-
1
-
-
0030061628
-
Inhibition of HIV-1 RNase H activity by nucleotide dimers and monomers
-
Allen SJW, Krawczyk SH, McGee LR, Bischofberger N, Mulato AS, Cherrington JM (1996) Inhibition of HIV-1 RNase H activity by nucleotide dimers and monomers. Antivir Chem Chemother 7(1):37-45
-
(1996)
Antivir Chem Chemother
, vol.7
, Issue.1
, pp. 37-45
-
-
Allen, S.J.W.1
Krawczyk, S.H.2
McGee, L.R.3
Bischofberger, N.4
Mulato, A.S.5
Cherrington, J.M.6
-
2
-
-
0037059743
-
Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones
-
Arion D, Sluis-Cremer N, Min KL, Abram ME, Fletcher RS, Parniak MA (2002) Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. J Biol Chem 277(2):1370-1374
-
(2002)
J Biol Chem
, vol.277
, Issue.2
, pp. 1370-1374
-
-
Arion, D.1
Sluis-Cremer, N.2
Min, K.L.3
Abram, M.E.4
Fletcher, R.S.5
Parniak, M.A.6
-
3
-
-
84866325636
-
Antiviral drug resistance and the need for development of new HIV-1 reverse transcriptase inhibitors
-
Asahchop EL, Wainberg MA, Sloan RD, Tremblay CL (2012) Antiviral drug resistance and the need for development of new HIV-1 reverse transcriptase inhibitors. Antimicrob Agents Chemother. doi: 10.1128/AAC.00591-12
-
(2012)
Antimicrob Agents Chemother
-
-
Asahchop, E.L.1
Wainberg, M.A.2
Sloan, R.D.3
Tremblay, C.L.4
-
4
-
-
64649098298
-
HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: Implications for RNase H inhibition
-
Beilhartz GL, Wendeler M, Baichoo N, Rausch J, Le Grice S, Gotte M (2009) HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition. J Mol Biol 388(3):462-474
-
(2009)
J Mol Biol
, vol.388
, Issue.3
, pp. 462-474
-
-
Beilhartz, G.L.1
Wendeler, M.2
Baichoo, N.3
Rausch, J.4
Le Grice, S.5
Gotte, M.6
-
5
-
-
0031000566
-
Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone
-
Borkow G, Fletcher RS, Barnard J, Arion D, Motakis D, Dmitrienko GI, Parniak MA (1997) Inhibition of the ribonuclease H and DNA polymerase activities of HIV-1 reverse transcriptase by N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone. Biochemistry 36(11): 3179-3185
-
(1997)
Biochemistry
, vol.36
, Issue.11
, pp. 3179-3185
-
-
Borkow, G.1
Fletcher, R.S.2
Barnard, J.3
Arion, D.4
Motakis, D.5
Dmitrienko, G.I.6
Parniak, M.A.7
-
6
-
-
20044387576
-
Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones
-
Budihas SR, Gorshkova I, Gaidamakov S, Wamiru A, Bona MK, Parniak MA et al (2005) Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. Nucleic Acids Res 33(4):1249-1256
-
(2005)
Nucleic Acids Res
, vol.33
, Issue.4
, pp. 1249-1256
-
-
Budihas, S.R.1
Gorshkova, I.2
Gaidamakov, S.3
Wamiru, A.4
Bona, M.K.5
Parniak, M.A.6
-
7
-
-
61349157313
-
Ribonuclease H: Properties, substrate specificity and roles in retroviral reverse transcription
-
Champoux JJ, Schultz SJ (2009) Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcription. FEBS J 276(6):1506-1516. doi: 10.1111/j.1742-4658.2009.06909.x
-
(2009)
FEBS J
, vol.276
, Issue.6
, pp. 1506-1516
-
-
Champoux, J.J.1
Schultz, S.J.2
-
8
-
-
77956131587
-
Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H
-
Chung S, Wendeler M, Rausch JW, Beilhartz G, Gotte M, O'Keefe BR et al (2010) Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H. Antimicrob Agents Chemother 54(9):3913-3921. doi: 10.1128/AAC.00434-10
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.9
, pp. 3913-3921
-
-
Chung, S.1
Wendeler, M.2
Rausch, J.W.3
Beilhartz, G.4
Gotte, M.5
O'Keefe, B.R.6
-
9
-
-
79960189034
-
Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H
-
Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW et al (2011) Synthesis, activity, and structural analysis of novel alpha-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. J Med Chem 54(13):4462-4473. doi: 10.1021/jm2000757
-
(2011)
J Med Chem
, vol.54
, Issue.13
, pp. 4462-4473
-
-
Chung, S.1
Himmel, D.M.2
Jiang, J.K.3
Wojtak, K.4
Bauman, J.D.5
Rausch, J.W.6
-
10
-
-
84863025474
-
Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity
-
Chung S, Miller JT, Johnson BC, Hughes SH, Le Grice SF (2012) Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity. J Biol Chem 287(6):4066-4075. doi: 10.1074/jbc.M111.314781
-
(2012)
J Biol Chem
, vol.287
, Issue.6
, pp. 4066-4075
-
-
Chung, S.1
Miller, J.T.2
Johnson, B.C.3
Hughes, S.H.4
Le Grice, S.F.5
-
11
-
-
0027244668
-
Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H
-
