Defining pancreatic endocrine precursors and their descendants

Diabetes

Volumn 57, Issue 3, 2008, Pages 654-668

  White, Peter ^a   May, Catherine Lee ^a,b   Lamounier, Rodrigo N ^a   Brestelli, John E ^a   Kaestner, Klaus H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; NEUROGENIN 3; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NERVE PROTEIN; NEUROG3 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; DIABETES MELLITUS; EMBRYO; FEMALE; FETUS DEVELOPMENT; GENE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; MALE; MOUSE; NEUROG3 GENE; NONHUMAN; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; ANIMAL; CLUSTER ANALYSIS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PRENATAL DEVELOPMENT; STEM CELL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MICE; NERVE TISSUE PROTEINS; PANCREAS; STEM CELLS;

EID: 40949142371     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1362     Document Type: Article

References (62)

1. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE: Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24:1392-1401, 2006
2. Bonner-Weir S, Weir GC: New sources of pancreatic beta-cells. Nat Biotechnol 23:857-861, 2005
3. Madsen OD: Stem cells and diabetes treatment. APMIS: Acta Pathol Microbiol Immunol Scand 113:858-875, 2005
4. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238, 2000
5. Edlund H: Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nat Rev Genet 3:524-532, 2002
6. Habener JF, Kemp DM, Thomas MK: Minireview: transcriptional regulation in pancreatic development. Endocrinology 146:1025-1034, 2005
7. Lantz KA, Kaestner KH: Winged-helix transcription factors and pancreatic development. Clin Sci 108:195-204, 2005
8. Wilson ME, Scheel D, German MS: Gene expression cascades in pancreatic development. Mech Dev 120:65-80, 2003
9. Jensen J: Gene regulatory factors in pancreatic development. Dev Dyn 229:176-200, 2004
10. Gradwohl G, Dierich A, LeMeur M, Guillemot F: neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97:1607-1611, 2000
11. Heller RS, Jenny M, Collombat P, Mansouri A, Tomasetto C, Madsen OD, Mellitzer G, Gradwohl G, Serup P: Genetic determinants of pancreatic epsilon-cell development. Dev Biol 286:217-224, 2005
12. Lee CS, Perreault N, Brestelli JE, Kaestner KH: Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev 16:1488-1497, 2002
13. Jenny M, Uhl C, Roche C, Duluc I, Guillermin V, Guillemot F, Jensen J, Kedinger M, Gradwohl G: Neurogenin3 is differentially required for endocrine cell fate specification in the intestinal and gastric epithelium. EMBO J 21:6338-6347, 2002
14. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ: Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11:2323-2334, 1997
15. Sosa-Pineda B, Chowdhury K, Torres M, Oliver G, Grass P: The Pax4 gene is essential for differentiation of msulin-producing beta cells in the mammalian pancreas. Nature 386:399 - 402, 1997
16. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS: Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127:3533- 3542, 2000
17. Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H: Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 159:303-312, 2002
18. Harb G, Heremans Y, Heimberg H, Korbutt GS: Ectopic expression of neurogenin 3 in neonatal pig pancreatic precursor cells induces (trans)dif- ferentiation to functional alpha cells. Diabetologia 49:1855-1863, 2006
19. Gu G, Brown JR, Melton DA: Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 120:35-43, 2003
20. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H: Notch signalling controls pancreatic cell differentiation. Nature 400:877-881, 1999
21. Jensen J, Heller RS, Funder-Nielsen T, Pedersen EE, Lindsell C, Weinmaster G, Madsen OD, Serup P: Independent development of pancreatic α- and β-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. Diabetes 49:163-176, 2000
22. Jacquemin P, Durviaux SM, Jensen J, Godfraind C, Gradwohl G, Guillemot F, Madsen OD, Carmeliet P, Dewerchin M, Collen D, et al: Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol Cell Biol 20:4445-4454, 2000
23. Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS: Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes 50:928-936, 2001
24. Smith SB, Watada H, German MS: Neurogenin3 activates the islet differentiation program while repressing its own expression. Mol Endocrinol 18:142-149, 2004
25. Smith SB, Gasa R, Watada H, Wang J, Griffen SC, German MS: Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4. J Biol Chem 278:38254-38259, 2003
26. Watada H, Scheel DW, Leung J, German MS: Distinct gene expression programs function in progenitor and mature islet cells. J Biol Chem 278:17130-17140, 2003
27. Huang HP, Liu M, El-Hodiri HM, Chu K, Jamrich M, Tsai MJ: Regulation of the pancreatic islet-specific gene BETA2 (neuro D) by neurogenin 3. Mol Cell Biol 20:3292-3307, 2000
28. Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH: Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation. Diabetes 55:2730-2736, 2006
29. Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ Jr, Gradwohl G, Clifton SW, Brown JR, Inoue H, Cras-Méneur C, Permutt MA: Transcriptional program of the endocrine pancreas in mice and humans. Diabetes 52:1604-1610, 2003
