Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

Structure

Volumn 17, Issue 12, 2009, Pages 1625-1635

  Himmel, Daniel M ^a   Maegley, Karen A ^b   Pauly, Tom A ^b   Bauman, Joseph D ^a   Das, Kalyan ^a   Dharia, Chhaya ^a   Clark Jr , Arthur D ^a   Ryan, Kevin ^b   Hickey, Michael J ^b   Love, Robert A ^b   Hughes, Stephen H ^c   Bergqvist, Simon ^b   Arnold, Eddy ^a  

^a RUTGERS UNIVERSITY   (United States)

^b PFIZER INC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

MICROBIO; PROTEINS; RNA

Indexed keywords

BETA THUJAPLICINOL; NUCLEOTIDYLTRANSFERASE INHIBITOR; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CHELATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; PRIORITY JOURNAL;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HIV REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASES; TROPOLONE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 71049185147     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2009.09.016     Document Type: Article

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