, Gerber HP, Ferrara N, Melton DA 2003 Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 13:1070-1074
-
(2003)
Curr Biol
, vol.13
, pp. 1070-1074
-
-
Lammert, E.1
Gu, G.2
McLaughlin, M.3
Brown, D.4
Brekken, R.5
Murtaugh, L.C.6
Gerber, H.P.7
Ferrara, N.8
Melton, D.A.9
-
29
-
-
47649116417
-
Signals from the neural crest regulate β-cell mass in the pancreas
-
Nekrep N, Wang J, Miyatsuka T, German MS 2008 Signals from the neural crest regulate β-cell mass in the pancreas. Development 135:2151-2160
-
(2008)
Development
, vol.135
, pp. 2151-2160
-
-
Nekrep, N.1
Wang, J.2
Miyatsuka, T.3
German, M.S.4
-
30
-
-
0001763783
-
Epitheliomesenchymal interaction in pancreatic morphogenesis
-
Golosow N, Grobstein C 1962 Epitheliomesenchymal interaction in pancreatic morphogenesis. Dev Biol 4:242-255
-
(1962)
Dev Biol
, vol.4
, pp. 242-255
-
-
Golosow, N.1
Grobstein, C.2
-
31
-
-
0034093614
-
Early mouse endoderm is patterned by soluble factors from adjacent germ layers
-
Wells JM, Melton DA 2000 Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 127:1563-1572
-
(2000)
Development
, vol.127
, pp. 1563-1572
-
-
Wells, J.M.1
Melton, D.A.2
-
32
-
-
0030681247
-
Notochord to endoderm signaling is required for pancreas development
-
Kim SK, Hebrok M, Melton DA 1997 Notochord to endoderm signaling is required for pancreas development. Development 124:4243-4252
-
(1997)
Development
, vol.124
, pp. 4243-4252
-
-
Kim, S.K.1
Hebrok, M.2
Melton, D.A.3
-
33
-
-
0035913967
-
Development. Endothelium-chicken soup for the endoderm
-
Bahary N, Zon LI 2001 Development. Endothelium-chicken soup for the endoderm. Science 294:530-531
-
(2001)
Science
, vol.294
, pp. 530-531
-
-
Bahary, N.1
Zon, L.I.2
-
35
-
-
33645075720
-
Hedgehog signaling in pancreas development and disease
-
Lau J, Kawahira H, Hebrok M 2006 Hedgehog signaling in pancreas development and disease. Cell Mol Life Sci 63:642-652
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 642-652
-
-
Lau, J.1
Kawahira, H.2
Hebrok, M.3
-
36
-
-
29744461931
-
FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo
-
Dessimoz J, Opoka R, Kordich JJ, Grapin-Botton A, Wells JM 2006 FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo. Mech Dev 123:42-55
-
(2006)
Mech Dev
, vol.123
, pp. 42-55
-
-
Dessimoz, J.1
Opoka, R.2
Kordich, J.J.3
Grapin-Botton, A.4
Wells, J.M.5
-
37
-
-
2642589990
-
Notochord repression of endodermal Sonic hedgehog permits pancreas development
-
Hebrok M, Kim SK, Melton DA 1998 Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 12:1705-1713
-
(1998)
Genes Dev
, vol.12
, pp. 1705-1713
-
-
Hebrok, M.1
Kim, S.K.2
Melton, D.A.3
-
38
-
-
0033869726
-
Activin receptor patterning of foregut organogenesis
-
Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, Lee JS, Melton DA 2000 Activin receptor patterning of foregut organogenesis. Genes Dev 14:1866-1871
-
(2000)
Genes Dev
, vol.14
, pp. 1866-1871
-
-
Kim, S.K.1
Hebrok, M.2
Li, E.3
Oh, S.P.4
Schrewe, H.5
Harmon, E.B.6
Lee, J.S.7
Melton, D.A.8
-
39
-
-
0031260579
-
Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
-
Apelqvist A, Ahlgren U, Edlund H 1997 Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 7:801-804
-
(1997)
Curr Biol
, vol.7
, pp. 801-804
-
-
Apelqvist, A.1
Ahlgren, U.2
Edlund, H.3
-
40
-
-
0033636981
-
Regulation of pancreas development by hedgehog signaling
-
Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA 2000 Regulation of pancreas development by hedgehog signaling. Development 127:4905-4913
-
(2000)
Development
, vol.127
, pp. 4905-4913
-
-
Hebrok, M.1
Kim, S.K.2
St Jacques, B.3
McMahon, A.P.4
Melton, D.A.5
-
41
-
-
14844331446
-
Hedgehog signaling regulates expansion of pancreatic epithelial cells
-
Kawahira H, Scheel DW, Smith SB, German MS, Hebrok M 2005 Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol 280:111-121
-
(2005)
Dev Biol
, vol.280
, pp. 111-121
-
-
Kawahira, H.1
Scheel, D.W.2
Smith, S.B.3
German, M.S.4
Hebrok, M.5
-
42
-
-
41849093727
-
Intra-endodermal interactions are required for pancreatic β cell induction
-
Chung WS, Stainier DY 2008 Intra-endodermal interactions are required for pancreatic β cell induction. Dev Cell 14:582-593
-
(2008)
Dev Cell
, vol.14
, pp. 582-593
-
-
Chung, W.S.1
Stainier, D.Y.2
-
43
-
-
0028963661
-
Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse
-
Ritvos O, Tuuri T, Erämaa M, Sainio K, Hildén K, Saxén L, Gilbert SF 1995 Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev 50:229-245
-
(1995)
Mech Dev
, vol.50
, pp. 229-245
-
-
Ritvos, O.1
Tuuri, T.2
Erämaa, M.3
Sainio, K.4
Hildén, K.5
Saxén, L.6
Gilbert, S.F.7
-
44
-
-
33751010205
-
Analysis of pancreatic endocrine development in GDF11-deficient mice
-
Dichmann DS, Yassin H, Serup P 2006 Analysis of pancreatic endocrine development in GDF11-deficient mice. Dev Dyn 235:3016-3025
-
(2006)
Dev Dyn
, vol.235
, pp. 3016-3025
-
-
Dichmann, D.S.1
Yassin, H.2
Serup, P.3
-
45
-
-
12344313566
-
GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development
-
Harmon EB, Apelqvist AA, Smart NG, Gu X, Osborne DH, Kim SK 2004 GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development. Development 131:6163-6174
-
(2004)
Development
, vol.131
, pp. 6163-6174
-
-
Harmon, E.B.1
Apelqvist, A.A.2
Smart, N.G.3
Gu, X.4
Osborne, D.H.5
Kim, S.K.6
-
46
-
-
0034182739
-
Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: Implications for lineage selection
-
Maldonado TS, Kadison AS, Crisera CA, Grau JB, Alkasab SL, Longaker MT, Gittes GK 2000 Ontogeny of activin B and follistatin in developing embryonic mouse pancreas: implications for lineage selection. J Gastrointest Surg 4:269-275
-
(2000)
J Gastrointest Surg
, vol.4
, pp. 269-275
-
-
Maldonado, T.S.1
Kadison, A.S.2
Crisera, C.A.3
Grau, J.B.4
Alkasab, S.L.5
Longaker, M.T.6
Gittes, G.K.7
-
47
-
-
0035694459
-
Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
-
Bhushan A, Itoh N, Kato S, Thiery JP, Czernichow P, Bellusci S, Scharfmann R 2001 Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128:5109-5117
-
(2001)
Development
, vol.128
, pp. 5109-5117
-
-
Bhushan, A.1
Itoh, N.2
Kato, S.3
Thiery, J.P.4
Czernichow, P.5
Bellusci, S.6
Scharfmann, R.7
-
48
-
-
30544438811
-
An endothelial-mesenchymal relay pathway regulates early phases of pancreas development
-
Jacquemin P, Yoshitomi H, Kashima Y, Rousseau GG, Lemaigre FP, Zaret KS 2006 An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol 290:189-199
-
(2006)
Dev Biol
, vol.290
, pp. 189-199
-
-
Jacquemin, P.1
Yoshitomi, H.2
Kashima, Y.3
Rousseau, G.G.4
Lemaigre, F.P.5
Zaret, K.S.6
-
49
-
-
1342263524
-
Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
-
Yoshitomi H, Zaret KS 2004 Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a. Development 131:807-817
-
(2004)
Development
, vol.131
, pp. 807-817
-
-
Yoshitomi, H.1
Zaret, K.S.2
-
50
-
-
0141593480
-
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells
-
Hart A, Papadopoulou S, Edlund H 2003 Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells. Dev Dyn 228:185-193
-
(2003)
Dev Dyn
, vol.228
, pp. 185-193
-
-
Hart, A.1
Papadopoulou, S.2
Edlund, H.3
-
51
-
-
31344468846
-
Interplay between FGF10 and Notch signalling is required for the self-renewal of pancreatic progenitors
-
Miralles F, Lamotte L, Couton D, Joshi RL 2006 Interplay between FGF10 and Notch signalling is required for the self-renewal of pancreatic progenitors. Int J Dev Biol 50:17-26
-
(2006)
Int J Dev Biol
, vol.50
, pp. 17-26
-
-
Miralles, F.1
Lamotte, L.2
Couton, D.3
Joshi, R.L.4
-
52
-
-
0344063697
-
FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development
-
Norgaard GA, Jensen JN, Jensen J 2003 FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev Biol 264:323-338
