Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

Nucleic Acids Research

Volumn 33, Issue 4, 2005, Pages 1249-1256

  Budihas, Scott R ^c   Gorshkova, Inna ^a   Gaidamakov, Sergei ^b   Wamiru, Antony ^c,d   Bona, Marion K ^d   Parniak, Michael A ^e   Crouch, Robert J ^b   McMahon, James B ^c   Beutler, John A ^c   Le Grice, Stuart F J ^c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d SAIC FREDERICK INC   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA THUJAPLICIN; BETA THUJAPLICINOL; CALANOLIDE A; DNA POLYMERASE; GAMMA THUJAPLICIN; HYDROXYL GROUP; MANICOL; NOOTKATIN; NUCLEIC ACID; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THUJAPLICIN; TROPOLONE DERIVATIVE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BETA-THUJAPLICINOL; COUMARIN DERIVATIVE; DRUG DERIVATIVE; FUSED ALICYCLIC AROMATIC COMPOUND; PYRANOCOUMARIN DERIVATIVE; TROPOLONE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG POTENTIATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IN VITRO STUDY; INTERCALATION COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; SURFACE PLASMON RESONANCE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; METABOLISM;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

ANTI-HIV AGENTS; BENZOCYCLOHEPTENES; BINDING SITES; COUMARINS; HIV-1; PYRANOCOUMARINS; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, CALF THYMUS; TROPOLONE;

EID: 20044387576     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki268     Document Type: Article

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