-
1
-
-
0346455774
-
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
-
Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, Depinho RA. 2003. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17: 3112-3126.
-
(2003)
Genes Dev
, vol.17
, pp. 3112-3126
-
-
Aguirre, A.J.1
Bardeesy, N.2
Sinha, M.3
Lopez, L.4
Tuveson, D.A.5
Horner, J.6
Redston, M.S.7
Depinho, R.A.8
-
2
-
-
34249879045
-
Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
-
Algul H, Treiber M, Lesina M, Nakhai H, Saur D, Geisler F, Pfeifer A, Paxian S, Schmid RM. 2007. Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis. J Clin Invest 117: 1490-1501.
-
(2007)
J Clin Invest
, vol.117
, pp. 1490-1501
-
-
Algul, H.1
Treiber, M.2
Lesina, M.3
Nakhai, H.4
Saur, D.5
Geisler, F.6
Pfeifer, A.7
Paxian, S.8
Schmid, R.M.9
-
3
-
-
0036883940
-
Pancreatic cancer biology and genetics
-
Bardeesy N, Depinho RA. 2002. Pancreatic cancer biology and genetics. Nat Rev Cancer 2: 897-909.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 897-909
-
-
Bardeesy, N.1
Depinho, R.A.2
-
4
-
-
84862150896
-
Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer
-
Bayne LJ, Beatty GL, Jhala N, Clark CE, Rhim AD, Stanger BZ, Vonderheide RH. 2012. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell 21: 822-835.
-
(2012)
Cancer Cell
, vol.21
, pp. 822-835
-
-
Bayne, L.J.1
Beatty, G.L.2
Jhala, N.3
Clark, C.E.4
Rhim, A.D.5
Stanger, B.Z.6
Vonderheide, R.H.7
-
6
-
-
48549095907
-
Hedgehog signaling is required for effective regeneration of exocrine pancreas
-
Fendrich V, Esni F, Garay MVR, Feldmann G, Habbe N, Jensen JN, Dor Y, Stoffers D, Jensen J, Leach SD, et al. 2008. Hedgehog signaling is required for effective regeneration of exocrine pancreas. Gastroenterology 135: 621-631.
-
(2008)
Gastroenterology
, vol.135
, pp. 621-631
-
-
Fendrich, V.1
Esni, F.2
Garay, M.V.R.3
Feldmann, G.4
Habbe, N.5
Jensen, J.N.6
Dor, Y.7
Stoffers, D.8
Jensen, J.9
Leach, S.D.10
-
7
-
-
78651228289
-
Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
-
Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, et al. 2011. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 43: 34-41.
-
(2011)
Nat Genet
, vol.43
, pp. 34-41
-
-
Furuyama, K.1
Kawaguchi, Y.2
Akiyama, H.3
Horiguchi, M.4
Kodama, S.5
Kuhara, T.6
Hosokawa, S.7
Elbahrawy, A.8
Soeda, T.9
Koizumi, M.10
-
8
-
-
58549093915
-
Developmental biology of the pancreas: A comprehensive review
-
Gittes G. 2009. Developmental biology of the pancreas: A comprehensive review. Dev Biol 326: 4-35.
-
(2009)
Dev Biol
, vol.326
, pp. 4-35
-
-
Gittes, G.1
-
9
-
-
0036340074
-
+ cells are islet progenitors and are distinct from duct progenitors
-
+ cells are islet progenitors and are distinct from duct progenitors. Development 129: 2447-2457.
-
(2002)
Development
, vol.129
, pp. 2447-2457
-
-
Gu, G.1
Dubauskaite, J.2
Melton, D.A.3
-
10
-
-
33847419143
-
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
-
Guerra C, Schuhmacher AJ, Cañamero M, Grippo PJ, Verdaguer L, Pérez-Gallego L, Dubus P, Sandgren EP, Barbacid M. 2007. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11: 291-302.
-
(2007)
Cancer Cell
, vol.11
, pp. 291-302
-
-
Guerra, C.1
Schuhmacher, A.J.2
Cañamero, M.3
Grippo, P.J.4
Verdaguer, L.5
Pérez-Gallego, L.6
Dubus, P.7
Sandgren, E.P.8
Barbacid, M.9
-
11
-
-
9144266295
-
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
-
Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, et al. 2003. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4: 437-450.
