Synthesis, activity, and structural analysis of novel α- hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4462-4473

  Chung, Suhman ^a   Himmel, Daniel M ^b   Jiang, Jian Kang ^c   Wojtak, Krzysztof ^b   Bauman, Joseph D ^b   Rausch, Jason W ^a   Wilson, Jennifer A ^a   Beutler, John A ^a   Thomas, Craig J ^c   Arnold, Eddy ^b   Le Grice, Stuart F J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 BENZYLAMINO ETHYL) 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 2 (1,2 DIHYDROXY 1 METHYLETHYL) 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 2 (2 BENZYLSULFANYL 1 HYDROXY 1 METHYLETHYL) 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 2 (2 DIETHYLAMINO 1 HYDROXY 1 METHYLETHYL) 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 2 (2 ETHANESULFONYL 1 HYDROXY 1 METHYLETHYL) 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 2 (2 ETHYLSULFANYL 1 HYDROXY 1 METHYLETHYL) 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 2 [2 (2 FLUORO BENZYLAMINO) 1 HYDROXY 1 METHYLETHYL] 5,7 DIHYDROXY 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 5,7 DIHYDROXY 2 (1 HYDROXY 1 METHYL 2 PHENYLAMINOETHYL) 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 5,7 DIHYDROXY 2 (1 HYDROXY 1 METHYL 2 PHENYLSULFANYLETHYL) 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; 5,7 DIHYDROXY 2 (1 HYDROXY 1 METHYL 2 PIPERIDIN 1 YLETHYL) 9 METHYL 1,2,3,4 TETRAHYDRO BENZOCYCLOHEPTEN 6 ONE; 5,7 DIHYDROXY 2 (1 HYDROXY 2 IMIDAZOL 1 YL 1 METHYLETHYL) 9 METHYL 1,2,3,4 TETRAHYDRO BENZOCYCLOHEPTEN 6 ONE; 5,7 DIHYDROXY 2 (1 HYDROXY ETHYL) 9 METHYL 1,2,3,4 TETRAHYDROBENZOCYCLOHEPTEN 6 ONE; ALPHA HYDROXYTROPOLONE INHIBITOR; BETA THUJAPLICINOL; DNA POLYMERASE; MANICOL; PROTEIN P51; PROTEIN P66; RIBONUCLEASE H; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

ANTI-HIV AGENTS; BENZOCYCLOHEPTENES; CATALYTIC DOMAIN; CATIONS, DIVALENT; CELL LINE; COORDINATION COMPLEXES; CRYSTALLOGRAPHY, X-RAY; DNA-DIRECTED DNA POLYMERASE; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MANGANESE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; NITRILES; PROTEIN CONFORMATION; PYRIMIDINES; RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPOLONE; VIRUS REPLICATION;

EID: 79960189034     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2000757     Document Type: Article

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