30. Scearce LM, Brestelli JE, McWeeney SK, Lee CS, Mazzarelli J, Pinney DF, Pizarro A, Stoeckert CJ Jr, Clifton SW, Permutt MA, Brown J, Melton DA, Kaestner KH: Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes 51:1997-2004, 2002
31. Gendeman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al.: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5:R80, 2004
32. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3:0034.1-0034.12, 2002
33. Leek JT, Monsen E, Dabney AR, Storey JD: EDGE: extraction and analysis of differential gene expression. Bioinformatics 22:507-508, 2006
34. Storey JD, Dai JY, Leek JT: The optimal discovery procedure for large- scale significance testing, with applications to comparative microarray experiments. Biostatistics 8:414-432, 2007
35. Tusher VG, Tibshirani R, Chu G: Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98:5116-5121, 2001
36. Grant GR, Liu J, Stoeckert CJ Jr: A practical false discovery rate approach to identifying patterns of differential expression in microarray data. Bioinformatics 21:2684-2690, 2005
37. Dennis G Jr, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4:P3, 2003
38. White P, Brestelli JE, Kaestner KH, Greenbaum LE: Identification of transcriptional networks during liver regeneration. J Biol Chem 280:3715- 3722, 2005
39. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L: Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 101:2924-2929, 2004
40. Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G, Grapin-Botton A: Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 12:457-465, 2007
41. Song HH, Shi W, Xiang YY, Filmus J: The loss of glypican-3 induces alterations in Wnt signaling. J Biol Chem 280:2116-2125, 2005
42. Grozdanov PN, Yovchev MI, Dabeva MD: The oncofetal protein glypican-3 is a novel marker of hepatic progenitor/oval cells. Lab Invest 86:1272-1284, 2006
43. Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA: Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development 131:165-179, 2004
44. Gasa E, Mrejen C, Leachman N, Otten M, Barnes M, Wang J, Chakrabarti S, Mirmira R, German M: Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. Proc Natl Acad Sci USA 101:13245- 13250, 2004
45. Mellitzer G, Bonne S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, et al: IAI is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J 25:1344-1352, 2006
46. Dor Y, Brown J, Martinez OI, Melton DA: Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429:41-46, 2004
47. Petri A, Ahnfelt-Ronne J, Frederiksen KS, Edwards DG, Madsen D, Serup P, Fleckner J, Heller RS: The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol 37:301-316, 2006
48. Herrera PL: Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 127:2317-2322, 2000
49. Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA: A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell 13:103-114, 2007
50. Artavanis-Tsakonas S, Rand MD, Lake RJ: Notch signaling: cell fate control and signal integration in development. Science 284:770-776, 1999
51. Sugimori M, Nagao M, Bertrand N, Parras CM, Guillemot F, Nakafuku M: Combinatorial actions of patterning and HLH transcription factors in the spatiotemporal control of neurogenesis and gliogenesis in the developing spinal cord. Development 134:1617-1629, 2007
52. Wice BM, Bernal-Mizrachi E, Permutt MA: Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells. Diabetologia 44:453-463, 2001
53. Hua H, Zhang YQ, Dabernat S, Kritzik M, Dietz D, Sterling L, Sarvetnick N: BMP4 regulates pancreatic progenitor cell expansion through Id2. J Biol Chem 281:13574-13580, 2006
54. Breslin MB, Wang HW, Pierce A, Aucoin R, Lan MS: Neurogenin 3 recruits CBP co-activator to facilitate histone H3/H4 acetylation in the target gene INSM1. FEES Lett 581:949-954, 2007
55. Michaud JL, Rosenquist T, May NR, Fan CM: Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev 12:3264-3275, 1998
56. Treff NR, Vincent RK, Budde ML, Browning VL, Magliocca JF, Kapur V, Odorico JS: Differentiation of embryonic stem cells conditionally expressing neurogenin 3. Stem, Cells 24:2529-2537, 2006
57. Murdaca J, Treins C, Monthouel-Kartmann MN, Pontier-Bres R, Kumar S, Van Obberghen E, Giorgetti-Peraldi S: Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J Biol Chew 279:26754-26761, 2004
58. Vecchione A, Marchese A, Henry P, Rotin D, Morrione A: The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor. Mol Cell Biol 23:3363-3372, 2003
59. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, Chen H, Roix JJ, Kathiresan S, Hirschhorn JN, Daly MJ, et al: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316:1331-1336, 2007
60. Scott LJ, Mohlke KL, Bonnycastle LL, Wilier CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, et al: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345, 2007
61. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, et al: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316:1336-1341, 2007
62. Fukada A, Kawaguchi Y, Furuyama K, Kodama S, Horiguchi M, Kuhara T, Koizumi M, Boyer DF, Fujimoto K, Doi R, et al: Ectopic pancreas formation in Hes1-knockout mice reveals plasticity of endodermal progenitors of the gut, bile duct, and pancreas. J Clin Invest 116:1484-1493, 2006