-
(2003)
Cancer Cell
, vol.4
, pp. 437-450
-
-
Hingorani, S.R.1
Petricoin, E.F.2
Maitra, A.3
Rajapakse, V.4
King, C.5
Jacobetz, M.A.6
Ross, S.7
Conrads, T.P.8
Veenstra, T.D.9
Hitt, B.A.10
-
12
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH, Rustgi AK, Chang S, Tuveson DA. 2005. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7: 469-483.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
Combs, C.4
Deramaudt, T.B.5
Hruban, R.H.6
Rustgi, A.K.7
Chang, S.8
Tuveson, D.A.9
-
13
-
-
48449105268
-
ConTra: A promoter alignment analysis tool for identification of transcription factor binding sites across species
-
Hooghe B, Hulpiau P, van Roy F, De Bleser P. 2008. ConTra: A promoter alignment analysis tool for identification of transcription factor binding sites across species. Nucleic Acids Res 36: W128-W132.
-
(2008)
Nucleic Acids Res
, vol.36
-
-
Hooghe, B.1
Hulpiau, P.2
van Roy, F.3
de Bleser, P.4
-
14
-
-
58549112996
-
Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
-
Huang DW, Sherman BT, Lempicki RA. 2009a. Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 1-13
-
-
Huang, D.W.1
Sherman, B.T.2
Lempicki, R.A.3
-
15
-
-
61449172037
-
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
-
Huang DW, Sherman BT, Lempicki RA. 2009b. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
-
(2009)
Nat Protoc
, vol.4
, pp. 44-57
-
-
Huang, D.W.1
Sherman, B.T.2
Lempicki, R.A.3
-
16
-
-
0142121516
-
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
-
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP. 2003. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264.
-
(2003)
Biostatistics
, vol.4
, pp. 249-264
-
-
Irizarry, R.A.1
Hobbs, B.2
Collin, F.3
Beazer-Barclay, Y.D.4
Antonellis, K.J.5
Scherf, U.6
Speed, T.P.7
-
17
-
-
0035893252
-
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
-
Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R, Jacks T, Tuveson DA. 2001. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev 15: 3243-3248.
-
(2001)
Genes Dev
, vol.15
, pp. 3243-3248
-
-
Jackson, E.L.1
Willis, N.2
Mercer, K.3
Bronson, R.T.4
Crowley, D.5
Montoya, R.6
Jacks, T.7
Tuveson, D.A.8
-
19
-
-
79951539242
-
+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
-
+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138: 653-665.
-
(2011)
Development
, vol.138
, pp. 653-665
-
-
Kopp, J.L.1
Dubois, C.L.2
Schaffer, A.E.3
Hao, E.4
Shih, H.P.5
Seymour, P.A.6
Ma, J.7
Sander, M.8
-
20
-
-
84870803922
-
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
-
Kopp JL, von Figura G, Mayes E, Liu F-F, Dubois CL, Morris JP, Pan FC, Akiyama H, Wright CVE, Jensen K, et al. 2012. Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell 22: 737-750.
-
(2012)
Cancer Cell
, vol.22
, pp. 737-750
-
-
Kopp, J.L.1
von Figura, G.2
Mayes, E.3
Liu, F.-F.4
Dubois, C.L.5
Morris, J.P.6
Pan, F.C.7
Akiyama, H.8
Wright, C.V.E.9
Jensen, K.10
-
21
-
-
0033000566
-
Prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme
-
Lu MF, Cheng HT, Kern MJ, Potter SS, Tran B, Diekwisch TG, Martin JF. 1999. prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme. Development 126: 495-504.
-
(1999)
Development
, vol.126
, pp. 495-504
-
-
Lu, M.F.1
Cheng, H.T.2
Kern, M.J.3
Potter, S.S.4
Tran, B.5
Diekwisch, T.G.6
Martin, J.F.7
-
22
-
-
34547525676
-
Sox9 coordinates a transcriptional network in pancreatic progenitor cells
-
Lynn FC, Smith SB, Wilson ME, Yang KY, Nekrep N, German MS. 2007. Sox9 coordinates a transcriptional network in pancreatic progenitor cells. Proc Natl Acad Sci 104: 10500-10505.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 10500-10505
-
-
Lynn, F.C.1
Smith, S.B.2
Wilson, M.E.3
Yang, K.Y.4
Nekrep, N.5
German, M.S.6
-
23
-
-
0034084930
-
Identification of a prx1 limb enhancer
-
Martin JF, Olson EN. 2000. Identification of a prx1 limb enhancer. Genesis 26: 225-229.
