Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

ACS Chemical Biology

Volumn 3, Issue 10, 2008, Pages 635-644

  Wendeler, Michaela ^a   Lee, Hsiu Fang ^b   Bermingham, Alun ^a   Miller, Jennifer T ^a   Chertov, Oleg ^c   Bona, Marion K ^c   Baichoo, Noel S ^a   Ehteshami, Maryam ^d   Beutler, John ^a   O'Keefe, Barry R ^a   Götte, Matthias ^d   Kvaratskhelia, Mamuka ^b   Le Grice, Stuart ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c SAIC FREDERICK INC   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; CYSTEINE; LYSINE; N [3 (AMINOCARBONYL) 4,5 DIMETHYL 2 THIENYL] 2 FURANCARBOXAMIDE; NSC 727447; NSC 727448; PROTEIN P51; PROTEIN P66; PROTEIN SUBUNIT; RIBONUCLEASE H; RIBONUCLEASE INHIBITOR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THUJAPLICIN; UNCLASSIFIED DRUG; VINYLOGOUS UREA DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; FURANS; HIV REVERSE TRANSCRIPTASE; HUMANS; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS; THIOPHENES; UREA;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 58149160464     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb8001039     Document Type: Article

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