Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid

Journal of Biological Chemistry

Volumn 278, Issue 5, 2003, Pages 2777-2780

  Shaw Reid, Cathryn A ^a   Munshi, Vandna ^a   Graham, Pia ^a   Wolfe, Abigail ^a   Witmer, Marc ^a   Danzeisen, Renee ^a   Olsen, David B ^a   Carroll, Steven S ^a   Embrey, Mark ^a   Wai, John S ^a   Miller, Michael D ^a   Cole, James L ^a,b   Hazuda, Daria J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME INHIBITION; POLYMERIZATION; VIRUSES;

REVERSE TRANSCRIPTASE (RT);

BIOCHEMISTRY;

3 [[(4,7 DICHLORO 1,3 BENZOXAZOL 2 YL)METHYL]AMINO] 5 ETHYL 6 METHYLPYRIDIN 2(1H) ONE; 4 [5 (BENZOYLAMINO)THIEN 2 YL] 2,4 DIOXOBUTANOIC ACID; 4 CHLOROPHENYLHYDRAZONE; BUTYRIC ACID DERIVATIVE; FOSCARNET; HYDRAZONE DERIVATIVE; MANGANESE; POLYPROTEIN; PYRIDINE DERIVATIVE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ZIDOVUDINE; 4 (5 (BENZOYLAMINO)THIEN 2 YL) 2,4 DIOXOBUTANOIC ACID; 4-(5-(BENZOYLAMINO)THIEN-2-YL)-2,4-DIOXOBUTANOIC ACID; ENZYME INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; THIOPHENE DERIVATIVE;

ALPHA HELIX; ARTICLE; CALORIMETRY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; MUTATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN DOMAIN; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

BUTYRIC ACIDS; ENZYME INHIBITORS; FOSCARNET; HIV-1; KINETICS; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, CALF THYMUS; RNA-DIRECTED DNA POLYMERASE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THIOPHENES;

EID: 0037474193     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200621200     Document Type: Article

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