Activity of the isolated HIV RNase H domain and specific inhibition by N-hydroxyimides

Biochemical and Biophysical Research Communications

Volumn 317, Issue 2, 2004, Pages 321-329

  Hang, Julie Qi ^a   Rajendran, Surendran ^a   Yang, Yanli ^a   Li, Yu ^a   In, Philippe Wong Kai ^b,c   Overton, Hilary ^b,c   Parkes, Kevin E B ^b,d   Cammack, Nick ^a,b   Martin, Joseph A ^a,b   Klumpp, Klaus ^a,b  

^a ROCHE BIOSCIENCE   (United States)

^b ROCHE PRODUCTS LTD   (United Kingdom)

^c OSI Pharmaceuticals   (United Kingdom)

^d MEDIVIR AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXY 4H ISOQUINOLINE 1,3 DIONE; AMINO ACID; ENZYME INHIBITOR; IMIDE; NUCLEOTIDE; RIBONUCLEASE H; RNA; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; ESCHERICHIA COLI; FLUORESCENCE; GENE DELETION; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PHOTOCHEMICAL QUENCHING; PRIORITY JOURNAL; RECESSIVE GENE; RNA CLEAVAGE;

AMINO ACID SUBSTITUTION; BINDING SITES; ENZYME ACTIVATION; ENZYME INHIBITORS; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HYDROLYSIS; IMIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; RIBONUCLEASE H, CALF THYMUS; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 11144355815     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.03.061     Document Type: Article

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