-
(2003)
Dev Biol
, vol.264
, pp. 323-338
-
-
Norgaard, G.A.1
Jensen, J.N.2
Jensen, J.3
-
53
-
-
24944487996
-
Pancreas-specific deletion of β-catenin reveals Wnt-dependent and Wnt-independent functions during development
-
Dessimoz J, Bonnard C, Huelsken J, Grapin-Botton A 2005 Pancreas-specific deletion of β-catenin reveals Wnt-dependent and Wnt-independent functions during development. Curr Biol 15:1677-1683
-
(2005)
Curr Biol
, vol.15
, pp. 1677-1683
-
-
Dessimoz, J.1
Bonnard, C.2
Huelsken, J.3
Grapin-Botton, A.4
-
54
-
-
33745084564
-
Stabilization of β-catenin impacts pancreas growth
-
Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M 2006 Stabilization of β-catenin impacts pancreas growth. Development 133:2023-2032
-
(2006)
Development
, vol.133
, pp. 2023-2032
-
-
Heiser, P.W.1
Lau, J.2
Taketo, M.M.3
Herrera, P.L.4
Hebrok, M.5
-
55
-
-
28044449357
-
β-Catenin is essential for pancreatic acinar but not islet development
-
Murtaugh LC, Law AC, Dor Y, Melton DA 2005 β-Catenin is essential for pancreatic acinar but not islet development. Development 132:4663-4674
-
(2005)
Development
, vol.132
, pp. 4663-4674
-
-
Murtaugh, L.C.1
Law, A.C.2
Dor, Y.3
Melton, D.A.4
-
56
-
-
34547516561
-
Wnt signaling regulates pancreatic β cell proliferation
-
Rulifson IC, Karnik SK, Heiser PW, ten Berge D, Chen H, Gu X, Taketo MM, Nusse R, Hebrok M, Kim SK 2007 Wnt signaling regulates pancreatic β cell proliferation. Proc Natl Acad Sci USA 104:6247-6252
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 6247-6252
-
-
Rulifson, I.C.1
Karnik, S.K.2
Heiser, P.W.3
Ten Berge, D.4
Chen, H.5
Gu, X.6
Taketo, M.M.7
Nusse, R.8
Hebrok, M.9
Kim, S.K.10
-
57
-
-
33846807059
-
Wnt/β-catenin signaling is required for development of the exocrine pancreas
-
Wells JM, Esni F, Boivin GP, Aronow BJ, Stuart W, Combs C, Sklenka A, Leach SD, Lowy AM 2007 Wnt/β-catenin signaling is required for development of the exocrine pancreas. BMC Dev Biol 7:4
-
(2007)
BMC Dev Biol
, vol.7
, pp. 4
-
-
Wells, J.M.1
Esni, F.2
Boivin, G.P.3
Aronow, B.J.4
Stuart, W.5
Combs, C.6
Sklenka, A.7
Leach, S.D.8
Lowy, A.M.9
-
58
-
-
33644537403
-
The vascular basement membrane: A niche for insulin gene expression and β cell proliferation
-
Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E 2006 The vascular basement membrane: a niche for insulin gene expression and β cell proliferation. Dev Cell 10:397-405
-
(2006)
Dev Cell
, vol.10
, pp. 397-405
-
-
Nikolova, G.1
Jabs, N.2
Konstantinova, I.3
Domogatskaya, A.4
Tryggvason, K.5
Sorokin, L.6
Fässler, R.7
Gu, G.8
Gerber, H.P.9
Ferrara, N.10
Melton, D.A.11
Lammert, E.12
-
59
-
-
58549093915
-
Developmental biology of the pancreas: A comprehensive review
-
Gittes GK 2009 Developmental biology of the pancreas: a comprehensive review. Dev Biol 326:4-35
-
(2009)
Dev Biol
, vol.326
, pp. 4-35
-
-
Gittes, G.K.1
-
60
-
-
0037213587
-
Gene expression cascades in pancreatic development
-
Wilson ME, Scheel D, German MS 2003 Gene expression cascades in pancreatic development. Mech Dev 120:65-80
-
(2003)
Mech Dev
, vol.120
, pp. 65-80
-
-
Wilson, M.E.1
Scheel, D.2
German, M.S.3
-
61
-
-
0036340074
-
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
-
Gu G, Dubauskaite J, Melton DA 2002 Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129:2447-2457
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
62
-
-
0034121735
-
Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
-
Herrera PL 2000 Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317-2322
-
(2000)
Development
, vol.127
, pp. 2317-2322
-
-
Herrera, P.L.1
-
63
-
-
0037125977
-
Experimental control of pancreatic development and maintenance
-
Holland AM, Hale MA, Kagami H, Hammer RE, MacDonald RJ 2002 Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci USA 99:12236-12241
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12236-12241
-
-
Holland, A.M.1
Hale, M.A.2
Kagami, H.3
Hammer, R.E.4
MacDonald, R.J.5
-
64
-
-
0036730427
-
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
-
Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV 2002 The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 32:128-134
-
(2002)
Nat Genet
, vol.32
, pp. 128-134
-
-
Kawaguchi, Y.1
Cooper, B.2
Gannon, M.3
Ray, M.4
MacDonald, R.J.5
Wright, C.V.6
-
65
-
-
0028149890
-
Insulin-promoter-factor 1 is required for pancreas development in mice
-
Jonsson J, Carlsson L, Edlund T, Edlund H 1994 Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-609
-
(1994)
Nature
, vol.371
, pp. 606-609
-
-
Jonsson, J.1
Carlsson, L.2
Edlund, T.3
Edlund, H.4
-
66
-
-
0029868156
-
PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
-
Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV 1996 PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 122:983-995
-
(1996)
Development
, vol.122
, pp. 983-995
-
-
Offield, M.F.1
Jetton, T.L.2
Labosky, P.A.3
Ray, M.4
Stein, R.W.5
Magnuson, M.A.6
Hogan, B.L.7
Wright, C.V.8
-
67
-
-
0141787919
-
Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1
-
Schwitzgebel VM, Mamin A, Brun T, Ritz-Laser B, Zaiko M, Maret A, Jornayvaz FR, Theintz GE, Michielin O, Melloul D, Philippe J 2003 Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1. J Clin Endocrinol Metab 88:4398-4406
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 4398-4406
-
-
Schwitzgebel, V.M.1
Mamin, A.2
Brun, T.3
Ritz-Laser, B.4
Zaiko, M.5
Maret, A.6
Jornayvaz, F.R.7
Theintz, G.E.8
Michielin, O.9
Melloul, D.10
Philippe, J.11
-
68
-
-
0031031571
-
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
-
Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF 1997 Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15:106-110
-
(1997)
Nat Genet
, vol.15
, pp. 106-110
-
-
Stoffers, D.A.1
Zinkin, N.T.2
Stanojevic, V.3
Clarke, W.L.4
Habener, J.F.5
-
69
-
-
40949099880
-
Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells
-
Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA 2008 Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol 316:74-86
-
(2008)
Dev Biol
, vol.316
, pp. 74-86
-
-
Burlison, J.S.1
Long, Q.2
Fujitani, Y.3
Wright, C.V.4
Magnuson, M.A.5
-
70
-
-
34548590734
-
Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to area III
-
Miyatsuka T, Matsuoka TA, Shiraiwa T, Yamamoto T, Kojima I, Kaneto H 2007 Ptf1a and RBP-J cooperate in activating Pdx1 gene expression through binding to area III. Biochem Biophys Res Commun 362:905-909
-
(2007)
Biochem Biophys Res Commun
, vol.362
, pp. 905-909
-
-
Miyatsuka, T.1
Matsuoka, T.A.2
Shiraiwa, T.3
Yamamoto, T.4
Kojima, I.5
Kaneto, H.6
-
71
-
-
34347345036
-
Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression
-
Wiebe PO, Kormish JD, Roper VT, Fujitani Y, Alston NI, Zaret KS, Wright CV, Stein RW, Gannon M 2007 Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression. Mol Cell Biol 27:4093-4104
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4093-4104
-
-
Wiebe, P.O.1
Kormish, J.D.2
Roper, V.T.3
Fujitani, Y.4
Alston, N.I.5
Zaret, K.S.6
Wright, C.V.7
Stein, R.W.8
Gannon, M.9
-
72
-
-
43449091944
-
PDX-1 and MafA play a crucial role in pancreatic β-cell differentiation and maintenance of mature β-cell function
-
Kaneto H, Miyatsuka T, Kawamori D, Yamamoto K, Kato K, Shiraiwa T, Katakami N, Yamasaki Y, Matsuhisa M, Matsuoka TA 2008 PDX-1 and MafA play a crucial role in pancreatic β-cell differentiation and maintenance of mature β-cell function. Endocr J 55:235-252
-
(2008)
Endocr J
, vol.55
, pp. 235-252
-
-
Kaneto, H.1
Miyatsuka, T.2
Kawamori, D.3
Yamamoto, K.4
Kato, K.5
Shiraiwa, T.6
Katakami, N.7
Yamasaki, Y.8
Matsuhisa, M.9
Matsuoka, T.A.10
-
73
-
-
0032860478
-
Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
-
Harrison KA, Thaler J, Pfaff SL, Gu H, Kehrl JH 1999 Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice. Nat Genet 23:71-75
-
(1999)
Nat Genet
, vol.23
, pp. 71-75
-
-
Harrison, K.A.1
Thaler, J.2
Pfaff, S.L.3
Gu, H.4
Kehrl, J.H.5
-
74
-
-
23144437373
-
NKX6 transcription factor activity is required for α- and β-cell development in the pancreas
-
Henseleit KD, Nelson SB, Kuhlbrodt K, Hennings JC, Ericson J, Sander M 2005 NKX6 transcription factor activity is required for α- and β-cell development in the pancreas. Development 132:3139-3149
-
(2005)
Development
, vol.132
, pp. 3139-3149
-
-
Henseleit, K.D.1
Nelson, S.B.2
Kuhlbrodt, K.3
Hennings, J.C.4
Ericson, J.5
Sander, M.6
-
75
-
-
0032844643
-
Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
-
Li H, Arber S, Jessell TM, Edlund H 1999 Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 23:67-70
-
(1999)
Nat Genet
, vol.23
, pp. 67-70
-
-
Li, H.1
Arber, S.2
Jessell, T.M.3
Edlund, H.4
-
76
-
-
33846910410
-
SOX9 is required for maintenance of the pancreatic progenitor cell pool
-
Seymour PA, Freude KK, Tran MN, Mayes EE, Jensen J, Kist R, Scherer G, Sander M 2007 SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci USA 104:1865-1870
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1865-1870
-
-
Seymour, P.A.1
Freude, K.K.2
Tran, M.N.3
Mayes, E.E.4
Jensen, J.5
Kist, R.6
Scherer, G.7
Sander, M.8
-
77
-
-
0031843386
-
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells
-
Sussel L, Kalamaras J, Hartigan-O'Connor DJ, Meneses JJ, Pedersen RA, Rubenstein JL, German MS 1998 Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells. Development 125:2213-2221
-
(1998)
Development
, vol.125
, pp. 2213-2221
-
-
Sussel, L.1
Kalamaras, J.2
Hartigan-O'Connor, D.J.3
Meneses, J.J.4
Pedersen, R.A.5
Rubenstein, J.L.6
German, M.S.7
-
78
-
-
18544404101
-
Control of endodermal endocrine development by Hes-1
-
Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD 2000 Control of endodermal endocrine development by Hes-1. Nat Genet 24:36-44
-
(2000)
Nat Genet
, vol.24
, pp. 36-44
-
-
Jensen, J.1
Pedersen, E.E.2
Galante, P.3
Hald, J.4
Heller, R.S.5
Ishibashi, M.6
Kageyama, R.7
Guillemot, F.8
Serup, P.9
Madsen, O.D.10
-
79
-
-
0035029838
-
Regulation of the pancreatic pro-endocrine gene neurogenin3
-
Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS 2001 Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50:928-936
-
(2001)
Diabetes
, vol.50
, pp. 928-936
-
-
Lee, J.C.1
Smith, S.B.2
Watada, H.3
Lin, J.4
Scheel, D.5
Wang, J.6
Mirmira, R.G.7
German, M.S.8
-
80
-
-
0034652287
-
Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
-
Gradwohl G, Dierich A, LeMeur M, Guillemot F 2000 neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1607-1611
-
-
Gradwohl, G.1
Dierich, A.2
Lemeur, M.3
Guillemot, F.4
-
81
-
-
19244372001
-
Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3
-
Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, Rousseau GG, Lemaigre FP 2000 Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 20:4445-4454
-
(2000)
Mol Cell Biol
, vol.20
, pp. 4445-4454
-
-
Jacquemin, P.1
Durviaux, S.M.2
Jensen, J.3
Godfraind, C.4
Gradwohl, G.5
Guillemot, F.6
Madsen, O.D.7
Carmeliet, P.8
Dewerchin, M.9
Collen, D.10
Rousseau, G.G.11
Lemaigre, F.P.12
-
82
-
-
34547525676
-
Sox9 coordinates a transcriptional network in pancreatic progenitor cells
-
Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS 2007 Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci USA 104:10500-10505
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 10500-10505
-
-
Lynn, F.C.1
Smith, S.B.2
Wilson, M.E.3
Yang, K.Y.4
Nekrep, N.5
German, M.S.6
-
83
-
-
0033606972
-
Notch signalling controls pancreatic cell differentiation
-
Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H 1999 Notch signalling controls pancreatic cell differentiation. Nature 400:877-881
-
(1999)
Nature
, vol.400
, pp. 877-881
-
-
Apelqvist, A.1
Li, H.2
Sommer, L.3
Beatus, P.4
Anderson, D.J.5
Honjo, T.6
Hrabe De Angelis, M.7
Lendahl, U.8
Edlund, H.9
-
84
-
-
0033825383
-
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
-
Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS 2000 Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533-3542
-
(2000)
Development
, vol.127
, pp. 3533-3542
-
-
Schwitzgebel, V.M.1
Scheel, D.W.2
Conners, J.R.3
Kalamaras, J.4
Lee, J.E.5
Anderson, D.J.6
Sussel, L.7
Johnson, J.D.8
German, M.S.9
-
85
-
-
0034695492
-
Transcription factor β2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter
-
Glick E, Leshkowitz D, Walker MD 2000 Transcription factor β2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter. J Biol Chem 275:2199-2204
-
(2000)
J Biol Chem
, vol.275
, pp. 2199-2204
-
-
Glick, E.1
Leshkowitz, D.2
Walker, M.D.3
-
86
-
-
0030886674
-
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in β2/neuroD-deficient mice
-
Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ 1997 Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in β2/neuroD-deficient mice. Genes Dev 11:2323-2334
-
(1997)
Genes Dev
, vol.11
, pp. 2323-2334
-
-
Naya, F.J.1
Huang, H.P.2
Qiu, Y.3
Mutoh, H.4
DeMayo, F.J.5
Leiter, A.B.6
Tsai, M.J.7
-
87
-
-
0028941181
-
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
-
Naya FJ, Stellrecht CM, Tsai MJ 1995 Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 9:1009-1019
-
(1995)
Genes Dev
, vol.9
, pp. 1009-1019
-
-
Naya, F.J.1
Stellrecht, C.M.2
Tsai, M.J.3
-
88
-
-
0036134978
-
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, β2, and E47
-
Qiu Y, Guo M, Huang S, Stein R 2002 Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, β2, and E47. Mol Cell Biol 22:412-420
-
(2002)
Mol Cell Biol
, vol.22
, pp. 412-420
-
-
Qiu, Y.1
Guo, M.2
Huang, S.3
Stein, R.4
-
89
-
-
34247183601
-
MafB is required for islet β cell maturation
-
Artner I, Blanchi B, Raum JC, Guo M, Kaneko T, Cordes S, Sieweke M, Stein R 2007 MafB is required for islet β cell maturation. Proc Natl Acad Sci USA 104:3853-3858
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 3853-3858
-
-
Artner, I.1
Blanchi, B.2
Raum, J.C.3
Guo, M.4
Kaneko, T.5
Cordes, S.6
Sieweke, M.7
Stein, R.8
-
90
-
-
34447521981
-
The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting β-cell fate specification in Pdx1+ pancreatic progenitor cells
-
Nelson SB, Schaffer AE, Sander M 2007 The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting β-cell fate specification in Pdx1+ pancreatic progenitor cells. Development 134:2491-2500
-
(2007)
Development
, vol.134
, pp. 2491-2500
-
-
Nelson, S.B.1
Schaffer, A.E.2
Sander, M.3
-
91
-
-
0347722280
-
The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation
-
Wang J, Elghazi L, Parker SE, Kizilocak H, Asano M, Sussel L, Sosa-Pineda B 2004 The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation. Dev Biol 266:178-189
-
(2004)
Dev Biol
, vol.266
, pp. 178-189
-
-
Wang, J.1
Elghazi, L.2
Parker, S.E.3
Kizilocak, H.4
Asano, M.5
Sussel, L.6
Sosa-Pineda, B.7
-
92
-
-
0032525981
-
β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes
-
Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H 1998 β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev 12:1763-1768
-
(1998)
Genes Dev
, vol.12
, pp. 1763-1768
-
-
Ahlgren, U.1
Jonsson, J.2
Jonsson, L.3
Simu, K.4
Edlund, H.5
-
93
-
-
0027384997
-
IPF1, a homeodomain-containing transactivator of the insulin gene
-
Ohlsson H, Karlsson K, Edlund T 1993 IPF1, a homeodomain-containing transactivator of the insulin gene. The EMBO journal 12:4251-4259
-
(1993)
The EMBO Journal
, vol.12
, pp. 4251-4259
-
-
Ohlsson, H.1
Karlsson, K.2
Edlund, T.3