Cirino NM, Kalayjian RC, Jentoft JE, Le Grice SF (1993) Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H. J Biol Chem 268(20):14743-14749
-
(1993)
J Biol Chem
, vol.268
, Issue.20
, pp. 14743-14749
-
-
Cirino, N.M.1
Kalayjian, R.C.2
Jentoft, J.E.3
Le Grice, S.F.4
-
12
-
-
0034002794
-
Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: Evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry
-
Cowan JA, Ohyama T, Howard K, Rausch JW, Cowan SM, Le Grice SF (2000) Metal-ion stoichiometry of the HIV-1 RT ribonuclease H domain: evidence for two mutually exclusive sites leads to new mechanistic insights on metal-mediated hydrolysis in nucleic acid biochemistry. J Biol Inorg Chem JBIC A Publ Soc Biol Inorg Chem 5(1):67-74
-
(2000)
J Biol Inorg Chem JBIC A Publ Soc Biol Inorg Chem
, vol.5
, Issue.1
, pp. 67-74
-
-
Cowan, J.A.1
Ohyama, T.2
Howard, K.3
Rausch, J.W.4
Cowan, S.M.5
Le Grice, S.F.6
-
13
-
-
85081861640
-
-
Curran DP, Parniak MA, Gabarda A (2004) USA Patent no. US 2004/0058948 A1. United States Patent Application Publication: U. S. P. Office
-
Curran DP, Parniak MA, Gabarda A (2004) USA Patent no. US 2004/0058948 A1. United States Patent Application Publication: U. S. P. Office
-
-
-
-
14
-
-
2342566918
-
The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus
-
Das D, Georgiadis MM (2004) The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus. Structure 12(5):819-829. doi: 10.1016/j.str.2004.02.032
-
(2004)
Structure
, vol.12
, Issue.5
, pp. 819-829
-
-
Das, D.1
Georgiadis, M.M.2
-
15
-
-
40349091258
-
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
-
Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ et al (2008) High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Proc Natl Acad Sci USA 105(5):1466-1471. doi: 10.1073/pnas.0711209105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.5
, pp. 1466-1471
-
-
Das, K.1
Bauman, J.D.2
Clark, A.D.3
Frenkel, Y.V.4
Lewi, P.J.5
Shatkin, A.J.6
-
16
-
-
84856711380
-
HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism
-
Das K, Martinez SE, Bauman JD, Arnold E (2012) HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat Struct Mol Biol 19(2):253-259. doi: 10.1038/nsmb.2223
-
(2012)
Nat Struct Mol Biol
, vol.19
, Issue.2
, pp. 253-259
-
-
Das, K.1
Martinez, S.E.2
Bauman, J.D.3
Arnold, E.4
-
17
-
-
0025908083
-
Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase
-
Davies JF 2nd, Hostomska Z, Hostomsky Z, Jordan SR, Matthews DA (1991) Crystal structure of the ribonuclease H domain of HIV-1 reverse transcriptase. Science 252(5002):88-95
-
(1991)
Science
, vol.252
, Issue.5002
, pp. 88-95
-
-
Davies, J.F.1
Hostomska, Z.2
Hostomsky, Z.3
Jordan, S.R.4
Matthews, D.A.5
-
18
-
-
80052957480
-
The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC
-
Davis CA, Parniak MA, Hughes SH (2011) The effects of RNase H inhibitors and nevirapine on the susceptibility of HIV-1 to AZT and 3TC. Virology 419(2):64-71. doi: 10.1016/j.virol.2011.08.010
-
(2011)
Virology
, vol.419
, Issue.2
, pp. 64-71
-
-
Davis, C.A.1
Parniak, M.A.2
Hughes, S.H.3
-
19
-
-
61449189645
-
Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV
-
De Clercq E (2009) Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV. Int J Antimicrob Agents 33(4):307-320. doi: 10.1016/j.ijantimicag.2008.10.010
-
(2009)
Int J Antimicrob Agents
, vol.33
, Issue.4
, pp. 307-320
-
-
De Clercq, E.1
-
20
-
-
34250811908
-
Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3′-azido-3′-deoxythymidine resistance
-
Delviks-Frankenberry KA, Nikolenko GN, Barr R, Pathak VK (2007) Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3′-azido-3′-deoxythymidine resistance. J Virol 81(13):6837-6845
-
(2007)
J Virol
, vol.81
, Issue.13
, pp. 6837-6845
-
-
Delviks-Frankenberry, K.A.1
Nikolenko, G.N.2
Barr, R.3
Pathak, V.K.4
-
21
-
-
49449103962
-
HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision
-
Delviks-Frankenberry KA, Nikolenko GN, Boyer PL, Hughes SH, Coffin JM, Jere A, Pathak VK (2008) HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision. Proc Natl Acad Sci USA 105(31):10943-10948. doi: 10.1073/pnas.0804660105.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.31
, pp. 10943-10948
-
-
Delviks-Frankenberry, K.A.1
Nikolenko, G.N.2
Boyer, P.L.3
Hughes, S.H.4
Coffin, J.M.5
Jere, A.6
Pathak, V.K.7
-
22
-
-
79952178100
-
The "connection" between HIV drug resistance and RNase H
