Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 9, 2010, Pages 3913-3921

  Chung, Suhman ^a   Wendeler, Michaela ^a   Rausch, Jason W ^a   Beilhartz, Greg ^b   Gotte, Matthias ^b   O'Keefe, Barry R ^a   Bermingham, Alun ^a   Beutler, John A ^a   Liu, Shixin ^c   Zhuang, Xiaowei ^c,d,e   Le Grice, Stuart F J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c HARVARD UNIVERSITY   (United States)

^d HARVARD UNIVERSITY   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; AMIDE; AMINE; ANTIVIRUS AGENT; CYCLOALKANE DERIVATIVE; CYCLOHEPTANE DERIVATIVE; CYCLOHEXANE DERIVATIVE; CYCLOOCTANE DERIVATIVE; ENZYME INHIBITOR; N [3 (AMINOCARBONYL) 4,5 DIMETHYL 2 THIENYL] 2 FURANCARBOXAMIDE; PROTEIN P51; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CATALYTIC DOMAIN; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS; TEMPERATURE; THERMODYNAMICS;

EID: 77956131587     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00434-10     Document Type: Article

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