-
94
-
-
33646194560
-
A switch from MafB to MafA expression accompanies differentiation to pancreatic β-cells
-
Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A 2006 A switch from MafB to MafA expression accompanies differentiation to pancreatic β-cells. Dev Biol 293:526-539
-
(2006)
Dev Biol
, vol.293
, pp. 526-539
-
-
Nishimura, W.1
Kondo, T.2
Salameh, T.3
El Khattabi, I.4
Dodge, R.5
Bonner-Weir, S.6
Sharma, A.7
-
95
-
-
0037192799
-
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion
-
Brissova M, Shiota M, Nicholson WE, Gannon M, Knobel SM, Piston DW, Wright CV, Powers AC 2002 Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem 277:11225-11232
-
(2002)
J Biol Chem
, vol.277
, pp. 11225-11232
-
-
Brissova, M.1
Shiota, M.2
Nicholson, W.E.3
Gannon, M.4
Knobel, S.M.5
Piston, D.W.6
Wright, C.V.7
Powers, A.C.8
-
96
-
-
11244311918
-
The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets
-
Brun T, Franklin I, St-Onge L, Biason-Lauber A, Schoenle EJ, Wollheim CB, Gauthier BR 2004 The diabetes-linked transcription factor PAX4 promotes β-cell proliferation and survival in rat and human islets. J Cell Biol 167:1123-1135
-
(2004)
J Cell Biol
, vol.167
, pp. 1123-1135
-
-
Brun, T.1
Franklin, I.2
St-Onge, L.3
Biason-Lauber, A.4
Schoenle, E.J.5
Wollheim, C.B.6
Gauthier, B.R.7
-
97
-
-
34547572645
-
Nkx2.2 regulates β-cell function in the mature islet
-
Doyle MJ, Sussel L 2007 Nkx2.2 regulates β-cell function in the mature islet. Diabetes 56:1999-2007
-
(2007)
Diabetes
, vol.56
, pp. 1999-2007
-
-
Doyle, M.J.1
Sussel, L.2
-
98
-
-
0242584873
-
Increased islet apoptosis in Pdx1+/- Mice
-
Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS 2003 Increased islet apoptosis in Pdx1+/- mice. J Clin Invest 111:1147-1160
-
(2003)
J Clin Invest
, vol.111
, pp. 1147-1160
-
-
Johnson, J.D.1
Ahmed, N.T.2
Luciani, D.S.3
Han, Z.4
Tran, H.5
Fujita, J.6
Misler, S.7
Edlund, H.8
Polonsky, K.S.9
-
99
-
-
21044433282
-
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β cells
-
Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB 2005 The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet β cells. Proc Natl Acad Sci USA 102:7297-7302
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7297-7302
-
-
Schisler, J.C.1
Jensen, P.B.2
Taylor, D.G.3
Becker, T.C.4
Knop, F.K.5
Takekawa, S.6
German, M.7
Weir, G.C.8
Lu, D.9
Mirmira, R.G.10
Newgard, C.B.11
-
100
-
-
20344368579
-
MafA is a key regulator of glucose-stimulated insulin secretion
-
Zhang C, Moriguchi T, Kajihara M, Esaki R, Harada A, Shimohata H, Oishi H, Hamada M, Morito N, Hasegawa K, Kudo T, Engel JD, Yamamoto M, Takahashi S 2005 MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol 25:4969-4976
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4969-4976
-
-
Zhang, C.1
Moriguchi, T.2
Kajihara, M.3
Esaki, R.4
Harada, A.5
Shimohata, H.6
Oishi, H.7
Hamada, M.8
Morito, N.9
Hasegawa, K.10
Kudo, T.11
Engel, J.D.12
Yamamoto, M.13
Takahashi, S.14
-
101
-
-
33744947093
-
Current status of pancreatic islet transplantation
-
(Lond)
-
Merani S, Shapiro AM 2006 Current status of pancreatic islet transplantation. Clin Sci (Lond) 110:611-625
-
(2006)
Clin Sci
, vol.110
, pp. 611-625
-
-
Merani, S.1
Shapiro, A.M.2
-
102
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos
-
Evans MJ, Kaufman MH 1981 Establishment in culture of pluripotential cells from mouse embryos. Nature 292:154-156
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
103
-
-
0034721123
-
Stem cells - Hype and hope
-
McKay R 2000 Stem cells - hype and hope. Nature 406:361-364
-
(2000)
Nature
, vol.406
, pp. 361-364
-
-
McKay, R.1
-
104
-
-
0035906902
-
Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
-
Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R 2001 Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389-1394
-
(2001)
Science
, vol.292
, pp. 1389-1394
-
-
Lumelsky, N.1
Blondel, O.2
Laeng, P.3
Velasco, I.4
Ravin, R.5
McKay, R.6
-
105
-
-
0033979603
-
Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
-
Soria B, Roche E, Berná G, León-Quinto T, Reig JA, Martín F 2000 Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 49:157-162
-
(2000)
Diabetes
, vol.49
, pp. 157-162
-
-
Soria, B.1
Roche, E.2
Berná, G.3
León-Quinto, T.4
Reig, J.A.5
Martín, F.6
-
106
-
-
4344671752
-
Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes
-
Lester LB, Kuo HC, Andrews L, Nauert B, Wolf DP 2004 Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes. Reprod Biol Endocrinol 2:42
-
(2004)
Reprod Biol Endocrinol
, vol.2
, pp. 42
-
-
Lester, L.B.1
Kuo, H.C.2
Andrews, L.3
Nauert, B.4
Wolf, D.P.5
-
107
-
-
0035434048
-
Insulin production by human embryonic stem cells
-
Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M 2001 Insulin production by human embryonic stem cells. Diabetes 50:1691-1697
-
(2001)
Diabetes
, vol.50
, pp. 1691-1697
-
-
Assady, S.1
Maor, G.2
Amit, M.3
Itskovitz-Eldor, J.4
Skorecki, K.L.5
Tzukerman, M.6
-
108
-
-
2942615532
-
Differentiation of human embryonic stem cells into insulin-producing clusters
-
Segev H, Fishman B, Ziskind A, Shulman M, Itskovitz-Eldor J 2004 Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 22:265-274
-
(2004)
Stem Cells
, vol.22
, pp. 265-274
-
-
Segev, H.1
Fishman, B.2
Ziskind, A.3
Shulman, M.4
Itskovitz-Eldor, J.5
-
109
-
-
0028310417
-
Insulin gene expression and insulin synthesis in mammalian neuronal cells
-
Devaskar SU, Giddings SJ, Rajakumar PA, Carnaghi LR, Menon RK, Zahm DS 1994 Insulin gene expression and insulin synthesis in mammalian neuronal cells. J Biol Chem 269:8445-8454
-
(1994)
J Biol Chem
, vol.269
, pp. 8445-8454
-
-
Devaskar, S.U.1
Giddings, S.J.2
Rajakumar, P.A.3
Carnaghi, L.R.4
Menon, R.K.5
Zahm, D.S.6
-
110
-
-
0027486662
-
Insulin II gene expression in rat central nervous system
-
Devaskar SU, Singh BS, Carnaghi LR, Rajakumar PA, Giddings SJ 1993 Insulin II gene expression in rat central nervous system. Regul Pept 48:55-63
-
(1993)
Regul Pept
, vol.48
, pp. 55-63
-
-
Devaskar, S.U.1
Singh, B.S.2
Carnaghi, L.R.3
Rajakumar, P.A.4
Giddings, S.J.5
-
111
-
-
0030796631
-
Pancreatic gene expression in rare cells of thymic medulla: Evidence for functional contribution to T cell tolerance
-
Smith KM, Olson DC, Hirose R, Hanahan D 1997 Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. Int Immunol 9:1355-1365
-
(1997)
Int Immunol
, vol.9
, pp. 1355-1365
-
-
Smith, K.M.1
Olson, D.C.2
Hirose, R.3
Hanahan, D.4
-
112
-
-
0037417958
-
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
-
Blyszczuk P, Czyz J, Kania G, Wagner M, Roll U, St-Onge L, Wobus AM 2003 Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci USA 100:998-1003
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 998-1003
-
-
Blyszczuk, P.1
Czyz, J.2
Kania, G.3
Wagner, M.4
Roll, U.5
St-Onge, L.6
Wobus, A.M.7
-
113
-
-
0037058934
-
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
-
Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK 2002 Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 99:16105-16110
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 16105-16110
-
-
Hori, Y.1
Rulifson, I.C.2
Tsai, B.C.3
Heit, J.J.4
Cahoy, J.D.5
Kim, S.K.6
-
114
-
-
0025190642
-
CNS stem cells express a new class of intermediate filament protein
-
Lendahl U, Zimmerman LB, McKay RD 1990 CNS stem cells express a new class of intermediate filament protein. Cell 60:585-595
-
(1990)
Cell
, vol.60
, pp. 585-595
-
-
Lendahl, U.1
Zimmerman, L.B.2
McKay, R.D.3
-
115
-
-
0043193868
-
Nestin expression in hair follicle sheath progenitor cells
-
Li L, Mignone J, Yang M, Matic M, Penman S, Enikolopov G, Hoffman RM 2003 Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci USA 100:9958-9961