-
Delviks-Frankenberry KA, Nikolenko GN, Pathak VK (2010) The "connection" between HIV drug resistance and RNase H. Viruses 2(7):1476-1503. doi: 10.3390/v2071476
-
(2010)
Viruses
, vol.2
, Issue.7
, pp. 1476-1503
-
-
Delviks-Frankenberry, K.A.1
Nikolenko, G.N.2
Pathak, V.K.3
-
23
-
-
0027328663
-
Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures
-
DeStefano JJ, Bambara RA, Fay PJ (1993) Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures. Biochemistry 32(27): 6908-6915
-
(1993)
Biochemistry
, vol.32
, Issue.27
, pp. 6908-6915
-
-
Destefano, J.J.1
Bambara, R.A.2
Fay, P.J.3
-
24
-
-
72049106109
-
Small molecule inhibitors of HIV RT Ribonuclease H
-
Di Grandi M, Olson M, Prashad AS, Bebernitz G, Luckay A, Mullen S et al (2010) Small molecule inhibitors of HIV RT Ribonuclease H. Bioorg Med Chem Lett 20(1):398-402. doi: 10.1016/j.bmcl.2009.10.043
-
(2010)
Bioorg Med Chem Lett
, vol.20
, Issue.1
, pp. 398-402
-
-
Di Grandi, M.1
Olson, M.2
Prashad, A.S.3
Bebernitz, G.4
Luckay, A.5
Mullen, S.6
-
25
-
-
0022498061
-
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV
-
(Washington, DC 1883)
-
Di Marzo Veronese F, Copeland TD, DeVico AL, Rahman R, Oroszlan S, Gallo RC, Sarngadharan MG (1986) Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science (Washington, DC 1883-) 231(4743):1289-1291
-
(1986)
Science
, vol.231
, Issue.4743
, pp. 1289-1291
-
-
Di Marzo-Veronese, F.1
Copeland, T.D.2
Devico, A.L.3
Rahman, R.4
Oroszlan, S.5
Gallo, R.C.6
Sarngadharan, M.G.7
-
26
-
-
52049107430
-
Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3′-azido-3′-deoxythymidine through both RNase H-dependent and -independent mechanisms
-
Ehteshami M, Beilhartz GL, Scarth BJ, Tchesnokov EP, McCormick S, Wynhoven B et al (2008) Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3′-azido-3′-deoxythymidine through both RNase H-dependent and -independent mechanisms. J Biol Chem 283(32):22222-22232
-
(2008)
J Biol Chem
, vol.283
, Issue.32
, pp. 22222-22232
-
-
Ehteshami, M.1
Beilhartz, G.L.2
Scarth, B.J.3
Tchesnokov, E.P.4
McCormick, S.5
Wynhoven, B.6
-
27
-
-
0025924750
-
Reverse transcriptase. RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities
-
Furfine ES, Reardon JE (1991) Reverse transcriptase. RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activities. J Biol Chem 266(1):406-412
-
(1991)
J Biol Chem
, vol.266
, Issue.1
, pp. 406-412
-
-
Furfine, E.S.1
Reardon, J.E.2
-
28
-
-
0032847978
-
Inhibitors of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase
-
Gabbara S, Davis WR, Hupe L, Hupe D, Peliska JA (1999) Inhibitors of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. Biochemistry 38(40):13070-13076
-
(1999)
Biochemistry
, vol.38
, Issue.40
, pp. 13070-13076
-
-
Gabbara, S.1
Davis, W.R.2
Hupe, L.3
Hupe, D.4
Peliska, J.A.5
-
29
-
-
0028945841
-
HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: Implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA
-
Gotte M, Fackler S, Hermann T, Perola E, Cellai L, Gross HJ et al (1995) HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA. EMBO J 14(4):833-841
-
(1995)
EMBO J
, vol.14
, Issue.4
, pp. 833-841
-
-
Gotte, M.1
Fackler, S.2
Hermann, T.3
Perola, E.4
Cellai, L.5
Gross, H.J.6
-
30
-
-
0039634849
-
Localization of the active site of HIV-1 reverse transcriptase-associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals
-
Gotte M, Maier G, Gross HJ, Heumann H (1998) Localization of the active site of HIV-1 reverse transcriptase-associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals. J Biol Chem 273(17):10139-10146
-
(1998)
J Biol Chem
, vol.273
, Issue.17
, pp. 10139-10146
-
-
Gotte, M.1
Maier, G.2
Gross, H.J.3
Heumann, H.4
-
31
-
-
77949567911
-
Reverse transcriptase in motion: Conformational dynamics of enzyme-substrate interactions
-
Gotte M, Rausch JW, Marchand B, Sarafianos S, Le Grice SF (2010) Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions. Biochim Biophys Acta 1804(5):1202-1212. doi: 10.1016/j.bbapap.2009.07.020
-
(2010)
Biochim Biophys Acta
, vol.1804
, Issue.5
, pp. 1202-1212
-
-
Gotte, M.1
Rausch, J.W.2
Marchand, B.3
Sarafianos, S.4
Le Grice, S.F.5
-
32
-
-
11144355815
-
Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides
-
Hang JQ, Rajendran S, Yang Y, Li Y, In PW, Overton H et al (2004) Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides. Biochem Biophys Res Commun 317(2):321-329