-
(2000)
Genesis
, vol.26
, pp. 225-229
-
-
Martin, J.F.1
Olson, E.N.2
-
24
-
-
0038070109
-
FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration
-
McKean DM, Sisbarro L, Ilic D, Kaplan-Alburquerque N, Nemenoff R, Weiser-Evans M, Kern MJ, Jones PL. 2003. FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration. J Cell Biol 161: 393-402.
-
(2003)
J Cell Biol
, vol.161
, pp. 393-402
-
-
McKean, D.M.1
Sisbarro, L.2
Ilic, D.3
Kaplan-Alburquerque, N.4
Nemenoff, R.5
Weiser-Evans, M.6
Kern, M.J.7
Jones, P.L.8
-
25
-
-
0035920222
-
The identification of Prx1 transcription regulatory domains provides a mechanism for unequal compensation by the Prx1 and Prx2 loci
-
Norris RA, Kern MJ. 2001. The identification of Prx1 transcription regulatory domains provides a mechanism for unequal compensation by the Prx1 and Prx2 loci. J Biol Chem 276: 26829-26837.
-
(2001)
J Biol Chem
, vol.276
, pp. 26829-26837
-
-
Norris, R.A.1
Kern, M.J.2
-
26
-
-
16444378654
-
Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells
-
Prasad NB, Biankin AV, Fukushima N, Maitra A, Dhara S, Elkahloun AG, Hruban RH, Goggins M, Leach SD. 2005. Gene expression profiles in pancreatic intraepithelial neoplasia reflect the effects of Hedgehog signaling on pancreatic ductal epithelial cells. Cancer Res 65: 1619-1626.
-
(2005)
Cancer Res
, vol.65
, pp. 1619-1626
-
-
Prasad, N.B.1
Biankin, A.V.2
Fukushima, N.3
Maitra, A.4
Dhara, S.5
Elkahloun, A.G.6
Hruban, R.H.7
Goggins, M.8
Leach, S.D.9
-
27
-
-
84868698484
-
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia
-
Prévot P-P, Simion A, Grimont A, Colletti M, Khalaileh A, Van den Steen G, Sempoux C, Xu X, Roelants V, Hald J, et al. 2012. Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia. Gut 61: 1723-1732.
-
(2012)
Gut
, vol.61
, pp. 1723-1732
-
-
Prévot, P.-P.1
Simion, A.2
Grimont, A.3
Colletti, M.4
Khalaileh, A.5
Van den, S.G.6
Sempoux, C.7
Xu, X.8
Roelants, V.9
Hald, J.10
-
28
-
-
84862147254
-
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
-
Pylayeva-Gupta Y, Lee KE, Hajdu CH, Miller G, Bar-Sagi D. 2012. Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia. Cancer Cell 21: 836-847.
-
(2012)
Cancer Cell
, vol.21
, pp. 836-847
-
-
Pylayeva-Gupta, Y.1
Lee, K.E.2
Hajdu, C.H.3
Miller, G.4
Bar-Sagi, D.5
-
29
-
-
84055193971
-
Pancreatic ductal cells in development, regeneration, and neoplasia
-
Reichert M, Rustgi AK. 2011. Pancreatic ductal cells in development, regeneration, and neoplasia. J Clin Invest 121: 4572-4578.
-
(2011)
J Clin Invest
, vol.121
, pp. 4572-4578
-
-
Reichert, M.1
Rustgi, A.K.2
-
30
-
-
84856088337
-
EMT and dissemination precede pancreatic tumor formation
-
Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, et al. 2012. EMT and dissemination precede pancreatic tumor formation. Cell 148: 349-361.
-
(2012)
Cell
, vol.148
, pp. 349-361
-
-
Rhim, A.D.1
Mirek, E.T.2
Aiello, N.M.3
Maitra, A.4
Bailey, J.M.5
McAllister, F.6
Reichert, M.7
Beatty, G.L.8
Rustgi, A.K.9
Vonderheide, R.H.10
-
31
-
-
76249094159
-
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
-
Rovira M, Scott S-G, Liss AS, Jensen J, Thayer SP, Leach SD. 2010. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc Natl Acad Sci 107: 75-80.
-
(2010)
Proc Natl Acad Sci
, vol.107
, pp. 75-80
-
-
Rovira, M.1
Scott, S.-G.2
Liss, A.S.3
Jensen, J.4
Thayer, S.P.5
Leach, S.D.6
-
32
-
-
3242697219
-
Successful growth and characterization of mouse pancreatic ductal cells: Functional properties of the Ki-RAS(G12V) oncogene
-
Schreiber FS, Deramaudt TB, Brunner TB, Boretti MI, Gooch KJ, Stoffers DA, Bernhard EJ, Rustgi AK. 2004. Successful growth and characterization of mouse pancreatic ductal cells: Functional properties of the Ki-RAS(G12V) oncogene. Gastroenterology 127: 250-260.