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9958-9961
-
-
Li, L.1
Mignone, J.2
Yang, M.3
Matic, M.4
Penman, S.5
Enikolopov, G.6
Hoffman, R.M.7
-
117
-
-
0346368084
-
Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas
-
Esni F, Stoffers DA, Takeuchi T, Leach SD 2004 Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev 121:15-25
-
(2004)
Mech Dev
, vol.121
, pp. 15-25
-
-
Esni, F.1
Stoffers, D.A.2
Takeuchi, T.3
Leach, S.D.4
-
118
-
-
4644222526
-
Artifactual insulin release from differentiated embryonic stem cells
-
Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MC, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P 2004 Artifactual insulin release from differentiated embryonic stem cells. Diabetes 53:2603-2609
-
(2004)
Diabetes
, vol.53
, pp. 2603-2609
-
-
Hansson, M.1
Tonning, A.2
Frandsen, U.3
Petri, A.4
Rajagopal, J.5
Englund, M.C.6
Heller, R.S.7
Håkansson, J.8
Fleckner, J.9
Sköld, H.N.10
Melton, D.11
Semb, H.12
Serup, P.13
-
119
-
-
0037449573
-
Insulin staining of ES cell progeny from insulin uptake
-
Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA 2003 Insulin staining of ES cell progeny from insulin uptake. Science 299:363
-
(2003)
Science
, vol.299
, pp. 363
-
-
Rajagopal, J.1
Anderson, W.J.2
Kume, S.3
Martinez, O.I.4
Melton, D.A.5
-
120
-
-
2342424743
-
Development of definitive endoderm from embryonic stem cells in culture
-
Kubo A, Shinozaki K, Shannon JM, Kouskoff V, Kennedy M, Woo S, Fehling HJ, Keller G 2004 Development of definitive endoderm from embryonic stem cells in culture. Development 131:1651-1662
-
(2004)
Development
, vol.131
, pp. 1651-1662
-
-
Kubo, A.1
Shinozaki, K.2
Shannon, J.M.3
Kouskoff, V.4
Kennedy, M.5
Woo, S.6
Fehling, H.J.7
Keller, G.8
-
121
-
-
12744279327
-
Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells
-
Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, Stanley EG 2005 Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes 54:301-305
-
(2005)
Diabetes
, vol.54
, pp. 301-305
-
-
Micallef, S.J.1
Janes, M.E.2
Knezevic, K.3
Davis, R.P.4
Elefanty, A.G.5
Stanley, E.G.6
-
122
-
-
33750846133
-
Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
-
D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE 2006 Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24:1392-1401
-
(2006)
Nat Biotechnol
, vol.24
, pp. 1392-1401
-
-
D'Amour, K.A.1
Bang, A.G.2
Eliazer, S.3
Kelly, O.G.4
Agulnick, A.D.5
Smart, N.G.6
Moorman, M.A.7
Kroon, E.8
Carpenter, M.K.9
Baetge, E.E.10
-
123
-
-
41849151748
-
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
-
Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, Young H, Richardson M, Smart NG, Cunningham J, Agulnick AD, D'Amour KA, Carpenter MK, Baetge EE 2008 Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 26:443-452
-
(2008)
Nat Biotechnol
, vol.26
, pp. 443-452
-
-
Kroon, E.1
Martinson, L.A.2
Kadoya, K.3
Bang, A.G.4
Kelly, O.G.5
Eliazer, S.6
Young, H.7
Richardson, M.8
Smart, N.G.9
Cunningham, J.10
Agulnick, A.D.11
D'Amour, K.A.12
Carpenter, M.K.13
Baetge, E.E.14
-
124
-
-
0035927727
-
Nodal signalling in the epiblast patterns the early mouse embryo
-
Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ 2001 Nodal signalling in the epiblast patterns the early mouse embryo. Nature 411:965-969
-
(2001)
Nature
, vol.411
, pp. 965-969
-
-
Brennan, J.1
Lu, C.C.2
Norris, D.P.3
Rodriguez, T.A.4
Beddington, R.S.5
Robertson, E.J.6
-
125
-
-
0028180752
-
A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
-
Conlon FL, Lyons KM, Takaesu N, Barth KS, Kispert A, Herrmann B, Robertson EJ 1994 A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development 120:1919-1928
-
(1994)
Development
, vol.120
, pp. 1919-1928
-
-
Conlon, F.L.1
Lyons, K.M.2
Takaesu, N.3
Barth, K.S.4
Kispert, A.5
Herrmann, B.6
Robertson, E.J.7
-
126
-
-
0028971954
-
Lack of β-catenin affects mouse development at gastrulation
-
Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K, Kemler R 1995 Lack of β-catenin affects mouse development at gastrulation. Development 121:3529-3537
-
(1995)
Development
, vol.121
, pp. 3529-3537
-
-
Haegel, H.1
Larue, L.2
Ohsugi, M.3
Fedorov, L.4
Herrenknecht, K.5
Kemler, R.6
-
127
-
-
2342441840
-
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
-
Kelly OG, Pinson KI, Skarnes WC 2004 The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development 131:2803-2815
-
(2004)
Development
, vol.131
, pp. 2803-2815
-
-
Kelly, O.G.1
Pinson, K.I.2
Skarnes, W.C.3
-
128
-
-
0032776833
-
Requirement for Wnt3 in vertebrate axis formation
-
Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR, Bradley A 1999 Requirement for Wnt3 in vertebrate axis formation. Nat Genet 22:361-365
-
(1999)
Nat Genet
, vol.22
, pp. 361-365
-
-
Liu, P.1
Wakamiya, M.2
Shea, M.J.3
Albrecht, U.4
Behringer, R.R.5
Bradley, A.6
-
129
-
-
28644448149
-
Efficient differentiation of human embryonic stem cells to definitive endoderm
-
D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE 2005 Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 23:1534-1541
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1534-1541
-
-
D'Amour, K.A.1
Agulnick, A.D.2
Eliazer, S.3
Kelly, O.G.4
Kroon, E.5
Baetge, E.E.6
-
130
-
-
33646474117
-
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions
-
Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S 2006 Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci USA 103:6907-6912
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 6907-6912
-
-
Yao, S.1
Chen, S.2
Clark, J.3
Hao, E.4
Beattie, G.M.5
Hayek, A.6
Ding, S.7
-
131
-
-
33845996144
-
Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed
-
McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S 2007 Activin A efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 25:29-38
-
(2007)
Stem Cells
, vol.25
, pp. 29-38
-
-
McLean, A.B.1
D'Amour, K.A.2
Jones, K.L.3
Krishnamoorthy, M.4
Kulik, M.J.5
Reynolds, D.M.6
Sheppard, A.M.7
Liu, H.8
Xu, Y.9
Baetge, E.E.10
Dalton, S.11
-
132
-
-
34547857040
-
Generation of insulin-producing islet-like clusters from human embryonic stem cells
-
Jiang J, Au M, Lu K, Eshpeter A, Korbutt G, Fisk G, Majumdar AS 2007 Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 25:1940-1953
-
(2007)
Stem Cells
, vol.25
, pp. 1940-1953
-
-
Jiang, J.1
Au, M.2
Lu, K.3
Eshpeter, A.4
Korbutt, G.5
Fisk, G.6
Majumdar, A.S.7
-
133
-
-
0032727268
-
Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
-
Barbacci E, Reber M, Ott MO, Breillat C, Huetz F, Cereghini S 1999 Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. Development 126:4795-4805
-
(1999)
Development
, vol.126
, pp. 4795-4805
-
-
Barbacci, E.1
Reber, M.2
Ott, M.O.3
Breillat, C.4
Huetz, F.5
Cereghini, S.6
-
134
-
-
0032585936
-
Expression of the vHNF1/HNF1β homeoprotein gene during mouse organogenesis
-
Coffinier C, Barra J, Babinet C, Yaniv M 1999 Expression of the vHNF1/HNF1β homeoprotein gene during mouse organogenesis. Mech Dev 89:211-213
-
(1999)
Mech Dev
, vol.89
, pp. 211-213
-
-
Coffinier, C.1
Barra, J.2
Babinet, C.3
Yaniv, M.4
-
135
-
-
0028031296
-
Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst
-
Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF, Darnell Jr JE 1994 Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci USA 91:7598-7602
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7598-7602
-
-
Duncan, S.A.1
Manova, K.2
Chen, W.S.3
Hoodless, P.4
Weinstein, D.C.5
Bachvarova, R.F.6
Darnell Jr., J.E.7
-
136
-
-
0038757830
-
Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis
-
Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA 2003 Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet 34:292-296