-
(2004)
Biochem Biophys Res Commun
, vol.317
, Issue.2
, pp. 321-329
-
-
Hang, J.Q.1
Rajendran, S.2
Yang, Y.3
Li, Y.4
In, P.W.5
Overton, H.6
-
33
-
-
33751538895
-
Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)
-
Hang JQ, Li Y, Yang Y, Cammack N, Mirzadegan T, Klumpp K (2007) Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs). Biochem Biophys Res Commun 352(2):341-350
-
(2007)
Biochem Biophys Res Commun
, vol.352
, Issue.2
, pp. 341-350
-
-
Hang, J.Q.1
Li, Y.2
Yang, Y.3
Cammack, N.4
Mirzadegan, T.5
Klumpp, K.6
-
34
-
-
0023673620
-
Identification and characterization of HIVspecific RNase H by monoclonal antibody
-
Hansen J, Schulze T, Mellert W, Moelling K (1988) Identification and characterization of HIVspecific RNase H by monoclonal antibody. EMBO J 7(1):239-243
-
(1988)
EMBO J
, vol.7
, Issue.1
, pp. 239-243
-
-
Hansen, J.1
Schulze, T.2
Mellert, W.3
Moelling, K.4
-
35
-
-
78650533230
-
Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. [Research support, Non-U.S. Gov't]
-
Hare S, Vos AM, Clayton RF, Thuring JW, Cummings MD, Cherepanov P (2010) Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance. [Research support, Non-U.S. Gov't]. Proc Natl Acad Sci USA 107(46):20057-20062. doi: 10.1073/pnas.1010246107
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.46
, pp. 20057-20062
-
-
Hare, S.1
Vos, A.M.2
Clayton, R.F.3
Thuring, J.W.4
Cummings, M.D.5
Cherepanov, P.6
-
36
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA et al (2000) Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science 287(5453):646-650
-
(2000)
Science
, vol.287
, Issue.5453
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
-
37
-
-
37249062449
-
HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site
-
Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T et al (2006) HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. ACS Chem Biol 1(11):702-712
-
(2006)
ACS Chem Biol
, vol.1
, Issue.11
, pp. 702-712
-
-
Himmel, D.M.1
Sarafianos, S.G.2
Dharmasena, S.3
Hossain, M.M.4
McCoy-Simandle, K.5
Ilina, T.6
-
38
-
-
71049185147
-
Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site
-
Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C et al (2009) Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure 17(12):1625-1635
-
(2009)
Structure
, vol.17
, Issue.12
, pp. 1625-1635
-
-
Himmel, D.M.1
Maegley, K.A.2
Pauly, T.A.3
Bauman, J.D.4
Das, K.5
Dharia, C.6
-
39
-
-
0032573488
-
Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: Implications for drug resistance
-
Huang H, Chopra R, Verdine GL, Harrison SC (1998) Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance. Science 282(5394): 1669-1675
-
(1998)
Science
, vol.282
, Issue.5394
, pp. 1669-1675
-
-
Huang, H.1
Chopra, R.2
Verdine, G.L.3
Harrison, S.C.4
-
40
-
-
0027318776
-
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA
-
Jacobo-Molina A, Ding J, Nanni RG, Clark AD Jr, Lu X, Tantillo C et al (1993) Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA. Proc Natl Acad Sci USA 90(13):6320-6324
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.13
, pp. 6320-6324
-
-
Jacobo-Molina, A.1
Ding, J.2
Nanni, R.G.3
Clark, A.D.4
Lu, X.5
Tantillo, C.6
-
41
-
-
0025162621
-
Three-dimensional structure of ribonuclease H from E. coli
-
Katayanagi K, Miyagawa M, Matsushima M, Ishikawa M, Kanaya S, Ikehara M et al (1990) Three-dimensional structure of ribonuclease H from E. coli. Nature 347(6290):306-309
-
(1990)
Nature
, vol.347
, Issue.6290
, pp. 306-309
-
-
Katayanagi, K.1
Miyagawa, M.2
Matsushima, M.3
Ishikawa, M.4
Kanaya, S.5
Ikehara, M.6
-
42
-
-
0028904435
-
Substitution of a highly basic helix/loop sequence into the RNase H domain of human immunodeficiency virus reverse transcriptase restores its Mn(2+)-dependent RNase H activity
-
Keck JL, Marqusee S (1995) Substitution of a highly basic helix/loop sequence into the RNase H domain of human immunodeficiency virus reverse transcriptase restores its Mn(2+)-dependent RNase H activity. Proc Natl Acad Sci USA 92(7):2740-2744
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.7
, pp. 2740-2744
-
-
Keck, J.L.1
Marqusee, S.2
-
43
-
-
0032545251
-
Activation/attenuation model for RNase H. A onemetal mechanism with second-metal inhibition
-
Keck JL, Goedken ER, Marqusee S (1998) Activation/attenuation model for RNase H. A onemetal mechanism with second-metal inhibition. J Biol Chem 273(51):34128-34133
