Reverse transcriptase in motion: Conformational dynamics of enzyme-substrate interactions

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1804, Issue 5, 2010, Pages 1202-1212

  Götte, Matthias ^a   Rausch, Jason W ^b   Marchand, Bruno ^c   Sarafianos, Stefan ^c   Le Grice, Stuart F J ^b  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL CANCER INSTITUTE   (United States)

^c University of Missouri   (United States)

Author keywords

Retrovirus; Reverse transcriptase; Ribonuclease H; Single molecule spectroscopy; Translocational equilibrium

Indexed keywords

ABACAVIR; DIDANOSINE; EMTRICITABINE; FOSCARNET; INDAZOLE DERIVATIVE; INDOLOPYRIDONE; LAMIVUDINE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; STAVUDINE; TENOFOVIR; UNCLASSIFIED DRUG; ZALCITABINE; ZIDOVUDINE;

CYTOMEGALOVIRUS INFECTION; DNA SYNTHESIS; DRUG MECHANISM; ENZYME CONFORMATION; ENZYME STRUCTURE, FUNCTION AND VARIABILITY; ENZYME SUBSTRATE COMPLEX; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA SYNTHESIS; SINGLE MOLECULE SPECTROSCOPY; SPECTROSCOPY; UNSPECIFIED SIDE EFFECT;

DNA, VIRAL; HIV REVERSE TRANSCRIPTASE; HUMANS; MOLECULAR CONFORMATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77949567911     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2009.07.020     Document Type: Review

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