Localization of the active site of HIV-1 reverse transcriptase- associated RNase H domain on a DNA template using site-specific generated hydroxyl radicals

Journal of Biological Chemistry

Volumn 273, Issue 17, 1998, Pages 10139-10146

  Götte, Matthias ^a,c   Maier, Gottfried ^a   Gross, Hans J ^b   Heumann, Hermann ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FERROUS ION; HYDROXYL RADICAL; MAGNESIUM ION; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE;

ARTICLE; BINDING COMPETITION; DNA CLEAVAGE; DNA FLANKING REGION; DNA TEMPLATE; ENZYME ACTIVE SITE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; RNA CLEAVAGE; SITE DIRECTED MUTAGENESIS;

BINDING SITES; DNA; DNA FOOTPRINTING; FERROUS COMPOUNDS; HIV-1 REVERSE TRANSCRIPTASE; HYDROLYSIS; HYDROXYL RADICAL; MAGNESIUM; RIBONUCLEASE H, CALF THYMUS; RNA; TEMPLATES, GENETIC;

EID: 0039634849     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.17.10139     Document Type: Article

References (38)

1. Skalka, A.-M., and Goff, S. P. (eds) (1993) Reverse Transcriptase, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
2. Litvak, S., Sarih-Cottin, L., Fournier, M., Andreola M., and Tarrago-Litvak, L. (1993) Trends Biochem. Sci. 19, 114-118
3. Jiang, M., Mak, J., Ladha, A., Cohen, E., Klein, M., Rovinaki, B., and Kleiman, L. (1993) J. Virol. 67, 3246-3253
4. Isel, C., Lanchy, J. M., Le Grice, S. F., Ehresmann, C., Ehresmann, B., and Marquet, R. (1996) EMBO J. 15, 917-924
5. Wöhrl, B. M., and Moelling, K. (1990) Biochemistry 29, 10141-10147
6. Schatz, O., Mous, J., and Le Grice, S. F. J. (1990) EMBO J. 9, 1171-1176
7. Gopalakrishnan, V., Peliska, J. A., and Benkovic, S. J. (1992) Proc. Natl. Acad. Sci. U. S. A., 89, 10763-10767
8. Peliska, J. A., and Benkovic, S. J. (1992) Science 258, 1112-1118
9. Götte, M., Fackler, S., Hermann, T., Perola, E., Cellai, L., Gross, H. J., Le Grice, S. F. J., and Heumann, H. (1995) EMBO J. 14, 833-841
10. Furfine, E. S., and Reardon, J. E. (1991) J. Biol. Chem. 266, 406-412
11. DeStefano, J. J., Buiser, R. G., Mallaber, L. M., Myers, T. W., Bambara, R. A., and Fay, P. J. (1991) J. Biol. Chem. 266, 7423-7431
12. DeStefano, J. J., Buiser, R. G., Mallaber, L. M., Bambara, R. A., and Fay, P. J. (1991) J. Biol. Chem. 266, 24295-24301
13. DeStefano, J. J., Mallaber, L. M., Fay, P. J., and Bambara, R. A. (1994) Nucleic Acids Res. 22, 3793-3800
14. Kati, W. M., Johnson, K. A., Jerva, L. F., and Anderson, K. S. (1992) J. Biol. Chem. 267, 25988-25997
15. Ben-Artzi, H., Zeelon, E., Le Grice, S. F. J., Gorecki, M., and Panet, A. (1992) Nucleic Acids Res. 89, 927-931
16. Hostomsky, Z., Hughes, S. H., Goff, S. P., and Le Grice, S. F. J. (1994) J. Virol. 68, 1970-1971
17. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Jr., Lu, X., Tantillo, C., Williams, R. L., Kamer, G., Ferris, A. L., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6320-6324
18. Metzger, W., Hermann, T., Schatz, O., Le Grice, S. F. J., and Heumann, H. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 5909-5913
19. Schatz, O., Cromme, F. V., Grüninger-Leitch, F., and Le Grice, S. F. J.(1989) FEBS Lett. 257, 311-314
20. Ettner, N., Metzger, J. W., Lederer, T., Hulmes, J. D., Kisker, C., Hinrichs, W., Ellestad, G. A., and Hillen, W. (1995) Biochemistry 34, 22-31
21. Zaychikov, E., Martin, E., Denissova, L., Kozlov, M., Markotsov, V., Kashlev, M., Heumann, H., Nikiforov, V., Goldfarb, A., and Mustaev, A. (1996) Science 273, 107-109
22. Tullius, T., and Dombroski, B. A. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 5469-5473
23. King, P. A., Anderson, V. E., Edwards, J. O., Gustafson, G., Plumb, R. C., and Suggs, J. W. (1992) J. Am. Chem. Soc. 114, 5430-5432
24. King, P. A., Jamison, E., Strahs, D., Anderson, V. E., and Brenowitz, M. (1993) Nucleic Acids Res. 21, 2473-2478
25. Götte, M., Marquet, R., Isel, C., Anderson, V. E., Keith, G., Gross, H. J., Ehresmann, C., Ehresmann, B., and Heumann, H. (1996) FEBS Lett. 390, 226-228
26. Davies, J. F., II, Hostomska, Z., Hostomsky, Z., Jordan, S. R., and Matthews, D. A. (1991) Science 252, 88-95
27. Maxam, A. M., and Gilbert, W. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 560-564
28. Sigman, D. S. (1990) Biochemistry 29, 9097-9105
29. Pogozelski, W. K., McNeese, T. J., and Tullius, T. D. (1995) J. Am. Chem. Soc. 117, 6428-6433
30. Pelletier, H., Sawaya, M. R., Kumar, R., Wilson, S. H., and Kraut, J. (1994) Science 264, 1891-1903
31. Wöhrl, B. A., Georgiadis, M. M., Telesnitsky, A., Hendrickson, W. A., and Le Grice, S. F. J. (1995) Science 267, 96-99
32. Le Grice, S. F. J., and Grüninger-Leitch, F. (1990) Eur. J. Biochem. 178, 307-314
33. Raba, M., Limburg, K., Burghagen, M., Katze, J. R., Simsek, M., Heckmann, J. E., RajBhandary, U. L., and Gross, H. J. (1979) Eur. J. Biochem. 97, 305-318
34. Laemmli, U. K. (1970) Nature 227, 680-685
35. Saenger, W. (1983) Principles of Nucleic Acid Structure, pp. 220-282, Springer Verlag, New York
36. Bruce, A. G., and Uhlenbeck, O. C. (1978) Nucleic Acids Res. 5, 3665-3677
37. Fedoroff, O. Y., Salazar, M., and Reid, B. R. (1993) J. Mol. Biol. 233, 509-523
38. Fedoroff, O. Y., Ge, Y., and Reid, B. R. (1997) J. Mol. Biol. 269, 225-239