-
(1998)
J Biol Chem
, vol.273
, Issue.51
, pp. 34128-34133
-
-
Keck, J.L.1
Goedken, E.R.2
Marqusee, S.3
-
44
-
-
70349638920
-
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: Design, biochemical activity, and structural information
-
Kirschberg TA, Balakrishnan M, Squires NH, Barnes T, Brendza KM, Chen X et al (2009) RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J Med Chem 52(19):5781-5784. doi: 10.1021/jm900597q
-
(2009)
J Med Chem
, vol.52
, Issue.19
, pp. 5781-5784
-
-
Kirschberg, T.A.1
Balakrishnan, M.2
Squires, N.H.3
Barnes, T.4
Brendza, K.M.5
Chen, X.6
-
45
-
-
33646497669
-
Recent progress in the design of small molecule inhibitors of HIV RNase H
-
Klumpp K, Mirzadegan T (2006) Recent progress in the design of small molecule inhibitors of HIV RNase H. Curr Pharm Des 12(15):1909-1922
-
(2006)
Curr Pharm des
, vol.12
, Issue.15
, pp. 1909-1922
-
-
Klumpp, K.1
Mirzadegan, T.2
-
46
-
-
10744226166
-
Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors
-
Klumpp K, Hang JQ, Rajendran S, Yang Y, Derosier A, Wong Kai In P et al (2003) Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors. Nucleic Acids Res 31(23):6852-6859
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.23
, pp. 6852-6859
-
-
Klumpp, K.1
Hang, J.Q.2
Rajendran, S.3
Yang, Y.4
Derosier, A.5
Wong Kai-In, P.6
-
47
-
-
0026693137
-
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor
-
Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA (1992) Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256(5065): 1783-1790
-
(1992)
Science
, vol.256
, Issue.5065
, pp. 1783-1790
-
-
Kohlstaedt, L.A.1
Wang, J.2
Friedman, J.M.3
Rice, P.A.4
Steitz, T.A.5
-
48
-
-
79956334444
-
Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors
-
Lansdon EB, Liu Q, Leavitt SA, Balakrishnan M, Perry JK, Lancaster-Moyer C et al (2011) Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors. Antimicrob Agents Chemother 55(6):2905-2915. doi: 10.1128/AAC.01594-10
-
(2011)
Antimicrob Agents Chemother
, vol.55
, Issue.6
, pp. 2905-2915
-
-
Lansdon, E.B.1
Liu, Q.2
Leavitt, S.A.3
Balakrishnan, M.4
Perry, J.K.5
Lancaster-Moyer, C.6
-
49
-
-
0025041016
-
The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives
-
Loya S, Hizi A (1990) The inhibition of human immunodeficiency virus type 1 reverse transcriptase by avarol and avarone derivatives. FEBS Lett 269(1):131-134
-
(1990)
FEBS Lett
, vol.269
, Issue.1
, pp. 131-134
-
-
Loya, S.1
Hizi, A.2
-
50
-
-
0027322533
-
The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses
-
Loya S, Hizi A (1993) The interaction of illimaquinone, a selective inhibitor of the RNase H activity, with the reverse transcriptases of human immunodeficiency and murine leukemia retroviruses. J Biol Chem 268(13):9323-9328
-
(1993)
J Biol Chem
, vol.268
, Issue.13
, pp. 9323-9328
-
-
Loya, S.1
Hizi, A.2
-
51
-
-
0024999408
-
Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase
-
Loya S, Tal R, Kashman Y, Hizi A (1990) Illimaquinone, a selective inhibitor of the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother 34(10):2009-2012
-
(1990)
Antimicrob Agents Chemother
, vol.34
, Issue.10
, pp. 2009-2012
-
-
Loya, S.1
Tal, R.2
Kashman, Y.3
Hizi, A.4
-
52
-
-
15844371219
-
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
-
Ma JB, Yuan YR, Meister G, Pei Y, Tuschl T, Patel DJ (2005) Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein. Nature 434(7033):666-670
-
(2005)
Nature
, vol.434
, Issue.7033
, pp. 666-670
-
-
Ma, J.B.1
Yuan, Y.R.2
Meister, G.3
Pei, Y.4
Tuschl, T.5
Patel, D.J.6
-
53
-
-
0036221012
-
Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase
-
Min BS, Miyashiro H, Hattori M (2002) Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase. Phytother Res PTR 16(Suppl 1):S57-S62
-
(2002)
Phytother Res PTR
, vol.16
, pp. S57-S62
-
-
Min, B.S.1
Miyashiro, H.2
Hattori, M.3
-
54
-
-
33846063300
-
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
-
Nikolenko GN, Delviks-Frankenberry KA, Palmer S, Maldarelli F, Fivash MJ Jr, Coffin JM, Pathak VK (2007) Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance. Proc Natl Acad Sci USA 104(1):317-322
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.1
, pp. 317-322
-
-
Nikolenko, G.N.1
Delviks-Frankenberry, K.A.2
Palmer, S.3