-
(2003)
Nat Genet
, vol.34
, pp. 292-296
-
-
Parviz, F.1
Matullo, C.2
Garrison, W.D.3
Savatski, L.4
Adamson, J.W.5
Ning, G.6
Kaestner, K.H.7
Rossi, J.M.8
Zaret, K.S.9
Duncan, S.A.10
-
137
-
-
0036829397
-
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
-
Chen JK, Taipale J, Cooper MK, Beachy PA 2002 Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev 16:2743-2748
-
(2002)
Genes Dev
, vol.16
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
138
-
-
0032486433
-
Teratogen-mediated inhibition of target tissue response to Shh signaling
-
Cooper MK, Porter JA, Young KE, Beachy PA 1998 Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280:1603-1607
-
(1998)
Science
, vol.280
, pp. 1603-1607
-
-
Cooper, M.K.1
Porter, J.A.2
Young, K.E.3
Beachy, P.A.4
-
139
-
-
34247898958
-
Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
-
Shim JH, Kim SE, Woo DH, Kim SK, Oh CH, McKay R, Kim JH 2007 Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 50:1228-1238
-
(2007)
Diabetologia
, vol.50
, pp. 1228-1238
-
-
Shim, J.H.1
Kim, S.E.2
Woo, D.H.3
Kim, S.K.4
Oh, C.H.5
McKay, R.6
Kim, J.H.7
-
140
-
-
33749185455
-
The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells
-
Lavon N, Yanuka O, Benvenisty N 2006 The effect of overexpression of Pdx1 and Foxa2 on the differentiation of human embryonic stem cells into pancreatic cells. Stem Cells 24:1923-1930
-
(2006)
Stem Cells
, vol.24
, pp. 1923-1930
-
-
Lavon, N.1
Yanuka, O.2
Benvenisty, N.3
-
141
-
-
1842527497
-
Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells
-
Miyazaki S, Yamato E, Miyazaki J 2004 Regulated expression of pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 53:1030-1037
-
(2004)
Diabetes
, vol.53
, pp. 1030-1037
-
-
Miyazaki, S.1
Yamato, E.2
Miyazaki, J.3
-
142
-
-
33750542712
-
Differentiation of embryonic stem cells conditionally expressing neurogenin 3
-
Treff NR, Vincent RK, Budde ML, Browning VL, Magliocca JF, Kapur V, Odorico JS 2006 Differentiation of embryonic stem cells conditionally expressing neurogenin 3. Stem Cells 24:2529-2537
-
(2006)
Stem Cells
, vol.24
, pp. 2529-2537
-
-
Treff, N.R.1
Vincent, R.K.2
Budde, M.L.3
Browning, V.L.4
Magliocca, J.F.5
Kapur, V.6
Odorico, J.S.7
-
143
-
-
33847217554
-
Temporal control of neurogenin 3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
-
Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A 2007 Temporal control of neurogenin 3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 12:457-465
-
(2007)
Dev Cell
, vol.12
, pp. 457-465
-
-
Johansson, K.A.1
Dursun, U.2
Jordan, N.3
Gu, G.4
Beermann, F.5
Gradwohl, G.6
Grapin-Botton, A.7
-
144
-
-
62549083921
-
Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic β-cells
-
Bernardo AS, H-H Cho C, Mason S, Docherty HM, Pedersen RA, Vallier L, Docherty K 2009 Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic β-cells. Stem Cells 27:341-351
-
(2009)
Stem Cells
, vol.27
, pp. 341-351
-
-
Bernardo, A.S.1
H-H Cho, C.2
Mason, S.3
Docherty, H.M.4
Pedersen, R.A.5
Vallier, L.6
Docherty, K.7
-
147
-
-
37549003596
-
Tumorigenesis and embryonic stem cell-derived therapy
-
Rao M 2007 Tumorigenesis and embryonic stem cell-derived therapy. Stem Cells Dev 16:903-904
-
(2007)
Stem Cells Dev
, vol.16
, pp. 903-904
-
-
Rao, M.1
-
148
-
-
37549001280
-
Human embryonic stem cells are prone to generate primitive, undifferentiated tumors in engrafted human fetal tissues in severe combined immunodeficient mice
-
Shih CC, Forman SJ, Chu P, Slovak M 2007 Human embryonic stem cells are prone to generate primitive, undifferentiated tumors in engrafted human fetal tissues in severe combined immunodeficient mice. Stem Cells Dev 16:893-902
-
(2007)
Stem Cells Dev
, vol.16
, pp. 893-902
-
-
Shih, C.C.1
Forman, S.J.2
Chu, P.3
Slovak, M.4
-
149
-
-
34247353657
-
In vitro derivation of functional insulin-producing cells from human embryonic stem cells
-
Jiang W, Shi Y, Zhao D, Chen S, Yong J, Zhang J, Qing T, Sun X, Zhang P, Ding M, Li D, Deng H 2007 In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res 17:333-344
-
(2007)
Cell Res
, vol.17
, pp. 333-344
-
-
Jiang, W.1
Shi, Y.2
Zhao, D.3
Chen, S.4
Yong, J.5
Zhang, J.6
Qing, T.7
Sun, X.8
Zhang, P.9
Ding, M.10
Li, D.11
Deng, H.12
-
150
-
-
0038714289
-
Endothelial signaling during development
-
Cleaver O, Melton DA 2003 Endothelial signaling during development. Nat Med 9:661-668
-
(2003)
Nat Med
, vol.9
, pp. 661-668
-
-
Cleaver, O.1
Melton, D.A.2
-
151
-
-
33947709902
-
Islet vasculature as a regulator of endocrine pancreas function
-
Ballian N, Brunicardi FC 2007 Islet vasculature as a regulator of endocrine pancreas function. World J Surg 31:705-714
-
(2007)
World J Surg
, vol.31
, pp. 705-714
-
-
Ballian, N.1
Brunicardi, F.C.2
-
152
-
-
0032992378
-
Pancreatic β-cell-to-β-cell interactions are required for integrated responses to nutrient stimuli: Enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets
-
Hauge-Evans AC, Squires PE, Persaud SJ, Jones PM 1999 Pancreatic β-cell-to-β-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets. Diabetes 48:1402-1408
-
(1999)
Diabetes
, vol.48
, pp. 1402-1408
-
-
Hauge-Evans, A.C.1
Squires, P.E.2
Persaud, S.J.3
Jones, P.M.4
-
153
-
-
53349178722
-
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
-
Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA 2008 In vivo reprogramming of adult pancreatic exocrine cells to β-cells. Nature 455:627-632
-
(2008)
Nature
, vol.455
, pp. 627-632
-
-
Zhou, Q.1
Brown, J.2
Kanarek, A.3
Rajagopal, J.4
Melton, D.A.5
-
154
-
-
3042744026
-
A role for chemistry in stem cell biology
-
Ding S, Schultz PG 2004 A role for chemistry in stem cell biology. Nat Biotechnol 22:833-840
-
(2004)
Nat Biotechnol
, vol.22
, pp. 833-840
-
-
Ding, S.1
Schultz, P.G.2
-
155
-
-
62949210744
-
Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells
-
Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA 2009 Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4:348-358
-
(2009)
Cell Stem Cell
, vol.4
, pp. 348-358
-
-
Borowiak, M.1
Maehr, R.2
Chen, S.3
Chen, A.E.4
Tang, W.5
Fox, J.L.6
Schreiber, S.L.7
Melton, D.A.8
-
156
-
-
62649138086
-
A small molecule that directs differentiation of human ESCs into the pancreatic lineage
-
Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D 2009 A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol 5:258-265
-
(2009)
Nat Chem Biol
, vol.5
, pp. 258-265
-
-
Chen, S.1
Borowiak, M.2
Fox, J.L.3
Maehr, R.4
Osafune, K.5
Davidow, L.6
Lam, K.7
Peng, L.F.8
Schreiber, S.L.9
Rubin, L.L.10
Melton, D.11
-
157
-
-
34547230077
-
CD3-specific antibodies: A portal to the treatment of autoimmunity
-
Chatenoud L, Bluestone JA 2007 CD3-specific antibodies: a portal to the treatment of autoimmunity. Nat Rev Immunol 7:622-632
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 622-632
-
-
Chatenoud, L.1
Bluestone, J.A.2
-
158
-
-
34347218592
-
Mechanisms of tolerance induced via mixed chimerism
-
Sykes M 2007 Mechanisms of tolerance induced via mixed chimerism. Front Biosci 12:2922-2934
-
(2007)
Front Biosci
, vol.12
, pp. 2922-2934
-
-
Sykes, M.1
-
159
-
-
35148845584
-
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells
-
Meissner A, Wernig M, Jaenisch R 2007 Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol 25:1177-1181
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1177-1181
-
-
Meissner, A.1
Wernig, M.2
Jaenisch, R.3
-
160
-
-
38049187707
-
Reprogramming of human somatic cells to pluripotency with defined factors
-
Park IH, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, Daley GQ 2008 Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146
-
(2008)
Nature