-
(2004)
Gastroenterology
, vol.127
, pp. 250-260
-
-
Schreiber, F.S.1
Deramaudt, T.B.2
Brunner, T.B.3
Boretti, M.I.4
Gooch, K.J.5
Stoffers, D.A.6
Bernhard, E.J.7
Rustgi, A.K.8
-
33
-
-
0027991262
-
Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila
-
Simeone A, D'Apice MR, Nigro V, Casanova J, Graziani F, Acampora D, Avantaggiato V. 1994. Orthopedia, a novel homeobox-containing gene expressed in the developing CNS of both mouse and Drosophila. Neuron 13: 83-101.
-
(1994)
Neuron
, vol.13
, pp. 83-101
-
-
Simeone, A.1
D'apice, M.R.2
Nigro, V.3
Casanova, J.4
Graziani, F.5
Acampora, D.6
Avantaggiato, V.7
-
34
-
-
34447560961
-
Analysis of gene expression data using BRB-ArrayTools
-
Simon R, Lam A, Li M-C, Ngan M, Menenzes S, Zhao Y. 2007. Analysis of gene expression data using BRB-ArrayTools. Cancer Inform 3: 11-17.
-
(2007)
Cancer Inform
, vol.3
, pp. 11-17
-
-
Simon, R.1
Lam, A.2
Li, M.-C.3
Ngan, M.4
Menenzes, S.5
Zhao, Y.6
-
35
-
-
38649140167
-
Notch signaling is required for exocrine regeneration after acute pancreatitis
-
Siveke JT, Lubeseder-Martellato C, Lee M, Mazur PK, Nakhai H, Radtke F, Schmid RM. 2008. Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology 134: 544-555.
-
(2008)
Gastroenterology
, vol.134
, pp. 544-555
-
-
Siveke, J.T.1
Lubeseder-Martellato, C.2
Lee, M.3
Mazur, P.K.4
Nakhai, H.5
Radtke, F.6
Schmid, R.M.7
-
36
-
-
36549077062
-
In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia
-
1999-2009
-
Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Castillo CFD, Warshaw AL, Thayer SP. 2007. In vivo lineage tracing defines the role of acinar-to-ductal transdifferentiation in inflammatory ductal metaplasia. Gastroenterology 133: 1999-2009.
-
(2007)
Gastroenterology
, vol.133
-
-
Strobel, O.1
Dor, Y.2
Alsina, J.3
Stirman, A.4
Lauwers, G.5
Trainor, A.6
Castillo, C.F.D.7
Warshaw, A.L.8
Thayer, S.P.9
-
37
-
-
0034889743
-
Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis
-
ten Berge D, Brouwer A, Korving J, Reijnen MJ, van Raaij EJ, Verbeek F, Gaffield W, Meijlink F. 2001. Prx1 and Prx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development 128: 2929-2938.
-
(2001)
Development
, vol.128
, pp. 2929-2938
-
-
Ten, B.D.1
Brouwer, A.2
Korving, J.3
Reijnen, M.J.4
Van Raaij, E.J.5
Verbeek, F.6
Gaffield, W.7
Meijlink, F.8
-
38
-
-
77957927710
-
The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding
-
von Burstin J, Reichert M, Wescott MP, Rustgi AK. 2010. The pancreatic and duodenal homeobox protein PDX-1 regulates the ductal specific keratin 19 through the degradation of MEIS1 and DNA binding. PLoS ONE 5: e12311.
-
(2010)
PLoS ONE
, vol.5
-
-
von Burstin, J.1
Reichert, M.2
Wescott, M.P.3
Rustgi, A.K.4
-
39
-
-
73949159687
-
Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor
-
Wescott MP, Rovira M, Reichert M, von Burstin J, Means A, Leach SD, Rustgi AK. 2009. Pancreatic ductal morphogenesis and the Pdx1 homeodomain transcription factor. Mol Biol Cell 20: 4838-4844.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 4838-4844
-
-
Wescott, M.P.1
Rovira, M.2
Reichert, M.3
von Burstin, J.4
Means, A.5
Leach, S.D.6
Rustgi, A.K.7
|