Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Biochemical and Biophysical Research Communications

Volumn 352, Issue 2, 2007, Pages 341-350

  Hang, Julie Q ^a   Li, Yu ^a   Yang, Yanli ^a   Cammack, Nick ^a   Mirzadegan, Tara ^a   Klumpp, Klaus ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

Antiviral; Non nucleoside; Polymerase; Reverse transcriptase; RNase H; RNase H inhibitor

Indexed keywords

CAPRAVIRINE; DNA DIRECTED DNA POLYMERASE; EFAVIRENZ; ETRAVIRINE; GW 8248; NEVIRAPINE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; DNA RNA HYBRIDIZATION; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENE MUTATION; GENETIC VARIABILITY; IC 50; INHIBITION KINETICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ENZYME ACTIVATION; ENZYME INHIBITORS; HIV; NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; RIBONUCLEASE H, CALF THYMUS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33751538895     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.11.018     Document Type: Article

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