, vol.451
, pp. 141-146
-
-
Park, I.H.1
Zhao, R.2
West, J.A.3
Yabuuchi, A.4
Huo, H.5
Ince, T.A.6
Lerou, P.H.7
Lensch, M.W.8
Daley, G.Q.9
-
161
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S 2007 Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
Ichisaka, T.5
Tomoda, K.6
Yamanaka, S.7
-
162
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA 2007 Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
Antosiewicz-Bourget, J.4
Frane, J.L.5
Tian, S.6
Nie, J.7
Jonsdottir, G.A.8
Ruotti, V.9
Stewart, R.10
Slukvin, I.I.11
Thomson, J.A.12
-
163
-
-
50549089957
-
Disease-specific induced pluripotent stem cells
-
Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ 2008 Disease-specific induced pluripotent stem cells. Cell 134:877-886
-
(2008)
Cell
, vol.134
, pp. 877-886
-
-
Park, I.H.1
Arora, N.2
Huo, H.3
Maherali, N.4
Ahfeldt, T.5
Shimamura, A.6
Lensch, M.W.7
Cowan, C.8
Hochedlinger, K.9
Daley, G.Q.10
-
164
-
-
46949085597
-
Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
-
Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA 2008 Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol 26:795-797
-
(2008)
Nat Biotechnol
, vol.26
, pp. 795-797
-
-
Huangfu, D.1
Maehr, R.2
Guo, W.3
Eijkelenboom, A.4
Snitow, M.5
Chen, A.E.6
Melton, D.A.7
-
165
-
-
55749104227
-
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
-
Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA 2008 Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 26:1269-1275
-
(2008)
Nat Biotechnol
, vol.26
, pp. 1269-1275
-
-
Huangfu, D.1
Osafune, K.2
Maehr, R.3
Guo, W.4
Eijkelenboom, A.5
Chen, S.6
Muhlestein, W.7
Melton, D.A.8
-
166
-
-
64749111225
-
Virus-free induction of pluripotency and subsequent excision of reprogramming factors
-
Kaji K, Norrby K, Paca A, Mileikovsky M, Mohseni P, Woltjen K 2009 Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458:771-775
-
(2009)
Nature
, vol.458
, pp. 771-775
-
-
Kaji, K.1
Norrby, K.2
Paca, A.3
Mileikovsky, M.4
Mohseni, P.5
Woltjen, K.6
-
167
-
-
64749083939
-
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
-
Woltjen K, Michael IP, Mohseni P, Desai R, Mileikovsky M, Hämäläinen R, Cowling R, Wang W, Liu P, Gertsenstein M, Kaji K, Sung HK, Nagy A 2009 piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 458:766-770
-
(2009)
Nature
, vol.458
, pp. 766-770
-
-
Woltjen, K.1
Michael, I.P.2
Mohseni, P.3
Desai, R.4
Mileikovsky, M.5
Hämäläinen, R.6
Cowling, R.7
Wang, W.8
Liu, P.9
Gertsenstein, M.10
Kaji, K.11
Sung, H.K.12
Nagy, A.13
-
168
-
-
33744920617
-
Molecular control of cell cycle progression in the pancreatic β-cell
-
Cozar-Castellano I, Fiaschi-Taesch N, Bigatel TA, Takane KK, Garcia-Ocaña A, Vasavada R, Stewart AF 2006 Molecular control of cell cycle progression in the pancreatic β-cell. Endocr Rev 27:356-370
-
(2006)
Endocr Rev
, vol.27
, pp. 356-370
-
-
Cozar-Castellano, I.1
Fiaschi-Taesch, N.2
Bigatel, T.A.3
Takane, K.K.4
Garcia-Ocaña, A.5
Vasavada, R.6
Stewart, A.F.7
-
169
-
-
0037677695
-
Increased islet volume but unchanged islet number in ob/ob mice
-
Bock T, Pakkenberg B, Buschard K 2003 Increased islet volume but unchanged islet number in ob/ob mice. Diabetes 52:1716-1722
-
(2003)
Diabetes
, vol.52
, pp. 1716-1722
-
-
Bock, T.1
Pakkenberg, B.2
Buschard, K.3
-
170
-
-
38449099624
-
Menin controls growth of pancreatic β-cells in pregnant mice and promotes gestational diabetes mellitus
-
Karnik SK, Chen H, McLean GW, Heit JJ, Gu X, Zhang AY, Fontaine M, Yen MH, Kim SK 2007 Menin controls growth of pancreatic β-cells in pregnant mice and promotes gestational diabetes mellitus. Science 318:806-809
-
(2007)
Science
, vol.318
, pp. 806-809
-
-
Karnik, S.K.1
Chen, H.2
McLean, G.W.3
Heit, J.J.4
Gu, X.5
Zhang, A.Y.6
Fontaine, M.7
Yen, M.H.8
Kim, S.K.9
-
171
-
-
0021777067
-
Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited
-
Klöppel G, Löhr M, Habich K, Oberholzer M, Heitz PU 1985 Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv Synth Pathol Res 4:110-125
-
(1985)
Surv Synth Pathol Res
, vol.4
, pp. 110-125
-
-
Klöppel, G.1
Löhr, M.2
Habich, K.3
Oberholzer, M.4
Heitz, P.U.5
-
172
-
-
0031913829
-
Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat
-
Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS 1998 Role of apoptosis in failure of β-cell mass compensation for insulin resistance and β-cell defects in the male Zucker diabetic fatty rat. Diabetes 47:358-364
-
(1998)
Diabetes
, vol.47
, pp. 358-364
-
-
Pick, A.1
Clark, J.2
Kubstrup, C.3
Levisetti, M.4
Pugh, W.5
Bonner-Weir, S.6
Polonsky, K.S.7
-
174
-
-
0034608816
-
In vitro cultivation of human islets from expanded ductal tissue
-
Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ 2000 In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97:7999-8004
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 7999-8004
-
-
Bonner-Weir, S.1
Taneja, M.2
Weir, G.C.3
Tatarkiewicz, K.4
Song, K.H.5
Sharma, A.6
O'Neil, J.J.7
-
175
-
-
33646492251
-
GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts
-
Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S 2006 GLP-1/exendin-4 facilitates β-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract 73:107-110
-
(2006)
Diabetes Res Clin Pract
, vol.73
, pp. 107-110
-
-
Xu, G.1
Kaneto, H.2
Lopez-Avalos, M.D.3
Weir, G.C.4
Bonner-Weir, S.5
-
176
-
-
38349052917
-
Evidence for the presence of stem cell-like progenitor cells in human
-
Zhao M, Amiel SA, Christie MR, Muiesan P, Srinivasan P, Littlejohn W, Rela M, Arno M, Heaton N, Huang GC 2007 Evidence for the presence of stem cell-like progenitor cells in human adult pancreas. J Endocrinol 195:407-414
-
(2007)
J Endocrinol
, vol.195
, pp. 407-414
-
-
Zhao, M.1
Amiel, S.A.2
Christie, M.R.3
Muiesan, P.4
Srinivasan, P.5
Littlejohn, W.6
Rela, M.7
Arno, M.8
Heaton, N.9
Huang, G.C.10
-
177
-
-
2342510386
-
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
-
Dor Y, Brown J, Martinez OI, Melton DA 2004 Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46
-
(2004)
Nature
, vol.429
, pp. 41-46
-
-
Dor, Y.1
Brown, J.2
Martinez, O.I.3
Melton, D.A.4
-
178
-
-
34247644369
-
Growth and regeneration of adult β cells does not involve specialized progenitors
-
Teta M, Rankin MM, Long SY, Stein GM, Kushner JA 2007 Growth and regeneration of adult β cells does not involve specialized progenitors. Dev Cell 12:817-826
-
(2007)
Dev Cell
, vol.12
, pp. 817-826
-
-
Teta, M.1
Rankin, M.M.2
Long, S.Y.3
Stein, G.M.4
Kushner, J.A.5
-
179
-
-
58149378342
-
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth
-
Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S 2008 Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci USA 105:19915-19919
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19915-19919
-
-
Inada, A.1
Nienaber, C.2
Katsuta, H.3
Fujitani, Y.4
Levine, J.5
Morita, R.6
Sharma, A.7
Bonner-Weir, S.8
-
180
-
-
38749108893
-
β-Cells can be generated from endogenous progenitors in injured adult mouse pancreas
-
Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H 2008 β-Cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 132:197-207
-
(2008)
Cell
, vol.132
, pp. 197-207
-
-
Xu, X.1
D'Hoker, J.2
Stangé, G.3
Bonné, S.4
De Leu, N.5
Xiao, X.6
Van De Casteele, M.7
Mellitzer, G.8
Ling, Z.9
Pipeleers, D.10
Bouwens, L.11
Scharfmann, R.12
Gradwohl, G.13
Heimberg, H.14
-
181
-
-
27744593347
-
In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells
-
Gao R, Ustinov J, Korsgren O, Otonkoski T 2005 In vitro neogenesis of human islets reflects the plasticity of differentiated human pancreatic cells. Diabetologia 48:2296-2304
-
(2005)
Diabetologia
, vol.48
, pp. 2296-2304
-
-
Gao, R.1
Ustinov, J.2
Korsgren, O.3
Otonkoski, T.4