Maldarelli, F.4
Fivash, M.J.5
Coffin, J.M.6
Pathak, V.K.7
-
55
-
-
59649101866
-
Retroviral integrase superfamily: The structural perspective
-
Nowotny M (2009) Retroviral integrase superfamily: the structural perspective. EMBO Rep 10(2):144-151. doi: 10.1038/embor.2008.256
-
(2009)
EMBO Rep
, vol.10
, Issue.2
, pp. 144-151
-
-
Nowotny, M.1
-
56
-
-
21244451435
-
Crystal structures of RNase H bound to an RNA/DNA hybrid: Substrate specificity and metal-dependent catalysis
-
Nowotny M, Gaidamakov SA, Crouch RJ, Yang W (2005) Crystal structures of RNase H bound to an RNA/DNA hybrid: substrate specificity and metal-dependent catalysis. Cell 121(7):1005-1016
-
(2005)
Cell
, vol.121
, Issue.7
, pp. 1005-1016
-
-
Nowotny, M.1
Gaidamakov, S.A.2
Crouch, R.J.3
Yang, W.4
-
57
-
-
35348978302
-
Structure of human RNase H1 complexed with an RNA/DNA hybrid: Insight into HIV reverse transcription
-
Nowotny M, Gaidamakov SA, Ghirlando R, Cerritelli SM, Crouch RJ, Yang W (2007) Structure of human RNase H1 complexed with an RNA/DNA hybrid: insight into HIV reverse transcription. Mol Cell 28(2):264-276
-
(2007)
Mol Cell
, vol.28
, Issue.2
, pp. 264-276
-
-
Nowotny, M.1
Gaidamakov, S.A.2
Ghirlando, R.3
Cerritelli, S.M.4
Crouch, R.J.5
Yang, W.6
-
58
-
-
0030029792
-
Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H
-
Palaniappan C, Fuentes GM, Rodriguez-Rodriguez L, Fay PJ, Bambara RA (1996) Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H. J Biol Chem 271(4):2063-2070
-
(1996)
J Biol Chem
, vol.271
, Issue.4
, pp. 2063-2070
-
-
Palaniappan, C.1
Fuentes, G.M.2
Rodriguez-Rodriguez, L.3
Fay, P.J.4
Bambara, R.A.5
-
59
-
-
0344453794
-
Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors
-
Parkes KE, Ermert P, Fassler J, Ives J, Martin JA, Merrett JH et al (2003) Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. J Med Chem 46(7): 1153-1164
-
(2003)
J Med Chem
, vol.46
, Issue.7
, pp. 1153-1164
-
-
Parkes, K.E.1
Ermert, P.2
Fassler, J.3
Ives, J.4
Martin, J.A.5
Merrett, J.H.6
-
60
-
-
0141758137
-
A fluorescence-based highthroughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity
-
Parniak MA, Min KL, Budihas SR, Le Grice SF, Beutler JA (2003) A fluorescence-based highthroughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity. Anal Biochem 322(1):33-39. doi: 10.1016/j.ab.2003.06.001
-
(2003)
Anal Biochem
, vol.322
, Issue.1
, pp. 33-39
-
-
Parniak, M.A.1
Min, K.L.2
Budihas, S.R.3
Le Grice, S.F.4
Beutler, J.A.5
-
61
-
-
0026486193
-
Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. [Research Support, U.S. Gov't, P.H.S.]
-
Peliska JA, Benkovic SJ (1992) Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase. [Research Support, U.S. Gov't, P.H.S.]. Science 258(5085):1112-1118
-
(1992)
Science
, vol.258
, Issue.5085
, pp. 1112-1118
-
-
Peliska, J.A.1
Benkovic, S.J.2
-
62
-
-
2942525660
-
'Binding, bending and bonding': Polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus
-
Rausch JW, Le Grice SF (2004) 'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus. Int J Biochem Cell Biol 36(9):1752-1766. doi: 10.1016/j.biocel.2004.02.016
-
(2004)
Int J Biochem Cell Biol
, vol.36
, Issue.9
, pp. 1752-1766
-
-
Rausch, J.W.1
Le Grice, S.F.2
-
63
-
-
0035965124
-
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors
-
Ren J, Nichols C, Bird L, Chamberlain P, Weaver K, Short S et al (2001) Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors. J Mol Biol 312(4):795-805. doi: 10.1006/jmbi.2001.4988
-
(2001)
J Mol Biol
, vol.312
, Issue.4
, pp. 795-805
-
-
Ren, J.1
Nichols, C.2
Bird, L.3
Chamberlain, P.4
Weaver, K.5
Short, S.6
-
64
-
-
0028842293
-
The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1
-
Rodgers DW, Gamblin SJ, Harris BA, Ray S, Culp JS, Hellmig B et al (1995) The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1. Proc Natl Acad Sci USA 92(4):1222-1226
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, Issue.4
, pp. 1222-1226
-
-
Rodgers, D.W.1
Gamblin, S.J.2
Harris, B.A.3
Ray, S.4
Culp, J.S.5
Hellmig, B.6
-
65
-
-
26844566830
-
Structure and mechanism of DNA polymerases
-
Rothwell PJ, Waksman G (2005) Structure and mechanism of DNA polymerases. Adv Protein Chem 71:401-440. doi: 10.1016/S0065-3233(04)71011-6
-
(2005)
Adv Protein Chem
, vol.71
, pp. 401-440
-
-
Rothwell, P.J.1
Waksman, G.2
-
66
-
-
4444309793
-
