Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2004, Pages 14-17

  Summa, Vincenzo ^a   Petrocchi, Alessia ^a   Pace, Paola ^a   Matassa, Victor G ^a,b   De Francesco, Raffaele ^a   Altamura, Sergio ^a   Tomei, Licia ^a   Koch, Uwe ^a   Neuner, Philippe ^a  

^a IRBM   (Italy)

^b Graffinity Pharmaceuticals AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DIKETO ACID; GAMMA DIKETO ACID; NUCLEOTIDYLTRANSFERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; HEPATITIS C VIRUS; IC 50; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

KETO ACIDS; MODELS, MOLECULAR; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0347361643     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0342109     Document Type: Article

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