Mutagenesis of human immunodeficiency virus reverse transcriptase p51 subunit defines residues contributing to vinylogous urea inhibition of ribonuclease H activity

Journal of Biological Chemistry

Volumn 287, Issue 6, 2012, Pages 4066-4075

  Chung, Suhman ^a   Miller, Jennifer T ^a   Johnson, Barry C ^a   Hughes, Stephen H ^a   Le Grice, Stuart F J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALANINE-SCANNING MUTAGENESIS; ALLOSTERIC INHIBITOR; C TERMINUS; CONNECTING LOOPS; DIVALENT METALS; HETERODIMERS; HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE; HUMAN IMMUNODEFICIENCY VIRUS-REVERSE TRANSCRIPTASE; MUTANT ENZYMES; NATURAL PRODUCTS; NON-CATALYTIC; PROTEIN FOOTPRINTING; RNASE H; SUBDOMAIN;

AMINO ACIDS; DISEASES; MUTAGENESIS; UREA; VIRUSES; X RAY CRYSTALLOGRAPHY;

METABOLISM;

2 AMINO 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBOXAMIDE; 5,6 DIMETHYL 2 (4 NITROPHENYL)THIENO[2,3 D]PYRIMIDIN 4(3H)ONE; CYSTEINE; LYSINE; NSC 727447; PARATHION; PROTEIN P51; PROTEIN P66; RIBONUCLEASE H; THREONINE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ALLOSTERISM; ALPHA HELIX; AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG SENSITIVITY; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; MUTAGENESIS; MUTANT; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HIV-1; HUMANS; MUTAGENESIS; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASE H, HUMAN IMMUNODEFICIENCY VIRUS; THIOPHENES;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84863025474     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.314781     Document Type: Article

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