-
182
-
-
0043268785
-
Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture
-
Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O, Otonkoski T 2003 Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52:2007-2015
-
(2003)
Diabetes
, vol.52
, pp. 2007-2015
-
-
Gao, R.1
Ustinov, J.2
Pulkkinen, M.A.3
Lundin, K.4
Korsgren, O.5
Otonkoski, T.6
-
183
-
-
33644828800
-
β-Cell differentiation from nonendocrine epithelial cells of the adult human pancreas
-
Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F 2006 β-Cell differentiation from nonendocrine epithelial cells of the adult human pancreas. Nat Med 12:310-316
-
(2006)
Nat Med
, vol.12
, pp. 310-316
-
-
Hao, E.1
Tyrberg, B.2
Itkin-Ansari, P.3
Lakey, J.R.4
Geron, I.5
Monosov, E.Z.6
Barcova, M.7
Mercola, M.8
Levine, F.9
-
184
-
-
34347384162
-
Differentiation of affinity-purified human pancreatic duct cells to β-cells
-
Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S 2007 Differentiation of affinity-purified human pancreatic duct cells to β-cells. Diabetes 56:1802-1809
-
(2007)
Diabetes
, vol.56
, pp. 1802-1809
-
-
Yatoh, S.1
Dodge, R.2
Akashi, T.3
Omer, A.4
Sharma, A.5
Weir, G.C.6
Bonner-Weir, S.7
-
185
-
-
26244466532
-
Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice
-
Zhao M, Amiel SA, Christie MR, Rela M, Heaton N, Huang GC 2005 Insulin-producing cells derived from human pancreatic non-endocrine cell cultures reverse streptozotocin-induced hyperglycaemia in mice. Diabetologia 48:2051-2061
-
(2005)
Diabetologia
, vol.48
, pp. 2051-2061
-
-
Zhao, M.1
Amiel, S.A.2
Christie, M.R.3
Rela, M.4
Heaton, N.5
Huang, G.C.6
-
186
-
-
4444235281
-
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro
-
Gasa R, Mrejen C, Leachman N, Otten M, Barnes M, Wang J, Chakrabarti S, Mirmira R, German M 2004 Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. Proc Natl Acad Sci USA 101:13245-13250
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13245-13250
-
-
Gasa, R.1
Mrejen, C.2
Leachman, N.3
Otten, M.4
Barnes, M.5
Wang, J.6
Chakrabarti, S.7
Mirmira, R.8
German, M.9
-
187
-
-
0037191099
-
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
-
Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H 2002 Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 159:303-312
-
(2002)
J Cell Biol
, vol.159
, pp. 303-312
-
-
Heremans, Y.1
Van De Casteele, M.2
In't Veld, P.3
Gradwohl, G.4
Serup, P.5
Madsen, O.6
Pipeleers, D.7
Heimberg, H.8
-
188
-
-
0028243350
-
Transitional cells in the regenerating pancreas
-
Gu D, Lee MS, Krahl T, Sarvetnick N 1994 Transitional cells in the regenerating pancreas. Development 120:1873-1881
-
(1994)
Development
, vol.120
, pp. 1873-1881
-
-
Gu, D.1
Lee, M.S.2
Krahl, T.3
Sarvetnick, N.4
-
189
-
-
0027276885
-
Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice
-
Gu D, Sarvetnick N 1993 Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 118:33-46
-
(1993)
Development
, vol.118
, pp. 33-46
-
-
Gu, D.1
Sarvetnick, N.2
-
190
-
-
27244437951
-
Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells
-
Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T, Seino S 2005 Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 102:15116-15121
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15116-15121
-
-
Minami, K.1
Okuno, M.2
Miyawaki, K.3
Okumachi, A.4
Ishizaki, K.5
Oyama, K.6
Kawaguchi, M.7
Ishizuka, N.8
Iwanaga, T.9
Seino, S.10
-
191
-
-
0028793314
-
Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats
-
Wang RN, Klöppel G, Bouwens L 1995 Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia 38:1405-1411
-
(1995)
Diabetologia
, vol.38
, pp. 1405-1411
-
-
Wang, R.N.1
Klöppel, G.2
Bouwens, L.3
-
192
-
-
53549130956
-
Can β-cells be derived from exocrine pancreas?
-
Baeyens L, Bouwens L 2008 Can β-cells be derived from exocrine pancreas? Diabetes Obes Metab 10(Suppl 4):170-178
-
(2008)
Diabetes Obes Metab
, vol.10
, Issue.SUPPL. 4
, pp. 170-178
-
-
Baeyens, L.1
Bouwens, L.2
-
193
-
-
33746500855
-
Liver stem cell-derived β-cell surrogates for treatment of type 1 diabetes
-
Yang LJ 2006 Liver stem cell-derived β-cell surrogates for treatment of type 1 diabetes. Autoimmun Rev 5:409-413
-
(2006)
Autoimmun Rev
, vol.5
, pp. 409-413
-
-
Yang, L.J.1
-
194
-
-
0041856137
-
Functional, persistent, and extended liver to pancreas transdifferentiation
-
Ber I, Shternhall K, Perl S, Ohanuna Z, Goldberg I, Barshack I, Benvenisti-Zarum L, Meivar-Levy I, Ferber S 2003 Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 278:31950-31957
-
(2003)
J Biol Chem
, vol.278
, pp. 31950-31957
-
-
Ber, I.1
Shternhall, K.2
Perl, S.3
Ohanuna, Z.4
Goldberg, I.5
Barshack, I.6
Benvenisti-Zarum, L.7
Meivar-Levy, I.8
Ferber, S.9
-
195
-
-
0034068602
-
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia
-
Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A 2000 Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6:568-572
-
(2000)
Nat Med
, vol.6
, pp. 568-572
-
-
Ferber, S.1
Halkin, A.2
Cohen, H.3
Ber, I.4
Einav, Y.5
Goldberg, I.6
Barshack, I.7
Seijffers, R.8
Kopolovic, J.9
Kaiser, N.10
Karasik, A.11
-
196
-
-
20344394437
-
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
-
Sapir T, Shternhall K, Meivar-Levy I, Blumenfeld T, Cohen H, Skutelsky E, Eventov-Friedman S, Barshack I, Goldberg I, Pri-Chen S, Ben-Dor L, Polak-Charcon S, Karasik A, Shimon I, Mor E, Ferber S 2005 Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA 102:7964-7969
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 7964-7969
-
-
Sapir, T.1
Shternhall, K.2
Meivar-Levy, I.3
Blumenfeld, T.4
Cohen, H.5
Skutelsky, E.6
Eventov-Friedman, S.7
Barshack, I.8
Goldberg, I.9
Pri-Chen, S.10
Ben-Dor, L.11
Polak-Charcon, S.12
Karasik, A.13
Shimon, I.14
Mor, E.15
Ferber, S.16
-
197
-
-
33746218331
-
Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation
-
Tang DQ, Cao LZ, Chou W, Shun L, Farag C, Atkinson MA, Li SW, Chang LJ, Yang LJ 2006 Role of Pax4 in Pdx1-VP16-mediated liver-to-endocrine pancreas transdifferentiation. Lab Invest 86:829-841
-
(2006)
Lab Invest
, vol.86
, pp. 829-841
-
-
Tang, D.Q.1
Cao, L.Z.2
Chou, W.3
Shun, L.4
Farag, C.5
Atkinson, M.A.6
Li, S.W.7
Chang, L.J.8
Yang, L.J.9
-
198
-
-
32844462637
-
Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors
-
Tang DQ, Lu S, Sun YP, Rodrigues E, Chou W, Yang C, Cao LZ, Chang LJ, Yang LJ 2006 Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors. Lab Invest 86:83-93
-
(2006)
Lab Invest
, vol.86
, pp. 83-93
-
-
Tang, D.Q.1
Lu, S.2
Sun, Y.P.3
Rodrigues, E.4
Chou, W.5
Yang, C.6
Cao, L.Z.7
Chang, L.J.8
Yang, L.J.9
-
199
-
-
24144467428
-
Differentiation of human liver-derived, insulin-producing cells toward the β-cell phenotype
-
Zalzman M, Anker-Kitai L, Efrat S 2005 Differentiation of human liver-derived, insulin-producing cells toward the β-cell phenotype. Diabetes 54:2568-2575
-
(2005)
Diabetes
, vol.54
, pp. 2568-2575
-
-
Zalzman, M.1
Anker-Kitai, L.2
Efrat, S.3
-
200
-
-
0038413922
-
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice
-
Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L 2003 NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9:596-603
-
(2003)
Nat Med
, vol.9
, pp. 596-603
-
-
Kojima, H.1
Fujimiya, M.2
Matsumura, K.3
Younan, P.4
Imaeda, H.5
Maeda, M.6
Chan, L.7
-
201
-
-
61749094740
-
Neurogenin 3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes
-
Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L 2009 Neurogenin 3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell 16:358-373
-
(2009)
Dev Cell
, vol.16
, pp. 358-373
-
-
Yechoor, V.1
Liu, V.2
Espiritu, C.3
Paul, A.4
Oka, K.5
Kojima, H.6
Chan, L.7
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