New nucleoside/nucleotide backbone options: A review of recent studies
-
Ruane PJ, DeJesus E (2004) New nucleoside/nucleotide backbone options: a review of recent studies. J Acquir Immune Defic Syndr 37(Suppl 1):S21-S29
-
(2004)
J Acquir Immune Defic Syndr
, vol.37
, pp. S21-S29
-
-
Ruane, P.J.1
Dejesus, E.2
-
67
-
-
0035868713
-
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA
-
Sarafianos SG, Das K, Tantillo C, Clark AD Jr, Ding J, Whitcomb JM et al (2001) Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA. EMBO J 20(6):1449-1461
-
(2001)
EMBO J
, vol.20
, Issue.6
, pp. 1449-1461
-
-
Sarafianos, S.G.1
Das, K.2
Tantillo, C.3
Clark, A.D.4
Ding, J.5
Whitcomb, J.M.6
-
68
-
-
0024847468
-
Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H function
-
Schatz O, Cromme FV, Gruninger-Leitch F, Le Grice SF (1989) Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H function. FEBS Lett 257(2):311-314
-
(1989)
FEBS Lett
, vol.257
, Issue.2
, pp. 311-314
-
-
Schatz, O.1
Cromme, F.V.2
Gruninger-Leitch, F.3
Le Grice, S.F.4
-
69
-
-
43049125772
-
RNase H activity: Structure, specificity, and function in reverse transcription
-
Schultz SJ, Champoux JJ (2008) RNase H activity: structure, specificity, and function in reverse transcription. Virus Res 134(1-2):86-103. doi: 10.1016/j.virusres.2007.12.007
-
(2008)
Virus Res
, vol.134
, Issue.1-2
, pp. 86-103
-
-
Schultz, S.J.1
Champoux, J.J.2
-
70
-
-
7944237580
-
Recognition of internal cleavage sites by retroviral RNases H
-
Schultz SJ, Zhang M, Champoux JJ (2004) Recognition of internal cleavage sites by retroviral RNases H. J Mol Biol 344(3):635-652. doi: 10.1016/j.jmb.2004.09.081
-
(2004)
J Mol Biol
, vol.344
, Issue.3
, pp. 635-652
-
-
Schultz, S.J.1
Zhang, M.2
Champoux, J.J.3
-
71
-
-
0037474193
-
Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid
-
Shaw-Reid CA, Munshi V, Graham P, Wolfe A, Witmer M, Danzeisen R et al (2003) Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid. J Biol Chem 278(5):2777-2780. doi: 10.1074/jbc.C200621200
-
(2003)
J Biol Chem
, vol.278
, Issue.5
, pp. 2777-2780
-
-
Shaw-Reid, C.A.1
Munshi, V.2
Graham, P.3
Wolfe, A.4
Witmer, M.5
Danzeisen, R.6
-
72
-
-
13444257639
-
Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reversetranscriptase activities
-
Shaw-Reid CA, Feuston B, Munshi V, Getty K, Krueger J, Hazuda DJ et al (2005) Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reversetranscriptase activities. Biochemistry 44(5):1595-1606. doi: 10.1021/bi0486740
-
(2005)
Biochemistry
, vol.44
, Issue.5
, pp. 1595-1606
-
-
Shaw-Reid, C.A.1
Feuston, B.2
Munshi, V.3
Getty, K.4
Krueger, J.5
Hazuda, D.J.6
-
73
-
-
0026052102
-
Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors
-
Shih CK, Rose JM, Hansen GL, Wu JC, Bacolla A, Griffin JA (1991) Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors. Proc Natl Acad Sci USA 88(21):9878-9882
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, Issue.21
, pp. 9878-9882
-
-
Shih, C.K.1
Rose, J.M.2
Hansen, G.L.3
Wu, J.C.4
Bacolla, A.5
Griffin, J.A.6
-
74
-
-
0033770149
-
Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs)
-
Sluis-Cremer N, Arion D, Parniak MA (2000) Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs). Cell Mol Life Sci CMLS 57(10): 1408-1422
-
(2000)
Cell Mol Life Sci CMLS
, vol.57
, Issue.10
, pp. 1408-1422
-
-
Sluis-Cremer, N.1
Arion, D.2
Parniak, M.A.3
-
75
-
-
0036076157
-
Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors
-
Sluis-Cremer N, Arion D, Parniak MA (2002) Destabilization of the HIV-1 reverse transcriptase dimer upon interaction with N-acyl hydrazone inhibitors. Mol Pharmacol 62(2):398-405
-
(2002)
Mol Pharmacol
, vol.62
, Issue.2
, pp. 398-405
-
-
Sluis-Cremer, N.1
Arion, D.2
Parniak, M.A.3
-
76
-
-
4444302947
-
Crystal structure of argonaute and its implications for RISC slicer activity
-
Song JJ, Smith SK, Hannon GJ, Joshua-Tor L (2004) Crystal structure of argonaute and its implications for RISC slicer activity. Science 305(5689):1434-1437
-
(2004)
Science
, vol.305
, Issue.5689
, pp. 1434-1437
-
-
Song, J.J.1
Smith, S.K.2
Hannon, G.J.3
Joshua-Tor, L.4
-
77
-
-
0027931296
-
Construction of an enzymatically active ribonuclease H domain of human immunodeficiency virus type 1 reverse transcriptase
-
Stahl SJ, Kaufman JD, Vikic-Topic S, Crouch RJ, Wingfield PT (1994) Construction of an enzymatically active ribonuclease H domain of human immunodeficiency virus type 1 reverse transcriptase. Protein Eng 7(9):1103-1108
