Development of the human pancreas from foregut to endocrine commitment

Diabetes

Volumn 62, Issue 10, 2013, Pages 3514-3522

  Jennings, Rachel E ^a,b   Berry, Andrew A ^a   Kirkwood Wilson, Rebecca ^a   Roberts, Neil A ^a   Hearn, Thomas ^c   Salisbury, Rachel J ^a   Blaylock, Jennifer ^a   Hanley, Karen Piper ^a   Hanley, Neil A ^a,b  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATOCYTE NUCLEAR FACTOR 3BETA; NEUROGENIN 3; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX9; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HOMEODOMAIN PROTEIN; NERVE PROTEIN; NEUROG3 PROTEIN, HUMAN; NEUROG3 PROTEIN, MOUSE; NKX 2.2 HOMEDOMAIN PROTEIN; NKX-2.2 HOMEDOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANTERIOR POSTERIOR AXIS; ARTICLE; BILE DUCT; CELL COUNTING; CELL DIFFERENTIATION; CELL LINEAGE; EMBRYO; EMBRYO DEVELOPMENT; ENDODERM; FETUS; GALLBLADDER; HUMAN; HUMAN EMBRYO; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROSCOPY; MOUSE; NONHUMAN; NOTOCHORD; ORGANOGENESIS; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; YOLK SAC; ANIMAL; ENDOCRINE SYSTEM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PREGNANCY; PRENATAL DEVELOPMENT; EMBRYOLOGY;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINEAGE; ENDOCRINE SYSTEM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; INSULIN-SECRETING CELLS; MICE; NERVE TISSUE PROTEINS; PANCREAS; PREGNANCY; TRANSCRIPTION FACTORS;

EID: 84891514946     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1479     Document Type: Article

References (43)

1. Best M, Carroll M, Hanley NA, Piper Hanley K. Embryonic stem cells to beta-cells by understanding pancreas development. Mol Cell Endocrinol 2008;288:86-94
2. Docherty K, Bernardo AS, Vallier L. Embryonic stem cell therapy for diabetes mellitus. Semin Cell Dev Biol 2007;18:827-838
3. D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-1541
4. Kroon E, Martinson LA, Kadoya K, et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulinsecreting cells in vivo. Nat Biotechnol 2008;26:443-452
5. Murtaugh LC. Pancreas and beta-cell development: from the actual to the possible. Development 2007;134:427-438
6. Jørgensen MC, Ahnfelt-Rønne J, Hald J, Madsen OD, Serup P, Hecksher- Sørensen J. An illustrated review of early pancreas development in the mouse. Endocr Rev 2007;28:685-705
7. Gittes GK. Developmental biology of the pancreas: a comprehensive review. Dev Biol 2009;326:4-35
8. Pan FC, Wright C. Pancreas organogenesis: from bud to plexus to gland. Dev Dyn 2011;240:530-565
9. Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development 1997;124:4243-4252
10. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998;12:1705-1713
11. Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001;294:564-567
12. Cleaver O, Dor Y. Vascular instruction of pancreas development. Development 2012;139:2833-2843
13. Schaffer AE, Freude KK, Nelson SB, Sander M. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell 2010;18:1022-1029
14. Sussel L, Kalamaras J, Hartigan-O'Connor DJ, et al. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Development 1998;125:2213-2221
15. Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B, Sussel L. Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A 2004;101:2924-2929
16. Castaing M, Duvillié B, Quemeneur E, Basmaciogullari A, Scharfmann R. Ex vivo analysis of acinar and endocrine cell development in the human embryonic pancreas. Dev Dyn 2005;234:339-345
17. Piper Hanley K, Hearn T, Berry A, et al. In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets. J Endocrinol 2010;207:151-161
18. Lyttle BM, Li J, Krishnamurthy M, et al. Transcription factor expression in the developing human fetal endocrine pancreas. Diabetologia 2008;51: 1169-1180
19. Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P. Early pattern of differentiation in the human pancreas. Diabetes 2000;49:225-232
20. Piper K, Brickwood S, Turnpenny LW, et al. Beta cell differentiation during early human pancreas development. J Endocrinol 2004;181:11-23
21. Sarkar SA, Kobberup S, Wong R, et al. Global gene expression profiling and histochemical analysis of the developing human fetal pancreas. Diabetologia 2008;51:285-297
22. Sugiyama T, Rodriguez RT, McLean GW, Kim SK. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A 2007;104:175-180
23. Jeon J, Correa-Medina M, Ricordi C, Edlund H, Diez JA. Endocrine cell clustering during human pancreas development. J Histochem Cytochem 2009;57:811-824
24. Piper K, Ball SG, Keeling JW, Mansoor S, Wilson DI, Hanley NA. Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia. Mech Dev 2002;116:223-226
25. Carrasco M, Delgado I, Soria B, Martín F, Rojas A. GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest 2012;122:3504-3515
26. Xuan S, Borok MJ, Decker KJ, et al. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest 2012;122:3516-3528
27. Lango Allen H, Flanagan SE, Shaw-Smith C, et al.; International Pancreatic Agenesis Consortium. GATA6 haploinsufficiency causes pancreatic agenesis in humans. Nat Genet 2012;44:20-22
28. Cleveland MH, Sawyer JM, Afelik S, Jensen J, Leach SD. Exocrine ontogenies: on the development of pancreatic acinar, ductal and centroacinar cells. Semin Cell Dev Biol 2012;23:711-719
29. Solar M, Cardalda C, Houbracken I, et al. Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. Dev Cell 2009;17:849-860
30. Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA. A multipotent progenitor domain guides pancreatic organogenesis. Dev Cell 2007;13:103-114
31. Ketola I, Otonkoski T, Pulkkinen MA, et al. Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol 2004;226:51-57
32. Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol 2006;298:415-429
33. Seymour PA, Freude KK, Tran MN, et al. SOX9 is required for maintenance of the pancreatic progenitor cell pool. Proc Natl Acad Sci U S A 2007;104: 1865-1870
34. Villasenor A, Chong DC, Cleaver O. Biphasic Ngn3 expression in the developing pancreas. Dev Dyn 2008;237:3270-3279
35. Ostrer H, Wilson DI, Hanley NA. Human embryo and early fetus research. Clin Genet 2006;70:98-107
36. Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R. Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci U S A 1999;96: 6267-6272
37. Kuo CT, Morrisey EE, Anandappa R, et al. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 1997;11:1048-1060
38. Molkentin JD, Lin Q, Duncan SA, Olson EN. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 1997;11:1061-1072
39. Kanai-Azuma M, Kanai Y, Gad JM, et al. Depletion of definitive gut endoderm in Sox17-null mutant mice. Development 2002;129:2367-2379
40. Spence JR, Lange AW, Lin SC, et al. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell 2009;17:62-74
41. Rodríguez-Seguí S, Akerman I, Ferrer J. GATA believe it: new essential regulators of pancreas development. J Clin Invest 2012;122:3469-3471
42. Pedersen JK, Nelson SB, Jorgensen MC, et al.; Beta Cell Biology Consortium. Endodermal expression of Nkx6 genes depends differentially on Pdx1. Dev Biol 2005;288:487-501
43. Watt AJ, Zhao R, Li J, Duncan SA. Development of the mammalian liver and ventral pancreas is dependent on GATA4. BMC Dev Biol 2007; 7:37