-
(1994)
Protein Eng
, vol.7
, Issue.9
, pp. 1103-1108
-
-
Stahl, S.J.1
Kaufman, J.D.2
Vikic-Topic, S.3
Crouch, R.J.4
Wingfield, P.T.5
-
78
-
-
0347361643
-
Discovery of alpha, gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase
-
Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S et al (2004) Discovery of alpha, gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. J Med Chem 47(1):14-17. doi: 10.1021/jm0342109
-
(2004)
J Med Chem
, vol.47
, Issue.1
, pp. 14-17
-
-
Summa, V.1
Petrocchi, A.2
Pace, P.3
Matassa, V.G.4
De Francesco, R.5
Altamura, S.6
-
79
-
-
0025812772
-
Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate
-
Tan CK, Civil R, Mian AM, So AG, Downey KM (1991) Inhibition of the RNase H activity of HIV reverse transcriptase by azidothymidylate. Biochemistry 30(20):4831-4835
-
(1991)
Biochemistry
, vol.30
, Issue.20
, pp. 4831-4835
-
-
Tan, C.K.1
Civil, R.2
Mian, A.M.3
So, A.G.4
Downey, K.M.5
-
80
-
-
0002296754
-
Reverse transcriptase and the generation of retroviral DNA
-
Coffin JM, Hughes SH, Varmus HE (eds). Cold Spring Harbor Laboratory Press, Plainview
-
Telesnitsky A, Goff SP (1997) Reverse transcriptase and the generation of retroviral DNA. In: Coffin JM, Hughes SH, Varmus HE (eds) Retroviruses. Cold Spring Harbor Laboratory Press, Plainview, pp. 121-160
-
(1997)
Retroviruses
, pp. 121-160
-
-
Telesnitsky, A.1
Goff, S.P.2
-
81
-
-
0028171260
-
Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds
-
Tomassini J, Selnick H, Davies ME, Armstrong ME, Baldwin J, Bourgeois M et al (1994) Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob Agents Chemother 38(12):2827-2837
-
(1994)
Antimicrob Agents Chemother
, vol.38
, Issue.12
, pp. 2827-2837
-
-
Tomassini, J.1
Selnick, H.2
Davies, M.E.3
Armstrong, M.E.4
Baldwin, J.5
Bourgeois, M.6
-
82
-
-
13544276913
-
6-[1-(4-Fluorophenyl) methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro
-
Tramontano E, Esposito F, Badas R, Di Santo R, Costi R, La Colla P (2005) 6-[1-(4-Fluorophenyl) methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the ribonuclease H activity in vitro. Antiviral Res 65(2):117-124
-
(2005)
Antiviral Res
, vol.65
, Issue.2
, pp. 117-124
-
-
Tramontano, E.1
Esposito, F.2
Badas, R.3
Di Santo, R.4
Costi, R.5
La Colla, P.6
-
83
-
-
0037465825
-
Dispensability of glutamic acid 48 and aspartic acid 134 for Mn2+-dependent activity of E. coli ribonuclease HI
-
Tsunaka Y, Haruki M, Morikawa M, Oobatake M, Kanaya S (2003) Dispensability of glutamic acid 48 and aspartic acid 134 for Mn2+-dependent activity of E. coli ribonuclease HI. Biochemistry 42(11):3366-3374. doi: 10.1021/bi0205606
-
(2003)
Biochemistry
, vol.42
, Issue.11
, pp. 3366-3374
-
-
Tsunaka, Y.1
Haruki, M.2
Morikawa, M.3
Oobatake, M.4
Kanaya, S.5
-
84
-
-
11844284013
-
Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E. coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography
-
Tsunaka Y, Takano K, Matsumura H, Yamagata Y, Kanaya S (2005) Identification of single Mn(2+) binding sites required for activation of the mutant proteins of E. coli RNase HI at Glu48 and/or Asp134 by X-ray crystallography. J Mol Biol 345(5):1171-1183
-
(2005)
J Mol Biol
, vol.345
, Issue.5
, pp. 1171-1183
-
-
Tsunaka, Y.1
Takano, K.2
Matsumura, H.3
Yamagata, Y.4
Kanaya, S.5
-
85
-
-
58149160464
-
Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity
-
Wendeler M, Lee HF, Bermingham A, Miller JT, Chertov O, Bona MK et al (2008) Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity. ACS Chem Biol 3(10):635-644
-
(2008)
ACS Chem Biol
, vol.3
, Issue.10
, pp. 635-644
-
-
Wendeler, M.1
Lee, H.F.2
Bermingham, A.3
Miller, J.T.4
Chertov, O.5
Bona, M.K.6
-
86
-
-
0028344281
-
Catalytically distinct conformations of the ribonuclease H of HIV-1 reverse transcriptase by substrate cleavage patterns and inhibition by azidothymidylate and N-ethylmaleimide
-
Zhan X, Tan CK, Scott WA, Mian AM, Downey KM, So AG (1994) Catalytically distinct conformations of the ribonuclease H of HIV-1 reverse transcriptase by substrate cleavage patterns and inhibition by azidothymidylate and N-ethylmaleimide. Biochemistry 33(6):1366-1372
-
(1994)
Biochemistry
, vol.33
, Issue.6
, pp. 1366-1372
-
-
Zhan, X.1
Tan, C.K.2
Scott, W.A.3
Mian, A.M.4
Downey, K.M.5
So, A.G.6
|